Aliases for SCAF1 Gene
Aliases for SCAF1 Gene
External Ids for SCAF1 Gene
- HGNC: 30403
- Entrez Gene: 58506
- Ensembl: ENSG00000126461
- OMIM: 617264
- UniProtKB: Q9H7N4
Previous GeneCards Identifiers for SCAF1 Gene
- GC19P054832
- GC19P050145
- GC19P046523
Summaries for SCAF1 Gene
GeneCards Summary for SCAF1 Gene
SCAF1 (SR-Related CTD Associated Factor 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding and protein domain specific binding. An important paralog of this gene is PHRF1.
UniProtKB/Swiss-Prot for SCAF1 Gene
-
May function in pre-mRNA splicing.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCAF1 Gene
Genomics for SCAF1 Gene
GeneHancer (GH) Regulatory Elements for SCAF1 Gene
Promoters and enhancers for SCAF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SCAF1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SCAF1 Gene
Genomic Locations for SCAF1 Gene
- chr19:49,640,503-49,658,649
- (GRCh38/hg38)
- Size:
- 18,147 bases
- Orientation:
- Plus strand
- chr19:50,145,382-50,161,906
- (GRCh37/hg19)
Genomic View for SCAF1 Gene
Genes around SCAF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by Ensembl
- 19q13.33 by Entrez Gene
- 19q13.3-q13.4 by HGNC
SCAF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SCAF1 Gene
Proteins for SCAF1 Gene
-
Protein details for SCAF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H7N4-SFR19_HUMAN
- Recommended name:
- Splicing factor, arginine/serine-rich 19
- Protein Accession:
- Q9H7N4
- Q7Z5V7
- Q8WVA1
- Q9NR59
Protein attributes for SCAF1 Gene
- Size:
- 1312 amino acids
- Molecular mass:
- 139270 Da
- Quaternary structure:
-
- Interacts with POLR2A.
- SequenceCaution:
-
- Sequence=BAB15734.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for SCAF1 Gene
Post-translational modifications for SCAF1 Gene
- Ubiquitination at posLast=5555, isoforms=158, and posLast=11231123
Other Protein References for SCAF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SCAF1
- Invitrogen Antibodies for SCAF1
- Search GeneTex for Antibodies for SCAF1
Protein Products
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- Novus Biologicals proteins for SCAF1
- Search GeneTex for Proteins for SCAF1
Assay Products
No data available for DME Specific Peptides for SCAF1 Gene
Domains & Families for SCAF1 Gene
Gene Families for SCAF1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SCAF1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SCAF1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H7N4- Family:
-
- Belongs to the splicing factor SR family.
Function for SCAF1 Gene
Molecular function for SCAF1 Gene
- UniProtKB/Swiss-Prot Function:
- May function in pre-mRNA splicing.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by estrogens, androgens and glucocorticoids.
Phenotypes From GWAS Catalog for SCAF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0019904 | protein domain specific binding | IEA | -- |
Phenotypes for SCAF1 Gene
- GenomeRNAi human phenotypes for SCAF1:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for SCAF1 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for SCAF1
- genomics-online: gRNA clones - Search results for 78 available SCAF1 gene related products
- Overview of 78 available SCAF1 gene related products
- Applied Biological Materials CRISPR for SCAF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SCAF1
- GenScript: Design CRISPR guide RNA sequences for SCAF1
miRNA for SCAF1 Gene
- miRTarBase miRNAs that target SCAF1
miRNA Products
- Search ViGene Biosciences for SCAF1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SCAF1
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- genomics-online: shRNA clones - Search results for 78 available SCAF1 gene related products
- Overview of 78 available SCAF1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SCAF1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SCAF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SCAF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SCAF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SCAF1
-
ViGene Biosciences adenoviral particle packaged cDNA for SCAF1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SCAF1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SCAF1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCAF1 Gene
Localization for SCAF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SCAF1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for SCAF1 Gene
No Data Available
Interacting Proteins for SCAF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0008380 | RNA splicing | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for SCAF1 Gene
Transcripts for SCAF1 Gene
mRNA/cDNA for SCAF1 Gene
- (4) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (148) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SCAF1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SCAF1
- genomics-online: gRNA clones - Search results for 78 available SCAF1 gene related products
- Overview of 78 available SCAF1 gene related products
- Applied Biological Materials CRISPR for SCAF1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SCAF1
- GenScript: Design CRISPR guide RNA sequences for SCAF1
miRNA Products
- Search ViGene Biosciences for SCAF1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SCAF1
- Browse OriGene Inhibitory RNA Products For SCAF1
- genomics-online: shRNA clones - Search results for 78 available SCAF1 gene related products
- Overview of 78 available SCAF1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SCAF1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SCAF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SCAF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SCAF1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SCAF1 Gene
This gene is overexpressed in Liver, secretome (12.9), Cerebrospinal fluid (11.2), and Peripheral blood mononuclear cells (10.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCAF1 Gene
NURSA nuclear receptor signaling pathways regulating expression of SCAF1 Gene:
SCAF1SOURCE GeneReport for Unigene cluster for SCAF1 Gene:
Hs.103521mRNA Expression by UniProt/SwissProt for SCAF1 Gene:
Q9H7N4-SFR19_HUMAN
Tissue specificity:
Ubiquitous. Highly expressed in fetal brain and liver, poorly expressed in salivary gland, heart, skin and ovary. Expressed in colorectal carcinomas and ovarian cancers. Overexpressed in colorectal carcinomas as compared to normal colonic mucosa.
Evidence on tissue expression from TISSUES for SCAF1 Gene
- Liver(4.4)
- Eye(4.2)
- Lung(4.2)
- Spleen(4.2)
- Stomach(2)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs for SCAF1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCAF1 Gene
Orthologs for SCAF1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SCAF1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SCAF1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SCAF1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Scaf1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | SCAF1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SCAF1 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | scaf1 34 |
|
OneToOne | |
| Dr.19086 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10928 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG2926 34 |
|
OneToMany | |
| corn (Zea mays) |
Liliopsida | Zm.10149 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for SCAF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SCAF1 Gene
Variants for SCAF1 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000166903 | -- | 49,649,242(+) | G/C | intron_variant | |
| rs1000194092 | -- | 49,648,832(+) | A/G | intron_variant | |
| rs1000241123 | -- | 49,642,436(+) | G/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant | |
| rs1000378568 | -- | 49,655,662(+) | G/A | intron_variant | |
| rs1000539579 | -- | 49,658,533(+) | C/G | 3_prime_UTR_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1160655 | CNV | deletion | 26073780 |
| nsv469715 | CNV | gain+loss | 16826518 |
| nsv470150 | CNV | gain | 18288195 |
| nsv579908 | CNV | loss | 21841781 |
| nsv579909 | CNV | loss | 21841781 |
| nsv817854 | CNV | gain | 17921354 |
| nsv828578 | CNV | loss | 20364138 |
| nsv833864 | CNV | gain | 17160897 |
| nsv833865 | CNV | gain+loss | 17160897 |
| nsv953600 | CNV | deletion | 24416366 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.03;
68.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SCAF1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SCAF1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCAF1 Gene
Disorders for SCAF1 Gene
Additional Disease Information for SCAF1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SCAF1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SCAF1 Gene
Publications for SCAF1 Gene
- Cloning of a gene (SR-A1), encoding for a new member of the human Ser/Arg-rich family of pre-mRNA splicing factors: overexpression in aggressive ovarian cancer. (PMID: 11461075) Scorilas A … Diamandis EP (British journal of cancer 2001) 2 3 4 22 58
- Expression analysis and prognostic significance of the SRA1 gene, in ovarian cancer. (PMID: 16631123) Leoutsakou T … Scorilas A (Biochemical and biophysical research communications 2006) 3 4 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for SCAF1 Gene
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- Invitrogen Antibodies for SCAF1
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- VectorBuilder custom plasmid, inducible vectors for SCAF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SCAF1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available SCAF1 related products ranked by validation data
- antibodies-online: Search results for available SCAF1 related products ranked by validation data
- antibodies-online: Search results for available SCAF1 related products ranked by validation data
- Search GeneTex for Antibodies for SCAF1
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- ViGene Biosciences adenoviral particle packaged cDNA for SCAF1 gene
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- genomics-online: cdna clones - Search results for 78 available SCAF1 gene related products
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- Overview of 78 available SCAF1 gene related products
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- Overview of 78 available SCAF1 gene related products
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- Overview of 78 available SCAF1 gene related products
Sources for SCAF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
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- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew