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Aliases for SCAI Gene

Aliases for SCAI Gene

  • Suppressor Of Cancer Cell Invasion 2 3 5
  • Suppressor Of Cancer Cell Invasion Protein 3 4
  • C9orf126 3 4
  • Chromosome 9 Open Reading Frame 126 2
  • Protein SCAI 3
  • NET40 3

External Ids for SCAI Gene

Previous HGNC Symbols for SCAI Gene

  • C9orf126

Previous GeneCards Identifiers for SCAI Gene

  • GC09M126755
  • GC09M127704
  • GC09M097317

Summaries for SCAI Gene

Entrez Gene Summary for SCAI Gene

  • This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

GeneCards Summary for SCAI Gene

SCAI (Suppressor Of Cancer Cell Invasion) is a Protein Coding gene. Diseases associated with SCAI include Vertebral Artery Insufficiency. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity.

UniProtKB/Swiss-Prot for SCAI Gene

  • Tumor suppressor which functions to suppress MKL1-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.

Additional gene information for SCAI Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAI Gene

Genomics for SCAI Gene

GeneHancer (GH) Regulatory Elements for SCAI Gene

Promoters and enhancers for SCAI Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I125142 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.3 346 2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 E2F8 ZNF207 ZNF143 FOS SCAI GAPVD1 RABEPK GOLGA1 GC09P125105
GH09I125198 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.6 -56.8 -56830 3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B RABEPK LOC105376271 PRPS1P2 SCAI GAPVD1 RPSAP76
GH09I124939 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.7 +202.3 202250 3 HDGF SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GC09P124941 GOLGA1 ARPC5L SCAI PPP6C GAPVD1 GC09M124944
GH09I125119 Enhancer 0.9 ENCODE dbSUPER 16.2 +22.1 22101 3.8 HDAC1 MEIS2 CTCF PKNOX1 FOXA2 TAF9B HLF DACH1 MNT FOSL1 SCAI RABEPK PRPS1P2 GC09P125105
GH09I125887 Enhancer 1.1 Ensembl ENCODE 12.4 -743.9 -743892 0.3 PKNOX1 FOXA2 ARNT FEZF1 ZNF213 YY2 TSHZ1 ZNF488 NFIL3 PRDM4 SCAI GC09P125878 GC09P125901 PBX3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SCAI on UCSC Golden Path with GeneCards custom track

Genomic Locations for SCAI Gene

Genomic Locations for SCAI Gene
200,952 bases
Minus strand

Genomic View for SCAI Gene

Genes around SCAI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAI Gene

Proteins for SCAI Gene

  • Protein details for SCAI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein SCAI
    Protein Accession:
    Secondary Accessions:
    • Q3SXZ1
    • Q3SXZ2
    • Q5T163
    • Q8N1I4

    Protein attributes for SCAI Gene

    606 amino acids
    Molecular mass:
    70399 Da
    Quaternary structure:
    • Interacts with DIAPH1 (By similarity). Forms a nuclear ternary complex with MKL1 and SRF.

    Alternative splice isoforms for SCAI Gene


neXtProt entry for SCAI Gene

Post-translational modifications for SCAI Gene

No Post-translational modifications

Other Protein References for SCAI Gene

No data available for DME Specific Peptides for SCAI Gene

Domains & Families for SCAI Gene

Gene Families for SCAI Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SCAI Gene

Suggested Antigen Peptide Sequences for SCAI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SCAI family.
  • Belongs to the SCAI family.
genes like me logo Genes that share domains with SCAI: view

Function for SCAI Gene

Molecular function for SCAI Gene

UniProtKB/Swiss-Prot Function:
Tumor suppressor which functions to suppress MKL1-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.

Phenotypes From GWAS Catalog for SCAI Gene

Gene Ontology (GO) - Molecular Function for SCAI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IMP 19350017
GO:0005515 protein binding IPI 19350017
genes like me logo Genes that share ontologies with SCAI: view
genes like me logo Genes that share phenotypes with SCAI: view

Animal Models for SCAI Gene

MGI Knock Outs for SCAI:
  • Scai tm1b(EUCOMM)Hmgu

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SCAI Gene

Localization for SCAI Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAI Gene

Membrane; Single-pass membrane protein. Nucleus. Cytoplasm. Note=Nuclear localization is required for inhibition of MKL1. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCAI gene
Compartment Confidence
nucleus 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SCAI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SCAI: view

Pathways & Interactions for SCAI Gene

genes like me logo Genes that share pathways with SCAI: view

Pathways by source for SCAI Gene

1 Cell Signaling Technology pathway for SCAI Gene

Gene Ontology (GO) - Biological Process for SCAI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009968 negative regulation of signal transduction IEA --
GO:0030336 negative regulation of cell migration IEA,IMP 19350017
GO:0035024 negative regulation of Rho protein signal transduction ISS,IEA --
genes like me logo Genes that share ontologies with SCAI: view

No data available for SIGNOR curated interactions for SCAI Gene

Drugs & Compounds for SCAI Gene

No Compound Related Data Available

Transcripts for SCAI Gene

Unigene Clusters for SCAI Gene

Suppressor of cancer cell invasion:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAI Gene

No ASD Table

Relevant External Links for SCAI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCAI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCAI Gene

Protein differential expression in normal tissues from HIPED for SCAI Gene

This gene is overexpressed in Brain (26.4), Frontal cortex (15.9), Fetal Brain (9.5), and Cervix (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCAI Gene

Protein tissue co-expression partners for SCAI Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCAI Gene:


SOURCE GeneReport for Unigene cluster for SCAI Gene:


Evidence on tissue expression from TISSUES for SCAI Gene

  • Heart(2.7)
genes like me logo Genes that share expression patterns with SCAI: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCAI Gene

Orthologs for SCAI Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SCAI Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCAI 33 34
  • 99.47 (n)
(Monodelphis domestica)
Mammalia SCAI 34
  • 96 (a)
(Bos Taurus)
Mammalia SCAI 33 34
  • 95.54 (n)
(Canis familiaris)
Mammalia SCAI 33 34
  • 93.22 (n)
(Rattus norvegicus)
Mammalia Scai 33
  • 91.8 (n)
(Mus musculus)
Mammalia Scai 33 16 34
  • 91.53 (n)
(Ornithorhynchus anatinus)
Mammalia SCAI 34
  • 68 (a)
(Gallus gallus)
Aves SCAI 33 34
  • 84.54 (n)
(Anolis carolinensis)
Reptilia SCAI 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scai 33
  • 78.21 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8413 33
(Danio rerio)
Actinopterygii scai 33 34
  • 71.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13293 33 34
  • 55.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005770 33
  • 54.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G03570 33
  • 46.48 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for SCAI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCAI Gene

Gene Tree for SCAI (if available)
Gene Tree for SCAI (if available)

Paralogs for SCAI Gene

(1) SIMAP similar genes for SCAI Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SCAI: view

No data available for Paralogs for SCAI Gene

Variants for SCAI Gene

Sequence variations from dbSNP and Humsavar for SCAI Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000019428 -- 125,097,075(-) G/T intron_variant
rs1000019576 -- 125,107,245(-) C/T intron_variant
rs1000026900 -- 125,064,893(-) T/C intron_variant
rs1000034955 -- 125,107,726(-) C/T intron_variant
rs1000052846 -- 125,014,392(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SCAI Gene

Variant ID Type Subtype PubMed ID
nsv1139999 CNV duplication 24896259
nsv1118367 CNV deletion 24896259
nsv1110062 CNV deletion 24896259
nsv1110061 CNV deletion 24896259
esv3621731 CNV loss 21293372
esv3573385 CNV loss 25503493
esv2739041 CNV deletion 23290073
esv2442459 CNV deletion 19546169

Variation tolerance for SCAI Gene

Residual Variation Intolerance Score: 14.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.16; 87.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCAI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAI Gene

Disorders for SCAI Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCAI Gene - From: DISEASES

Disorder Aliases PubMed IDs
vertebral artery insufficiency
  • vertebral artery syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SCAI in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SCAI

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SCAI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCAI Gene

Publications for SCAI Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. (PMID: 19350017) Brandt DT … Grosse R (Nature cell biology 2009) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SCAI Gene

Sources for SCAI Gene

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