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The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
SCG2 (Secretogranin II) is a Protein Coding gene. Diseases associated with SCG2 include Collagenous Colitis and Neuroendocrine Tumor. Gene Ontology (GO) annotations related to this gene include cytokine activity and chemoattractant activity.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02J223598 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE | 250.7 | +2.0 | 2024 | 4.2 | MXD4 CTCF THAP11 REST ZNF511 SAP130 MIER3 ZSCAN9 RARA TEAD3 | SCG2 piR-31292-109 KCNE4 | |
GH02J223602 | Promoter | 0.9 | Ensembl | 250.7 | -0.3 | -340 | 0.2 | MXD4 CTCF THAP11 ZNF511 SAP130 REST MIER3 ZSCAN9 TCF7L2 RAD21 | SCG2 lnc-MRPL44-4 AP1S3 | |
GH02J223603 | Enhancer | 0.3 | FANTOM5 | 268 | -0.8 | -804 | 0.2 | CEBPB | SCG2 lnc-MRPL44-4 AP1S3 | |
GH02J223956 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas | 10.2 | -355.8 | -355784 | 4.1 | CHD2 TBP ZBTB10 BCL11A SP1 MXD4 FEZF1 CEBPA SIX5 NR2C1 | MRPL44 lnc-WDFY1-4 piR-41482 WDFY1 ANKRD49P1 SCG2 SERPINE2 | |
GH02J224483 | Promoter/Enhancer | 1.2 | Ensembl ENCODE | 10.5 | -882.8 | -882804 | 2.8 | CEBPA FOXA1 ZNF217 ELF1 ZIC2 HOMEZ KDM6A THAP11 FOXA2 SMAD4 | lnc-FAM124B-1 ANKRD49P1 SCG2 CUL3 HSALNG0022637 FAM124B |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | IDA | 14970115 |
GO:0005515 | protein binding | IPI | 21516116 |
GO:0042056 | chemoattractant activity | IDA | 9473216 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IDA | 9473216 |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0030141 | secretory granule | IEA,IBA | 21873635 |
GO:0031045 | dense core granule | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | IDA | 14970115 |
GO:0001525 | angiogenesis | IEA,IDA | 14970115 |
GO:0001937 | negative regulation of endothelial cell proliferation | TAS | 9473216 |
GO:0001938 | positive regulation of endothelial cell proliferation | IDA | 14970115 |
GO:0006954 | inflammatory response | TAS | 14970115 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Calcium | Nutra | 6876 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||
SP2: | - | - | |||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SCG2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SCG2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SCG2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Scg2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Scg2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SCG2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SCG2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SCG2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SCG2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | scg2 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | LOC397939 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | scg2b 30 31 |
|
OneToMany | |
scg2a 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs16864974 | Benign: not provided | 223,597,489(-) |
G/A NM_003469.5(SCG2):c.1794C>T (p.Asn598=) |
SYNONYMOUS | |
rs1438157 | - |
p.Ala196Val |
|||
rs16864976 | - |
p.Tyr61His |
|||
rs17852053 | - |
p.Asp294Gly |
|||
rs17852054 | - |
p.Asp535Gly |
Disorder | Aliases | PubMed IDs |
---|---|---|
collagenous colitis |
|
|
neuroendocrine tumor |
|
|
intracranial primitive neuroectodermal tumor |
|
|
pheochromocytoma |
|
|
neuroendocrine carcinoma |
|
|