Aliases for SCGB2A1 Gene

Aliases for SCGB2A1 Gene

  • Secretoglobin Family 2A Member 1 2 3 4 5
  • Lacryglobin 2 3 4
  • UGB3 2 3 4
  • Mammaglobin-B 3 4
  • Mammaglobin-2 3 4
  • Lipophilin C 2 3
  • LPHC 2 3
  • MGB2 3 4
  • Mammaglobin B 2
  • Mammaglobin 2 2
  • Lipophilin-C 4
  • MGC71973 2
  • SCGB2A1 5
  • LIPHC 4
  • LPNC 3

External Ids for SCGB2A1 Gene

Previous HGNC Symbols for SCGB2A1 Gene

  • MGB2

Previous GeneCards Identifiers for SCGB2A1 Gene

  • GC11P064489
  • GC11P063552
  • GC11P061751
  • GC11P061732
  • GC11P061976
  • GC11P058304

Summaries for SCGB2A1 Gene

GeneCards Summary for SCGB2A1 Gene

SCGB2A1 (Secretoglobin Family 2A Member 1) is a Protein Coding gene. Diseases associated with SCGB2A1 include Hypotrichosis 13 and Febrile Seizures, Familial, 4. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is SCGB2A2.

UniProtKB/Swiss-Prot Summary for SCGB2A1 Gene

  • May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

Gene Wiki entry for SCGB2A1 Gene

Additional gene information for SCGB2A1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCGB2A1 Gene

Genomics for SCGB2A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SCGB2A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J062208 Promoter 0.6 EPDnew 600.7 0.0 -19 0.1 PRDM10 ZNF512 FOXA1 ESR1 ZSCAN21 CTCF SCGB2A1 lnc-SCGB1D4-3 SCGB1D1
GH11J062241 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 16.3 +33.4 33392 0.9 CREB1 ZNF629 FOXA1 ZIC2 PATZ1 ZNF600 ZNF341 ZNF561 SCRT2 ZBTB20 SCGB1D2 SCGB2A1 NXF1 SNHG1 SCGB2A2 GANAB CPSF7 EML3 TMEM138 MTA2
GH11J062394 Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 5.7 +190.2 190191 8.8 CTCF PRDM10 LEF1 IKZF1 ZNF692 JUND DDX20 ZNF143 MTA2 RFX1 NXF1 CPSF7 CSKMT ASRGL1 GANAB SNHG1 EML3 RN7SL23P INTS5 STX5
GH11J062191 Enhancer 0.5 Ensembl 14.1 -13.4 -13372 1.8 CTCF PKNOX1 REST EHMT2 SAP130 CREM ATF1 RAD21 ZNF143 piR-40154-029 piR-40163-015 piR-49423-044 INCENP SCGB2A1 SCGB1D1
GH11J062380 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 5.4 +173.3 173279 2.9 GATAD2A CTCF RFX1 REST RAD21 TRIM22 ZNF600 ZNF561 SOX13 ZBTB44 piR-36887-008 ASRGL1 SCGB1A1 ENSG00000255446 ENSG00000250659 MTA2 ENSG00000257058 ENSG00000254964 AHNAK EML3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCGB2A1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SCGB2A1

Top Transcription factor binding sites by QIAGEN in the SCGB2A1 gene promoter:
  • aMEF-2
  • MEF-2A
  • TBP

Genomic Locations for SCGB2A1 Gene

Genomic Locations for SCGB2A1 Gene
chr11:62,208,673-62,213,943
(GRCh38/hg38)
Size:
5,271 bases
Orientation:
Plus strand
chr11:61,976,140-61,981,411
(GRCh37/hg19)
Size:
5,272 bases
Orientation:
Plus strand

Genomic View for SCGB2A1 Gene

Genes around SCGB2A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB2A1 Gene

Proteins for SCGB2A1 Gene

  • Protein details for SCGB2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75556-SG2A1_HUMAN
    Recommended name:
    Mammaglobin-B
    Protein Accession:
    O75556

    Protein attributes for SCGB2A1 Gene

    Size:
    95 amino acids
    Molecular mass:
    10884 Da
    Quaternary structure:
    • Heterodimer of a lipophilin A and a lipophilin C (mammaglobin B) monomer associated head to head.

neXtProt entry for SCGB2A1 Gene

Post-translational modifications for SCGB2A1 Gene

  • Glycosylation at Asn68
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SG2A1_HUMAN (1487)

Other Protein References for SCGB2A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

  • Signalway Proteins for SCGB2A1

No data available for DME Specific Peptides for SCGB2A1 Gene

Domains & Families for SCGB2A1 Gene

Gene Families for SCGB2A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for SCGB2A1 Gene

InterPro:
Blocks:
  • Uteroglobin subtype
ProtoNet:

Suggested Antigen Peptide Sequences for SCGB2A1 Gene

GenScript: Design optimal peptide antigens:
  • Secretoglobin family 2A member 1 (SG2A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75556

UniProtKB/Swiss-Prot:

SG2A1_HUMAN :
  • Belongs to the secretoglobin family. Lipophilin subfamily.
Family:
  • Belongs to the secretoglobin family. Lipophilin subfamily.
genes like me logo Genes that share domains with SCGB2A1: view

Function for SCGB2A1 Gene

Molecular function for SCGB2A1 Gene

UniProtKB/Swiss-Prot Function:
May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

Phenotypes From GWAS Catalog for SCGB2A1 Gene

Gene Ontology (GO) - Molecular Function for SCGB2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9720917
genes like me logo Genes that share ontologies with SCGB2A1: view
genes like me logo Genes that share phenotypes with SCGB2A1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCGB2A1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCGB2A1 Gene

Localization for SCGB2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB2A1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCGB2A1 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SCGB2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA,IDA 9720917
genes like me logo Genes that share ontologies with SCGB2A1: view

Pathways & Interactions for SCGB2A1 Gene

PathCards logo

SuperPathways for SCGB2A1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCGB2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030521 androgen receptor signaling pathway IBA,IDA 16020486
genes like me logo Genes that share ontologies with SCGB2A1: view

No data available for Pathways by source and SIGNOR curated interactions for SCGB2A1 Gene

Drugs & Compounds for SCGB2A1 Gene

No Compound Related Data Available

Transcripts for SCGB2A1 Gene

mRNA/cDNA for SCGB2A1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCGB2A1

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB2A1 Gene

No ASD Table

Relevant External Links for SCGB2A1 Gene

GeneLoc Exon Structure for
SCGB2A1

Expression for SCGB2A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCGB2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Uterus (Reproductive System)
  • Eye (Sensory Organs)

mRNA differential expression in normal tissues according to GTEx for SCGB2A1 Gene

This gene is overexpressed in Cervix - Endocervix (x27.0), Uterus (x7.7), and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for SCGB2A1 Gene

This gene is overexpressed in Cervix (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCGB2A1 Gene



Protein tissue co-expression partners for SCGB2A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SCGB2A1

SOURCE GeneReport for Unigene cluster for SCGB2A1 Gene:

Hs.97644

mRNA Expression by UniProt/SwissProt for SCGB2A1 Gene:

O75556-SG2A1_HUMAN
Tissue specificity: Expressed in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.

Evidence on tissue expression from TISSUES for SCGB2A1 Gene

  • Thyroid gland(4.3)
  • Intestine(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with SCGB2A1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SCGB2A1 Gene

Orthologs for SCGB2A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB2A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SCGB2A1 30 31
  • 99.18 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 46 (a)
ManyToMany
-- 31
  • 43 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia SCGB2A2 31
  • 46 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Scgb2a2 31
  • 34 (a)
OneToMany
Species where no ortholog for SCGB2A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SCGB2A1 Gene

ENSEMBL:
Gene Tree for SCGB2A1 (if available)
TreeFam:
Gene Tree for SCGB2A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCGB2A1: view image

Paralogs for SCGB2A1 Gene

Paralogs for SCGB2A1 Gene

(1) SIMAP similar genes for SCGB2A1 Gene using alignment to 1 proteins:

  • SG2A1_HUMAN
genes like me logo Genes that share paralogs with SCGB2A1: view

Variants for SCGB2A1 Gene

Additional dbSNP identifiers (rs#s) for SCGB2A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SCGB2A1 Gene

Variant ID Type Subtype PubMed ID
nsv1035554 CNV gain 25217958
nsv1113397 CNV deletion 24896259

Variation tolerance for SCGB2A1 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCGB2A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCGB2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SCGB2A1 Gene

Disorders for SCGB2A1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SCGB2A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypotrichosis 13
  • hypt13
febrile seizures, familial, 4
  • feb4
hypotrichosis 7
  • hypt7
ovarian cancer
  • ovarian cancer, somatic
familial febrile seizures
  • familial febrile convulsions
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with SCGB2A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB2A1 Gene

Publications for SCGB2A1 Gene

  1. Identification of mammaglobin B, a novel member of the uteroglobin gene family. (PMID: 9806831) Becker RM … Fleming TP (Genomics 1998) 2 3 4 23
  2. Lipophilins: human peptides homologous to rat prostatein. (PMID: 10066439) Zhao C … Lehrer RI (Biochemical and biophysical research communications 1999) 3 4 23
  3. Lipophilin, a novel heterodimeric protein of human tears. (PMID: 9720917) Lehrer RI … Glasgow BJ (FEBS letters 1998) 3 4 23
  4. Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value. (PMID: 9504814) Molloy MP … Walsh BJ (Electrophoresis 1997) 3 4 23
  5. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson BC … Vasiliou V (Human genomics 2011) 2 3

Products for SCGB2A1 Gene

  • Signalway Proteins for SCGB2A1

Sources for SCGB2A1 Gene