This gene encodes an integral membrane protein that belongs to the secretory carrier membrane protein family. The encoded protein functions as a carrier to the cell surface in post-golgi recycling pathways. This protein is also involved in protein trafficking in endosomal pathways. Two transcript variants encoding different isoforms have been found for this gene.[provided by Re... See more...

Aliases for SCAMP3 Gene

Aliases for SCAMP3 Gene

  • Secretory Carrier Membrane Protein 3 2 3 4 5
  • Secretory Carrier-Associated Membrane Protein 3 3 4
  • Propin 1 2 3
  • C1orf3 3 4
  • PROPIN1 4

External Ids for SCAMP3 Gene

Previous HGNC Symbols for SCAMP3 Gene

  • C1orf3

Previous GeneCards Identifiers for SCAMP3 Gene

  • GC01M153083
  • GC01M150966
  • GC01M152003
  • GC01M152442
  • GC01M152038
  • GC01M153494
  • GC01M155225
  • GC01M126588

Summaries for SCAMP3 Gene

Entrez Gene Summary for SCAMP3 Gene

  • This gene encodes an integral membrane protein that belongs to the secretory carrier membrane protein family. The encoded protein functions as a carrier to the cell surface in post-golgi recycling pathways. This protein is also involved in protein trafficking in endosomal pathways. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

GeneCards Summary for SCAMP3 Gene

SCAMP3 (Secretory Carrier Membrane Protein 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is SCAMP1.

UniProtKB/Swiss-Prot Summary for SCAMP3 Gene

  • Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

Gene Wiki entry for SCAMP3 Gene

Additional gene information for SCAMP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCAMP3 Gene

Genomics for SCAMP3 Gene

GeneHancer (GH) Regulatory Elements for SCAMP3 Gene

Promoters and enhancers for SCAMP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J155260 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.4 394 3 ZBTB40 ZNF217 SIN3A NRF1 MYC TCF12 USF1 POLR2G SP1 NCOR1 NONHSAG003063.2 SCAMP3 lnc-CLK2-2 CLK2 KHDC4 GON4L ENSG00000271267 THBS3 RUSC1-AS1 SHC1
GH01J155206 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 +53.3 53264 5.5 EP300 ZBTB40 ZNF217 CTCF SIN3A NRF1 TCF12 POLR2G NCOR1 GTF2E2 THBS3 MTX1 KRTCAP2 TRIM46 FAM189B SCAMP3 LMNA DAP3 FDPS POU5F1P4
GH01J155307 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 12.2 -46.8 -46761 4 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 MYC POLR2G USF1 SP1 FDPS PKLR lnc-PKLR-1 GBA GON4L HCN3 CLK2 FAM189B THBS3 KHDC4
GH01J155319 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.4 -60.7 -60693 6.3 RXRA HNRNPK ZBTB40 ZNF217 CTCF SIN3A NRF1 POLR2G USF1 SP1 RUSC1 RUSC1-AS1 DPM3 SCAMP3 FAM189B GBA MIR555 ASH1L CLK2 RNU6-1297P
GH01J155648 Promoter/Enhancer 1.1 EPDnew ENCODE 10.7 -386.3 -386253 1.1 ZNF217 EP300 CTCF TCF12 FOS REST TGIF2 TEAD1 CTBP1 SIN3A ASH1L LOC100419799 GBA SCAMP3 FAM189B RUSC1-AS1 RUSC1 MIR555 DAP3 LOC100419798
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCAMP3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SCAMP3

Top Transcription factor binding sites by QIAGEN in the SCAMP3 gene promoter:
  • AhR
  • Arnt
  • Bach2
  • ITF-2
  • MAZR
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1beta

Genomic Locations for SCAMP3 Gene

Genomic Locations for SCAMP3 Gene
chr1:155,255,979-155,262,434
(GRCh38/hg38)
Size:
6,456 bases
Orientation:
Minus strand
chr1:155,225,770-155,232,221
(GRCh37/hg19)
Size:
6,452 bases
Orientation:
Minus strand

Genomic View for SCAMP3 Gene

Genes around SCAMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP3 Gene

Proteins for SCAMP3 Gene

  • Protein details for SCAMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14828-SCAM3_HUMAN
    Recommended name:
    Secretory carrier-associated membrane protein 3
    Protein Accession:
    O14828
    Secondary Accessions:
    • A9Z1W6
    • B1AVS6
    • O15128
    • Q96FR8
    • Q9BPY0

    Protein attributes for SCAMP3 Gene

    Size:
    347 amino acids
    Molecular mass:
    38287 Da
    Quaternary structure:
    • Interacts with NEDD4, NEDD4L and TSG101. Interacts with RNF126.

    Alternative splice isoforms for SCAMP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAMP3 Gene

Post-translational modifications for SCAMP3 Gene

  • Monoubiquitinated.
  • Ubiquitination at Lys74, Lys81, Lys101, Lys102, and Lys313
  • Modification sites at PhosphoSitePlus

Other Protein References for SCAMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCAMP3 Gene

Domains & Families for SCAMP3 Gene

Gene Families for SCAMP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SCAMP3 Gene

Blocks:
  • SCAMP
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SCAMP3 Gene

GenScript: Design optimal peptide antigens:
  • SCAMP3 protein (Q6FHJ5_HUMAN)
  • Secretory carrier-associated membrane protein 3 (SCAM3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14828

UniProtKB/Swiss-Prot:

SCAM3_HUMAN :
  • Belongs to the SCAMP family.
Family:
  • Belongs to the SCAMP family.
genes like me logo Genes that share domains with SCAMP3: view

Function for SCAMP3 Gene

Molecular function for SCAMP3 Gene

UniProtKB/Swiss-Prot Function:
Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
GENATLAS Biochemistry:
secretory carrier membrane protein 3,widely expressed,as component of post-Golgi membranes,homolog of rat secretory carrier membrane protein 37 (SCAMP37),involved in cell surface recycling

Phenotypes From GWAS Catalog for SCAMP3 Gene

Gene Ontology (GO) - Molecular Function for SCAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IPI 23418353
genes like me logo Genes that share ontologies with SCAMP3: view
genes like me logo Genes that share phenotypes with SCAMP3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCAMP3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCAMP3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAMP3 Gene

Localization for SCAMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCAMP3 gene
Compartment Confidence
plasma membrane 4
endosome 4
golgi apparatus 4
lysosome 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SCAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA 21873635
GO:0005794 Golgi apparatus IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032588 trans-Golgi network membrane IBA 21873635
genes like me logo Genes that share ontologies with SCAMP3: view

Pathways & Interactions for SCAMP3 Gene

PathCards logo

SuperPathways for SCAMP3 Gene

No Data Available

SIGNOR curated interactions for SCAMP3 Gene

Other effect:

Gene Ontology (GO) - Biological Process for SCAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006892 post-Golgi vesicle-mediated transport TAS 9378760
GO:0015031 protein transport IBA 21873635
genes like me logo Genes that share ontologies with SCAMP3: view

No data available for Pathways by source for SCAMP3 Gene

Drugs & Compounds for SCAMP3 Gene

No Compound Related Data Available

Transcripts for SCAMP3 Gene

mRNA/cDNA for SCAMP3 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCAMP3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ·
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - -
SP9: - -
SP10: - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - -
SP12: - - - - - -
SP13: - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - -
SP16: -
SP17: - - - - - - - - -
SP18: - - - - - - - - - - -
SP19:

ExUns: 9c ^ 10a · 10b · 10c · 10d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for SCAMP3 Gene

GeneLoc Exon Structure for
SCAMP3

Expression for SCAMP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCAMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCAMP3 Gene

This gene is overexpressed in Nasal epithelium (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SCAMP3 Gene



Protein tissue co-expression partners for SCAMP3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SCAMP3

SOURCE GeneReport for Unigene cluster for SCAMP3 Gene:

Hs.200600

mRNA Expression by UniProt/SwissProt for SCAMP3 Gene:

O14828-SCAM3_HUMAN
Tissue specificity: Widely expressed, with highest expression in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for SCAMP3 Gene

  • Nervous system(4.6)
  • Liver(4.2)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with SCAMP3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCAMP3 Gene

Orthologs for SCAMP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAMP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCAMP3 31 30
  • 99.9 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SCAMP3 31 30
  • 92.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SCAMP3 31 30
  • 92.51 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Scamp3 17 31 30
  • 88.18 (n)
rat
(Rattus norvegicus)
Mammalia Scamp3 30
  • 87.51 (n)
oppossum
(Monodelphis domestica)
Mammalia SCAMP3 31
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 43 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SCAMP3 31
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCAMP3 31
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scamp3 30
  • 71.16 (n)
Str.1919 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.12686 30
zebrafish
(Danio rerio)
Actinopterygii scamp3 31 30
  • 64.57 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Scamp 31 32
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scm-1 31
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8273 31
  • 46 (a)
OneToMany
Species where no ortholog for SCAMP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAMP3 Gene

ENSEMBL:
Gene Tree for SCAMP3 (if available)
TreeFam:
Gene Tree for SCAMP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCAMP3: view image

Paralogs for SCAMP3 Gene

Paralogs for SCAMP3 Gene

(4) SIMAP similar genes for SCAMP3 Gene using alignment to 2 proteins:

  • SCAM3_HUMAN
  • Q6FHJ5_HUMAN
genes like me logo Genes that share paralogs with SCAMP3: view

Variants for SCAMP3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SCAMP3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1318328 - p.Val235Ala
rs760073 - p.Leu38Arg
rs909106 - p.Ile239Asn
rs909107 - p.Val242Asp

Additional dbSNP identifiers (rs#s) for SCAMP3 Gene

Structural Variations from Database of Genomic Variants (DGV) for SCAMP3 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV loss 17160897
esv23319 CNV gain 19812545
esv2758971 CNV gain 17122850
esv33869 CNV loss 17666407
nsv1008748 CNV loss 25217958
nsv1011773 CNV gain 25217958
nsv436027 CNV insertion 17901297
nsv470741 CNV loss 18288195
nsv831636 CNV loss 17160897

Variation tolerance for SCAMP3 Gene

Residual Variation Intolerance Score: 19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCAMP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCAMP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAMP3 Gene

Disorders for SCAMP3 Gene

Additional Disease Information for SCAMP3

No disorders were found for SCAMP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAMP3 Gene

Publications for SCAMP3 Gene

  1. Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease. (PMID: 9331372) Winfield SL … Sidransky E (Genome research 1997) 2 3 4 54
  2. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. (PMID: 23418353) Smith CJ … McGlade CJ (Journal of cell science 2013) 3 4 54
  3. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PMID: 21102463) Franke A … Parkes M (Nature genetics 2010) 3 41 54
  4. SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling. (PMID: 19158374) Aoh QL … Castle JD (Molecular biology of the cell 2009) 3 4 54
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 54

Products for SCAMP3 Gene

Sources for SCAMP3 Gene