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Aliases for SBNO1 Gene
Aliases for SBNO1 Gene
External Ids for SBNO1 Gene
- HGNC: 22973
- NCBI Entrez Gene: 55206
- Ensembl: ENSG00000139697
- OMIM®: 614274
- UniProtKB/Swiss-Prot: A3KN83
Previous GeneCards Identifiers for SBNO1 Gene
- GC12M123587
- GC12M122216
- GC12M122217
- GC12M122305
- GC12M123780
- GC12M120734
- GC12M123774
Summaries for SBNO1 Gene
GeneCards Summary for SBNO1 Gene
SBNO1 (Strawberry Notch Homolog 1) is a Protein Coding gene. Diseases associated with SBNO1 include Congenital Muscular Dystrophy-Dystroglycanopathy Type A6. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and hydrolase activity. An important paralog of this gene is SBNO2.
Additional gene information for SBNO1 Gene
- HGNC (22973)
- NCBI Entrez Gene (55206)
- Ensembl (ENSG00000139697)
- OMIM® (614274)
- UniProtKB/Swiss-Prot (A3KN83)
- Open Targets Platform(ENSG00000139697)
- Search for SBNO1 at DataMed
- Search for SBNO1 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SBNO1 Gene
Genomics for SBNO1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SBNO1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SBNO1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SBNO1
- Top Transcription factor binding sites by QIAGEN in the SBNO1 gene promoter:
-
- AREB6
- Egr-2
- Oct-B1
- oct-B2
- oct-B3
- POU2F1
- Sp1
- SRY
- USF-1
- USF1
Genomic Locations for SBNO1 Gene
Latest Assembly
- chr12:123,289,109-123,364,847
- (GRCh38/hg38)
- Size:
- 75,739 bases
- Orientation:
- Minus strand
Previous Assembly
- chr12:123,773,656-123,849,394
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 75,739 bases
- Orientation:
- Minus strand
- chr12:123,773,656-123,849,390
- (GRCh37/hg19 by Ensembl)
- Size:
- 75,735 bases
- Orientation:
- Minus strand
Genomic View for SBNO1 Gene
Genes around SBNO1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by HGNC
- 12q24.31 by Entrez Gene
- 12q24.31 by Ensembl
SBNO1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SBNO1 Gene
Proteins for SBNO1 Gene
-
Protein details for SBNO1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A3KN83-SBNO1_HUMAN
- Recommended name:
- Protein strawberry notch homolog 1
- Protein Accession:
- A3KN83
- Q05C06
- Q3ZTS3
- Q9H3T8
- Q9NVB2
Protein attributes for SBNO1 Gene
- Size:
- 1393 amino acids
- Molecular mass:
- 154312 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAQ76814.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for SBNO1 Gene
Post-translational modifications for SBNO1 Gene
Other Protein References for SBNO1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for SBNO1
-
Abcam antibodies for SBNO1
- Invitrogen Antibodies for SBNO1 (AFLGC-SBNO1)
- antibodies-online: Show 14 available SBNO1 Antibodies ranked by validation data
-
Santa Cruz Biotechnology (SCBT) Antibodies for SBNO1
- Sino Biological Antibodies for SBNO1
Protein products for research
-
OriGene Purified Proteins for SBNO1
- Search Origene for MassSpec and Protein Over-expression Lysates for SBNO1
- Origene Custom Protein Services for SBNO1
-
Abcam proteins for SBNO1
Assay products for research
No data available for DME Specific Peptides for SBNO1 Gene
Domains & Families for SBNO1 Gene
Gene Families for SBNO1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SBNO1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SBNO1 Gene
- GenScript: Design optimal peptide antigens:
-
- Monocyte protein 3 (SBNO1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
A3KN83- Family:
-
- Belongs to the SBNO family.
Function for SBNO1 Gene
Phenotypes From GWAS Catalog for SBNO1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0031490 | chromatin DNA binding | IBA | 21873635 |
| GO:0042393 | histone binding | IBA | 21873635 |
Phenotypes for SBNO1 Gene
- MGI mutant phenotypes for SBNO1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SBNO1:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- no effect
- Decreased viability
- Decreased ionizing radiation sensitivity
- Decreased vaccinia virus (VACV) infection
- Decreased NF-kappaB reporter expression
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Proliferating cells
Animal Models for SBNO1 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SBNO1 - Starting at $85 >
- * SBNO1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SBNO1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SBNO1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SBNO1
miRNA for SBNO1 Gene
- miRTarBase miRNAs that target SBNO1
-
- mmu-miR-425-5p (MIRT008474)
- mmu-miR-26a-5p (MIRT011094)
- mmu-miR-136-5p (MIRT014892)
- hsa-miR-188-5p (MIRT044901)
- hsa-miR-218-5p (MIRT046997)
- hsa-miR-196a-5p (MIRT048283)
- hsa-miR-450b-5p (MIRT184667)
- hsa-miR-153-5p (MIRT184693)
- hsa-miR-4659a-5p (MIRT270702)
- hsa-miR-4659b-5p (MIRT270703)
- hsa-miR-5590-5p (MIRT270705)
- hsa-miR-4776-3p (MIRT510814)
- hsa-miR-6848-3p (MIRT510815)
- hsa-miR-6843-3p (MIRT510816)
- hsa-miR-4776-5p (MIRT510817)
- hsa-miR-19b-2-5p (MIRT510818)
- hsa-miR-19b-1-5p (MIRT510819)
- hsa-miR-19a-5p (MIRT510820)
- hsa-miR-4800-5p (MIRT510821)
- hsa-miR-3138 (MIRT510822)
- hsa-miR-3619-3p (MIRT510823)
- hsa-miR-3663-5p (MIRT510824)
- hsa-miR-6131 (MIRT510825)
- hsa-miR-4657 (MIRT510826)
- hsa-miR-4491 (MIRT510827)
- hsa-miR-1911-3p (MIRT510828)
- hsa-miR-374b-3p (MIRT521188)
- hsa-miR-4524b-5p (MIRT521189)
- hsa-miR-4524a-5p (MIRT521190)
- hsa-miR-922 (MIRT521191)
- hsa-miR-646 (MIRT521192)
- hsa-miR-503-5p (MIRT521193)
- hsa-miR-32-3p (MIRT521194)
- hsa-miR-548av-3p (MIRT521195)
- hsa-miR-548f-3p (MIRT521196)
- hsa-miR-548e-3p (MIRT521197)
- hsa-miR-548az-3p (MIRT521198)
- hsa-miR-548ar-3p (MIRT521199)
- hsa-miR-548a-3p (MIRT521200)
- hsa-miR-15b-5p (MIRT521201)
- hsa-miR-497-5p (MIRT521202)
- hsa-miR-424-5p (MIRT521203)
- hsa-miR-195-5p (MIRT521204)
- hsa-miR-6838-5p (MIRT521205)
- hsa-miR-16-5p (MIRT521206)
- hsa-miR-15a-5p (MIRT521207)
- hsa-miR-8073 (MIRT521208)
- hsa-miR-221-5p (MIRT521209)
- hsa-miR-5089-5p (MIRT521210)
- hsa-miR-6807-5p (MIRT521211)
- hsa-miR-5589-5p (MIRT521212)
- hsa-miR-4731-5p (MIRT521213)
- hsa-miR-6506-5p (MIRT521214)
- hsa-miR-619-5p (MIRT521215)
- hsa-miR-4433b-3p (MIRT521216)
- hsa-miR-302b-3p (MIRT521217)
- hsa-miR-302c-3p (MIRT521218)
- hsa-miR-520d-3p (MIRT521219)
- hsa-miR-302d-3p (MIRT521220)
- hsa-miR-302e (MIRT521221)
- hsa-miR-520b (MIRT521222)
- hsa-miR-372-3p (MIRT521223)
- hsa-miR-520e (MIRT521224)
- hsa-miR-520c-3p (MIRT521225)
- hsa-miR-373-3p (MIRT521226)
- hsa-miR-520a-3p (MIRT521227)
- hsa-miR-302a-3p (MIRT521228)
- mmu-miR-3104-5p (MIRT581197)
- hsa-miR-129-5p (MIRT622342)
- hsa-miR-3680-3p (MIRT622343)
- hsa-miR-557 (MIRT622344)
- hsa-miR-507 (MIRT622345)
- hsa-miR-6516-5p (MIRT622346)
- hsa-miR-455-3p (MIRT622347)
- hsa-miR-4524a-3p (MIRT622348)
- hsa-miR-4328 (MIRT622349)
- hsa-miR-5698 (MIRT666476)
- hsa-miR-744-3p (MIRT666477)
- hsa-miR-4674 (MIRT666478)
- hsa-miR-4423-5p (MIRT666479)
- hsa-miR-6501-5p (MIRT666480)
- hsa-miR-143-5p (MIRT666481)
- hsa-miR-4437 (MIRT666482)
- hsa-miR-4430 (MIRT666483)
- hsa-miR-3652 (MIRT666484)
- hsa-miR-4634 (MIRT666485)
- hsa-miR-122-5p (MIRT666486)
- hsa-miR-504-3p (MIRT666487)
- hsa-miR-3135b (MIRT666488)
- hsa-miR-6499-3p (MIRT666489)
- hsa-miR-367-5p (MIRT666490)
- hsa-miR-1267 (MIRT666491)
- hsa-miR-378g (MIRT666492)
- hsa-miR-4486 (MIRT666493)
- hsa-miR-6860 (MIRT666494)
- hsa-miR-612 (MIRT666495)
- hsa-miR-5189-5p (MIRT666496)
- hsa-miR-3187-5p (MIRT666497)
- hsa-miR-1285-3p (MIRT666498)
- hsa-miR-5693 (MIRT666499)
- hsa-miR-1298-3p (MIRT666500)
- hsa-miR-1184 (MIRT735900)
- hsa-miR-1205 (MIRT735990)
- hsa-miR-1207-5p (MIRT736056)
- hsa-miR-127-5p (MIRT736948)
- hsa-miR-17-3p (MIRT738007)
- hsa-miR-1909-3p (MIRT738375)
- hsa-miR-1914-3p (MIRT738522)
- hsa-miR-3154 (MIRT740422)
- hsa-miR-3158-5p (MIRT740482)
- hsa-miR-3173-3p (MIRT740620)
- hsa-miR-3179 (MIRT740752)
- hsa-miR-3942-5p (MIRT743158)
- hsa-miR-4270 (MIRT743594)
- hsa-miR-4271 (MIRT743638)
- hsa-miR-4434 (MIRT744411)
- hsa-miR-4436b-3p (MIRT744477)
- hsa-miR-4441 (MIRT744561)
- hsa-miR-4516 (MIRT745764)
- hsa-miR-4527 (MIRT745952)
- hsa-miR-4533 (MIRT746031)
- hsa-miR-4632-5p (MIRT746286)
- hsa-miR-4685-5p (MIRT746973)
- hsa-miR-4703-5p (MIRT747311)
- hsa-miR-4725-3p (MIRT747719)
- hsa-miR-4747-5p (MIRT748276)
- hsa-miR-4763-3p (MIRT748564)
- hsa-miR-4779 (MIRT748763)
- hsa-miR-5194 (MIRT749986)
- hsa-miR-5196-5p (MIRT750060)
- hsa-miR-5703 (MIRT751367)
- hsa-miR-6132 (MIRT752333)
- hsa-miR-6503-5p (MIRT752920)
- hsa-miR-6721-5p (MIRT753835)
- hsa-miR-6722-3p (MIRT753888)
- hsa-miR-6735-5p (MIRT754189)
- hsa-miR-6738-5p (MIRT754281)
- hsa-miR-6754-5p (MIRT754736)
- hsa-miR-6760-5p (MIRT754942)
- hsa-miR-6770-5p (MIRT755293)
- hsa-miR-6780b-5p (MIRT755650)
- hsa-miR-6783-5p (MIRT755761)
- hsa-miR-6823-5p (MIRT756928)
- hsa-miR-6836-5p (MIRT757227)
- hsa-miR-6837-5p (MIRT757255)
- hsa-miR-6878-5p (MIRT758225)
- hsa-miR-6879-5p (MIRT758278)
- hsa-miR-6891-5p (MIRT758679)
- hsa-miR-7843-3p (MIRT759750)
- hsa-miR-7843-5p (MIRT759778)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SBNO1
- Browse OriGene Inhibitory RNA Products For SBNO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SBNO1
Clone products for research
- Applied Biological Materials (abm): Clones for SBNO1 - Starting at $45 >
- * SBNO1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SBNO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SBNO1
Cell Lines for research
-
Horizon Cell Lines for SBNO1
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SBNO1 Gene
Localization for SBNO1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 1 |
| cytoskeleton | 1 |
| cytosol | 0 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005634 | nucleus | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for SBNO1 Gene
Pathways & Interactions for SBNO1 Gene
Interacting Proteins for SBNO1 Gene
GPS-Prot Interaction Network for SBNO1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IBA | 21873635 |
| GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for SBNO1 Gene
Transcripts for SBNO1 Gene
mRNA/cDNA for SBNO1 Gene
- 2 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000267176 11121 nts (view in UCSC)
- ENST00000420886 10981 nts (view in UCSC)
- ENST00000602398 11128 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SBNO1 - Starting at $85 >
- * SBNO1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SBNO1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SBNO1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SBNO1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SBNO1
- Browse OriGene Inhibitory RNA Products For SBNO1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SBNO1
Clone products for research
- Applied Biological Materials (abm): Clones for SBNO1 - Starting at $45 >
- * SBNO1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for SBNO1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SBNO1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - |
| ExUns: | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: | |||||||||||||||||
| SP3: | - | ||||||||||||||||
| SP4: | |||||||||||||||||
| SP5: | |||||||||||||||||
| SP6: | |||||||||||||||||
| SP7: |
Relevant External Links for SBNO1 Gene
- GeneLoc Exon Structure for
- SBNO1
Expression for SBNO1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
This gene is overexpressed in Testis (28.8), Peripheral blood mononuclear cells (8.7), and Fetal ovary (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SBNO1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SBNO1
SOURCE GeneReport for Unigene cluster for SBNO1 Gene:
Hs.7012Evidence on tissue expression from TISSUES for SBNO1 Gene
- Blood(4.3)
- Nervous system(3.7)
Primer products for research
-
OriGene qPCR primer pairs for SBNO1
-
OriGene qPCR primer pairs and template standards for SBNO1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SBNO1 Gene
Orthologs for SBNO1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SBNO1 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | SBNO1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SBNO1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Sbno1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Sbno1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SBNO1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SBNO1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SBNO1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sbno1 30 |
|
||
| Str.16725 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.19331 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | sbno1 30 |
|
||
| SBNO1 31 |
|
OneToOne | |||
| Dr.25585 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13697 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | sno 30 31 |
|
ManyToMany | |
| CG3491 31 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011199 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | let-765 30 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | EMB1135 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os08g0223700 30 |
|
||
| Os.14486 30 |
|
||||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.5085 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5929 30 |
|
- Species where no ortholog for SBNO1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SBNO1 Gene
- ENSEMBL:
- Gene Tree for SBNO1 (if available)
- TreeFam:
- Gene Tree for SBNO1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SBNO1: view image
Paralogs for SBNO1 Gene
Variants for SBNO1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SBNO1 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1060105 | -. - |
p.Ser728Asnp.Ser729Asn |
|||
| rs114314586 | Likely Benign: not provided | 123,321,537(-) |
T/C NM_001167856.3(SBNO1):c.2321A>G (p.Asn774Ser) |
MISSENSE | |
| rs115621242 | Benign: not provided | 123,298,083(-) |
G/A NM_001167856.3(SBNO1):c.3934C>T (p.Leu1312=) |
SYNONYMOUS | |
| rs116725625 | Benign: not provided | 123,341,088(-) |
G/A NM_001167856.3(SBNO1):c.551C>T (p.Thr184Ile) |
MISSENSE | |
| rs118119987 | Benign: not provided | 123,341,093(-) |
G/A NM_001167856.3(SBNO1):c.551-5C>T |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2746502 | CNV | deletion | 23290073 |
| esv2746503 | CNV | deletion | 23290073 |
| esv2746504 | CNV | deletion | 23290073 |
| esv3549920 | CNV | deletion | 23714750 |
| nsv1127301 | CNV | deletion | 24896259 |
| nsv1144662 | CNV | deletion | 24896259 |
| nsv477316 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
1.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.13;
80.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SBNO1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SBNO1 Gene
Disorders for SBNO1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| congenital muscular dystrophy-dystroglycanopathy type a6 |
|
|
Search SBNO1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SBNO1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SBNO1 Gene
Publications for SBNO1 Gene
- Common variants at 12q15 and 12q24 are associated with infant head circumference. (PMID: 22504419) Taal HR … Jaddoe VWV (Nature genetics 2012) 3 41
- Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 41
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 41
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for SBNO1 Gene
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- antibodies-online: Show 14 available SBNO1 Antibodies ranked by validation data
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Sources for SBNO1 Gene
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