Aliases for SBK2 Gene

Aliases for SBK2 Gene

  • SH3 Domain Binding Kinase Family Member 2 2 3 5
  • SH3-Binding Domain Kinase Family, Member 2 2 3
  • Serine/Threonine-Protein Kinase SBK2 3 4
  • Sugen Kinase 69 3 4
  • EC 2.7.11.1 4 52
  • SGK069 3 4
  • SH3 Domain Binding Kinase Family, Member 2 2
  • SH3-Binding Domain Kinase Family Member 2 4
  • EC 2.7.11 52
  • SgK069 4

External Ids for SBK2 Gene

Previous GeneCards Identifiers for SBK2 Gene

  • GC19M060736
  • GC19M056041
  • GC19M052354

Summaries for SBK2 Gene

GeneCards Summary for SBK2 Gene

SBK2 (SH3 Domain Binding Kinase Family Member 2) is a Protein Coding gene. Diseases associated with SBK2 include Adult Astrocytic Tumour. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP4K4.

Additional gene information for SBK2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SBK2 Gene

Genomics for SBK2 Gene

GeneHancer (GH) Regulatory Elements for SBK2 Gene

Promoters and enhancers for SBK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J055536 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 510.7 -0.5 -544 1.8 CTCF TCF12 ZNF10 ZBTB7A POLR2A KLF9 RAD21 RFX5 KLF8 ZNF335 SBK2 lnc-SSC5D-2 NAT14
GH19J055538 Enhancer 0.3 Ensembl 500.7 -1.7 -1727 0.2 ZNF121 SBK2 lnc-SSC5D-2 SBK3
GH19J055516 Promoter/Enhancer 1.6 ENCODE CraniofacialAtlas dbSUPER 12.4 +20.0 20007 1.3 RXRA HNRNPK ZNF217 EP300 CTCF TCF12 SP1 ZIC2 ZBTB10 ZBTB11 SBK2 SBK3 SSC5D NAT14 ZNF628 ZNF580 ZNF581 CCDC106 FIZ1 ZNF524
GH19J055544 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 7 -10.8 -10808 6.2 TCF12 POLR2G FOS TEAD4 ZIC2 FOXA1 TOE1 TGIF2 CTBP1 EP300 SBK3 SBK2 ENSG00000266932 KIR2DS4 SSC5D ZNF471 piR-34163-013
GH19J055526 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.7 +10.0 9957 3.6 ZNF217 TCF12 ZNF300 ZNF10 ZIC2 ZBTB10 CLOCK ZNF423 ZBTB26 ZNF274 lnc-SSC5D-1 lnc-SBK2-1 FIZ1 ZNF471 ZNF542P ZNF582 ZNF583 NAT14 ZNF582-AS1 ENSG00000267776
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SBK2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SBK2

Top Transcription factor binding sites by QIAGEN in the SBK2 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • HSF1 (long)
  • HSF1short
  • MAZR
  • PPAR-gamma1
  • PPAR-gamma2
  • SRF
  • SRF (504 AA)
  • ZID

Genomic Locations for SBK2 Gene

Genomic Locations for SBK2 Gene
chr19:55,529,336-55,537,174
(GRCh38/hg38)
Size:
7,839 bases
Orientation:
Minus strand
chr19:56,041,100-56,048,456
(GRCh37/hg19)
Size:
7,357 bases
Orientation:
Minus strand

Genomic View for SBK2 Gene

Genes around SBK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SBK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SBK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SBK2 Gene

Proteins for SBK2 Gene

  • Protein details for SBK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C263-SBK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase SBK2
    Protein Accession:
    P0C263

    Protein attributes for SBK2 Gene

    Size:
    348 amino acids
    Molecular mass:
    38088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SBK2 Gene

Selected DME Specific Peptides for SBK2 Gene

P0C263:
  • IPYTAPE
  • RDLKPEN

Post-translational modifications for SBK2 Gene

No Post-translational modifications

Other Protein References for SBK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SBK2 Gene

Gene Families for SBK2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for SBK2 Gene

Suggested Antigen Peptide Sequences for SBK2 Gene

GenScript: Design optimal peptide antigens:
  • Sugen kinase 69 (SBK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0C263

UniProtKB/Swiss-Prot:

SBK2_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
genes like me logo Genes that share domains with SBK2: view

Function for SBK2 Gene

Molecular function for SBK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for SBK2 Gene

Phenotypes From GWAS Catalog for SBK2 Gene

Gene Ontology (GO) - Molecular Function for SBK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0004708 MAP kinase kinase activity IBA 21873635
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with SBK2: view
genes like me logo Genes that share phenotypes with SBK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SBK2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SBK2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SBK2 Gene

Localization for SBK2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SBK2 gene
Compartment Confidence
extracellular 1
mitochondrion 1
nucleus 1
cytosol 1
plasma membrane 0
peroxisome 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for SBK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with SBK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SBK2 Gene

Pathways & Interactions for SBK2 Gene

PathCards logo

SuperPathways for SBK2 Gene

No Data Available

Interacting Proteins for SBK2 Gene

;

Gene Ontology (GO) - Biological Process for SBK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity IBA 21873635
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0023014 signal transduction by protein phosphorylation IBA 21873635
genes like me logo Genes that share ontologies with SBK2: view

No data available for Pathways by source and SIGNOR curated interactions for SBK2 Gene

Drugs & Compounds for SBK2 Gene

No Compound Related Data Available

Transcripts for SBK2 Gene

mRNA/cDNA for SBK2 Gene

2 REFSEQ mRNAs :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SBK2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SBK2 Gene

No ASD Table

Relevant External Links for SBK2 Gene

GeneLoc Exon Structure for
SBK2

Expression for SBK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SBK2 Gene

mRNA differential expression in normal tissues according to GTEx for SBK2 Gene

This gene is overexpressed in Heart - Atrial Appendage (x48.7).

Protein differential expression in normal tissues from HIPED for SBK2 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SBK2 Gene



Protein tissue co-expression partners for SBK2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SBK2

SOURCE GeneReport for Unigene cluster for SBK2 Gene:

Hs.532676
genes like me logo Genes that share expression patterns with SBK2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SBK2 Gene

Orthologs for SBK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SBK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SBK2 31 30
  • 98.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SBK2 31 30
  • 85.09 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SBK2 31 30
  • 81.84 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sbk2 17 31 30
  • 79.44 (n)
rat
(Rattus norvegicus)
Mammalia Sbk2 30
  • 78.96 (n)
oppossum
(Monodelphis domestica)
Mammalia SBK2 31
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SBK2 31
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves SBK2 31 30
  • 61.63 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SBK2 31
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492557 30
  • 55.37 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-8e10.3 30
  • 53.55 (n)
SBK2 31
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11221 31
  • 19 (a)
ManyToMany
CG4945 31
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C01C4.3 31
  • 19 (a)
OneToMany
Species where no ortholog for SBK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SBK2 Gene

ENSEMBL:
Gene Tree for SBK2 (if available)
TreeFam:
Gene Tree for SBK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SBK2: view image

Paralogs for SBK2 Gene

(3) SIMAP similar genes for SBK2 Gene using alignment to 1 proteins:

  • SBK2_HUMAN
genes like me logo Genes that share paralogs with SBK2: view

Variants for SBK2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SBK2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs34316437 - p.Glu20Lys
rs56158623 - p.Gly102Asp
VAR_041078 - p.Ala41Glu

Additional dbSNP identifiers (rs#s) for SBK2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SBK2 Gene

Variant ID Type Subtype PubMed ID
dgv1821n106 CNV deletion 24896259
dgv230e215 CNV deletion 23714750
esv1510388 CNV deletion 17803354
esv2718980 CNV deletion 23290073
esv3082679 CNV deletion 24192839
esv3893252 CNV loss 25118596
esv4756 CNV loss 18987735
esv7136 CNV loss 19470904
esv997838 CNV deletion 20482838
nsv1071554 CNV deletion 25765185
nsv1077868 CNV duplication 25765185
nsv1152574 CNV deletion 26484159
nsv138153 CNV deletion 16902084
nsv953624 CNV deletion 24416366

Variation tolerance for SBK2 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SBK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SBK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SBK2 Gene

Disorders for SBK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SBK2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
adult astrocytic tumour
  • adult astrocytoma
- elite association - COSMIC cancer census association via MalaCards
Search SBK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SBK2

genes like me logo Genes that share disorders with SBK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SBK2 Gene

Publications for SBK2 Gene

  1. Patterns of somatic mutation in human cancer genomes. (PMID: 17344846) Greenman C … Stratton MR (Nature 2007) 3 4 54
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 54
  3. The protein kinase complement of the human genome. (PMID: 12471243) Manning G … Sudarsanam S (Science (New York, N.Y.) 2002) 3 4 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for SBK2 Gene

Sources for SBK2 Gene