This gene product belongs to the SCAMP family of proteins, which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that these protein family members may function at the same site... See more...

Aliases for SCAMP1 Gene

Aliases for SCAMP1 Gene

  • Secretory Carrier Membrane Protein 1 2 3 4 5
  • Secretory Carrier-Associated Membrane Protein 1 3 4
  • SCAMP37 2 3
  • SCAMP 3 4
  • SCAMP1 5

External Ids for SCAMP1 Gene

Previous GeneCards Identifiers for SCAMP1 Gene

  • GC05P076461
  • GC05P077893
  • GC05P077695
  • GC05P077740
  • GC05P077692
  • GC05P072862
  • GC05P077656

Summaries for SCAMP1 Gene

Entrez Gene Summary for SCAMP1 Gene

  • This gene product belongs to the SCAMP family of proteins, which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that these protein family members may function at the same site during vesicular transport rather than in separate pathways. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for SCAMP1 Gene

SCAMP1 (Secretory Carrier Membrane Protein 1) is a Protein Coding gene. Diseases associated with SCAMP1 include Branchiootorenal Syndrome 1 and Childhood Kidney Cell Carcinoma. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein domain specific binding. An important paralog of this gene is SCAMP3.

UniProtKB/Swiss-Prot Summary for SCAMP1 Gene

  • Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.

Gene Wiki entry for SCAMP1 Gene

Additional gene information for SCAMP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SCAMP1 Gene

Genomics for SCAMP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SCAMP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCAMP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SCAMP1

Top Transcription factor binding sites by QIAGEN in the SCAMP1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Evi-1
  • LCR-F1
  • Pax-2
  • Zic1

Genomic Locations for SCAMP1 Gene

Genomic Locations for SCAMP1 Gene
chr5:78,360,530-78,480,739
(GRCh38/hg38)
Size:
120,210 bases
Orientation:
Plus strand
chr5:77,656,339-77,776,562
(GRCh37/hg19)
Size:
120,224 bases
Orientation:
Plus strand

Genomic View for SCAMP1 Gene

Genes around SCAMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAMP1 Gene

Proteins for SCAMP1 Gene

  • Protein details for SCAMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15126-SCAM1_HUMAN
    Recommended name:
    Secretory carrier-associated membrane protein 1
    Protein Accession:
    O15126
    Secondary Accessions:
    • O43587
    • Q6FG23
    • Q96BX1
    • Q96QK5

    Protein attributes for SCAMP1 Gene

    Size:
    338 amino acids
    Molecular mass:
    37920 Da
    Quaternary structure:
    • Interacts with SYNRG and ITSN1 (By similarity). Interacts with SLC9A7.
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for SCAMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCAMP1 Gene

Post-translational modifications for SCAMP1 Gene

  • Ubiquitination at Lys89, Lys298, Lys311, and Lys334
  • Modification sites at PhosphoSitePlus

Other Protein References for SCAMP1 Gene

Antibody Products

  • Abcam antibodies for SCAMP1
  • Boster Bio Antibodies for SCAMP1

No data available for DME Specific Peptides for SCAMP1 Gene

Domains & Families for SCAMP1 Gene

Gene Families for SCAMP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SCAMP1 Gene

InterPro:
Blocks:
  • SCAMP
ProtoNet:

Suggested Antigen Peptide Sequences for SCAMP1 Gene

GenScript: Design optimal peptide antigens:
  • Secretory carrier-associated membrane protein 1 (SCAM1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15126

UniProtKB/Swiss-Prot:

SCAM1_HUMAN :
  • Belongs to the SCAMP family.
Family:
  • Belongs to the SCAMP family.
genes like me logo Genes that share domains with SCAMP1: view

Function for SCAMP1 Gene

Molecular function for SCAMP1 Gene

UniProtKB/Swiss-Prot Function:
Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
GENATLAS Biochemistry:
secretory carrier membrane protein 1,widely distributed as component of post-Golgi membranes,involved in cell surface recycling

Phenotypes From GWAS Catalog for SCAMP1 Gene

Gene Ontology (GO) - Molecular Function for SCAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15840657
genes like me logo Genes that share ontologies with SCAMP1: view
genes like me logo Genes that share phenotypes with SCAMP1: view

Animal Models for SCAMP1 Gene

MGI Knock Outs for SCAMP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCAMP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCAMP1 Gene

Localization for SCAMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAMP1 Gene

Golgi apparatus, trans-Golgi network membrane. Multi-pass membrane protein. Recycling endosome membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCAMP1 gene
Compartment Confidence
endosome 5
golgi apparatus 5
plasma membrane 4
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SCAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA 21873635
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IBA 21873635
GO:0005802 trans-Golgi network IDA 15840657
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SCAMP1: view

Pathways & Interactions for SCAMP1 Gene

PathCards logo

SuperPathways for SCAMP1 Gene

genes like me logo Genes that share pathways with SCAMP1: view

Pathways by source for SCAMP1 Gene

3 Reactome pathways for SCAMP1 Gene

Gene Ontology (GO) - Biological Process for SCAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0006892 post-Golgi vesicle-mediated transport TAS 9378760
GO:0015031 protein transport IEA,IDA 15840657
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with SCAMP1: view

No data available for SIGNOR curated interactions for SCAMP1 Gene

Drugs & Compounds for SCAMP1 Gene

No Compound Related Data Available

Transcripts for SCAMP1 Gene

mRNA/cDNA for SCAMP1 Gene

3 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SCAMP1

Alternative Splicing Database (ASD) splice patterns (SP) for SCAMP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - - -
SP3:
SP4: - -

Relevant External Links for SCAMP1 Gene

GeneLoc Exon Structure for
SCAMP1

Expression for SCAMP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SCAMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SCAMP1 Gene

This gene is overexpressed in Fetal Brain (13.0) and Pancreas (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SCAMP1 Gene



Protein tissue co-expression partners for SCAMP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SCAMP1

SOURCE GeneReport for Unigene cluster for SCAMP1 Gene:

Hs.482587

mRNA Expression by UniProt/SwissProt for SCAMP1 Gene:

O15126-SCAM1_HUMAN
Tissue specificity: Widely expressed, with highest expression in brain.

Evidence on tissue expression from TISSUES for SCAMP1 Gene

  • Nervous system(4.3)
  • Blood(4.2)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with SCAMP1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCAMP1 Gene

Orthologs for SCAMP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAMP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SCAMP1 30
  • 99.7 (n)
Dog
(Canis familiaris)
Mammalia SCAMP1 30 31
  • 95.07 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SCAMP1 30 31
  • 92.44 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SCAMP1 31
  • 91 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SCAMP1 31
  • 90 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Scamp1 30
  • 87.18 (n)
Mouse
(Mus musculus)
Mammalia Scamp1 30 17 31
  • 86.49 (n)
OneToOne
Chicken
(Gallus gallus)
Aves SCAMP1 30 31
  • 85.5 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SCAMP1 31
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia scamp1 30
  • 77.15 (n)
Zebrafish
(Danio rerio)
Actinopterygii scamp1 30 31
  • 70.61 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Scamp 30 31 32
  • 51.27 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002922 30
  • 49.67 (n)
Worm
(Caenorhabditis elegans)
Secernentea scm-1 30 31
  • 50.23 (n)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8273 31
  • 53 (a)
OneToMany
Species where no ortholog for SCAMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SCAMP1 Gene

ENSEMBL:
Gene Tree for SCAMP1 (if available)
TreeFam:
Gene Tree for SCAMP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SCAMP1: view image

Paralogs for SCAMP1 Gene

Paralogs for SCAMP1 Gene

(4) SIMAP similar genes for SCAMP1 Gene using alignment to 2 proteins:

  • SCAM1_HUMAN
  • U3KQ30_HUMAN

Pseudogenes.org Pseudogenes for SCAMP1 Gene

genes like me logo Genes that share paralogs with SCAMP1: view

Variants for SCAMP1 Gene

Additional dbSNP identifiers (rs#s) for SCAMP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SCAMP1 Gene

Variant ID Type Subtype PubMed ID
esv1508933 CNV deletion 17803354
esv1526123 CNV insertion 17803354
esv2026918 CNV deletion 18987734
esv2730334 CNV deletion 23290073
esv2730335 CNV deletion 23290073
esv2730336 CNV deletion 23290073
esv3566142 CNV deletion 23714750
esv3605509 CNV loss 21293372
nsv1021871 CNV gain 25217958
nsv1123963 CNV deletion 24896259
nsv1140551 CNV deletion 24896259
nsv1142632 CNV deletion 24896259
nsv1147240 CNV deletion 26484159
nsv328878 CNV deletion 16902084
nsv950096 CNV duplication 24416366
nsv955832 CNV deletion 24416366

Variation tolerance for SCAMP1 Gene

Gene Damage Index Score: 2.63; 45.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCAMP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCAMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SCAMP1 Gene

Disorders for SCAMP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SCAMP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
branchiootorenal syndrome 1
  • bor1
childhood kidney cell carcinoma
  • pediatric renal cell carcinoma
branchiootorenal syndrome
  • branchiootorenal dysplasia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SCAMP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SCAMP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCAMP1 Gene

Publications for SCAMP1 Gene

  1. Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions. (PMID: 9378760) Singleton DR … Castle JD (Journal of cell science 1997) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. (PMID: 19668339) Potkin SG … Alzheimer's Disease Neuroimaging Initiative (PloS one 2009) 3 41
  4. Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7. (PMID: 15840657) Lin PJ … Numata M (Journal of cell science 2005) 3 4
  5. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman RT … Brenner SE (Genome biology 2004) 3 4

Products for SCAMP1 Gene

  • Signalway ELISA kits for SCAMP1
  • Signalway Proteins for SCAMP1

Sources for SCAMP1 Gene