Aliases for SCGB2B2 Gene

Aliases for SCGB2B2 Gene

  • Secretoglobin Family 2B Member 2 2 3 4 5
  • SCGB4A2 2 3 4
  • Secretoglobin-Like Protein 3 4
  • SCGBL 3 4
  • Secretoglobin-Like 2
  • SCGB2B2 5

External Ids for SCGB2B2 Gene

Previous HGNC Symbols for SCGB2B2 Gene

  • SCGBL

Previous GeneCards Identifiers for SCGB2B2 Gene

  • GC19M035085

Summaries for SCGB2B2 Gene

GeneCards Summary for SCGB2B2 Gene

SCGB2B2 (Secretoglobin Family 2B Member 2) is a Protein Coding gene. Diseases associated with SCGB2B2 include Prolidase Deficiency and Chromosome 19Q13.11 Deletion Syndrome.

Additional gene information for SCGB2B2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCGB2B2 Gene

Genomics for SCGB2B2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SCGB2B2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCGB2B2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SCGB2B2

Genomic Locations for SCGB2B2 Gene

Genomic Locations for SCGB2B2 Gene
chr19:34,590,625-34,675,699
(GRCh38/hg38)
Size:
85,075 bases
Orientation:
Minus strand
chr19:35,084,234-35,166,604
(GRCh37/hg19)
Size:
82,371 bases
Orientation:
Minus strand

Genomic View for SCGB2B2 Gene

Genes around SCGB2B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB2B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB2B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB2B2 Gene

Proteins for SCGB2B2 Gene

  • Protein details for SCGB2B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G0G5-SC2B2_HUMAN
    Recommended name:
    Secretoglobin family 2B member 2
    Protein Accession:
    Q4G0G5

    Protein attributes for SCGB2B2 Gene

    Size:
    96 amino acids
    Molecular mass:
    10563 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCGB2B2 Gene

Post-translational modifications for SCGB2B2 Gene

No Post-translational modifications

Other Protein References for SCGB2B2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB2B2 Gene

Domains & Families for SCGB2B2 Gene

Gene Families for SCGB2B2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SCGB2B2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCGB2B2 Gene

GenScript: Design optimal peptide antigens:
  • Secretoglobin-like protein (SCGBL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q4G0G5

UniProtKB/Swiss-Prot:

SC2B2_HUMAN :
  • Belongs to the secretoglobin family.
Family:
  • Belongs to the secretoglobin family.
genes like me logo Genes that share domains with SCGB2B2: view

Function for SCGB2B2 Gene

Phenotypes From GWAS Catalog for SCGB2B2 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCGB2B2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCGB2B2 Gene

Localization for SCGB2B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB2B2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCGB2B2 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for SCGB2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SCGB2B2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCGB2B2 Gene

Pathways & Interactions for SCGB2B2 Gene

PathCards logo

SuperPathways for SCGB2B2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCGB2B2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCGB2B2 Gene

Drugs & Compounds for SCGB2B2 Gene

No Compound Related Data Available

Transcripts for SCGB2B2 Gene

mRNA/cDNA for SCGB2B2 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCGB2B2

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB2B2 Gene

No ASD Table

Relevant External Links for SCGB2B2 Gene

GeneLoc Exon Structure for
SCGB2B2

Expression for SCGB2B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCGB2B2 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB2B2 Gene

This gene is overexpressed in Testis (x4.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SCGB2B2

SOURCE GeneReport for Unigene cluster for SCGB2B2 Gene:

Hs.656990
genes like me logo Genes that share expression patterns with SCGB2B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCGB2B2 Gene

Orthologs for SCGB2B2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SCGB2B2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SCGBL 30
  • 96.47 (n)
SCGB2B2 31
  • 96 (a)
OneToOne
Species where no ortholog for SCGB2B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SCGB2B2 Gene

ENSEMBL:
Gene Tree for SCGB2B2 (if available)
TreeFam:
Gene Tree for SCGB2B2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCGB2B2: view image

Paralogs for SCGB2B2 Gene

Pseudogenes.org Pseudogenes for SCGB2B2 Gene

genes like me logo Genes that share paralogs with SCGB2B2: view

No data available for Paralogs for SCGB2B2 Gene

Variants for SCGB2B2 Gene

Additional dbSNP identifiers (rs#s) for SCGB2B2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SCGB2B2 Gene

Variant ID Type Subtype PubMed ID
esv2718486 CNV deletion 23290073
esv3329051 OTHER inversion 20981092
esv5547 OTHER inversion 19470904
nsv1071533 CNV deletion 25765185

Variation tolerance for SCGB2B2 Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCGB2B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCGB2B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SCGB2B2 Gene

Disorders for SCGB2B2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SCGB2B2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
prolidase deficiency
  • pd
chromosome 19q13.11 deletion syndrome
  • 19q13.11 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with SCGB2B2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB2B2 Gene

Publications for SCGB2B2 Gene

  1. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson BC … Vasiliou V (Human genomics 2011) 2 3
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for SCGB2B2 Gene

Sources for SCGB2B2 Gene