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Aliases for SAXO2 Gene

Aliases for SAXO2 Gene

  • Stabilizer Of Axonemal Microtubules 2 2 3 5
  • Family With Sequence Similarity 154, Member B 2 3
  • FAM154B 3 4
  • Protein FAM154B 3

External Ids for SAXO2 Gene

Previous HGNC Symbols for SAXO2 Gene

  • FAM154B

Summaries for SAXO2 Gene

GeneCards Summary for SAXO2 Gene

SAXO2 (Stabilizer Of Axonemal Microtubules 2) is a Protein Coding gene. An important paralog of this gene is SAXO1.

Additional gene information for SAXO2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAXO2 Gene

Genomics for SAXO2 Gene

GeneHancer (GH) Regulatory Elements for SAXO2 Gene

Promoters and enhancers for SAXO2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I082260 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 598.5 -0.5 -456 3.1 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 YY1 SAXO2 EFL1 CSPG4P10 HDGFL3 CPEB1 AP3B2 GC15M082251
GH15I082708 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 23.9 +446.5 446521 2 ZNF133 ARID4B SIN3A ZNF48 ZNF766 GLIS2 ZNF213 ELK1 ZNF143 KLF7 AP3B2 SAXO2 C15orf40 WHAMM SNHG21 RPL9P9 CPEB1 HDGFL3 EFL1 PIR57194
GH15I082177 Enhancer 0.9 Ensembl ENCODE dbSUPER 47.9 -84.7 -84716 1.5 ZNF316 MAX MAFK EMSY PRDM1 SPI1 SAXO2 RNU1-77P GC15M082175 GC15P082195 EFL1
GH15I082159 Enhancer 0.7 ENCODE dbSUPER 47.8 -102.5 -102476 1.7 JUND POLR2A INSM2 FOS ZNF600 SAXO2 CSPG4P10 AP3B2 PIR43496 RNU1-77P GC15M082175 EFL1
GH15I082267 Enhancer 1 ENCODE dbSUPER 19.5 +5.5 5534 2.7 HDAC1 MEIS2 PKNOX1 FOXA2 TEAD4 TAL1 E4F1 TCF12 CTBP1 NCOR1 CSPG4P10 SAXO2 GC15P082281
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SAXO2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SAXO2 Gene

Genomic Locations for SAXO2 Gene
chr15:82,262,810-82,284,930
(GRCh38/hg38)
Size:
22,121 bases
Orientation:
Plus strand
chr15:82,555,151-82,577,271
(GRCh37/hg19)

Genomic View for SAXO2 Gene

Genes around SAXO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAXO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAXO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAXO2 Gene

Proteins for SAXO2 Gene

  • Protein details for SAXO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q658L1-SAXO2_HUMAN
    Recommended name:
    Stabilizer of axonemal microtubules 2
    Protein Accession:
    Q658L1
    Secondary Accessions:
    • B4E2M2

    Protein attributes for SAXO2 Gene

    Size:
    398 amino acids
    Molecular mass:
    45933 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SAXO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAXO2 Gene

Post-translational modifications for SAXO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SAXO2 Gene

Domains & Families for SAXO2 Gene

Gene Families for SAXO2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SAXO2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SAXO2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q658L1

UniProtKB/Swiss-Prot:

SAXO2_HUMAN :
  • Belongs to the FAM154 family.
Family:
  • Belongs to the FAM154 family.
genes like me logo Genes that share domains with SAXO2: view

Function for SAXO2 Gene

Gene Ontology (GO) - Molecular Function for SAXO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with SAXO2: view

Phenotypes for SAXO2 Gene

GenomeRNAi human phenotypes for SAXO2:
genes like me logo Genes that share phenotypes with SAXO2: view

miRNA for SAXO2 Gene

miRTarBase miRNAs that target SAXO2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAXO2 Gene

Localization for SAXO2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAXO2 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SAXO2 Gene

Pathways & Interactions for SAXO2 Gene

SuperPathways for SAXO2 Gene

No Data Available

Interacting Proteins for SAXO2 Gene

Gene Ontology (GO) - Biological Process for SAXO2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAXO2 Gene

Drugs & Compounds for SAXO2 Gene

No Compound Related Data Available

Transcripts for SAXO2 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAXO2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - - -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for SAXO2 Gene

GeneLoc Exon Structure for
SAXO2
ECgene alternative splicing isoforms for
SAXO2

Expression for SAXO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAXO2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SAXO2 Gene:

SAXO2

Evidence on tissue expression from TISSUES for SAXO2 Gene

  • Stomach(4.1)
genes like me logo Genes that share expression patterns with SAXO2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAXO2 Gene

Orthologs for SAXO2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAXO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM154B 33 34
  • 98.58 (n)
dog
(Canis familiaris)
Mammalia FAM154B 33 34
  • 87.1 (n)
mouse
(Mus musculus)
Mammalia Fam154b 33 34
  • 86.68 (n)
Saxo2 16
rat
(Rattus norvegicus)
Mammalia Fam154b 33
  • 86.6 (n)
cow
(Bos Taurus)
Mammalia FAM154B 33 34
  • 79.91 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM154B 34
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM154B 34
  • 24 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM154B 33 34
  • 67.28 (n)
lizard
(Anolis carolinensis)
Reptilia FAM154B 34
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam154b 33
  • 65.54 (n)
zebrafish
(Danio rerio)
Actinopterygii fam154b 33 34
  • 55.44 (n)
Dr.15468 33
worm
(Caenorhabditis elegans)
Secernentea T08G11.3 34
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
Species where no ortholog for SAXO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAXO2 Gene

ENSEMBL:
Gene Tree for SAXO2 (if available)
TreeFam:
Gene Tree for SAXO2 (if available)

Paralogs for SAXO2 Gene

Paralogs for SAXO2 Gene

Pseudogenes.org Pseudogenes for SAXO2 Gene

genes like me logo Genes that share paralogs with SAXO2: view

Variants for SAXO2 Gene

Sequence variations from dbSNP and Humsavar for SAXO2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000022697 -- 82,271,137(+) A/G intron_variant
rs1000113023 -- 82,268,175(+) TTTTTTT/TTTTTT intron_variant
rs1000227961 -- 82,267,864(+) C/G intron_variant
rs1000241321 -- 82,275,797(+) A/G intron_variant
rs1000398392 -- 82,275,250(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SAXO2 Gene

Variant ID Type Subtype PubMed ID
dgv321n27 CNV gain 19166990
dgv457e214 CNV gain 21293372
dgv4682n54 CNV gain 21841781
esv2663603 CNV deletion 23128226
esv3552760 CNV deletion 23714750
esv3637056 CNV loss 21293372
esv3637057 CNV loss 21293372
nsv1041040 CNV gain 25217958
nsv1041506 CNV loss 25217958
nsv1120052 OTHER inversion 24896259
nsv977743 CNV duplication 23825009

Variation tolerance for SAXO2 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 20.17; 99.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAXO2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAXO2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAXO2 Gene

Disorders for SAXO2 Gene

Additional Disease Information for SAXO2

No disorders were found for SAXO2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAXO2 Gene

Publications for SAXO2 Gene

  1. Human FAM154A (SAXO1) is a microtubule-stabilizing protein specific to cilia and related structures. (PMID: 25673876) Dacheux D … Bonhivers M (Journal of cell science 2015) 2 3 58
  2. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for SAXO2 Gene

Sources for SAXO2 Gene

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