This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript vari... See more...

Aliases for SCAP Gene

Aliases for SCAP Gene

  • SREBF Chaperone 2 3 5
  • Sterol Regulatory Element-Binding Protein Cleavage-Activating Protein 3 4
  • SREBP Cleavage-Activating Protein 3 4
  • SREBP Cleavage Activating Protein 2
  • KIAA0199 4

External Ids for SCAP Gene

Previous GeneCards Identifiers for SCAP Gene

  • GC03M047243
  • GC03M046675
  • GC03M047415
  • GC03M047430

Summaries for SCAP Gene

Entrez Gene Summary for SCAP Gene

  • This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SCAP Gene

SCAP (SREBF Chaperone) is a Protein Coding gene. Diseases associated with SCAP include Malt Worker's Lung and Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency. Among its related pathways are Chks in Checkpoint Regulation and Regulation of cholesterol biosynthesis by SREBP (SREBF). Gene Ontology (GO) annotations related to this gene include cholesterol binding. An important paralog of this gene is NPC1L1.

UniProtKB/Swiss-Prot Summary for SCAP Gene

  • Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).

Gene Wiki entry for SCAP Gene

Additional gene information for SCAP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCAP Gene

Genomics for SCAP Gene

GeneHancer (GH) Regulatory Elements for SCAP Gene

Promoters and enhancers for SCAP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J047474 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 507 +1.5 1538 3.2 ZBTB40 EP300 CTCF SIN3A NRF1 MYC POLR2G USF1 SP1 PHF8 SCAP LOC105377073 lnc-PTPN23-3 NBEAL2 TREX1 ZNF589 MAP4 ENSG00000276925
GH03J047477 Enhancer 0.3 ENCODE 500.7 -1.1 -1059 0.6 MEIS2 LOC105377073 SCAP PTH1R lnc-PTPN23-3 piR-57460-484
GH03J047778 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 22.1 -303.7 -303674 5.2 HNRNPK ZBTB40 ZNF217 SIN3A NRF1 MYC POLR2G USF1 SP1 GTF2E2 DHX30 SMARCC1 NME6 SETD2 ATRIP ZNF589 SCAP TMEM89 BOLA2P2 PTPN23
GH03J048085 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 -610.8 -610775 5.3 ZNF217 EP300 ZSCAN5C SIN3A NRF1 MYC POLR2G SP1 BCLAF1 PHF8 MAP4 lnc-CDC25A-2 DHX30 ATRIP ENSG00000235236 ZNF589 PTPN23 SETD2 BOLA2P2 KLHL18
GH03J047280 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.3 +193.7 193727 4.8 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G KIF9 KLHL18 lnc-SETD2-3 SETD2 DHX30 PTPN23 BOLA2P2 ZNF589 NBEAL2 SCAP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCAP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SCAP

Top Transcription factor binding sites by QIAGEN in the SCAP gene promoter:
  • c-Rel
  • Egr-4
  • FOXO3
  • FOXO3a
  • FOXO3b
  • GR
  • GR-alpha
  • Max1
  • Pax-5
  • RORalpha1

Genomic Locations for SCAP Gene

Genomic Locations for SCAP Gene
chr3:47,413,681-47,477,126
(GRCh38/hg38)
Size:
63,446 bases
Orientation:
Minus strand
chr3:47,455,184-47,518,616
(GRCh37/hg19)
Size:
63,433 bases
Orientation:
Minus strand

Genomic View for SCAP Gene

Genes around SCAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAP Gene

Proteins for SCAP Gene

  • Protein details for SCAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12770-SCAP_HUMAN
    Recommended name:
    Sterol regulatory element-binding protein cleavage-activating protein
    Protein Accession:
    Q12770
    Secondary Accessions:
    • Q8N2E0
    • Q8WUA1

    Protein attributes for SCAP Gene

    Size:
    1279 amino acids
    Molecular mass:
    139729 Da
    Quaternary structure:
    • Membrane region forms a homotetramer. Forms a stable complex with SREBF1/SREBP1 or SREBF2/SREBP2 through its C-terminal cytoplasmic domain. Forms a ternary complex with INSIG1 or INSIG2 through its transmembrane domains at high sterol concentrations. Interacts with the SEC23/SEC24 complex in a SAR1-GTP-dependent manner through an ER export signal in its third cytoplasmic loop. Binds cholesterol through its SSC domain (By similarity). Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing. Interacts with RNF139; the interaction inhibits the interaction of SCAP with SEC24B and hampering the ER to Golgi transport of the SCAP/SREBP complex.
    SequenceCaution:
    • Sequence=BAA12111.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11673.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SCAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAP Gene

Post-translational modifications for SCAP Gene

  • Ubiquitinated at Lys-454 and Lys-466. RNF145 triggers ubiquitination of SCAP, likely inhibiting SCAP:SREBPF2 complex transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2.
  • Glycosylation at Asn590, Asn641, and Asn263
  • Ubiquitination at Lys454, Lys466, and Lys842
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SCAP Gene

Domains & Families for SCAP Gene

Gene Families for SCAP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for SCAP Gene

GenScript: Design optimal peptide antigens:
  • SCAP protein (Q6PIX8_HUMAN)
  • Sterol regulatory element-binding protein cleavage-activating protein (SCAP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q12770

UniProtKB/Swiss-Prot:

SCAP_HUMAN :
  • Cholesterol bound to SSC domain of SCAP or oxysterol bound to INSIG1/2 leads to masking of an ER export signal on SCAP possibly by moving the signal further away from the ER membrane.
  • Belongs to the WD repeat SCAP family.
Domain:
  • Cholesterol bound to SSC domain of SCAP or oxysterol bound to INSIG1/2 leads to masking of an ER export signal on SCAP possibly by moving the signal further away from the ER membrane.
Family:
  • Belongs to the WD repeat SCAP family.
genes like me logo Genes that share domains with SCAP: view

Function for SCAP Gene

Molecular function for SCAP Gene

UniProtKB/Swiss-Prot Function:
Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).
UniProtKB/Swiss-Prot Induction:
By androgen-bound AR and glucocorticoid-bound NR3C1 in a prostate cancer cell line (LNCaP).

Phenotypes From GWAS Catalog for SCAP Gene

Gene Ontology (GO) - Molecular Function for SCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 19706601
GO:0032934 sterol binding IEA --
GO:0044877 protein-containing complex binding IEA --
GO:0051082 unfolded protein binding NAS 11726962
genes like me logo Genes that share ontologies with SCAP: view
genes like me logo Genes that share phenotypes with SCAP: view

Animal Model Products

CRISPR Products

miRNA for SCAP Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCAP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAP Gene

Localization for SCAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAP Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCAP gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 4
extracellular 2
mitochondrion 2
peroxisome 2
nucleus 2
endosome 2
cytosol 2
lysosome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum NAS 11726962
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus NAS 11726962
GO:0012507 ER to Golgi transport vesicle membrane IEA --
genes like me logo Genes that share ontologies with SCAP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SCAP Gene

Pathways & Interactions for SCAP Gene

genes like me logo Genes that share pathways with SCAP: view

Pathways by source for SCAP Gene

1 GeneGo (Thomson Reuters) pathway for SCAP Gene
  • Transcription Androgen Receptor nuclear signaling
1 Qiagen pathway for SCAP Gene
  • SREBP Proteolysis
1 Cell Signaling Technology pathway for SCAP Gene

SIGNOR curated interactions for SCAP Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SCAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0006629 lipid metabolic process IEA --
GO:0006955 immune response IEA --
GO:0007568 aging IEA --
GO:0008202 steroid metabolic process IEA --
genes like me logo Genes that share ontologies with SCAP: view

Drugs & Compounds for SCAP Gene

(10) Drugs for SCAP Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 574
Atorvastatin Approved Pharma Competitive, Inhibitor 875
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for SCAP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SCAP: view

Transcripts for SCAP Gene

mRNA/cDNA for SCAP Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCAP

Alternative Splicing Database (ASD) splice patterns (SP) for SCAP Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4:
SP5: - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: -
SP8:
SP9: -
SP10: -
SP11:
SP12:

ExUns: 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SCAP Gene

GeneLoc Exon Structure for
SCAP

Expression for SCAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCAP Gene

Protein differential expression in normal tissues from HIPED for SCAP Gene

This gene is overexpressed in Testis (37.3), Fetal testis (14.5), and Retina (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SCAP Gene



Protein tissue co-expression partners for SCAP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SCAP

SOURCE GeneReport for Unigene cluster for SCAP Gene:

Hs.531789

Evidence on tissue expression from TISSUES for SCAP Gene

  • Nervous system(4.7)
  • Liver(4.6)
  • Intestine(4.3)
  • Bone marrow(4.2)
  • Kidney(2.4)
genes like me logo Genes that share expression patterns with SCAP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCAP Gene

Orthologs for SCAP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SCAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCAP 31 30
  • 98.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SCAP 31 30
  • 90.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SCAP 31 30
  • 88.75 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scap 30
  • 87.77 (n)
mouse
(Mus musculus)
Mammalia Scap 17 31 30
  • 87.7 (n)
oppossum
(Monodelphis domestica)
Mammalia SCAP 31
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCAP 31 30
  • 74.67 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCAP 31
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scap 30
  • 70.28 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16805 30
zebrafish
(Danio rerio)
Actinopterygii scap 31
  • 70 (a)
OneToOne
LOC558292 30
  • 67.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011336 30
  • 48.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta SCAP 31 32 30
  • 46.92 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea scp-1 31 32 30
  • 41.82 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NCR1 31
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
OneToOne
Species where no ortholog for SCAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAP Gene

ENSEMBL:
Gene Tree for SCAP (if available)
TreeFam:
Gene Tree for SCAP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCAP: view image

Paralogs for SCAP Gene

Paralogs for SCAP Gene

genes like me logo Genes that share paralogs with SCAP: view

Variants for SCAP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SCAP Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
724329 Benign: not provided 47,414,034(-) G/C SYNONYMOUS_VARIANT
772861 Benign: not provided 47,414,632(-) C/A SYNONYMOUS_VARIANT
777773 Benign: not provided 47,414,198(-) C/T SYNONYMOUS_VARIANT
786877 Benign: not provided 47,418,852(-) G/A INTRON_VARIANT
789983 Benign: not provided 47,414,240(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SCAP Gene

Structural Variations from Database of Genomic Variants (DGV) for SCAP Gene

Variant ID Type Subtype PubMed ID
dgv125n73 CNV deletion 24416366
dgv1374e212 CNV loss 25503493
dgv2521n106 CNV deletion 24896259
dgv805n67 CNV loss 20364138
dgv8309n54 CNV loss 21841781
dgv8310n54 CNV loss 21841781
dgv8311n54 CNV gain+loss 21841781
dgv8312n54 CNV loss 21841781
dgv8313n54 CNV gain 21841781
esv1471808 CNV insertion 17803354
esv23620 CNV loss 19812545
esv2677458 CNV deletion 23128226
esv2725241 CNV deletion 23290073
esv3380699 CNV duplication 20981092
esv3561841 CNV deletion 23714750
esv3568736 CNV loss 25503493
esv3596080 CNV loss 21293372
esv4049 CNV loss 18987735
esv7925 CNV loss 19470904
esv998559 CNV insertion 20482838
nsv1071495 CNV deletion 25765185
nsv3805 CNV insertion 18451855
nsv3806 CNV deletion 18451855
nsv428417 CNV loss 18775914
nsv436375 CNV deletion 17901297
nsv498999 CNV loss 21111241
nsv511233 CNV loss 21212237
nsv513046 CNV loss 21212237
nsv514150 CNV loss 21397061
nsv590212 CNV gain 21841781
nsv590226 CNV gain+loss 21841781
nsv954480 CNV deletion 24416366

Variation tolerance for SCAP Gene

Residual Variation Intolerance Score: 1.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.19; 92.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCAP Gene

Human Gene Mutation Database (HGMD)
SCAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCAP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAP Gene

Disorders for SCAP Gene

MalaCards: The human disease database

(5) MalaCards diseases for SCAP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malt worker's lung
  • alveolitis due to aspergillus clavatus
dystonia, dopa-responsive, due to sepiapterin reductase deficiency
  • sepiapterin reductase deficiency; srd
lipid metabolism disorder
  • dyslipidemia
hypercholesterolemia, familial, 1
  • fhcl1
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search SCAP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SCAP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SCAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCAP Gene

Publications for SCAP Gene

  1. Genomic structure and chromosomal mapping of the human sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) gene. (PMID: 10570913) Nakajima T … Emi M (Journal of human genetics 1999) 2 3 4 23 54
  2. Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population. (PMID: 19740467) Liu X … Gu D (Atherosclerosis 2010) 3 23 41 54
  3. The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage. (PMID: 19706601) Irisawa M … Sato R (The Journal of biological chemistry 2009) 3 4 23 54
  4. Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death. (PMID: 19116028) Fan YM … Lehtimäki T (Thrombosis journal 2008) 3 23 41 54
  5. The relationship of sterol regulatory element-binding protein cleavage-activation protein and apolipoprotein E gene polymorphisms with metabolic changes during weight reduction. (PMID: 17570245) Nieminen T … Lehtimäki T (Metabolism: clinical and experimental 2007) 3 23 41 54

Products for SCAP Gene

Sources for SCAP Gene