SCGB1A1 Gene (Protein Coding)

Secretoglobin Family 1A Member 1

GC11P062405
GIFtS:
41
This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010] See more...

Aliases for SCGB1A1 Gene

Aliases for SCGB1A1 Gene

  • Secretoglobin Family 1A Member 1 2 3 4 5
  • Uteroglobin 2 3 4
  • CC10 2 3 4
  • CCSP 2 3 4
  • Clara Cell Phospholipid-Binding Protein 3 4
  • Clara Cells 10 KDa Secretory Protein 3 4
  • Urinary Protein 1 3 4
  • Urine Protein 1 3 4
  • CCPBP 3 4
  • CC16 2 3
  • UP-1 3 4
  • UGB 3 4
  • UP1 3 4
  • Secretoglobin, Family 1A, Member 1 (Uteroglobin) 3
  • Uteroglobin (Clara-Cell Specific 10-KD Protein) 2
  • Blastokinin 3
  • SCGB1A1 5

External Ids for SCGB1A1 Gene

Previous HGNC Symbols for SCGB1A1 Gene

  • UGB

Previous GeneCards Identifiers for SCGB1A1 Gene

  • GC11P064700
  • GC11P063762
  • GC11P062437
  • GC11P061961
  • GC11P061943
  • GC11P062188
  • GC11P058514

Summaries for SCGB1A1 Gene

Entrez Gene Summary for SCGB1A1 Gene

  • This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]

GeneCards Summary for SCGB1A1 Gene

SCGB1A1 (Secretoglobin Family 1A Member 1) is a Protein Coding gene. Diseases associated with SCGB1A1 include Bronchopulmonary Dysplasia and Bronchiolitis Obliterans. Among its related pathways are Prostaglandin Synthesis and Regulation and FOXA1 transcription factor network. Gene Ontology (GO) annotations related to this gene include binding and phospholipase A2 inhibitor activity. An important paralog of this gene is SCGB1C2.

UniProtKB/Swiss-Prot Summary for SCGB1A1 Gene

  • Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

Gene Wiki entry for SCGB1A1 Gene

Additional gene information for SCGB1A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCGB1A1 Gene

Genomics for SCGB1A1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SCGB1A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCGB1A1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SCGB1A1

Top Transcription factor binding sites by QIAGEN in the SCGB1A1 gene promoter:
  • AML1a
  • FOXF2
  • GATA-3
  • LyF-1
  • Nkx6-1
  • POU2F1
  • POU2F1a
  • RP58
  • SRF
  • SRF (504 AA)

Genomic Locations for SCGB1A1 Gene

Latest Assembly
chr11:62,405,103-62,423,195
(GRCh38/hg38)
Size:
18,093 bases
Orientation:
Plus strand

Previous Assembly
chr11:62,186,505-62,190,667
(GRCh37/hg19 by Entrez Gene)
Size:
4,163 bases
Orientation:
Plus strand

chr11:62,172,575-62,190,667
(GRCh37/hg19 by Ensembl)
Size:
18,093 bases
Orientation:
Plus strand

Genomic View for SCGB1A1 Gene

Genes around SCGB1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB1A1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SCGB1A1 Gene

Proteins for SCGB1A1 Gene

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  3. Assay products for research

  • Protein details for SCGB1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11684-UTER_HUMAN
    Recommended name:
    Uteroglobin
    Protein Accession:
    P11684
    Secondary Accessions:
    • B2R5F2
    • Q6FHH3
    • Q9UCM2
    • Q9UCM4

    Protein attributes for SCGB1A1 Gene

    Size:
    91 amino acids
    Molecular mass:
    9994 Da
    Quaternary structure:
    • Antiparallel homodimer; disulfide-linked (PubMed:7664082). Interaction with LMBR1L has been observed in PubMed:16423471, but not in PubMed:23964685 (PubMed:16423471, PubMed:23964685).

neXtProt entry for SCGB1A1 Gene

Protein Expression for SCGB1A1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SCGB1A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCGB1A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for SCGB1A1 Gene

Domains & Families for SCGB1A1 Gene

Gene Families for SCGB1A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SCGB1A1 Gene

InterPro:
Blocks:
  • Uteroglobin subtype
ProtoNet:

Suggested Antigen Peptide Sequences for SCGB1A1 Gene

GenScript: Design optimal peptide antigens:
  • Urinary protein 1 (UTER_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P11684

UniProtKB/Swiss-Prot:

UTER_HUMAN :
  • Belongs to the secretoglobin family.
Family:
  • Belongs to the secretoglobin family.
genes like me logo Genes that share domains with SCGB1A1: view

Function for SCGB1A1 Gene

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  6. Cell Lines for research

Molecular function for SCGB1A1 Gene

UniProtKB/Swiss-Prot Function:
Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

Phenotypes From GWAS Catalog for SCGB1A1 Gene

Gene Ontology (GO) - Molecular Function for SCGB1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16423471
GO:0019834 phospholipase A2 inhibitor activity IEA --
GO:0097160 polychlorinated biphenyl binding IEA --
genes like me logo Genes that share ontologies with SCGB1A1: view
genes like me logo Genes that share phenotypes with SCGB1A1: view

Animal Models for SCGB1A1 Gene

MGI Knock Outs for SCGB1A1:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCGB1A1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SCGB1A1 Gene

Localization for SCGB1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB1A1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCGB1A1 gene
Compartment Confidence
extracellular 5
nucleus 3
endoplasmic reticulum 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SCGB1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IDA 21805676
GO:0005635 nuclear envelope IEA --
GO:0005737 cytoplasm IEA,IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with SCGB1A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCGB1A1 Gene

Pathways & Interactions for SCGB1A1 Gene

genes like me logo Genes that share pathways with SCGB1A1: view

Pathways by source for SCGB1A1 Gene

Gene Ontology (GO) - Biological Process for SCGB1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0007165 signal transduction NAS,IEA --
GO:0007565 female pregnancy NAS 10587371
GO:0007566 embryo implantation TAS 10587371
GO:0009410 response to xenobiotic stimulus IEA --
genes like me logo Genes that share ontologies with SCGB1A1: view

No data available for SIGNOR curated interactions for SCGB1A1 Gene

Drugs & Compounds for SCGB1A1 Gene

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(20) Drugs for SCGB1A1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL Experimental Pharma Target 0
L-Dilinoleoyllecithin Experimental Pharma 0

(16) Additional Compounds for SCGB1A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CE(22:0)
  • 1-Tetradecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine
  • GPCho(14:0/18:0)
  • Phosphatidylcholine(14:0/18:0)
  • 1-Myristoyl-2-stearoylphosphatidylcholine
  • 1m-2S-PC
 61510-09-6
PC(18:1(9Z)e/2:0)
  • (2-Acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
PC(20:2(11Z,14Z)/18:1(11Z))
  • Phosphatidylcholine(20:2/18:1)
  • GPCho(20:2/18:1)
  • Phosphatidylcholine(38:3)
  • PC(38:3)
  • Lecithin
PC(22:4(7Z,10Z,13Z,16Z)/18:1(11Z))
  • PC(22:4/18:1)
  • Phosphatidylcholine(22:4/18:1)
  • Phosphatidylcholine(40:5)
  • 1-Adrenoyl-2-vaccenoyl-sn-glycero-3-phosphocholine
  • GPCho(40:5)
 2461-62-3
Phosphatidylcholines Group A
  • (R-(Z,Z))-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • 1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
  • 1,2-Dioleoyl-L-alpha-lecithin
  • 1-(9Z)-Octadecenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine
  • 1-C18:1(Omega-9)-2-C18:1(omega-9)-phosphatidylcholine
 4235-95-4, 18194-24-6, 92345-33-0, 944466-40-4, 253127-60-5, 203393-41-3, 85046-19-1, 56421-10-4, 53595-24-7, 27098-24-4, 59403-51-9, 85082-02-6, 26853-31-6, 17708-90-6, 203393-39-9, 35418-59-8, 17041-44-0, 35418-58-7, 2701-19-1, 1191905-21-1, 85082-03-7, 324054-21-9, 182820-31-1
genes like me logo Genes that share compounds with SCGB1A1: view

Transcripts for SCGB1A1 Gene

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mRNA/cDNA for SCGB1A1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCGB1A1

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB1A1 Gene

No ASD Table

Relevant External Links for SCGB1A1 Gene

GeneLoc Exon Structure for
SCGB1A1

Expression for SCGB1A1 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCGB1A1 Gene

mRNA expression in normal human tissues for SCGB1A1 Gene
mRNA expression by GTEx for SCGB1A1 GenemRNA expression by BioGPS for SCGB1A1 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB1A1 Gene

This gene is overexpressed in Lung (x49.8).

Protein differential expression in normal tissues from HIPED for SCGB1A1 Gene

This gene is overexpressed in Urine (30.9), Nasal epithelium (22.2), and Neutrophil (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SCGB1A1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SCGB1A1

SOURCE GeneReport for Unigene cluster for SCGB1A1 Gene:

Hs.523732

mRNA Expression by UniProt/SwissProt for SCGB1A1 Gene:

P11684-UTER_HUMAN
Tissue specificity: Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

Evidence on tissue expression from TISSUES for SCGB1A1 Gene

  • Lung(4.9)
  • Urine(4.4)
  • Pancreas(4.2)
  • Blood(2.2)
  • Intestine(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with SCGB1A1: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCGB1A1 Gene

Orthologs for SCGB1A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB1A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SCGB1A1 30 31
  • 98.53 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SCGB1A1 30 31
  • 75.93 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Scgb1a1 30 17 31
  • 70.74 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Scgb1a1 30
  • 70 (n)
Cow
(Bos Taurus)
 Mammalia SCGB1A1 31
  • 53 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia SCGB1A1 31
  • 34 (a)
 OneToOne
Species where no ortholog for SCGB1A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SCGB1A1 Gene

ENSEMBL:
Gene Tree for SCGB1A1 (if available)
TreeFam:
Gene Tree for SCGB1A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCGB1A1: view image

Paralogs for SCGB1A1 Gene

Paralogs for SCGB1A1 Gene

(1) SIMAP similar genes for SCGB1A1 Gene using alignment to 2 proteins:

  • UTER_HUMAN
  • E9PN95_HUMAN
genes like me logo Genes that share paralogs with SCGB1A1: view

Variants for SCGB1A1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SCGB1A1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs202225101 Likely Benign: not provided 62,422,240(+) G/A
NM_003357.5(SCGB1A1):c.75G>A (p.Pro25=) 		SYNONYMOUS
rs41364547 Uncertain Significance: Asthma, susceptibility to 62,419,058(+) G/.
NM_003357.5(SCGB1A1):c.-38= 		NO_SEQUENCE_ALTERATION
rs41465250 Benign: not provided 62,422,264(+) C/T
NM_003357.5(SCGB1A1):c.99C>T (p.Thr33=) 		SYNONYMOUS
rs1802632 - p.Thr68Ala
rs1802634 - p.Arg56Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SCGB1A1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for SCGB1A1 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCGB1A1 Gene

Human Gene Mutation Database (HGMD)
SCGB1A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCGB1A1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCGB1A1 Gene

Disorders for SCGB1A1 Gene

MalaCards: The human disease database

(37) MalaCards diseases for SCGB1A1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
bronchopulmonary dysplasia
  • bpd
bronchiolitis obliterans
  • bronchiolitis exudativa
silicosis
  • pneumoconiosis due to silicates
asthma
  • asthma, susceptibility to
paraquat lung
  • paraquat induced lung disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SCGB1A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SCGB1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB1A1 Gene

Publications for SCGB1A1 Gene

  1. Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines. (PMID: 1284526) Wolf M … Suske G (Human molecular genetics 1992) 2 3 4 23
  2. Cross-sectional and longitudinal association of the secretoglobin 1A1 gene A38G polymorphism with asthma phenotype in the Perth Infant Asthma Follow-up cohort. (PMID: 19128353) Laing IA … Perth Infant Asthma Follow-up Cohort (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009) 3 23 41
  3. Opposite gene by environment interactions in Karelia for CD14 and CC16 single nucleotide polymorphisms and allergy. (PMID: 19222419) Zhang G … Le Souëf PN (Allergy 2009) 3 23 41
  4. Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study. (PMID: 17716718) Yang KD … Huang SK (The Journal of allergy and clinical immunology 2007) 3 23 41
  5. No association between the Clara cell secretory protein (CC16) gene polymorphism and personality traits. (PMID: 16764982) Tochigi M … Sasaki T (Progress in neuro-psychopharmacology & biological psychiatry 2006) 3 23 41

ExternalLinks

View latest publications for SCGB1A1 gene in Mastermind

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Sources for SCGB1A1 Gene