Aliases for SCGB2A2 Gene

Aliases for SCGB2A2 Gene

  • Secretoglobin Family 2A Member 2 2 3 4 5
  • UGB2 2 3 4
  • Prostatic Steroid Binding Protein 1 2 3
  • Mammaglobin 1 2 3
  • Mammaglobin-A 3 4
  • MGB1 3 4
  • Prostatic Steroid-Binding Protein 1 2
  • Mammaglobin A 2
  • Mammaglobin-1 4
  • MGC71974 2
  • SCGB2A2 5
  • PSBP1 3

External Ids for SCGB2A2 Gene

Previous HGNC Symbols for SCGB2A2 Gene

  • MGB1
  • PSBP1

Previous GeneCards Identifiers for SCGB2A2 Gene

  • GC11P064551
  • GC11P063613
  • GC11P062288
  • GC11P061812
  • GC11P061794
  • GC11P062038
  • GC11P058366

Summaries for SCGB2A2 Gene

GeneCards Summary for SCGB2A2 Gene

SCGB2A2 (Secretoglobin Family 2A Member 2) is a Protein Coding gene. Diseases associated with SCGB2A2 include Breast Cancer and Mammary Analogue Secretory Carcinoma. An important paralog of this gene is SCGB2A1.

Gene Wiki entry for SCGB2A2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCGB2A2 Gene

Genomics for SCGB2A2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SCGB2A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J062270 Promoter 0.4 EPDnew 250.7 +0.0 9 0.1 CTCF HSALNG0084590 SCGB2A2 SCGB2A1 SCGB1D4
GH11J062241 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 11.9 -28.0 -28030 1 ZNF217 ZIC2 ZNF341 SIN3A ZNF843 SMC3 TBP SMARCE1 FOXA1 MAZ SCGB1D2 SCGB2A1 NXF1 SNHG1 SCGB2A2 GANAB CPSF7 EML3 TMEM138 MTA2
GH11J062325 Enhancer 1 Ensembl ENCODE 11 +56.0 55970 3 CEBPA CTCF THAP11 SIN3A REST SMAD4 SMC3 TEAD3 YY1 SKIL ASRGL1 ENSG00000255126 SCGB1A1 SCGB2A2 SCGB2A1 LBHD1 lnc-SCGB1D4-5 lnc-SCGB1D4-4 SCGB1D4
GH11J062041 Enhancer 1.4 Ensembl ENCODE dbSUPER 5.8 -224.7 -224702 8.1 FEZF1 ZNF217 MNT IKZF1 HES1 MBD2 BRCA1 BHLHE40 NONO CEBPB HSALNG0084580 CSKMT CPSF7 SNHG1 GANAB LOC105369332 MTA2 TMEM138 TUT1 NXF1
GH11J062247 Enhancer 0.2 Ensembl 12.2 -22.3 -22329 0.4 SCGB2A2 ASRGL1 ENSG00000255126 SCGB1A1 MYRF-AS1 MYRF SCGB2A1 SCGB1D2 ENSG00000254404
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCGB2A2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SCGB2A2

Top Transcription factor binding sites by QIAGEN in the SCGB2A2 gene promoter:
  • aMEF-2
  • MEF-2A
  • p53
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • RSRFC4
  • Sox5

Genomic Locations for SCGB2A2 Gene

Latest Assembly
chr11:62,270,130-62,273,160
(GRCh38/hg38)
Size:
3,031 bases
Orientation:
Plus strand

Previous Assembly
chr11:62,037,630-62,040,632
(GRCh37/hg19 by Entrez Gene)
Size:
3,003 bases
Orientation:
Plus strand

chr11:62,037,627-62,040,628
(GRCh37/hg19 by Ensembl)
Size:
3,002 bases
Orientation:
Plus strand

Genomic View for SCGB2A2 Gene

Genes around SCGB2A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB2A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB2A2 Gene

Proteins for SCGB2A2 Gene

  • Protein details for SCGB2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13296-SG2A2_HUMAN
    Recommended name:
    Mammaglobin-A
    Protein Accession:
    Q13296
    Secondary Accessions:
    • A1A522
    • Q86WH8

    Protein attributes for SCGB2A2 Gene

    Size:
    93 amino acids
    Molecular mass:
    10499 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCGB2A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCGB2A2 Gene

Post-translational modifications for SCGB2A2 Gene

  • Glycosylation at Asn53 and Asn68
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SG2A2_HUMAN (1486)

Other Protein References for SCGB2A2 Gene

No data available for DME Specific Peptides for SCGB2A2 Gene

Domains & Families for SCGB2A2 Gene

Gene Families for SCGB2A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for SCGB2A2 Gene

InterPro:
Blocks:
  • Uteroglobin subtype
ProtoNet:

Suggested Antigen Peptide Sequences for SCGB2A2 Gene

GenScript: Design optimal peptide antigens:
  • Secretoglobin family 2A member 2 (SG2A2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13296

UniProtKB/Swiss-Prot:

SG2A2_HUMAN :
  • Belongs to the secretoglobin family. Lipophilin subfamily.
Family:
  • Belongs to the secretoglobin family. Lipophilin subfamily.
genes like me logo Genes that share domains with SCGB2A2: view

Function for SCGB2A2 Gene

Phenotypes From GWAS Catalog for SCGB2A2 Gene

Gene Ontology (GO) - Molecular Function for SCGB2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SCGB2A2: view
genes like me logo Genes that share phenotypes with SCGB2A2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCGB2A2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCGB2A2 Gene

Localization for SCGB2A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB2A2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCGB2A2 gene
Compartment Confidence
extracellular 4
plasma membrane 1
cytoskeleton 1
nucleus 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SCGB2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with SCGB2A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCGB2A2 Gene

Pathways & Interactions for SCGB2A2 Gene

PathCards logo

SuperPathways for SCGB2A2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCGB2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0030521 androgen receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with SCGB2A2: view

No data available for Pathways by source and SIGNOR curated interactions for SCGB2A2 Gene

Drugs & Compounds for SCGB2A2 Gene

(1) Drugs for SCGB2A2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SCGB2A2: view

Transcripts for SCGB2A2 Gene

mRNA/cDNA for SCGB2A2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCGB2A2

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB2A2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b
SP1: -
SP2: - -
SP3:

Relevant External Links for SCGB2A2 Gene

GeneLoc Exon Structure for
SCGB2A2

Expression for SCGB2A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCGB2A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCGB2A2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.5), Skin - Not Sun Exposed (Suprapubic) (x14.0), Breast - Mammary Tissue (x13.0), and Cervix - Endocervix (x6.5).

Protein differential expression in normal tissues from HIPED for SCGB2A2 Gene

This gene is overexpressed in Cervix (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCGB2A2 Gene



Protein tissue co-expression partners for SCGB2A2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SCGB2A2

SOURCE GeneReport for Unigene cluster for SCGB2A2 Gene:

Hs.46452

mRNA Expression by UniProt/SwissProt for SCGB2A2 Gene:

Q13296-SG2A2_HUMAN
Tissue specificity: Mammary gland specific. Over-expressed in breast cancer.

Evidence on tissue expression from TISSUES for SCGB2A2 Gene

  • Skin(2.9)
genes like me logo Genes that share expression patterns with SCGB2A2: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SCGB2A2 Gene

Orthologs for SCGB2A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB2A2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SCGB2A2 30 31
  • 98.57 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SCGB2A2 30
  • 67.78 (n)
Dog
(Canis familiaris)
Mammalia SCGB2A2 30
  • 67.38 (n)
-- 31
  • 51 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Gm2617 31
  • 35 (a)
ManyToMany
Species where no ortholog for SCGB2A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SCGB2A2 Gene

ENSEMBL:
Gene Tree for SCGB2A2 (if available)
TreeFam:
Gene Tree for SCGB2A2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCGB2A2: view image

Paralogs for SCGB2A2 Gene

Paralogs for SCGB2A2 Gene

(1) SIMAP similar genes for SCGB2A2 Gene using alignment to 2 proteins:

  • SG2A2_HUMAN
  • Q6NX70_HUMAN
genes like me logo Genes that share paralogs with SCGB2A2: view

Variants for SCGB2A2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SCGB2A2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SCGB2A2 Gene

Variant ID Type Subtype PubMed ID
esv33305 CNV loss 17666407

Variation tolerance for SCGB2A2 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCGB2A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCGB2A2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SCGB2A2 Gene

Disorders for SCGB2A2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SCGB2A2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
mammary analogue secretory carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SCGB2A2

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SCGB2A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB2A2 Gene

Publications for SCGB2A2 Gene

  1. Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13. (PMID: 9488047) Watson MA … Fleming TP (Oncogene 1998) 2 3 4
  2. Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer. (PMID: 8631025) Watson MA … Fleming TP (Cancer research 1996) 2 3 4
  3. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson BC … Vasiliou V (Human genomics 2011) 2 3
  4. Diagnostic utility of mammaglobin and GCDFP-15 in the identification of metastatic breast carcinoma in fluid specimens. (PMID: 19217055) Yan Z … Chhieng DC (Diagnostic cytopathology 2009) 3 23
  5. A small subgroup of operable breast cancer patients with poor prognosis identified by quantitative real-time RT-PCR detection of mammaglobin A and trefoil factor 1 mRNA expression in bone marrow. (PMID: 18846421) Tjensvoll K … Nordgård O (Breast cancer research and treatment 2009) 3 23

Products for SCGB2A2 Gene

Sources for SCGB2A2 Gene