Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]
SCGB1A1 (Secretoglobin Family 1A Member 1) is a Protein Coding gene. Diseases associated with SCGB1A1 include Bronchopulmonary Dysplasia and Bronchiolitis Obliterans. Among its related pathways are Prostaglandin Synthesis and Regulation and FOXA1 transcription factor network. Gene Ontology (GO) annotations related to this gene include binding and phospholipase A2 inhibitor activity. An important paralog of this gene is SCGB1C2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 16423471 |
GO:0019834 | phospholipase A2 inhibitor activity | IEA | -- |
GO:0097160 | polychlorinated biphenyl binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IEA,IDA | 21805676 |
GO:0005635 | nuclear envelope | IEA | -- |
GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
GO:0005783 | endoplasmic reticulum | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | FOXA1 transcription factor network | ||
2 | Prostaglandin Synthesis and Regulation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0007165 | signal transduction | NAS,IEA | -- |
GO:0007565 | female pregnancy | NAS | 10587371 |
GO:0007566 | embryo implantation | TAS | 10587371 |
GO:0009410 | response to xenobiotic stimulus | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
CE(22:0) |
|
61510-09-6 |
|
|||
PC(18:1(9Z)e/2:0) |
|
|
||||
PC(20:2(11Z,14Z)/18:1(11Z)) |
|
|
||||
PC(22:4(7Z,10Z,13Z,16Z)/18:1(11Z)) |
|
2461-62-3 |
|
|||
Phosphatidylcholines Group A |
|
4235-95-4, 18194-24-6, 92345-33-0, 944466-40-4, 253127-60-5, 203393-41-3, 85046-19-1, 56421-10-4, 53595-24-7, 27098-24-4, 59403-51-9, 85082-02-6, 26853-31-6, 17708-90-6, 203393-39-9, 35418-59-8, 17041-44-0, 35418-58-7, 2701-19-1, 1191905-21-1, 85082-03-7, 324054-21-9, 182820-31-1 |
|
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SCGB1A1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SCGB1A1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Scgb1a1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Scgb1a1 30 |
|
||
Cow (Bos Taurus) |
Mammalia | SCGB1A1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SCGB1A1 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs202225101 | Likely Benign: not provided | 62,422,240(+) |
G/A NM_003357.5(SCGB1A1):c.75G>A (p.Pro25=) |
SYNONYMOUS | |
rs41364547 | Uncertain Significance: Asthma, susceptibility to | 62,419,058(+) |
G/. NM_003357.5(SCGB1A1):c.-38= |
NO_SEQUENCE_ALTERATION | |
rs41465250 | Benign: not provided | 62,422,264(+) |
C/T NM_003357.5(SCGB1A1):c.99C>T (p.Thr33=) |
SYNONYMOUS | |
rs1802632 | - |
p.Thr68Ala |
|||
rs1802634 | - |
p.Arg56Gly |
Disorder | Aliases | PubMed IDs |
---|---|---|
bronchopulmonary dysplasia |
|
|
bronchiolitis obliterans |
|
|
silicosis |
|
|
asthma |
|
|
paraquat lung |
|
|