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The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
SCG2 (Secretogranin II) is a Protein Coding gene. Diseases associated with SCG2 include Collagenous Colitis and Intracranial Primitive Neuroectodermal Tumor. Gene Ontology (GO) annotations related to this gene include cytokine activity and chemoattractant activity.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02J223598 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE | 600.7 | +2.0 | 2024 | 4.2 | CREB1 ATF7 ZNF629 REST TFE3 CTCF JUND POLR2A RXRB IRF2 | SCG2 piR-31292-109 KCNE4 | |
GH02J223603 | Enhancer | 0.5 | FANTOM5 Ensembl | 618 | -0.8 | -782 | 0.3 | CEBPB | SCG2 lnc-MRPL44-4 AP1S3 | |
GH02J223956 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas | 9.7 | -355.7 | -355684 | 3.9 | ZNF221 SP1 HNRNPL GATAD2A TEAD4 PRDM10 ZNF629 TFE3 SIX5 LEF1 | MRPL44 lnc-WDFY1-4 piR-41482 WDFY1 ANKRD49P1 SCG2 SERPINE2 | |
GH02J224483 | Enhancer | 1.1 | Ensembl ENCODE | 10.5 | -882.8 | -882840 | 4 | HNRNPL GATAD2A TEAD4 PRDM10 TFE3 LEF1 NFKBIZ RCOR2 FOXA1 ZIC2 | lnc-FAM124B-1 ANKRD49P1 SCG2 CUL3 ENSG00000274629 FAM124B | |
GH02J223587 | Enhancer | 0.6 | FANTOM5 Ensembl | 4.8 | +14.1 | 14060 | 1.4 | ATF7 USF1 ATF2 | SCG2 piR-31292-109 HSALNG0022585 KCNE4 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | IDA | 14970115 |
GO:0005515 | protein binding | IPI | 21516116 |
GO:0042056 | chemoattractant activity | IDA | 9473216 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IDA | 9473216 |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0030141 | secretory granule | IEA,IBA | 21873635 |
GO:0031045 | dense core granule | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | IDA | 14970115 |
GO:0001525 | angiogenesis | IEA,IDA | 14970115 |
GO:0001937 | negative regulation of endothelial cell proliferation | TAS | 9473216 |
GO:0001938 | positive regulation of endothelial cell proliferation | IDA | 14970115 |
GO:0006954 | inflammatory response | TAS | 14970115 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Calcium | Nutra | 6556 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||
SP2: | - | - | |||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SCG2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SCG2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SCG2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Scg2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Scg2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SCG2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SCG2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SCG2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SCG2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | scg2 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | LOC397939 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | scg2b 30 31 |
|
OneToMany | |
scg2a 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
783210 | Benign: not provided | 223,597,489(-) | G/A | SYNONYMOUS_VARIANT | |
rs1438157 | - | p.Ala196Val | |||
rs16864976 | - | p.Tyr61His | |||
rs17852053 | - | p.Asp294Gly | |||
rs17852054 | - | p.Asp535Gly |
Disorder | Aliases | PubMed IDs |
---|---|---|
collagenous colitis |
|
|
intracranial primitive neuroectodermal tumor |
|
|
neuroendocrine tumor |
|
|
pheochromocytoma |
|
|
neuroendocrine carcinoma |
|