SCARB1 Gene (Protein Coding)

Scavenger Receptor Class B Member 1

GC12M124776
GIFtS:
46
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2019] See more...

Aliases for SCARB1 Gene

Aliases for SCARB1 Gene

  • Scavenger Receptor Class B Member 1 2 3 4 5
  • CLA-1 2 3 4
  • SR-BI 2 3 4
  • CLA1 2 3 4
  • SRB1 2 3 4
  • CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor)-Like 1 2 3
  • CD36 And LIMPII Analogous 1 3 4
  • CD36L1 3 4
  • Collagen Type I Receptor, Thrombospondin Receptor-Like 1 4
  • Scavenger Receptor Class B, Member 1 2
  • Scavenger Receptor Class B Type III 3
  • CD36 Antigen-Like 1 4
  • CD36 Antigen 4
  • HDLQTL6 3
  • SCARB1 5

External Ids for SCARB1 Gene

Previous HGNC Symbols for SCARB1 Gene

  • CD36L1

Previous GeneCards Identifiers for SCARB1 Gene

  • GC12M123982
  • GC12M125008
  • GC12M123615
  • GC12M123787
  • GC12M125262
  • GC12M122224

Summaries for SCARB1 Gene

Entrez Gene Summary for SCARB1 Gene

  • The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2019]

GeneCards Summary for SCARB1 Gene

SCARB1 (Scavenger Receptor Class B Member 1) is a Protein Coding gene. Diseases associated with SCARB1 include High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6 and Hepatitis C. Among its related pathways are Vesicle-mediated transport and Phagosome. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and phosphatidylserine binding. An important paralog of this gene is SCARB2.

UniProtKB/Swiss-Prot Summary for SCARB1 Gene

  • Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218).
  • (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). Mediates uptake of M.fortuitum, E.coli and S.aureus (PubMed:16020694).

Gene Wiki entry for SCARB1 Gene

Additional gene information for SCARB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCARB1 Gene

Genomics for SCARB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SCARB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J124909 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 261.6 -34.7 -34657 16.4 ZSCAN16 CHD2 TBP ZBTB10 SP1 BCL11A MXD4 FEZF1 CEBPA NR2C1 SCARB1 UBC MIR5188 NCOR2 DHX37 ENSG00000270130 ENSG00000269938 ENSG00000269997 ENSG00000270061 BRI3BP
GH12J124861 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.4 +19.5 19520 3.2 ZSCAN16 TBP SP1 MXD4 MNT SMAD5 POLR2A ELF1 NONO ZIC2 lnc-BRI3BP-7 SCARB1 UBC RFLNA lnc-UBC-1 RF00017-1333 NCOR2
GH12J124881 Promoter/Enhancer 1.1 Ensembl CraniofacialAtlas 250.7 +1.3 1340 0.5 CEBPA HOMEZ GABPA SMAD4 SAP130 ETV4 GABPB1 RARA TEAD3 DMAP1 SCARB1 lnc-UBC-1 NCOR2
GH12J124882 Enhancer 0.8 dbSUPER 250.7 -0.3 -318 0.4 ZFP64 ZBTB7B NBN TRIM22 TRIM25 NKRF HLTF TARDBP MCM7 ZNF318 lnc-BRI3BP-3 SCARB1 LOC105370051 UBC
GH12J124832 Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.3 +46.5 46468 6.8 ZSCAN16 MXD4 FEZF1 CEBPA DEK IKZF1 ZNF217 BRCA1 ZIC2 HOMEZ SCARB1 BRI3BP RF00017-1333 lnc-UBC-2 NCOR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCARB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SCARB1

Top Transcription factor binding sites by QIAGEN in the SCARB1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • NF-kappaB1
  • PPAR-gamma1
  • PPAR-gamma2
  • SREBP-1a

Genomic Locations for SCARB1 Gene

Latest Assembly
chr12:124,776,856-124,882,668
(GRCh38/hg38)
Size:
105,813 bases
Orientation:
Minus strand

Previous Assembly
chr12:125,261,402-125,348,410
(GRCh37/hg19 by Entrez Gene)
Size:
87,009 bases
Orientation:
Minus strand

chr12:125,261,402-125,367,214
(GRCh37/hg19 by Ensembl)
Size:
105,813 bases
Orientation:
Minus strand

Genomic View for SCARB1 Gene

Genes around SCARB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCARB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCARB1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SCARB1 Gene

Proteins for SCARB1 Gene

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  • Protein details for SCARB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTV0-SCRB1_HUMAN
    Recommended name:
    Scavenger receptor class B member 1
    Protein Accession:
    Q8WTV0
    Secondary Accessions:
    • F8W8N0
    • Q14016
    • Q52LZ5
    • Q6KFX4

    Protein attributes for SCARB1 Gene

    Size:
    552 amino acids
    Molecular mass:
    60878 Da
    Quaternary structure:
    • The C-terminal region binds to PDZK1.
    • (Microbial infection) Interacts with hepatitis C virus E1:E2 glycoproteins.
    Miscellaneous:
    • [Isoform 3]: May be due to a competing donor splice site.

    Alternative splice isoforms for SCARB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCARB1 Gene

Protein Expression for SCARB1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SCARB1 Gene

  • N-glycosylated.
  • The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.
  • Glycosylation at Asn102, Asn173, Asn108, Asn212, Asn227, Asn255, Asn310, Asn330, and Asn383
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SCRB1_HUMAN (1722)

Other Protein References for SCARB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for SCARB1 Gene

Domains & Families for SCARB1 Gene

Gene Families for SCARB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SCARB1 Gene

InterPro:
Blocks:
  • Adhesion molecule CD36 family signature
ProtoNet:

Suggested Antigen Peptide Sequences for SCARB1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ42118 fis, clone TESTI2005610, highly similar to Scavenger receptor class B member 1 (B3KW46_HUMAN)
  • cDNA FLJ55139, highly similar to Scavenger receptor class B member 1 (B4DZ71_HUMAN)
  • SR-BI (SCRB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WTV0

UniProtKB/Swiss-Prot:

SCRB1_HUMAN :
  • Belongs to the CD36 family.
Family:
  • Belongs to the CD36 family.
genes like me logo Genes that share domains with SCARB1: view

Function for SCARB1 Gene

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  6. Cell Lines for research

Molecular function for SCARB1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). Mediates uptake of M.fortuitum, E.coli and S.aureus (PubMed:16020694).

Phenotypes From GWAS Catalog for SCARB1 Gene

Gene Ontology (GO) - Molecular Function for SCARB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 12651854
GO:0001540 amyloid-beta binding IEA --
GO:0001618 virus receptor activity IEA --
GO:0001786 phosphatidylserine binding IEA,ISS --
GO:0001875 lipopolysaccharide receptor activity IDA 12651854
genes like me logo Genes that share ontologies with SCARB1: view
genes like me logo Genes that share phenotypes with SCARB1: view

Animal Models for SCARB1 Gene

MGI Knock Outs for SCARB1:

Animal Models for research

  • Taconic Biosciences Mouse Models for SCARB1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCARB1

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCARB1 Gene

Localization for SCARB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCARB1 Gene

Cell membrane. Multi-pass membrane protein. Membrane, caveola. Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCARB1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
endoplasmic reticulum 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
endosome 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Lysosomes (2)
  • Rods & Rings (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SCARB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA 21873635
GO:0005764 lysosome IDA --
GO:0005765 lysosomal membrane HDA 17897319
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with SCARB1: view

Pathways & Interactions for SCARB1 Gene

genes like me logo Genes that share pathways with SCARB1: view

SIGNOR curated interactions for SCARB1 Gene

Activates:

Gene Ontology (GO) - Biological Process for SCARB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001935 endothelial cell proliferation IEA --
GO:0006702 androgen biosynthetic process IEA --
GO:0006707 cholesterol catabolic process IEA --
GO:0006869 lipid transport IEA --
GO:0006898 receptor-mediated endocytosis TAS --
genes like me logo Genes that share ontologies with SCARB1: view

Drugs & Compounds for SCARB1 Gene

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(44) Drugs for SCARB1 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atorvastatin Approved Pharma 919
Fenofibrate Approved Pharma PPARalpha agonist 190
Tocopherol Approved, Investigational Pharma Transporter 558
Tocofersolan Approved Pharma Transporter, substrate 0
alpha-Tocopherol acetate Approved, Vet_approved Nutra Transporter, substrate 0

(175) Additional Compounds for SCARB1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CE(10:0)
  • 3b-(Decanoyloxy)-5-cholestene
  • 5-Cholesten-3b-ol caprate
  • Cholest-5-en-3b-ol caprate
  • Cholesterol 3-decanoate
  • Cholesterol 3-decanoic acid
 1183-04-6
CE(12:0)
  • (3beta)-Cholest-5-en-3-ol dodecanoate
  • (3beta)-Cholest-5-en-3-ol dodecanoic acid
  • 12:0 Cholesterol ester
  • Cholest-5-en-3-beta-yl laurate
  • Cholest-5-en-3-yl laurate
 1908-11-8
CE(14:0)
  • 1-Myristoyl-cholesterol
  • CE(14:0/0:0)
  • Cholesterol 1-tetradecanoic acid
  • Cholesterol ester(14:0)
  • Cholesterol ester(14:0/0:0)
 1989-52-2
CE(14:1(9Z))
  • 1-Myristoleoyl-cholesterol
  • 14:1(9Z) Cholesterol ester
  • CE(14:1)
  • CE(14:1/0:0)
  • CE(14:1n5/0:0)
CE(16:0)
  • Cholesterol Ester(16:0)
  • 1-Palmitoyl-cholesterol
  • Cholesteryl 1-hexadecanoic acid
  • Cholesterol Ester(16:0/0:0)
  • 16:0 Cholesterol ester
 601-34-3
genes like me logo Genes that share compounds with SCARB1: view

Transcripts for SCARB1 Gene

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mRNA/cDNA for SCARB1 Gene

11 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCARB1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for SCARB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16
SP1: - - - - - - -
SP2:
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - -
SP8:

Relevant External Links for SCARB1 Gene

GeneLoc Exon Structure for
SCARB1

Expression for SCARB1 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCARB1 Gene

mRNA expression in normal human tissues for SCARB1 Gene
mRNA expression by BioGPS for SCARB1 GenemRNA expression by GTEx for SCARB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCARB1 Gene

This gene is overexpressed in Adrenal Gland (x20.9) and Liver (x6.3).

Protein differential expression in normal tissues from HIPED for SCARB1 Gene

This gene is overexpressed in Adrenal (49.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SCARB1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SCARB1

SOURCE GeneReport for Unigene cluster for SCARB1 Gene:

Hs.731377

mRNA Expression by UniProt/SwissProt for SCARB1 Gene:

Q8WTV0-SCRB1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for SCARB1 Gene

  • Liver(4.7)
  • Nervous system(4.3)
  • Skin(3.7)
  • Adrenal gland(3.6)
  • Intestine(2.7)
  • Heart(2.7)
  • Pancreas(2.7)
  • Blood(2.6)
  • Gall bladder(2.6)
  • Muscle(2.5)
  • Lymph node(2.5)
  • Spleen(2.4)
  • Kidney(2.4)
  • Thyroid gland(2.1)
  • Lung(2.1)
  • Bone marrow(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with SCARB1: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCARB1 Gene

Orthologs for SCARB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCARB1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SCARB1 30 31
  • 99.54 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SCARB1 30 31
  • 85.14 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SCARB1 30 31
  • 85 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Scarb1 30 17 31
  • 80.29 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Scarb1 30
  • 79.57 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia SCARB1 31
  • 74 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia SCARB1 31
  • 71 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves SCARB1 30 31
  • 68.4 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia SCARB1 31
  • 55 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia scarb1 30
  • 62.42 (n)
Zebrafish
(Danio rerio)
 Actinopterygii scarb1 30 31
  • 63.5 (n)
 OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.3433 30
Fruit Fly
(Drosophila melanogaster)
 Insecta crq 30 31
  • 46.81 (n)
 OneToMany
emp 31
  • 27 (a)
 OneToMany
CG31741 31
  • 24 (a)
 OneToMany
ninaD 31
  • 24 (a)
 OneToMany
santa-maria 31
  • 23 (a)
 OneToMany
CG10345 31
  • 23 (a)
 OneToMany
pes 31
  • 23 (a)
 OneToMany
Snmp1 31
  • 22 (a)
 OneToMany
CG7227 31
  • 21 (a)
 OneToMany
CG1887 31
  • 21 (a)
 OneToMany
CG3829 31
  • 21 (a)
 OneToMany
CG2736 31
  • 20 (a)
 OneToMany
CG40006 31
  • 18 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea scav-3 31
  • 23 (a)
 OneToMany
scav-5 31
  • 20 (a)
 OneToMany
scav-4 31
  • 19 (a)
 OneToMany
scav-6 31
  • 19 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 24 (a)
 OneToOne
Species where no ortholog for SCARB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SCARB1 Gene

ENSEMBL:
Gene Tree for SCARB1 (if available)
TreeFam:
Gene Tree for SCARB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCARB1: view image

Paralogs for SCARB1 Gene

Paralogs for SCARB1 Gene

(2) SIMAP similar genes for SCARB1 Gene using alignment to 7 proteins:

  • SCRB1_HUMAN
  • B3KW46_HUMAN
  • B4DZ71_HUMAN
  • B7ZKQ9_HUMAN
  • F5H4X0_HUMAN
  • F5H5E8_HUMAN
  • F8W8N0_HUMAN

Pseudogenes.org Pseudogenes for SCARB1 Gene

genes like me logo Genes that share paralogs with SCARB1: view

Variants for SCARB1 Gene

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Polymorphic Variants from UniProtKB/Swiss-Prot for SCARB1 Gene

SCRB1_HUMAN-Q8WTV0
Genetic variations in SCARB1 define the high density lipoprotein cholesterol level quantitative trait locus 6 (HDLCQ16) [MIM:610762].

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SCARB1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs10396208 Benign: not provided 124,863,658(-) G/A
NM_005505.5(SCARB1):c.63C>T (p.Cys21=) 		NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs1379084217 Likely Benign: not provided 124,817,561(-) G/T
NM_005505.5(SCARB1):c.273C>A (p.Pro91=) 		NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
rs187831231 Association: High density lipoprotein cholesterol level quantitative trait locus 6 124,814,309(-) T/C
NM_005505.5(SCARB1):c.523A>G (p.Thr175Ala) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs371132142 Uncertain Significance: not provided 124,787,461(-) G/T
NM_005505.5(SCARB1):c.1203-4C>A 		INTRON
rs387906791 Association: High density lipoprotein cholesterol level quantitative trait locus 6. - 124,807,881(-) G/Ap.Pro297Ser
NM_005505.5(SCARB1):c.889C>T (p.Pro297Ser) 		MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SCARB1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SCARB1 Gene

Variant ID Type Subtype PubMed ID
dgv889n106 CNV deletion 24896259
esv1953401 CNV deletion 18987734
esv2665124 CNV deletion 23128226
esv2746550 CNV deletion 23290073
esv3549941 CNV deletion 23714750
esv3631025 CNV loss 21293372
esv3631026 CNV loss 21293372
nsv1119994 CNV deletion 24896259
nsv1122780 CNV deletion 24896259
nsv52719 CNV deletion 16902084
nsv560543 CNV gain 21841781
nsv560595 CNV gain 21841781
nsv957260 CNV deletion 24416366

Variation tolerance for SCARB1 Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.33; 76.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCARB1 Gene

Human Gene Mutation Database (HGMD)
SCARB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCARB1

SNP Genotyping and Copy Number Assays for research

Disorders for SCARB1 Gene

MalaCards: The human disease database

(26) MalaCards diseases for SCARB1 Gene - From: OMI, CVR, GTR, COP, and GCD

Disorder Aliases PubMed IDs
high density lipoprotein cholesterol level quantitative trait locus 6
  • hdlcq6
hepatitis c
  • chronic hepatitis c
hepatitis
  • acute and subacute liver necrosis
hepatitis c virus
  • hepatitis c virus, susceptibility to
hyperalphalipoproteinemia 1
  • halp1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SCARB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SCARB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCARB1 Gene

Publications for SCARB1 Gene

  1. Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. (PMID: 7689561) Calvo D ā€¦ Vega MA (The Journal of biological chemistry 1993) 2 3 4 23
  2. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM ā€¦ Kathiresan S (Nature 2010) 3 4 41
  3. Influence of SCARB1 polymorphisms on serum lipids of hypercholesterolemic individuals treated with atorvastatin. (PMID: 20064494) Cerda A ā€¦ Hirata RD (Clinica chimica acta; international journal of clinical chemistry 2010) 3 23 41
  4. Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women. (PMID: 19489872) Lamon-Fava S ā€¦ Herrington DM (Clinical endocrinology 2010) 3 23 41
  5. Scavenger receptor class B type I protein as an independent predictor of high-density lipoprotein cholesterol levels in subjects with hyperalphalipoproteinemia. (PMID: 19158204) West M ā€¦ Rodriguez A (The Journal of clinical endocrinology and metabolism 2009) 3 23 41

ExternalLinks

View latest publications for SCARB1 gene in Mastermind

Products for SCARB1 Gene

Sources for SCARB1 Gene