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This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]
SCGB1A1 (Secretoglobin Family 1A Member 1) is a Protein Coding gene. Diseases associated with SCGB1A1 include Bronchopulmonary Dysplasia and Paraquat Lung. Among its related pathways are FOXA1 transcription factor network and Prostaglandin Synthesis and Regulation. Gene Ontology (GO) annotations related to this gene include binding and phospholipase A2 inhibitor activity. An important paralog of this gene is SCGB1C2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 18243143 |
GO:0019834 | phospholipase A2 inhibitor activity | IEA | -- |
GO:0097160 | polychlorinated biphenyl binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IDA,IEA | 21805676 |
GO:0005635 | nuclear envelope | IEA | -- |
GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
GO:0005783 | endoplasmic reticulum | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | FOXA1 transcription factor network | ||
2 | Prostaglandin Synthesis and Regulation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0007165 | signal transduction | IEA,NAS | -- |
GO:0007565 | female pregnancy | NAS | 10587371 |
GO:0007566 | embryo implantation | TAS | 10587371 |
GO:0009410 | response to xenobiotic stimulus | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
PC(18:1(9Z)e/2:0) |
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Phosphatidylcholines Group A |
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68737-67-7 |
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Phosphatidylcholines Group B |
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88542-95-4 |
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This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SCGB1A1 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | SCGB1A1 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Scgb1a1 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Scgb1a1 32 |
|
||
cow (Bos Taurus) |
Mammalia | SCGB1A1 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | SCGB1A1 33 |
|
OneToOne |
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs41364547 | uncertain-significance, Asthma, susceptibility to | 62,419,058(+) | G/A | 5_prime_UTR_variant | |
rs1000177743 | -- | 62,423,154(+) | G/A | 3_prime_UTR_variant | |
rs1000862508 | -- | 62,422,917(+) | C/T | intron_variant | |
rs1000947752 | -- | 62,418,708(+) | C/T | upstream_transcript_variant | |
rs1001496405 | -- | 62,417,600(+) | T/A | upstream_transcript_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
bronchopulmonary dysplasia |
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paraquat lung |
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bronchiolitis obliterans |
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silicosis |
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meconium aspiration syndrome |
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