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Aliases for SBK2 Gene

Aliases for SBK2 Gene

  • SH3 Domain Binding Kinase Family Member 2 2 3 5
  • SH3-Binding Domain Kinase Family, Member 2 2 3
  • Sugen Kinase 69 3 4
  • EC 2.7.11.1 4 56
  • SGK069 3 4
  • SH3 Domain Binding Kinase Family, Member 2 2
  • SH3-Binding Domain Kinase Family Member 2 4
  • Serine/Threonine-Protein Kinase SBK2 3
  • EC 2.7.11 56

External Ids for SBK2 Gene

Previous GeneCards Identifiers for SBK2 Gene

  • GC19M060736
  • GC19M056041
  • GC19M052354

Summaries for SBK2 Gene

GeneCards Summary for SBK2 Gene

SBK2 (SH3 Domain Binding Kinase Family Member 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SBK3.

Additional gene information for SBK2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SBK2 Gene

Genomics for SBK2 Gene

GeneHancer (GH) Regulatory Elements for SBK2 Gene

Promoters and enhancers for SBK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055536 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 560.8 -0.5 -515 1.9 CTCF KLF1 MAZ ZNF10 RAD21 SP1 ZNF335 RFXANK POLR2A GLIS1 SBK2 NAT14 SBK3
GH19I055516 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.4 +20.0 20007 1.3 HDGF ATF1 ARID4B SIN3A GLI4 BRCA1 CBX5 ARID2 ZNF143 FOS SBK2 SBK3 SSC5D NAT14 ZNF580 ZNF581 CCDC106 ZNF628 FIZ1 ZNF524
GH19I055544 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7 -10.8 -10808 6.2 FOXA2 ARID4B SIN3A ZNF48 TCF12 ZNF143 FOS ATF7 SP5 NCOA1 SBK3 SBK2 LOC646709 KIR2DS4 SSC5D ZNF471 GC19P055562
GH19I055619 Enhancer 0.8 Ensembl ENCODE 11.7 -83.8 -83849 3.6 PAF1 ZNF362 CEBPB MAX CEBPG ZFP69B ATF4 POLR2A RUNX3 MYC GC19M055621 ZNF524 SBK3 SBK2 ENSG00000268593 ZNF580 ZNF784 ENSG00000276488
GH19I055528 Enhancer 0.8 dbSUPER 5.9 +8.4 8439 0.8 RAD21 ZNF48 ZEB1 ZNF335 ZNF121 ZNF23 ZNF366 SCRT2 RCOR1 ZNF398 ZNF471 ZNF542P ZNF582 ZNF583 FIZ1 ZNF582-AS1 ENSG00000267776 ZNF667 ZNF667-AS1 LOC729999
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SBK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SBK2 gene promoter:

Genomic Locations for SBK2 Gene

Genomic Locations for SBK2 Gene
chr19:55,529,336-55,537,174
(GRCh38/hg38)
Size:
7,839 bases
Orientation:
Minus strand
chr19:56,041,100-56,048,456
(GRCh37/hg19)

Genomic View for SBK2 Gene

Genes around SBK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SBK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SBK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SBK2 Gene

Proteins for SBK2 Gene

  • Protein details for SBK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C263-SBK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase SBK2
    Protein Accession:
    P0C263

    Protein attributes for SBK2 Gene

    Size:
    348 amino acids
    Molecular mass:
    38088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SBK2 Gene

Selected DME Specific Peptides for SBK2 Gene

P0C263:
  • IPYTAPE
  • RDLKPEN

Post-translational modifications for SBK2 Gene

No Post-translational modifications

Other Protein References for SBK2 Gene

Domains & Families for SBK2 Gene

Gene Families for SBK2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for SBK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C263

UniProtKB/Swiss-Prot:

SBK2_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
genes like me logo Genes that share domains with SBK2: view

Function for SBK2 Gene

Molecular function for SBK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for SBK2 Gene

Phenotypes From GWAS Catalog for SBK2 Gene

Gene Ontology (GO) - Molecular Function for SBK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SBK2: view
genes like me logo Genes that share phenotypes with SBK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SBK2

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SBK2 Gene

Localization for SBK2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SBK2 gene
Compartment Confidence
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SBK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with SBK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SBK2 Gene

Pathways & Interactions for SBK2 Gene

No Data Available

Interacting Proteins for SBK2 Gene

Gene Ontology (GO) - Biological Process for SBK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007266 Rho protein signal transduction IBA --
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0016310 phosphorylation IEA --
GO:0016477 cell migration IBA --
genes like me logo Genes that share ontologies with SBK2: view

No data available for Pathways by source and SIGNOR curated interactions for SBK2 Gene

Drugs & Compounds for SBK2 Gene

No Compound Related Data Available

Transcripts for SBK2 Gene

mRNA/cDNA for SBK2 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SBK2 Gene

SH3-binding domain kinase family, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SBK2 Gene

No ASD Table

Relevant External Links for SBK2 Gene

GeneLoc Exon Structure for
SBK2
ECgene alternative splicing isoforms for
SBK2

Expression for SBK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SBK2 Gene

mRNA differential expression in normal tissues according to GTEx for SBK2 Gene

This gene is overexpressed in Heart - Atrial Appendage (x48.7).

Protein differential expression in normal tissues from HIPED for SBK2 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SBK2 Gene



Protein tissue co-expression partners for SBK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SBK2 Gene:

SBK2

SOURCE GeneReport for Unigene cluster for SBK2 Gene:

Hs.532676
genes like me logo Genes that share expression patterns with SBK2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SBK2 Gene

Orthologs for SBK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SBK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SBK2 33 34
  • 98.56 (n)
dog
(Canis familiaris)
Mammalia SBK2 33 34
  • 85.09 (n)
cow
(Bos Taurus)
Mammalia SBK2 33 34
  • 81.84 (n)
mouse
(Mus musculus)
Mammalia Sbk2 33 16 34
  • 79.44 (n)
rat
(Rattus norvegicus)
Mammalia Sbk2 33
  • 78.96 (n)
oppossum
(Monodelphis domestica)
Mammalia SBK2 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SBK2 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves SBK2 33 34
  • 61.63 (n)
lizard
(Anolis carolinensis)
Reptilia SBK2 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492557 33
  • 55.37 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-8e10.3 33
  • 53.55 (n)
SBK2 34
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11221 34
  • 19 (a)
ManyToMany
CG4945 34
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C01C4.3 34
  • 19 (a)
OneToMany
Species where no ortholog for SBK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SBK2 Gene

ENSEMBL:
Gene Tree for SBK2 (if available)
TreeFam:
Gene Tree for SBK2 (if available)

Paralogs for SBK2 Gene

Paralogs for SBK2 Gene

(3) SIMAP similar genes for SBK2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SBK2: view

Variants for SBK2 Gene

Sequence variations from dbSNP and Humsavar for SBK2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000427906 -- 55,529,955(-) C/A coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant
rs1000806750 -- 55,536,400(-) C/T intron_variant
rs1001265594 -- 55,530,304(-) G/A coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant
rs1001283178 -- 55,533,296(-) A/G intron_variant
rs1001586997 -- 55,533,528(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SBK2 Gene

Variant ID Type Subtype PubMed ID
dgv1821n106 CNV deletion 24896259
dgv230e215 CNV deletion 23714750
esv1510388 CNV deletion 17803354
esv2718980 CNV deletion 23290073
esv3082679 CNV deletion 24192839
esv3893252 CNV loss 25118596
esv4756 CNV loss 18987735
esv7136 CNV loss 19470904
esv997838 CNV deletion 20482838
nsv1071554 CNV deletion 25765185
nsv1077868 CNV duplication 25765185
nsv1152574 CNV deletion 26484159
nsv138153 CNV deletion 16902084
nsv953624 CNV deletion 24416366

Variation tolerance for SBK2 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SBK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SBK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SBK2 Gene

Disorders for SBK2 Gene

Additional Disease Information for SBK2

No disorders were found for SBK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SBK2 Gene

Publications for SBK2 Gene

  1. Patterns of somatic mutation in human cancer genomes. (PMID: 17344846) Greenman C … Stratton MR (Nature 2007) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. The protein kinase complement of the human genome. (PMID: 12471243) Manning G … Sudarsanam S (Science (New York, N.Y.) 2002) 3 4 58

Products for SBK2 Gene

Sources for SBK2 Gene

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