This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript vari... See more...

Aliases for SCAP Gene

Aliases for SCAP Gene

  • SREBF Chaperone 2 3 5
  • Sterol Regulatory Element-Binding Protein Cleavage-Activating Protein 3 4
  • SREBP Cleavage-Activating Protein 3 4
  • KIAA0199 2 4
  • SREBP Cleavage Activating Protein 2
  • SCAP 5

External Ids for SCAP Gene

Previous GeneCards Identifiers for SCAP Gene

  • GC03M047243
  • GC03M046675
  • GC03M047415
  • GC03M047430

Summaries for SCAP Gene

Entrez Gene Summary for SCAP Gene

  • This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SCAP Gene

SCAP (SREBF Chaperone) is a Protein Coding gene. Diseases associated with SCAP include Malt Worker's Lung and Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Metabolism. Gene Ontology (GO) annotations related to this gene include cholesterol binding. An important paralog of this gene is DISP1.

UniProtKB/Swiss-Prot Summary for SCAP Gene

  • Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity). Binds cholesterol via its SSD domain (By similarity).

Gene Wiki entry for SCAP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCAP Gene

Genomics for SCAP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SCAP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCAP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SCAP

Top Transcription factor binding sites by QIAGEN in the SCAP gene promoter:
  • c-Rel
  • Egr-4
  • FOXO3
  • FOXO3a
  • FOXO3b
  • GR
  • GR-alpha
  • Max1
  • Pax-5
  • RORalpha1

Genomic Locations for SCAP Gene

Latest Assembly
chr3:47,413,681-47,477,126
(GRCh38/hg38)
Size:
63,446 bases
Orientation:
Minus strand

Previous Assembly
chr3:47,455,171-47,517,431
(GRCh37/hg19 by Entrez Gene)
Size:
62,261 bases
Orientation:
Minus strand

chr3:47,455,203-47,518,616
(GRCh37/hg19 by Ensembl)
Size:
63,414 bases
Orientation:
Minus strand

Genomic View for SCAP Gene

Genes around SCAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAP Gene

Proteins for SCAP Gene

  • Protein details for SCAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12770-SCAP_HUMAN
    Recommended name:
    Sterol regulatory element-binding protein cleavage-activating protein
    Protein Accession:
    Q12770
    Secondary Accessions:
    • Q8N2E0
    • Q8WUA1

    Protein attributes for SCAP Gene

    Size:
    1279 amino acids
    Molecular mass:
    139729 Da
    Quaternary structure:
    • Membrane region forms a homotetramer (By similarity). Component of the SCAP-SREBP complex (composed of SCAP and SREBF1/SREBP1 or SREBF2/SREBP2); interacts with SREBF1/SREBP1 or SREBF2/SREBP2 through its C-terminal cytoplasmic domain (By similarity). Forms a ternary complex with INSIG1 or INSIG2 through its transmembrane domains at high sterol concentrations (PubMed:17428920, PubMed:26160948). Interacts with the SEC23-SEC24 complex in a SAR1-GTP-dependent manner through an ER export signal in its third cytoplasmic loop (By similarity). Interacts with RNF139; the interaction inhibits the interaction of SCAP with SEC24B and hampering the ER to Golgi transport of the SCAP-SREBP complex (PubMed:19706601). Interacts with SPRING1 (PubMed:32111832).
    SequenceCaution:
    • Sequence=BAA12111.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11673.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SCAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAP Gene

Post-translational modifications for SCAP Gene

  • Ubiquitinated at Lys-454 and Lys-466. RNF145 triggers ubiquitination of SCAP, likely inhibiting SCAP-SREBP complex transport to the Golgi apparatus and the subsequent processing/maturation of SREBF2/SREBP2.
  • Glycosylation at Asn590, Asn641, and Asn263
  • Ubiquitination at Lys454, Lys466, and Lys842
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SCAP Gene

Domains & Families for SCAP Gene

Gene Families for SCAP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for SCAP Gene

GenScript: Design optimal peptide antigens:
  • SCAP protein (Q6PIX8_HUMAN)
  • Sterol regulatory element-binding protein cleavage-activating protein (SCAP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q12770

UniProtKB/Swiss-Prot:

SCAP_HUMAN :
  • Loop-1 binds to loop-7, enabling interaction with COPII-coated vesicles. When levels of cholesterol in the endoplasmic reticulum increase, Loop-1 binds to cholesterol instead, thereby disrupting direct binding between the two loops and preventing the SCAP-SREBP complex from exiting the endoplasmic reticulum.
  • Belongs to the WD repeat SCAP family.
Domain:
  • Loop-1 binds to loop-7, enabling interaction with COPII-coated vesicles. When levels of cholesterol in the endoplasmic reticulum increase, Loop-1 binds to cholesterol instead, thereby disrupting direct binding between the two loops and preventing the SCAP-SREBP complex from exiting the endoplasmic reticulum.
  • Cholesterol bound to SSD domain of SCAP or oxysterol bound to INSIG (INSIG1 or INSIG2) leads to masking of an ER export signal (also named MELADL motif) on SCAP possibly by moving the signal further away from the ER membrane.
Family:
  • Belongs to the WD repeat SCAP family.
genes like me logo Genes that share domains with SCAP: view

Function for SCAP Gene

Molecular function for SCAP Gene

UniProtKB/Swiss-Prot Function:
Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2 (By similarity). At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum (By similarity). Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity). Binds cholesterol via its SSD domain (By similarity).
UniProtKB/Swiss-Prot Induction:
By androgen-bound AR and glucocorticoid-bound NR3C1 in a prostate cancer cell line (LNCaP).

Phenotypes From GWAS Catalog for SCAP Gene

Gene Ontology (GO) - Molecular Function for SCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 17428920
GO:0008289 lipid binding IEA --
GO:0032934 sterol binding IEA,ISS --
GO:0044877 protein-containing complex binding IEA --
GO:0051082 unfolded protein binding NAS 11726962
genes like me logo Genes that share ontologies with SCAP: view
genes like me logo Genes that share phenotypes with SCAP: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCAP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAP Gene

Localization for SCAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAP Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein. Golgi apparatus membrane. Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane. Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols (By similarity). Requires the presence of SPRING1 for proper localization to endoplasmic reticulum (PubMed:32111832). {ECO:0000250 UniProtKB:P97260, ECO:0000269 PubMed:32111832}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCAP gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 4
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 2
endosome 2
cytosol 2
lysosome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA,TAS --
GO:0005783 endoplasmic reticulum NAS 11726962
GO:0005789 endoplasmic reticulum membrane IEA,IDA 32111832
GO:0005794 Golgi apparatus IEA,NAS 11726962
GO:0012507 ER to Golgi transport vesicle membrane IEA --
genes like me logo Genes that share ontologies with SCAP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCAP Gene

Pathways & Interactions for SCAP Gene

genes like me logo Genes that share pathways with SCAP: view

Pathways by source for SCAP Gene

1 GeneGo (Thomson Reuters) pathway for SCAP Gene
  • Transcription Androgen Receptor nuclear signaling
1 Qiagen pathway for SCAP Gene
  • SREBP Proteolysis
1 Cell Signaling Technology pathway for SCAP Gene

SIGNOR curated interactions for SCAP Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006955 immune response IEA --
GO:0007568 aging IEA --
GO:0008202 steroid metabolic process IEA --
genes like me logo Genes that share ontologies with SCAP: view

Drugs & Compounds for SCAP Gene

(10) Drugs for SCAP Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Simvastatin Approved Pharma HMG-CoA reductase inhibitor 592
Atorvastatin Approved Pharma 928
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for SCAP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SCAP: view

Transcripts for SCAP Gene

mRNA/cDNA for SCAP Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCAP

Alternative Splicing Database (ASD) splice patterns (SP) for SCAP Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4:
SP5: - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: -
SP8:
SP9: -
SP10: -
SP11:
SP12:

ExUns: 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SCAP Gene

GeneLoc Exon Structure for
SCAP

Expression for SCAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCAP Gene

This gene is overexpressed in Testis (37.3), Fetal testis (14.5), and Retina (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SCAP Gene



Protein tissue co-expression partners for SCAP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SCAP

SOURCE GeneReport for Unigene cluster for SCAP Gene:

Hs.531789

Evidence on tissue expression from TISSUES for SCAP Gene

  • Nervous system(4.8)
  • Liver(4.7)
  • Intestine(4.5)
  • Bone marrow(4.3)
  • Kidney(2.7)
  • Muscle(2.6)
  • Blood(2.3)
  • Heart(2.3)
  • Adrenal gland(2.3)
  • Skin(2.2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with SCAP: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCAP Gene

Orthologs for SCAP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SCAP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SCAP 29 30
  • 98.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SCAP 29 30
  • 90.14 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SCAP 29 30
  • 88.75 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Scap 29
  • 87.77 (n)
Mouse
(Mus musculus)
Mammalia Scap 29 16 30
  • 87.7 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SCAP 30
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SCAP 29 30
  • 74.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SCAP 30
  • 71 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia scap 29
  • 70.28 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16805 29
Zebrafish
(Danio rerio)
Actinopterygii scap 30
  • 70 (a)
OneToOne
LOC558292 29
  • 67.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011336 29
  • 48.99 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta SCAP 29 30 31
  • 46.92 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea scp-1 29 30 31
  • 41.82 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NCR1 30
  • 10 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 36 (a)
OneToOne
Species where no ortholog for SCAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SCAP Gene

ENSEMBL:
Gene Tree for SCAP (if available)
TreeFam:
Gene Tree for SCAP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCAP: view image
Alliance of Genome Resources:
Additional Orthologs for SCAP

Paralogs for SCAP Gene

Paralogs for SCAP Gene

genes like me logo Genes that share paralogs with SCAP: view

Variants for SCAP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SCAP Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs112830289 Benign: not provided 47,413,929(-) G/A
NM_012235.4(SCAP):c.3765C>T (p.Asn1255=)
SYNONYMOUS
rs115332706 Benign: not provided 47,418,852(-) G/A
NM_012235.4(SCAP):c.1941-9C>T
INTRON
rs140861904 Benign: not provided 47,414,632(-) C/A
NM_012235.4(SCAP):c.3327G>T (p.Ser1109=)
SYNONYMOUS
rs145894255 Benign: not provided 47,414,034(-) G/C
NM_012235.4(SCAP):c.3660C>G (p.Gly1220=)
SYNONYMOUS
rs151014440 Benign: not provided 47,414,198(-) C/T
NM_012235.4(SCAP):c.3576G>A (p.Lys1192=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SCAP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SCAP Gene

Variant ID Type Subtype PubMed ID
dgv125n73 CNV deletion 24416366
dgv1374e212 CNV loss 25503493
dgv2521n106 CNV deletion 24896259
dgv805n67 CNV loss 20364138
dgv8309n54 CNV loss 21841781
dgv8310n54 CNV loss 21841781
dgv8311n54 CNV gain+loss 21841781
dgv8312n54 CNV loss 21841781
dgv8313n54 CNV gain 21841781
esv1471808 CNV insertion 17803354
esv23620 CNV loss 19812545
esv2677458 CNV deletion 23128226
esv2725241 CNV deletion 23290073
esv3380699 CNV duplication 20981092
esv3561841 CNV deletion 23714750
esv3568736 CNV loss 25503493
esv3596080 CNV loss 21293372
esv4049 CNV loss 18987735
esv7925 CNV loss 19470904
esv998559 CNV insertion 20482838
nsv1071495 CNV deletion 25765185
nsv3805 CNV insertion 18451855
nsv3806 CNV deletion 18451855
nsv428417 CNV loss 18775914
nsv436375 CNV deletion 17901297
nsv498999 CNV loss 21111241
nsv511233 CNV loss 21212237
nsv513046 CNV loss 21212237
nsv514150 CNV loss 21397061
nsv590212 CNV gain 21841781
nsv590226 CNV gain+loss 21841781
nsv954480 CNV deletion 24416366

Variation tolerance for SCAP Gene

Residual Variation Intolerance Score: 1.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.19; 92.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCAP Gene

Human Gene Mutation Database (HGMD)
SCAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCAP
Leiden Open Variation Database (LOVD)
SCAP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAP Gene

Disorders for SCAP Gene

MalaCards: The human disease database

(8) MalaCards diseases for SCAP Gene - From: COP and GCD

Disorder Aliases PubMed IDs
malt worker's lung
  • alveolitis due to aspergillus clavatus
dystonia, dopa-responsive, due to sepiapterin reductase deficiency
  • sepiapterin reductase deficiency; srd
lipid metabolism disorder
  • dyslipidemia
prostate cancer
  • prostate cancer, somatic
mckusick-kaufman syndrome
  • mkks
- elite association - COSMIC cancer census association via MalaCards
Search SCAP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SCAP

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SCAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCAP Gene

Publications for SCAP Gene

  1. Genomic structure and chromosomal mapping of the human sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) gene. (PMID: 10570913) Nakajima T … Emi M (Journal of human genetics 1999) 2 3 4 22
  2. Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population. (PMID: 19740467) Liu X … Gu D (Atherosclerosis 2010) 3 22 40
  3. The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage. (PMID: 19706601) Irisawa M … Sato R (The Journal of biological chemistry 2009) 3 4 22
  4. Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death. (PMID: 19116028) Fan YM … Lehtimäki T (Thrombosis journal 2008) 3 22 40
  5. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. (PMID: 17428920) Radhakrishnan A … Goldstein JL (Proceedings of the National Academy of Sciences of the United States of America 2007) 3 4 22

Products for SCAP Gene

Sources for SCAP Gene