Aliases for SCG5 Gene
External Ids for SCG5 Gene
Previous HGNC Symbols for SCG5 Gene
Previous GeneCards Identifiers for SCG5 Gene
This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]
GeneCards Summary for SCG5 Gene
SCG5 (Secretogranin V) is a Protein Coding gene. Diseases associated with SCG5 include Polyposis Syndrome, Hereditary Mixed, 1 and Hereditary Mixed Polyposis Syndrome. Gene Ontology (GO) annotations related to this gene include GTP binding and enzyme inhibitor activity.
UniProtKB/Swiss-Prot Summary for SCG5 Gene
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.