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Aliases for SBNO2 Gene

Aliases for SBNO2 Gene

  • Strawberry Notch Homolog 2 2 3 5
  • KIAA0963 2 3 4
  • Strawberry Notch Homolog 2 (Drosophila) 2
  • Protein Strawberry Notch Homolog 2 3
  • STNO 3
  • Sno 3

External Ids for SBNO2 Gene

Previous HGNC Symbols for SBNO2 Gene

  • KIAA0963

Previous GeneCards Identifiers for SBNO2 Gene

  • GC19M001059
  • GC19M000881

Summaries for SBNO2 Gene

GeneCards Summary for SBNO2 Gene

SBNO2 (Strawberry Notch Homolog 2) is a Protein Coding gene. An important paralog of this gene is SBNO1.

UniProtKB/Swiss-Prot for SBNO2 Gene

  • Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162). Plays a role as a regulator in the proinflammatory cascade (PubMed:18025162).

Additional gene information for SBNO2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SBNO2 Gene

Genomics for SBNO2 Gene

GeneHancer (GH) Regulatory Elements for SBNO2 Gene

Promoters and enhancers for SBNO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I001164 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 556.4 +4.6 4627 10.5 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B NEUROD1 SIN3A ZNF2 YY1 SBNO2 LOC102725180 DAZAP1 LOC100288123 TMEM259 PTBP1 TCF3 MIER2 CIRBP MED16
GH19I001130 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 580.4 +41.7 41749 4.3 HDGF HDAC1 PKNOX1 RB1 SIN3A ZBTB40 KLF5 YY1 ZNF121 EGR1 SBNO2 MIDN ARHGAP45 POLR2E SHC2 R3HDM4 ABCA7 ARID3A CIRBP TMEM259
GH19I001236 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.2 -82.6 -82576 41.1 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 CIRBP C19orf24 MIDN CBARP ATP5F1D SF3A2 TCF3 TMEM259 LOC100288123 PTBP1
GH19I000569 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12 +601.0 600959 7.4 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 LOC105372233 BSG GC19P000572 GC19P000573 TMEM259 DAZAP1 PTBP1 ENSG00000267317 SBNO2 MED16
GH19I001125 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 29.7 +47.8 47816 1.9 BCOR MXI1 JUN TAL1 MAX CC2D1A TCF12 NCOR1 CBFA2T2 PRDM10 SBNO2 STK11 POLR2E MIDN GC19M001134 GC19P001106
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SBNO2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SBNO2 gene promoter:

Genomic Locations for SBNO2 Gene

Genomic Locations for SBNO2 Gene
chr19:1,107,634-1,174,283
(GRCh38/hg38)
Size:
66,650 bases
Orientation:
Minus strand
chr19:1,107,633-1,174,282
(GRCh37/hg19)

Genomic View for SBNO2 Gene

Genes around SBNO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SBNO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SBNO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SBNO2 Gene

Proteins for SBNO2 Gene

  • Protein details for SBNO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2G9-SBNO2_HUMAN
    Recommended name:
    Protein strawberry notch homolog 2
    Protein Accession:
    Q9Y2G9
    Secondary Accessions:
    • A8K8P2
    • B3KWJ1
    • O75257
    • Q3KQX0
    • Q8TEM0

    Protein attributes for SBNO2 Gene

    Size:
    1366 amino acids
    Molecular mass:
    150275 Da
    Quaternary structure:
    • Interacts with TAL1; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF.
    SequenceCaution:
    • Sequence=AAC28919.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA76807.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB84928.1; Type=Frameshift; Positions=1236; Evidence={ECO:0000305};

    Alternative splice isoforms for SBNO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SBNO2 Gene

Post-translational modifications for SBNO2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SBNO2 Gene

Domains & Families for SBNO2 Gene

Gene Families for SBNO2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SBNO2 Gene

Suggested Antigen Peptide Sequences for SBNO2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2G9

UniProtKB/Swiss-Prot:

SBNO2_HUMAN :
  • Belongs to the SBNO family.
Family:
  • Belongs to the SBNO family.
genes like me logo Genes that share domains with SBNO2: view

Function for SBNO2 Gene

Molecular function for SBNO2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162). Plays a role as a regulator in the proinflammatory cascade (PubMed:18025162).
UniProtKB/Swiss-Prot Induction:
Up-regulated by interleukin IL6 and soluble interleukin receptor IL6R in astrocytes (PubMed:25903009).

Phenotypes From GWAS Catalog for SBNO2 Gene

genes like me logo Genes that share phenotypes with SBNO2: view

Animal Models for SBNO2 Gene

MGI Knock Outs for SBNO2:

Animal Model Products

CRISPR Products

miRNA for SBNO2 Gene

miRTarBase miRNAs that target SBNO2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SBNO2 Gene

Localization for SBNO2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SBNO2 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SBNO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with SBNO2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SBNO2 Gene

Pathways & Interactions for SBNO2 Gene

SuperPathways for SBNO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SBNO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002281 macrophage activation involved in immune response IMP 18025162
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
GO:0030282 bone mineralization IEA --
genes like me logo Genes that share ontologies with SBNO2: view

No data available for Pathways by source and SIGNOR curated interactions for SBNO2 Gene

Drugs & Compounds for SBNO2 Gene

No Compound Related Data Available

Transcripts for SBNO2 Gene

Unigene Clusters for SBNO2 Gene

Strawberry notch homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SBNO2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18 ^
SP1:
SP2: -
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for SBNO2 Gene

GeneLoc Exon Structure for
SBNO2
ECgene alternative splicing isoforms for
SBNO2

Expression for SBNO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SBNO2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SBNO2 Gene

This gene is overexpressed in Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for SBNO2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (39.1), Spleen (15.0), and Cervix (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SBNO2 Gene



Protein tissue co-expression partners for SBNO2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SBNO2 Gene:

SBNO2

SOURCE GeneReport for Unigene cluster for SBNO2 Gene:

Hs.408708

mRNA Expression by UniProt/SwissProt for SBNO2 Gene:

Q9Y2G9-SBNO2_HUMAN
Tissue specificity: Detected in macrophages. IL10 regulates expression in a STAT3-dependent way.

Evidence on tissue expression from TISSUES for SBNO2 Gene

  • Spleen(4.3)
  • Nervous system(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with SBNO2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SBNO2 Gene

Orthologs for SBNO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SBNO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SBNO2 33 34
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia SBNO2 33 34
  • 86.36 (n)
cow
(Bos Taurus)
Mammalia SBNO2 33 34
  • 85.69 (n)
rat
(Rattus norvegicus)
Mammalia Sbno2 33
  • 82.16 (n)
mouse
(Mus musculus)
Mammalia Sbno2 33 16 34
  • 80.59 (n)
oppossum
(Monodelphis domestica)
Mammalia SBNO2 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SBNO2 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SBNO2 33 34
  • 66 (a)
lizard
(Anolis carolinensis)
Reptilia SBNO2 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sbno2 33
  • 63.24 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100002292 33
  • 65.28 (n)
sbno2a 34
  • 64 (a)
OneToMany
SBNO2 (2 of 2) 34
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sno 34
  • 31 (a)
ManyToMany
CG3491 34
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea let-765 34
  • 28 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.17075 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5085 34
  • 42 (a)
OneToMany
Species where no ortholog for SBNO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SBNO2 Gene

ENSEMBL:
Gene Tree for SBNO2 (if available)
TreeFam:
Gene Tree for SBNO2 (if available)

Paralogs for SBNO2 Gene

Paralogs for SBNO2 Gene

(1) SIMAP similar genes for SBNO2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SBNO2: view

Variants for SBNO2 Gene

Sequence variations from dbSNP and Humsavar for SBNO2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000011064 -- 1,150,998(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000034376 -- 1,163,923(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000042851 -- 1,108,824(-) G/A coding_sequence_variant, synonymous_variant
rs1000059511 -- 1,168,569(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000090208 -- 1,168,734(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SBNO2 Gene

Variant ID Type Subtype PubMed ID
nsv9662 CNV gain 18304495
nsv953939 CNV deletion 24416366
nsv833704 CNV gain 17160897
nsv828367 CNV gain 20364138
nsv578255 CNV gain+loss 21841781
nsv578241 CNV gain 21841781
nsv578223 CNV gain 21841781
nsv578216 CNV gain 21841781
nsv578215 CNV gain 21841781
nsv526080 CNV loss 19592680
nsv516646 CNV loss 19592680
nsv513506 CNV insertion 21212237
nsv480760 CNV novel sequence insertion 20440878
nsv476585 CNV novel sequence insertion 20440878
nsv475858 CNV novel sequence insertion 20440878
nsv474580 CNV novel sequence insertion 20440878
nsv470104 CNV loss 18288195
nsv470103 CNV gain 18288195
nsv470102 CNV loss 18288195
nsv469845 CNV loss 16826518
nsv2386 CNV insertion 18451855
nsv138169 CNV deletion 16902084
nsv1160555 CNV deletion 26073780
nsv1153793 CNV insertion 26484159
nsv1142249 CNV tandem duplication 24896259
nsv1141784 CNV insertion 24896259
nsv1126499 CNV deletion 24896259
nsv1116289 CNV deletion 24896259
nsv1071489 CNV deletion 25765185
nsv1071488 CNV deletion 25765185
nsv1071487 CNV deletion 25765185
nsv1058677 CNV loss 25217958
nsv1056200 CNV gain 25217958
esv3555835 CNV deletion 23714750
esv3387368 CNV duplication 20981092
esv29901 CNV gain 19812545
esv2855014 CNV duplication 24192839
esv2758743 CNV gain+loss 17122850
esv2717830 CNV deletion 23290073
esv2717828 CNV deletion 23290073
esv2717827 CNV deletion 23290073
esv2717826 CNV deletion 23290073
esv27094 CNV gain 19812545
esv2663150 CNV deletion 23128226
esv2640042 CNV loss 19546169
esv2616658 CNV insertion 19546169
esv2538063 CNV insertion 19546169
esv1785958 CNV deletion 17803354
esv1649795 CNV insertion 17803354
esv1428489 CNV insertion 17803354
esv1210673 CNV insertion 17803354
esv1002029 CNV insertion 20482838
dgv6195n54 CNV loss 21841781
dgv6194n54 CNV gain+loss 21841781
dgv6193n54 CNV gain 21841781
dgv6192n54 CNV loss 21841781
dgv6191n54 CNV loss 21841781
dgv6190n54 CNV gain 21841781
dgv6189n54 CNV gain+loss 21841781
dgv6188n54 CNV loss 21841781
dgv6187n54 CNV gain 21841781
dgv6186n54 CNV gain 21841781
dgv6185n54 CNV gain 21841781
dgv1683n106 CNV deletion 24896259
dgv1682n106 CNV deletion 24896259
dgv136n111 CNV deletion 26073780
dgv135n111 CNV deletion 26073780

Variation tolerance for SBNO2 Gene

Gene Damage Index Score: 5.78; 73.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SBNO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SBNO2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SBNO2 Gene

Disorders for SBNO2 Gene

Additional Disease Information for SBNO2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SBNO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SBNO2 Gene

Publications for SBNO2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system. (PMID: 25903009) Grill M … Campbell IL (Glia 2015) 3 4 58
  3. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. (PMID: 19760754) Törkvist L … Pettersson S (Inflammatory bowel diseases 2010) 3 44 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for SBNO2 Gene

Sources for SBNO2 Gene

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