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Aliases for SBK3 Gene

Aliases for SBK3 Gene

  • SH3 Domain Binding Kinase Family Member 3 2 3 5
  • SH3-Binding Domain Kinase Family Member 3 3 4
  • Sugen Kinase 110 3 4
  • SGK110 3 4
  • Uncharacterized Serine/Threonine-Protein Kinase SBK3 3
  • SH3 Domain Binding Kinase Family, Member 3 2
  • EC 4

External Ids for SBK3 Gene

Previous GeneCards Identifiers for SBK3 Gene

  • GC19M056055

Summaries for SBK3 Gene

GeneCards Summary for SBK3 Gene

SBK3 (SH3 Domain Binding Kinase Family Member 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SBK2.

Additional gene information for SBK3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SBK3 Gene

Genomics for SBK3 Gene

GeneHancer (GH) Regulatory Elements for SBK3 Gene

Promoters and enhancers for SBK3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055519 Enhancer 1.4 FANTOM5 Ensembl ENCODE 14.3 +25.3 25334 1 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 ZNF548 FOS ATF7 U2AF2 ZNF471 FIZ1 ZNF582 ZNF581 ZNF580 SSC5D ENSG00000267523 NAT14 ZNF667
GH19I055516 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.4 +28.4 28376 1.3 HDGF ATF1 ARID4B SIN3A GLI4 BRCA1 CBX5 ARID2 ZNF143 FOS SBK2 SBK3 SSC5D NAT14 ZNF580 ZNF581 CCDC106 ZNF628 FIZ1 ZNF524
GH19I055544 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.7 -2.4 -2439 6.2 FOXA2 ARID4B SIN3A ZNF48 TCF12 ZNF143 FOS ATF7 SP5 NCOA1 SBK3 SBK2 LOC646709 KIR2DS4 SSC5D ZNF471 GC19P055562
GH19I055619 Enhancer 0.8 Ensembl ENCODE 11.7 -75.5 -75480 3.6 PAF1 ZNF362 CEBPB MAX CEBPG ZFP69B ATF4 POLR2A RUNX3 MYC GC19M055621 ZNF524 SBK3 SBK2 ENSG00000268593 ZNF580 ZNF784 ENSG00000276488
GH19I055521 Enhancer 0.5 ENCODE dbSUPER 13.3 +23.7 23659 0.7 ZSCAN4 SBK3 ZNF524 FIZ1 SSC5D NAT14 SYT5 EPS8L1 RDH13 TMEM86B SBK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SBK3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SBK3 Gene

Genomic Locations for SBK3 Gene
4,985 bases
Minus strand

Genomic View for SBK3 Gene

Genes around SBK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SBK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SBK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SBK3 Gene

Proteins for SBK3 Gene

  • Protein details for SBK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized serine/threonine-protein kinase SBK3
    Protein Accession:

    Protein attributes for SBK3 Gene

    359 amino acids
    Molecular mass:
    38488 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SBK3 Gene

Post-translational modifications for SBK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SBK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SBK3 Gene

Domains & Families for SBK3 Gene

Gene Families for SBK3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for SBK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
genes like me logo Genes that share domains with SBK3: view

Function for SBK3 Gene

Molecular function for SBK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for SBK3 Gene

Phenotypes From GWAS Catalog for SBK3 Gene

Gene Ontology (GO) - Molecular Function for SBK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SBK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SBK3

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SBK3 Gene

Localization for SBK3 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SBK3 Gene

Pathways & Interactions for SBK3 Gene

No Data Available

Interacting Proteins for SBK3 Gene

Gene Ontology (GO) - Biological Process for SBK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with SBK3: view

No data available for Pathways by source and SIGNOR curated interactions for SBK3 Gene

Drugs & Compounds for SBK3 Gene

No Compound Related Data Available

Transcripts for SBK3 Gene

mRNA/cDNA for SBK3 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SBK3 Gene

No ASD Table

Relevant External Links for SBK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SBK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SBK3 Gene

mRNA differential expression in normal tissues according to GTEx for SBK3 Gene

This gene is overexpressed in Heart - Atrial Appendage (x30.8), Muscle - Skeletal (x6.7), and Heart - Left Ventricle (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of SBK3 Gene:

genes like me logo Genes that share expression patterns with SBK3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SBK3 Gene

Orthologs for SBK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SBK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SBK3 34
  • 100 (a)
(Bos Taurus)
Mammalia SBK3 33
  • 82.96 (n)
(Canis familiaris)
Mammalia SGK110 33
  • 82.82 (n)
SBK3 34
  • 78 (a)
(Mus musculus)
Mammalia Sbk3 33 16
  • 81.05 (n)
Gm1078 34
  • 76 (a)
(Rattus norvegicus)
Mammalia Sbk3 33
  • 81.05 (n)
(Monodelphis domestica)
Mammalia SBK3 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia SBK3 34
  • 52 (a)
(Gallus gallus)
Aves LOC101748417 33
  • 57.59 (n)
SBK3 34
  • 47 (a)
(Anolis carolinensis)
Reptilia SBK3 34
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135243 33
  • 48.73 (n)
(Danio rerio)
Actinopterygii zgc:172086 34
  • 31 (a)
si:ch211-171h4.3 34
  • 28 (a)
CABZ01038514.1 34
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11221 34
  • 19 (a)
CG4945 34
  • 15 (a)
(Caenorhabditis elegans)
Secernentea C01C4.3 34
  • 18 (a)
Species where no ortholog for SBK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SBK3 Gene

Gene Tree for SBK3 (if available)
Gene Tree for SBK3 (if available)

Paralogs for SBK3 Gene

Paralogs for SBK3 Gene

(5) SIMAP similar genes for SBK3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SBK3: view

Variants for SBK3 Gene

Sequence variations from dbSNP and Humsavar for SBK3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000103830 -- 55,540,166(-) G/C downstream_transcript_variant
rs1000361849 -- 55,546,949(-) C/T upstream_transcript_variant
rs1000462783 -- 55,544,683(-) C/G intron_variant
rs1000522810 -- 55,544,502(-) C/T intron_variant
rs1002015009 -- 55,544,934(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SBK3 Gene

Variant ID Type Subtype PubMed ID
esv2661748 CNV deletion 23128226
esv3893252 CNV loss 25118596
nsv1071950 CNV deletion 25765185
nsv953624 CNV deletion 24416366

Variation tolerance for SBK3 Gene

Gene Damage Index Score: 3.81; 58.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SBK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SBK3 Gene

Disorders for SBK3 Gene

Additional Disease Information for SBK3

No disorders were found for SBK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SBK3 Gene

Publications for SBK3 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  2. The protein kinase complement of the human genome. (PMID: 12471243) Manning G … Sudarsanam S (Science (New York, N.Y.) 2002) 3 4 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for SBK3 Gene

Sources for SBK3 Gene

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