Aliases for SBNO1 Gene

Aliases for SBNO1 Gene

  • Strawberry Notch Homolog 1 2 3 5
  • MOP3 2 3 4
  • Protein Strawberry Notch Homolog 1 3 4
  • Monocyte Protein 3 3 4
  • Sno 2 3
  • Sno, Strawberry Notch Homolog 1 (Drosophila) 2
  • FLJ10701 2
  • FLJ10833 2
  • SBNO1 5
  • MOP-3 4

External Ids for SBNO1 Gene

Previous GeneCards Identifiers for SBNO1 Gene

  • GC12M123587
  • GC12M122216
  • GC12M122217
  • GC12M122305
  • GC12M123780
  • GC12M120734
  • GC12M123774

Summaries for SBNO1 Gene

GeneCards Summary for SBNO1 Gene

SBNO1 (Strawberry Notch Homolog 1) is a Protein Coding gene. Diseases associated with SBNO1 include Congenital Muscular Dystrophy-Dystroglycanopathy Type A6. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and hydrolase activity. An important paralog of this gene is SBNO2.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SBNO1 Gene

Genomics for SBNO1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SBNO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SBNO1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SBNO1

Top Transcription factor binding sites by QIAGEN in the SBNO1 gene promoter:
  • AREB6
  • Egr-2
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • Sp1
  • SRY
  • USF-1
  • USF1

Genomic Locations for SBNO1 Gene

Latest Assembly
75,739 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
75,739 bases
Minus strand

(GRCh37/hg19 by Ensembl)
75,735 bases
Minus strand

Genomic View for SBNO1 Gene

Genes around SBNO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SBNO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SBNO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SBNO1 Gene

Proteins for SBNO1 Gene

  • Protein details for SBNO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein strawberry notch homolog 1
    Protein Accession:
    Secondary Accessions:
    • Q05C06
    • Q3ZTS3
    • Q9H3T8
    • Q9NVB2

    Protein attributes for SBNO1 Gene

    1393 amino acids
    Molecular mass:
    154312 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ76814.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SBNO1 Gene


neXtProt entry for SBNO1 Gene

Post-translational modifications for SBNO1 Gene

  • Glycosylation at Thr112
  • Ubiquitination at Lys155 and Lys378
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SBNO1_HUMAN (2874)

Other Protein References for SBNO1 Gene

No data available for DME Specific Peptides for SBNO1 Gene

Domains & Families for SBNO1 Gene

Gene Families for SBNO1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SBNO1 Gene

Suggested Antigen Peptide Sequences for SBNO1 Gene

GenScript: Design optimal peptide antigens:
  • Monocyte protein 3 (SBNO1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SBNO family.
  • Belongs to the SBNO family.
genes like me logo Genes that share domains with SBNO1: view

Function for SBNO1 Gene

Phenotypes From GWAS Catalog for SBNO1 Gene

Gene Ontology (GO) - Molecular Function for SBNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0031490 chromatin DNA binding IBA 21873635
GO:0042393 histone binding IBA 21873635
genes like me logo Genes that share ontologies with SBNO1: view
genes like me logo Genes that share phenotypes with SBNO1: view

Animal Models for SBNO1 Gene

MGI Knock Outs for SBNO1:
  • Sbno1 Sbno1<tm1.1Hssk>
  • Sbno1 Sbno1<tm1b(EUCOMM)Hmgu>

miRNA for SBNO1 Gene

miRTarBase miRNAs that target SBNO1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SBNO1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SBNO1 Gene

Localization for SBNO1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SBNO1 gene
Compartment Confidence
nucleus 5
extracellular 1
cytoskeleton 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SBNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with SBNO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SBNO1 Gene

Pathways & Interactions for SBNO1 Gene

PathCards logo

SuperPathways for SBNO1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SBNO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SBNO1: view

No data available for Pathways by source and SIGNOR curated interactions for SBNO1 Gene

Drugs & Compounds for SBNO1 Gene

No Compound Related Data Available

Transcripts for SBNO1 Gene

mRNA/cDNA for SBNO1 Gene

15 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SBNO1

Alternative Splicing Database (ASD) splice patterns (SP) for SBNO1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP7: -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33
SP3: -

Relevant External Links for SBNO1 Gene

GeneLoc Exon Structure for

Expression for SBNO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SBNO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for SBNO1 Gene

This gene is overexpressed in Testis (28.8), Peripheral blood mononuclear cells (8.7), and Fetal ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SBNO1 Gene

Protein tissue co-expression partners for SBNO1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SBNO1

SOURCE GeneReport for Unigene cluster for SBNO1 Gene:


Evidence on tissue expression from TISSUES for SBNO1 Gene

  • Blood(4.3)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with SBNO1: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SBNO1 Gene

Orthologs for SBNO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SBNO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SBNO1 30 31
  • 99.71 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 96 (a)
-- 31
  • 95 (a)
-- 31
  • 95 (a)
-- 31
  • 86 (a)
(Canis familiaris)
Mammalia SBNO1 30 31
  • 94.09 (n)
(Bos Taurus)
Mammalia SBNO1 30 31
  • 93.41 (n)
(Rattus norvegicus)
Mammalia Sbno1 30
  • 89.58 (n)
(Mus musculus)
Mammalia Sbno1 30 17 31
  • 89.33 (n)
(Monodelphis domestica)
Mammalia SBNO1 31
  • 89 (a)
(Gallus gallus)
Aves SBNO1 30 31
  • 82.33 (n)
(Anolis carolinensis)
Reptilia SBNO1 31
  • 79 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sbno1 30
  • 76.74 (n)
Str.16725 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.19331 30
(Danio rerio)
Actinopterygii sbno1 30
  • 70.25 (n)
SBNO1 31
  • 19 (a)
Dr.25585 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13697 30
Fruit Fly
(Drosophila melanogaster)
Insecta sno 30 31
  • 58.24 (n)
CG3491 31
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011199 30
  • 26.36 (n)
(Caenorhabditis elegans)
Secernentea let-765 30 31
  • 59.86 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons EMB1135 30
  • 52.06 (n)
(Oryza sativa)
Liliopsida Os08g0223700 30
  • 53.25 (n)
Os.14486 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5085 31
  • 51 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5929 30
Species where no ortholog for SBNO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SBNO1 Gene

Gene Tree for SBNO1 (if available)
Gene Tree for SBNO1 (if available)
Evolutionary constrained regions (ECRs) for SBNO1: view image

Paralogs for SBNO1 Gene

Paralogs for SBNO1 Gene

(1) SIMAP similar genes for SBNO1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SBNO1: view

Variants for SBNO1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SBNO1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs1060105 -. - p.Ser728Asnp.Ser729Asn
rs114314586 Likely Benign: not provided 123,321,537(-) T/C
NM_001167856.3(SBNO1):c.2321A>G (p.Asn774Ser)
rs115621242 Benign: not provided 123,298,083(-) G/A
NM_001167856.3(SBNO1):c.3934C>T (p.Leu1312=)
rs116725625 Benign: not provided 123,341,088(-) G/A
NM_001167856.3(SBNO1):c.551C>T (p.Thr184Ile)
rs118119987 Benign: not provided 123,341,093(-) G/A

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SBNO1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SBNO1 Gene

Variant ID Type Subtype PubMed ID
esv2746502 CNV deletion 23290073
esv2746503 CNV deletion 23290073
esv2746504 CNV deletion 23290073
esv3549920 CNV deletion 23714750
nsv1127301 CNV deletion 24896259
nsv1144662 CNV deletion 24896259
nsv477316 CNV novel sequence insertion 20440878

Variation tolerance for SBNO1 Gene

Residual Variation Intolerance Score: 1.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.13; 80.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SBNO1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SBNO1 Gene

Disorders for SBNO1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SBNO1 Gene - From: COP

Disorder Aliases PubMed IDs
congenital muscular dystrophy-dystroglycanopathy type a6
  • congenital muscular dystrophy-dystroglycanopathy with brain and eye anomalies type a6
- elite association - COSMIC cancer census association via MalaCards
Search SBNO1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SBNO1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SBNO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SBNO1 Gene

Publications for SBNO1 Gene

  1. Common variants at 12q15 and 12q24 are associated with infant head circumference. (PMID: 22504419) Taal HR … Jaddoe VWV (Nature genetics 2012) 3 41
  2. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 41
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 41
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for SBNO1 Gene

Sources for SBNO1 Gene