Aliases for SCGB1D4 Gene
Aliases for SCGB1D4 Gene
External Ids for SCGB1D4 Gene
- HGNC: 31748
- Entrez Gene: 404552
- Ensembl: ENSG00000197745
- OMIM: 615062
- UniProtKB: Q6XE38
Previous GeneCards Identifiers for SCGB1D4 Gene
- GC00U916714
- GC11M061820
- GC11M062063
- GC11M058392
Summaries for SCGB1D4 Gene
GeneCards Summary for SCGB1D4 Gene
SCGB1D4 (Secretoglobin Family 1D Member 4) is a Protein Coding gene. An important paralog of this gene is SCGB1D2.
UniProtKB/Swiss-Prot for SCGB1D4 Gene
-
Seems to be involved in the regulation of chemotactic cell migration and invasion.
Additional gene information for SCGB1D4 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB1D4 Gene
Genomics for SCGB1D4 Gene
GeneHancer (GH) Regulatory Elements for SCGB1D4 Gene
Promoters and enhancers for SCGB1D4 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11I062299 | Promoter | 0.5 | EPDnew | 550.8 | 0.0 | -31 | 0.1 | SCGB1D4 NPM1P35 | ||
| GH11I062311 | Enhancer | 1 | Ensembl ENCODE | 0.4 | -12.4 | -12444 | 1 | RB1 KLF17 SIN3A ZNF2 IRF4 ZNF48 RAD21 RARA GLIS2 ARID2 | ASRGL1 SCGB2A1 SCGB1D4 NPM1P35 | |
| GH11I062325 | Enhancer | 0.8 | ENCODE | 0.3 | -26.0 | -26020 | 0.2 | CTCF ATF1 RB1 ARID4B MAX SIN3A CEBPG ZNF644 RAD21 TEAD3 | SCGB2A2 NPM1P35 SCGB1D4 | |
| GH11I062270 | Promoter | 0.6 | EPDnew | 0.3 | +28.9 | 28925 | 0.1 | CTCF | SCGB2A2 SCGB2A1 SCGB1D4 | |
| GH11I062322 | Enhancer | 0.2 | ENCODE | 0.3 | -23.7 | -23670 | 0.8 | ENSG00000255126 SCGB1A1 ASRGL1 NPM1P35 SCGB1D4 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SCGB1D4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SCGB1D4 gene promoter:
Regulatory Element Products
Genomic Locations for SCGB1D4 Gene
Genomic Locations for SCGB1D4 Gene
- chr11:62,296,277-62,299,064
- (GRCh38/hg38)
- Size:
- 2,788 bases
- Orientation:
- Minus strand
- chr11:62,063,754-62,066,536
- (GRCh37/hg19)
Genomic View for SCGB1D4 Gene
Genes around SCGB1D4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.3 by Ensembl
- 11q12.3 by Entrez Gene
- 11q12.3 by HGNC
SCGB1D4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SCGB1D4 Gene
Proteins for SCGB1D4 Gene
-
Protein details for SCGB1D4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6XE38-SG1D4_HUMAN
- Recommended name:
- Secretoglobin family 1D member 4
- Protein Accession:
- Q6XE38
- A1L4Q8
Protein attributes for SCGB1D4 Gene
- Size:
- 83 amino acids
- Molecular mass:
- 9201 Da
- Quaternary structure:
- No Data Available
Protein Expression for SCGB1D4 Gene
Post-translational modifications for SCGB1D4 Gene
No Post-translational modifications
Other Protein References for SCGB1D4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for SCGB1D4
Protein Products
-
OriGene Purified Proteins for SCGB1D4
- Search Origene for MassSpec and Protein Over-expression Lysates for SCGB1D4
- Origene Custom Protein Services for SCGB1D4
- Search GeneTex for Proteins for SCGB1D4
Assay Products
No data available for DME Specific Peptides for SCGB1D4 Gene
Domains & Families for SCGB1D4 Gene
Gene Families for SCGB1D4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for SCGB1D4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SCGB1D4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6XE38- Family:
-
- Belongs to the secretoglobin family. Lipophilin subfamily.
Function for SCGB1D4 Gene
Molecular function for SCGB1D4 Gene
- UniProtKB/Swiss-Prot Function:
- Seems to be involved in the regulation of chemotactic cell migration and invasion.
- UniProtKB/Swiss-Prot Induction:
- By IFNG/IFN-gamma.
Phenotypes From GWAS Catalog for SCGB1D4 Gene
Phenotypes for SCGB1D4 Gene
- GenomeRNAi human phenotypes for SCGB1D4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SCGB1D4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SCGB1D4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SCGB1D4 gene
- Search ViGene Biosciences for SCGB1D4
CRISPR Products
-
OriGene CRISPR knockouts for SCGB1D4
- genomics-online: gRNA clones - Search results for available SCGB1D4 gene related products
- Applied Biological Materials CRISPR for SCGB1D4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SCGB1D4
miRNA Products
- Search ViGene Biosciences for SCGB1D4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SCGB1D4
- Browse OriGene Inhibitory RNA Products For SCGB1D4
- genomics-online: shRNA clones - Search results for available SCGB1D4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SCGB1D4 gene
Clone Products
- Sino Biological Human cDNA Clone for SCGB1D4
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- VectorBuilder custom plasmid, inducible vectors for SCGB1D4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SCGB1D4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SCGB1D4 gene related products
- orf clones - Search results for available SCGB1D4 gene related products
- Applied Biological Materials Clones for SCGB1D4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SCGB1D4
-
ViGene Biosciences adenoviral particle packaged cDNA for SCGB1D4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SCGB1D4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SCGB1D4 gene
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCGB1D4 Gene
Localization for SCGB1D4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SCGB1D4 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCGB1D4 Gene
Transcripts for SCGB1D4 Gene
mRNA/cDNA for SCGB1D4 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SCGB1D4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SCGB1D4
- genomics-online: gRNA clones - Search results for available SCGB1D4 gene related products
- Applied Biological Materials CRISPR for SCGB1D4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SCGB1D4
miRNA Products
- Search ViGene Biosciences for SCGB1D4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SCGB1D4
- Browse OriGene Inhibitory RNA Products For SCGB1D4
- genomics-online: shRNA clones - Search results for available SCGB1D4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SCGB1D4 gene
Clone Products
- Sino Biological Human cDNA Clone for SCGB1D4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SCGB1D4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SCGB1D4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SCGB1D4 gene related products
- orf clones - Search results for available SCGB1D4 gene related products
- Applied Biological Materials Clones for SCGB1D4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SCGB1D4 Gene
mRNA differential expression in normal tissues according to GTEx for SCGB1D4 Gene
This gene is overexpressed in Cervix - Endocervix (x22.6), Fallopian Tube (x17.0), and Uterus (x9.9).
This gene is overexpressed in Platelet (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCGB1D4 Gene
NURSA nuclear receptor signaling pathways regulating expression of SCGB1D4 Gene:
SCGB1D4SOURCE GeneReport for Unigene cluster for SCGB1D4 Gene:
Hs.473247mRNA Expression by UniProt/SwissProt for SCGB1D4 Gene:
Q6XE38-SG1D4_HUMAN
Tissue specificity:
Expressed in all tissues; the highest level of expression is detectable in lymph nodes, tonsil, cultured lymphoblasts and ovary.
Evidence on tissue expression from TISSUES for SCGB1D4 Gene
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs for SCGB1D4
- genomics-online: primer clones - Search results for available SCGB1D4 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCGB1D4 Gene
Orthologs for SCGB1D4 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SCGB1D4 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SCGB1D 34 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany |
- Species where no ortholog for SCGB1D4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for SCGB1D4 Gene
(2) SIMAP similar genes for SCGB1D4 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for SCGB1D4 Gene
Variants for SCGB1D4 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000450885 | -- | 62,299,530(-) | AAA/AA | upstream_transcript_variant | |
| rs1000592393 | -- | 62,297,411(-) | T/G | intron_variant | |
| rs1001171455 | -- | 62,297,826(-) | A/G | intron_variant | |
| rs1001271993 | -- | 62,299,122(-) | G/C | upstream_transcript_variant | |
| rs1002096912 | -- | 62,297,754(-) | T/C | intron_variant |
Residual Variation Intolerance Score:
59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.59;
12.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SCGB1D4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SCGB1D4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCGB1D4 Gene
Disorders for SCGB1D4 Gene
Additional Disease Information for SCGB1D4
No disorders were found for SCGB1D4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCGB1D4 Gene
Publications for SCGB1D4 Gene
- IFN-gamma stimulates the expression of a novel secretoglobin that regulates chemotactic cell migration and invasion. (PMID: 15034037) Choi MS … Mukherjee AB (Journal of immunology (Baltimore, Md. : 1950) 2004) 2 3 4 22 58
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 2 3 4 58
- Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson BC … Vasiliou V (Human genomics 2011) 2 3 58
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for SCGB1D4 Gene
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- OriGene Purified Proteins for SCGB1D4
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- OriGene qPCR primer pairs for SCGB1D4
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- VectorBuilder custom plasmid, inducible vectors for SCGB1D4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SCGB1D4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for SCGB1D4
- Search GeneTex for Proteins for SCGB1D4
- ViGene Biosciences adenoviral particle packaged cDNA for SCGB1D4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SCGB1D4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SCGB1D4 gene
- Search ViGene Biosciences for SCGB1D4
- Horizon Cell Lines for SCGB1D4
- genomics-online: cdna clones - Search results for available SCGB1D4 gene related products
- orf clones - Search results for available SCGB1D4 gene related products
- genomics-online: gRNA clones - Search results for available SCGB1D4 gene related products
- genomics-online: primer clones - Search results for available SCGB1D4 gene related products
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Sources for SCGB1D4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew