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The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008]
SCGB1D2 (Secretoglobin Family 1D Member 2) is a Protein Coding gene. Diseases associated with SCGB1D2 include Breast Cancer. An important paralog of this gene is SCGB1D1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J062241 | Promoter/Enhancer | 1.3 | EPDnew Ensembl ENCODE | 250.7 | -0.1 | -139 | 1 | ZNF217 ZIC2 ZNF341 SIN3A ZNF843 SMC3 TBP SMARCE1 FOXA1 MAZ | SCGB1D2 SCGB2A1 NXF1 SNHG1 SCGB2A2 GANAB CPSF7 EML3 TMEM138 MTA2 | |
GH11J062259 | Enhancer | 0.9 | Ensembl | 0.4 | +18.4 | 18362 | 0.8 | CEBPA FOXA1 HOMEZ KDM6A THAP11 ZNF511 FOXA2 SMAD4 SAP130 MIER3 | ENSG00000254404 TTC9C DAGLA SCGB2A2 SCGB1D2 | |
GH11J062264 | Enhancer | 0.3 | Ensembl | 0.3 | +22.3 | 22262 | 1.4 | REST HLF | SCGB2A1 ENSG00000254404 HSALNG0084590 SCGB2A2 SCGB1D2 | |
GH11J062247 | Enhancer | 0.2 | Ensembl | 0.4 | +5.6 | 5562 | 0.4 | SCGB2A2 ASRGL1 ENSG00000255126 SCGB1A1 MYRF-AS1 MYRF SCGB2A1 SCGB1D2 ENSG00000254404 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | TAS,IBA | 21873635 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SCGB1D2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SCGB1D 30 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
breast cancer |
|
|