Aliases for SBNO2 Gene
External Ids for SBNO2 Gene
Previous HGNC Symbols for SBNO2 Gene
Previous GeneCards Identifiers for SBNO2 Gene
GeneCards Summary for SBNO2 Gene
SBNO2 (Strawberry Notch Homolog 2) is a Protein Coding gene. An important paralog of this gene is SBNO1.
UniProtKB/Swiss-Prot Summary for SBNO2 Gene
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162). Plays a role as a regulator in the proinflammatory cascade (PubMed:18025162).