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Aliases for SCEL Gene

Aliases for SCEL Gene

External Ids for SCEL Gene

Previous GeneCards Identifiers for SCEL Gene

  • GC13P076077
  • GC13P072104
  • GC13P076986
  • GC13P075907
  • GC13P076854
  • GC13P078109
  • GC13P058807

Summaries for SCEL Gene

Entrez Gene Summary for SCEL Gene

  • The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCEL Gene

SCEL (Sciellin) is a Protein Coding gene. An important paralog of this gene is ZNF185.

UniProtKB/Swiss-Prot for SCEL Gene

  • May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.

Gene Wiki entry for SCEL Gene

Additional gene information for SCEL Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCEL Gene

Genomics for SCEL Gene

GeneHancer (GH) Regulatory Elements for SCEL Gene

Promoters and enhancers for SCEL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I077535 Promoter/Enhancer 0.8 EPDnew ENCODE 550.8 +0.0 32 0.9 FOS SCEL SCEL-AS1
GH13I077507 Enhancer 0.8 ENCODE 12.1 -27.0 -26971 2.4 CTCF KLF1 JUN INSM2 FEZF1 ZEB1 HIC1 ZNF335 ZNF366 POLR2A SCEL LOC105370271
GH13I077513 Enhancer 0.6 ENCODE 12.1 -21.7 -21733 0.2 CBFB BACH1 JUNB EBF1 DPF2 BATF HDAC2 BCL11A IKZF1 RUNX3 SCEL LOC105370271
GH13I077515 Enhancer 1 FANTOM5 Ensembl ENCODE 0.4 -19.2 -19245 1 JUN JUNB JUND POLR2A BCL11A IKZF1 NFATC1 ZNF24 ETV6 SCEL-AS1 SCEL LOC105370271
GH13I077520 Enhancer 0.7 Ensembl ENCODE 0.4 -13.9 -13874 2 SP1 ZNF146 MNT FOSL2 FOS SCEL LOC105370271
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SCEL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SCEL gene promoter:

Genomic Locations for SCEL Gene

Genomic Locations for SCEL Gene
109,590 bases
Plus strand

Genomic View for SCEL Gene

Genes around SCEL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCEL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCEL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCEL Gene

Proteins for SCEL Gene

  • Protein details for SCEL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B7Z797
    • F5H651
    • Q53H61
    • Q5W0S8
    • Q5W0S9
    • Q86X00

    Protein attributes for SCEL Gene

    688 amino acids
    Molecular mass:
    77552 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCEL Gene


neXtProt entry for SCEL Gene

Post-translational modifications for SCEL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SCEL Gene

Domains & Families for SCEL Gene

Gene Families for SCEL Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SCEL Gene


Suggested Antigen Peptide Sequences for SCEL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SCEL: view

No data available for UniProtKB/Swiss-Prot for SCEL Gene

Function for SCEL Gene

Molecular function for SCEL Gene

GENATLAS Biochemistry:
sciellin,precursor of the cornified envelopes of keratinizing tissues,expressed in the stratum granulosum (in stratified squamous epithelia
UniProtKB/Swiss-Prot Function:
May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.

Gene Ontology (GO) - Molecular Function for SCEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14632196
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SCEL: view
genes like me logo Genes that share phenotypes with SCEL: view

Animal Models for SCEL Gene

MGI Knock Outs for SCEL:

Clone Products

  • Addgene plasmids for SCEL

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SCEL Gene

Localization for SCEL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCEL Gene

Cytoplasm. Membrane. Note=May become cross-linked to membrane proteins by transglutaminase.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCEL gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SCEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope TAS 9813070
GO:0005737 cytoplasm ISS 11112355
GO:0016020 membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 19211270
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with SCEL: view

Pathways & Interactions for SCEL Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development TAS 9813070
GO:0009612 response to mechanical stimulus IEP 19211270
GO:0009790 embryo development ISS 11112355
GO:0030216 keratinocyte differentiation IDA 14632196
GO:0090263 positive regulation of canonical Wnt signaling pathway IMP 27013588
genes like me logo Genes that share ontologies with SCEL: view

No data available for Pathways by source and SIGNOR curated interactions for SCEL Gene

Drugs & Compounds for SCEL Gene

No Compound Related Data Available

Transcripts for SCEL Gene

Unigene Clusters for SCEL Gene

Representative Sequences:

Clone Products

  • Addgene plasmids for SCEL

Alternative Splicing Database (ASD) splice patterns (SP) for SCEL Gene

No ASD Table

Relevant External Links for SCEL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCEL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCEL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCEL Gene

This gene is overexpressed in Esophagus - Mucosa (x21.2), Skin - Sun Exposed (Lower leg) (x8.9), Skin - Not Sun Exposed (Suprapubic) (x8.2), and Vagina (x5.8).

Protein differential expression in normal tissues from HIPED for SCEL Gene

This gene is overexpressed in Cervix (45.9) and Saliva (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCEL Gene

NURSA nuclear receptor signaling pathways regulating expression of SCEL Gene:


SOURCE GeneReport for Unigene cluster for SCEL Gene:


mRNA Expression by UniProt/SwissProt for SCEL Gene:

Tissue specificity: Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue, foreskin stratum spinosum and stratum granulosum, hair follicle and nail.

Evidence on tissue expression from TISSUES for SCEL Gene

  • Intestine(4.1)
  • Skin(3.2)
genes like me logo Genes that share expression patterns with SCEL: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCEL Gene

Orthologs for SCEL Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCEL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCEL 33 34
  • 98.89 (n)
(Bos Taurus)
Mammalia SCEL 33 34
  • 85.26 (n)
(Rattus norvegicus)
Mammalia Scel 33
  • 79.68 (n)
(Mus musculus)
Mammalia Scel 33 16 34
  • 79.25 (n)
(Canis familiaris)
Mammalia SCEL 33 34
  • 77.59 (n)
(Ornithorhynchus anatinus)
Mammalia SCEL 34
  • 55 (a)
(Monodelphis domestica)
Mammalia SCEL 34
  • 54 (a)
(Gallus gallus)
Aves SCEL 33 34
  • 64.21 (n)
(Anolis carolinensis)
Reptilia SCEL 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scel 33
  • 50.75 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15658 33
(Danio rerio)
Actinopterygii scel 34
  • 18 (a)
Species where no ortholog for SCEL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCEL Gene

Gene Tree for SCEL (if available)
Gene Tree for SCEL (if available)

Paralogs for SCEL Gene

Paralogs for SCEL Gene

genes like me logo Genes that share paralogs with SCEL: view

Variants for SCEL Gene

Sequence variations from dbSNP and Humsavar for SCEL Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000035019 -- 77,594,938(+) G/A intron_variant
rs1000039649 -- 77,550,776(+) T/A intron_variant
rs1000045521 -- 77,558,129(+) A/G intron_variant
rs1000064980 -- 77,537,038(+) T/C intron_variant
rs1000136695 -- 77,549,362(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SCEL Gene

Variant ID Type Subtype PubMed ID
esv22418 CNV loss 19812545
esv2659703 CNV deletion 23128226
esv2677047 CNV deletion 23128226
esv27309 CNV loss 19812545
esv3307018 CNV mobile element insertion 20981092
esv3307484 CNV mobile element insertion 20981092
esv3409082 CNV insertion 20981092
esv3415394 CNV duplication 20981092
esv3422056 CNV insertion 20981092
esv3632778 CNV loss 21293372
esv3632781 CNV loss 21293372
nsv476670 CNV novel sequence insertion 20440878
nsv562375 CNV loss 21841781

Variation tolerance for SCEL Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.93; 94.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCEL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCEL Gene

Disorders for SCEL Gene

Additional Disease Information for SCEL

No disorders were found for SCEL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCEL Gene

Publications for SCEL Gene

  1. cDNA cloning and characterization of sciellin, a LIM domain protein of the keratinocyte cornified envelope. (PMID: 9813070) Champliaud MF … Olson PF (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Biomechanical stress induces novel arterial intima-enriched genes: implications for vascular adaptation to stress. (PMID: 19211270) Pyle AL … Young PP (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2010) 3 22 58
  3. Analysis of Sciellin (SCEL) as a candidate gene in esophageal squamous cell carcinoma. (PMID: 15274303) Corona W … Wadleigh R (Anticancer research 2004) 3 22 58
  4. The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes. (PMID: 14632196) Champliaud MF … Baden HP (The Journal of investigative dermatology 2003) 3 22 58
  5. Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties. (PMID: 11112355) Champliaud MF … Viel A (Genomics 2000) 3 22 58

Products for SCEL Gene

  • Addgene plasmids for SCEL

Sources for SCEL Gene

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