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Aliases for SCAF4 Gene

Aliases for SCAF4 Gene

  • SR-Related CTD Associated Factor 4 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 15 2 3
  • CTD-Binding SR-Like Protein RA4 3 4
  • SFRS15 3 4
  • SR-Related And CTD-Associated Factor 4 4
  • Splicing Factor Serine Alanine 15 3
  • Pre-MRNA Splicing SR Protein RA4 3
  • SR-Like CTD-Associated Factor 4 3
  • KIAA1172 4
  • SRA4 3

External Ids for SCAF4 Gene

Previous HGNC Symbols for SCAF4 Gene

  • SFRS15

Previous GeneCards Identifiers for SCAF4 Gene

  • GC21M033044

Summaries for SCAF4 Gene

Entrez Gene Summary for SCAF4 Gene

  • This gene likely encodes a member of the arginine/serine-rich splicing factor family. A similar protein in Rat appears to bind the large subunit of RNA polymerase II and provide a link between transcription and pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for SCAF4 Gene

SCAF4 (SR-Related CTD Associated Factor 4) is a Protein Coding gene. Diseases associated with SCAF4 include Wells Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SCAF8.

UniProtKB/Swiss-Prot for SCAF4 Gene

  • May act to physically and functionally link transcription and pre-mRNA processing.

Additional gene information for SCAF4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAF4 Gene

Genomics for SCAF4 Gene

GeneHancer (GH) Regulatory Elements for SCAF4 Gene

Promoters and enhancers for SCAF4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J031730 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 715.7 0.0 -32 4.1 HDGF PKNOX1 ARNT SIN3A DMAP1 IRF4 YY1 POLR2B ZNF766 CBX5 SCAF4 MIS18A URB1 ENSG00000238390 EVA1C SOD1 ENSG00000273091
GH21J032611 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 86.8 -880.3 -880329 2.9 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 ZFP41 CFAP298 ENSG00000265590 SCAF4 PAXBP1 SON TMEM50B GART MIS18A EVA1C DONSON
GH21J032492 Enhancer 1.3 Ensembl ENCODE dbSUPER 90.4 -762.6 -762562 4.6 PKNOX1 ZNF493 ZFP64 FEZF1 BATF ZNF48 RFX5 ZNF213 EGR1 ZNF350 PAXBP1 TMEM50B SCAF4 EVA1C URB1 CFAP298 MIS18A C21orf62-AS1 ENSG00000238390 ENSG00000252045
GH21J032726 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 45.9 -995.6 -995648 2.7 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A YY1 SLC30A9 POLR2B ZNF213 SYNJ1 PAXBP1-AS1 PAXBP1 SCAF4 MIS18A DONSON TMEM50B SON C21orf62-AS1 GART
GH21J032258 Enhancer 1.1 Ensembl ENCODE 82.3 -526.4 -526383 0.6 FOXA2 ZNF493 ZFP64 ZNF213 ARID2 ZNF143 RUNX3 DEK ZNF202 ZC3H11A PAXBP1 SCAF4 EVA1C CFAP298 URB1 MIS18A PAXBP1-AS1 C21orf62-AS1 LINC00846 ENSG00000238390
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SCAF4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SCAF4 Gene

Genomic Locations for SCAF4 Gene
61,119 bases
Minus strand
61,119 bases
Minus strand

Genomic View for SCAF4 Gene

Genes around SCAF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCAF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCAF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCAF4 Gene

Proteins for SCAF4 Gene

  • Protein details for SCAF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Splicing factor, arginine/serine-rich 15
    Protein Accession:
    Secondary Accessions:
    • C9JLZ0
    • Q0P5W8
    • Q6P1M5
    • Q8N3I8
    • Q9UFM1
    • Q9ULP8

    Protein attributes for SCAF4 Gene

    1147 amino acids
    Molecular mass:
    125869 Da
    Quaternary structure:
    • Interacts with the repetitive C-terminal domain (CTD) of RNA polymerase II.
    • Sequence=AAD09327.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SCAF4 Gene


neXtProt entry for SCAF4 Gene

Post-translational modifications for SCAF4 Gene

  • Ubiquitination at isoforms=2, 3583 and posLast=119119
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SCAF4 Gene

Domains & Families for SCAF4 Gene

Gene Families for SCAF4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SCAF4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the splicing factor SR family.
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SCAF4: view

Function for SCAF4 Gene

Molecular function for SCAF4 Gene

UniProtKB/Swiss-Prot Function:
May act to physically and functionally link transcription and pre-mRNA processing.

Phenotypes From GWAS Catalog for SCAF4 Gene

Gene Ontology (GO) - Molecular Function for SCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IEA 22681889
genes like me logo Genes that share ontologies with SCAF4: view
genes like me logo Genes that share phenotypes with SCAF4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAF4 Gene

Localization for SCAF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCAF4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCAF4 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SCAF4: view

Pathways & Interactions for SCAF4 Gene

SuperPathways for SCAF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCAF4 Gene


No data available for Pathways by source and SIGNOR curated interactions for SCAF4 Gene

Drugs & Compounds for SCAF4 Gene

No Compound Related Data Available

Transcripts for SCAF4 Gene

Unigene Clusters for SCAF4 Gene

SR-related CTD-associated factor 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCAF4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15a · 15b · 15c ^
SP2: -
SP3: -
SP4: - - -
SP5: -
SP7: -
SP8: -
SP9: -

ExUns: 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c
SP11: -
SP12: - -

Relevant External Links for SCAF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCAF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCAF4 Gene

Protein differential expression in normal tissues from HIPED for SCAF4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.1), Urine (8.1), and Blymphocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SCAF4 Gene

Protein tissue co-expression partners for SCAF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCAF4 Gene:


SOURCE GeneReport for Unigene cluster for SCAF4 Gene:


Evidence on tissue expression from TISSUES for SCAF4 Gene

  • Nervous system(4.6)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with SCAF4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCAF4 Gene

Orthologs for SCAF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCAF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCAF4 34 33
  • 99.85 (n)
(Canis familiaris)
Mammalia SCAF4 34 33
  • 92.24 (n)
(Bos Taurus)
Mammalia SCAF4 34 33
  • 90.51 (n)
(Monodelphis domestica)
Mammalia SCAF4 34
  • 89 (a)
(Mus musculus)
Mammalia Scaf4 16 34 33
  • 88.3 (n)
(Rattus norvegicus)
Mammalia Scaf4 33
  • 83.63 (n)
(Ornithorhynchus anatinus)
Mammalia SCAF4 34
  • 80 (a)
(Gallus gallus)
Aves SCAF4 34
  • 81 (a)
(Anolis carolinensis)
Reptilia SCAF4 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scaf4 33
  • 71.13 (n)
(Danio rerio)
Actinopterygii scaf4a 34
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4266 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea nrd-1 34
  • 27 (a)
Species where no ortholog for SCAF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCAF4 Gene

Gene Tree for SCAF4 (if available)
Gene Tree for SCAF4 (if available)
Evolutionary constrained regions (ECRs) for SCAF4: view image

Paralogs for SCAF4 Gene

Paralogs for SCAF4 Gene

(2) SIMAP similar genes for SCAF4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCAF4: view

Variants for SCAF4 Gene

Sequence variations from dbSNP and Humsavar for SCAF4 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs386352359 uncertain-significance, not provided 31,692,445(-) G/A coding_sequence_variant, synonymous_variant
rs1000028384 -- 31,729,262(-) C/T intron_variant
rs1000078094 -- 31,693,796(-) C/T intron_variant
rs1000151364 -- 31,708,614(-) G/A intron_variant
rs1000178624 -- 31,690,042(-) T/C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SCAF4 Gene

Variant ID Type Subtype PubMed ID
esv2520415 CNV deletion 19546169
esv3306440 CNV mobile element insertion 20981092
esv3309278 CNV mobile element insertion 20981092
esv3324185 CNV insertion 20981092
esv3394837 CNV insertion 20981092
esv3450908 CNV insertion 20981092
esv3575385 CNV gain 25503493
esv992169 CNV gain 20482838
nsv1067151 CNV gain 25217958
nsv1123552 CNV deletion 24896259
nsv510792 CNV deletion 20534489
nsv519899 CNV gain 19592680
nsv820180 CNV gain 19587683
nsv834079 CNV loss 17160897
nsv953354 CNV duplication 24416366

Variation tolerance for SCAF4 Gene

Residual Variation Intolerance Score: 6.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCAF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAF4 Gene

Disorders for SCAF4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCAF4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
wells syndrome
  • bullous cellulitis with eosinophilia
- elite association - COSMIC cancer census association via MalaCards
Search SCAF4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SCAF4

genes like me logo Genes that share disorders with SCAF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCAF4 Gene

Publications for SCAF4 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SCAF4 Gene

Sources for SCAF4 Gene

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