Aliases for SCD5 Gene
External Ids for SCD5 Gene
Previous HGNC Symbols for SCD5 Gene
Previous GeneCards Identifiers for SCD5 Gene
Stearoyl-CoA desaturase (SCD; EC 22.214.171.124) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SCD5 Gene
SCD5 (Stearoyl-CoA Desaturase 5) is a Protein Coding gene. Diseases associated with SCD5 include Lipodystrophy, Congenital Generalized, Type 3 and Chronic Maxillary Sinusitis. Among its related pathways are Metabolism and oleate biosynthesis. Gene Ontology (GO) annotations related to this gene include iron ion binding and stearoyl-CoA 9-desaturase activity. An important paralog of this gene is SCD.
UniProtKB/Swiss-Prot Summary for SCD5 Gene
Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15610069, PubMed:15907797, PubMed:22745828). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069, PubMed:15907797). Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways (PubMed:22745828).