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Aliases for SCGB1A1 Gene

Aliases for SCGB1A1 Gene

  • Secretoglobin Family 1A Member 1 2 3 4 5
  • Clara Cell Phospholipid-Binding Protein 3 4
  • Clara Cells 10 KDa Secretory Protein 3 4
  • Urinary Protein 1 3 4
  • Urine Protein 1 3 4
  • Uteroglobin 2 3
  • CCPBP 3 4
  • CC10 3 4
  • CCSP 3 4
  • UP-1 3 4
  • UGB 3 4
  • UP1 3 4
  • Secretoglobin, Family 1A, Member 1 (Uteroglobin) 3
  • Uteroglobin (Clara-Cell Specific 10-KD Protein) 2
  • Blastokinin 3
  • CC16 3

External Ids for SCGB1A1 Gene

Previous HGNC Symbols for SCGB1A1 Gene

  • UGB

Previous GeneCards Identifiers for SCGB1A1 Gene

  • GC11P064700
  • GC11P063762
  • GC11P061961
  • GC11P061943
  • GC11P062188
  • GC11P058514

Summaries for SCGB1A1 Gene

Entrez Gene Summary for SCGB1A1 Gene

  • This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]

GeneCards Summary for SCGB1A1 Gene

SCGB1A1 (Secretoglobin Family 1A Member 1) is a Protein Coding gene. Diseases associated with SCGB1A1 include Bronchopulmonary Dysplasia and Newborn Respiratory Distress Syndrome. Among its related pathways are Prostaglandin Synthesis and Regulation and FOXA1 transcription factor network. Gene Ontology (GO) annotations related to this gene include binding and phospholipase A2 inhibitor activity.

UniProtKB/Swiss-Prot for SCGB1A1 Gene

  • Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

Gene Wiki entry for SCGB1A1 Gene

Additional gene information for SCGB1A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB1A1 Gene

Genomics for SCGB1A1 Gene

GeneHancer (GH) Regulatory Elements for SCGB1A1 Gene

Promoters and enhancers for SCGB1A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I062417 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 550.4 +13.4 13383 1.1 L3MBTL2 SOX6 NCOA1 CBFA2T3 DPF2 ZEB2 E4F1 ZNF592 CTBP1 HDAC2 SCGB1A1 RPLP0P2 ASRGL1 INCENP LOC102723765
GH11I062405 Enhancer 0.4 ENCODE dbSUPER 550.8 +1.1 1060 1 SCGB1A1 INCENP LOC102723765
GH11I062551 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +152.1 152073 12.9 CLOCK FEZF1 DMAP1 YBX1 IRF4 E2F8 ZNF143 SP3 NFYC MEF2D AHNAK EML3 MTA2 TUT1 TAF6L NXF1 LOC105369332 WDR74 STX5 INTS5
GH11I062498 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +96.2 96223 4.7 HDGF PKNOX1 ATF1 FOXA2 ARNT ARID4B ZNF48 ZNF121 ATF7 NFYC AHNAK ENSG00000250659 ENSG00000257058 SCGB1A1 ENSG00000255126 ASRGL1 LOC102723765 EEF1G ENSG00000255508 TUT1
GH11I062504 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11 +101.9 101885 5.9 PKNOX1 CLOCK FOXA2 ARID4B SIN3A DMAP1 ZNF48 ETS1 GATA2 ZNF143 ENSG00000250659 ENSG00000257058 AHNAK LOC102723765 SCGB1A1 ENSG00000255126 ASRGL1 EEF1G ENSG00000255508 TUT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SCGB1A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SCGB1A1 gene promoter:

Genomic Locations for SCGB1A1 Gene

Genomic Locations for SCGB1A1 Gene
chr11:62,405,103-62,423,206
(GRCh38/hg38)
Size:
18,104 bases
Orientation:
Plus strand
chr11:62,172,575-62,190,678
(GRCh37/hg19)

Genomic View for SCGB1A1 Gene

Genes around SCGB1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB1A1 Gene

Proteins for SCGB1A1 Gene

  • Protein details for SCGB1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11684-UTER_HUMAN
    Recommended name:
    Uteroglobin
    Protein Accession:
    P11684
    Secondary Accessions:
    • B2R5F2
    • Q6FHH3
    • Q9UCM2
    • Q9UCM4

    Protein attributes for SCGB1A1 Gene

    Size:
    91 amino acids
    Molecular mass:
    9994 Da
    Quaternary structure:
    • Homodimer; antiparallel disulfide-linked.

neXtProt entry for SCGB1A1 Gene

Post-translational modifications for SCGB1A1 Gene

No Post-translational modifications

Other Protein References for SCGB1A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

  • Cloud-Clone Corp. Proteins for SCGB1A1

No data available for DME Specific Peptides for SCGB1A1 Gene

Domains & Families for SCGB1A1 Gene

Gene Families for SCGB1A1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SCGB1A1 Gene

Suggested Antigen Peptide Sequences for SCGB1A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11684

UniProtKB/Swiss-Prot:

UTER_HUMAN :
  • Belongs to the secretoglobin family.
Family:
  • Belongs to the secretoglobin family.
genes like me logo Genes that share domains with SCGB1A1: view

Function for SCGB1A1 Gene

Molecular function for SCGB1A1 Gene

UniProtKB/Swiss-Prot Function:
Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

Phenotypes From GWAS Catalog for SCGB1A1 Gene

Gene Ontology (GO) - Molecular Function for SCGB1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18243143
GO:0019834 phospholipase A2 inhibitor activity IEA --
GO:0097160 polychlorinated biphenyl binding IEA --
genes like me logo Genes that share ontologies with SCGB1A1: view
genes like me logo Genes that share phenotypes with SCGB1A1: view

Animal Models for SCGB1A1 Gene

MGI Knock Outs for SCGB1A1:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SCGB1A1 Gene

Localization for SCGB1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCGB1A1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCGB1A1 gene
Compartment Confidence
extracellular 5
nucleus 3
endoplasmic reticulum 3
cytoskeleton 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SCGB1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,IEA 21805676
GO:0005622 intracellular IEA --
GO:0005635 nuclear envelope IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SCGB1A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCGB1A1 Gene

Pathways & Interactions for SCGB1A1 Gene

genes like me logo Genes that share pathways with SCGB1A1: view

Pathways by source for SCGB1A1 Gene

Gene Ontology (GO) - Biological Process for SCGB1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0007165 signal transduction IEA,NAS --
GO:0007565 female pregnancy NAS 10587371
GO:0007566 embryo implantation TAS 10587371
GO:0009410 response to xenobiotic stimulus IEA --
genes like me logo Genes that share ontologies with SCGB1A1: view

No data available for SIGNOR curated interactions for SCGB1A1 Gene

Drugs & Compounds for SCGB1A1 Gene

(18) Drugs for SCGB1A1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL Experimental Pharma Target 0

(14) Additional Compounds for SCGB1A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-eicosenoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/20:1)
  • GPCho(16:0/20:1n9)
  • GPCho(16:0/20:1w9)
  • GPCho(36:1)
88542-95-4
genes like me logo Genes that share compounds with SCGB1A1: view

Transcripts for SCGB1A1 Gene

mRNA/cDNA for SCGB1A1 Gene

Unigene Clusters for SCGB1A1 Gene

Secretoglobin, family 1A, member 1 (uteroglobin):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB1A1 Gene

No ASD Table

Relevant External Links for SCGB1A1 Gene

GeneLoc Exon Structure for
SCGB1A1
ECgene alternative splicing isoforms for
SCGB1A1

Expression for SCGB1A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCGB1A1 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB1A1 Gene

This gene is overexpressed in Lung (x49.8).

Protein differential expression in normal tissues from HIPED for SCGB1A1 Gene

This gene is overexpressed in Urine (30.9), Nasal epithelium (22.2), and Neutrophil (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCGB1A1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SCGB1A1 Gene:

SCGB1A1

SOURCE GeneReport for Unigene cluster for SCGB1A1 Gene:

Hs.523732

mRNA Expression by UniProt/SwissProt for SCGB1A1 Gene:

P11684-UTER_HUMAN
Tissue specificity: Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).

Evidence on tissue expression from TISSUES for SCGB1A1 Gene

  • Lung(4.9)
  • Urine(4.3)
  • Pancreas(4)
genes like me logo Genes that share expression patterns with SCGB1A1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCGB1A1 Gene

Orthologs for SCGB1A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB1A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGB1A1 33 34
  • 98.53 (n)
dog
(Canis familiaris)
Mammalia SCGB1A1 33 34
  • 75.93 (n)
mouse
(Mus musculus)
Mammalia Scgb1a1 33 16 34
  • 70.74 (n)
rat
(Rattus norvegicus)
Mammalia Scgb1a1 33
  • 70 (n)
cow
(Bos Taurus)
Mammalia SCGB1A1 34
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCGB1A1 34
  • 34 (a)
OneToOne
Species where no ortholog for SCGB1A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB1A1 Gene

ENSEMBL:
Gene Tree for SCGB1A1 (if available)
TreeFam:
Gene Tree for SCGB1A1 (if available)

Paralogs for SCGB1A1 Gene

(1) SIMAP similar genes for SCGB1A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCGB1A1: view

No data available for Paralogs for SCGB1A1 Gene

Variants for SCGB1A1 Gene

Sequence variations from dbSNP and Humsavar for SCGB1A1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs41364547 uncertain-significance, Asthma, susceptibility to 62,419,058(+) G/A 5_prime_UTR_variant
rs1000177743 -- 62,423,154(+) G/A 3_prime_UTR_variant
rs1000862508 -- 62,422,917(+) C/T intron_variant
rs1000947752 -- 62,418,708(+) C/T upstream_transcript_variant
rs1001496405 -- 62,417,600(+) T/A upstream_transcript_variant

Variation tolerance for SCGB1A1 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCGB1A1 Gene

Human Gene Mutation Database (HGMD)
SCGB1A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCGB1A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCGB1A1 Gene

Disorders for SCGB1A1 Gene

MalaCards: The human disease database

(20) MalaCards diseases for SCGB1A1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bronchopulmonary dysplasia
  • bpd
newborn respiratory distress syndrome
  • hmd - hyaline membrane disease
paraquat lung
  • paraquat induced lung disease
bronchiolitis obliterans
  • bronchiolitis exudativa
silicosis
  • pneumoconiosis due to silicates
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SCGB1A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SCGB1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB1A1 Gene

Publications for SCGB1A1 Gene

  1. Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines. (PMID: 1284526) Wolf M … Suske G (Human molecular genetics 1992) 2 3 4 22 58
  2. Cross-sectional and longitudinal association of the secretoglobin 1A1 gene A38G polymorphism with asthma phenotype in the Perth Infant Asthma Follow-up cohort. (PMID: 19128353) Laing IA … Perth Infant Asthma Follow-up Cohort (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009) 3 22 44 58
  3. Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study. (PMID: 17716718) Yang KD … Huang SK (The Journal of allergy and clinical immunology 2007) 3 22 44 58
  4. No association between the Clara cell secretory protein (CC16) gene polymorphism and personality traits. (PMID: 16764982) Tochigi M … Sasaki T (Progress in neuro-psychopharmacology & biological psychiatry 2006) 3 22 44 58
  5. Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity. (PMID: 16387800) Martin AC … LeSouëf PN (American journal of respiratory and critical care medicine 2006) 3 22 44 58

Products for SCGB1A1 Gene

Sources for SCGB1A1 Gene

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