This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016] See more...

Aliases for SATB1 Gene

Aliases for SATB1 Gene

  • SATB Homeobox 1 2 3 5
  • Special AT-Rich Sequence Binding Protein 1 (Binds To Nuclear Matrix/Scaffold-Associating DNA) 2 3
  • DNA-Binding Protein SATB1 3 4
  • Special AT-Rich Sequence-Binding Protein 1 4

External Ids for SATB1 Gene

Previous GeneCards Identifiers for SATB1 Gene

  • GC03U990069
  • GC03M018050
  • GC03M018264

Summaries for SATB1 Gene

Entrez Gene Summary for SATB1 Gene

  • This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016]

GeneCards Summary for SATB1 Gene

SATB1 (SATB Homeobox 1) is a Protein Coding gene. Diseases associated with SATB1 include Periampullary Adenocarcinoma and Bladder Urothelial Carcinoma. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Apoptotic cleavage of cellular proteins. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is SATB2.

UniProtKB/Swiss-Prot Summary for SATB1 Gene

  • Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity).

Gene Wiki entry for SATB1 Gene

Additional gene information for SATB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SATB1 Gene

Genomics for SATB1 Gene

GeneHancer (GH) Regulatory Elements for SATB1 Gene

Promoters and enhancers for SATB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J018438 Promoter/Enhancer 2.4 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 509.6 +5.1 5087 14.6 ZSCAN5C USF1 CTCF ZNF10 FOXA1 ZBTB10 ZBTB26 SAP30 EZH2 MXI1 SATB1 lnc-EFHB-5 TBC1D5 SATB1-AS1
GH03J018421 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 522.5 +21.0 20987 6.8 HNRNPK ZBTB40 ZNF217 SP1 RBAK ZNF10 ZIC2 ZBTB10 ZNF423 ZBTB26 SATB1 TBC1D5 SATB1-AS1 ENSG00000272477 lnc-EFHB-5
GH03J018349 Promoter 0.4 EPDnew 500.2 +96.1 96121 0.1 EGR2 SATB1 piR-46002-381 piR-39858-442 TBC1D5
GH03J018739 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -296.6 -296581 5.1 EP300 TRIM22 BCL11A CBFB GATA3 SRF ZNF207 ARNT MEF2B NBN SATB1 TBC1D5 SATB1-AS1 LOC105376976 L13714-311
GH03J018368 Enhancer 1.6 UCNEbase Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +70.7 70687 12.2 EP300 ZSCAN5C USF1 ZNF639 ZIC2 ZEB1 MXI1 OSR2 WT1 GATA3 SATB1-AS1 TBC1D5 SATB1 piR-39858-442 piR-46002-381
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SATB1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SATB1

Top Transcription factor binding sites by QIAGEN in the SATB1 gene promoter:
  • ATF-2
  • CUTL1
  • IRF-1
  • p300
  • RelA

Genomic Locations for SATB1 Gene

Genomic Locations for SATB1 Gene
chr3:18,345,377-18,445,588
(GRCh38/hg38)
Size:
100,212 bases
Orientation:
Minus strand
chr3:18,386,879-18,487,080
(GRCh37/hg19)
Size:
100,202 bases
Orientation:
Minus strand

Genomic View for SATB1 Gene

Genes around SATB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SATB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SATB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SATB1 Gene

Proteins for SATB1 Gene

  • Protein details for SATB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01826-SATB1_HUMAN
    Recommended name:
    DNA-binding protein SATB1
    Protein Accession:
    Q01826
    Secondary Accessions:
    • B3KXF1
    • C9JTR6
    • Q59EQ0

    Protein attributes for SATB1 Gene

    Size:
    763 amino acids
    Molecular mass:
    85957 Da
    Quaternary structure:
    • Interacts with CUX1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity). Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least of SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and promotes transcription repression. Interacts with PCAF. Interacts with sumoylated PML and HDAC1 via the PDZ-like dimerization domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300.
    • (Microbial infection) Interacts (via the PDZ-like dimerization domain) with HIV-1 Tat.
    SequenceCaution:
    • Sequence=BAD92998.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SATB1 Gene

    Alternative splice isoforms for SATB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SATB1 Gene

Post-translational modifications for SATB1 Gene

  • Sumoylated. Sumoylation promotes cleavage by caspases.
  • Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation.
  • Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The cleaved forms cannot dimerize and lose transcription regulation function because of impaired DNA and chromatin association.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for SATB1

No data available for DME Specific Peptides for SATB1 Gene

Domains & Families for SATB1 Gene

Gene Families for SATB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SATB1 Gene

Suggested Antigen Peptide Sequences for SATB1 Gene

GenScript: Design optimal peptide antigens:
  • Special AT-rich sequence-binding protein 1 (SATB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q01826

UniProtKB/Swiss-Prot:

SATB1_HUMAN :
  • Belongs to the CUT homeobox family.
Family:
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with SATB1: view

Function for SATB1 Gene

Molecular function for SATB1 Gene

UniProtKB/Swiss-Prot Function:
Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity).
GENATLAS Biochemistry:
special A-T rich binding protein 1,binding selectively to nuclear matrix/scaffold associated regions of DNA,i.e. MARbeta,upstream of the T cell receptor beta gene,with five or more CAG repeats

Phenotypes From GWAS Catalog for SATB1 Gene

Gene Ontology (GO) - Molecular Function for SATB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 15851481
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 15851481
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with SATB1: view
genes like me logo Genes that share phenotypes with SATB1: view

Animal Models for SATB1 Gene

MGI Knock Outs for SATB1:
  • Satb1 Satb1<tm1b(EUCOMM)Hmgu>
  • Satb1 Satb1<tm1Kos>
  • Satb1 Satb1<tm1a(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SATB1

Clone Products

  • Addgene plasmids for SATB1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SATB1 Gene

Localization for SATB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SATB1 Gene

Nucleus matrix. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SATB1 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SATB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IDA,IBA 18408014
GO:0005654 nucleoplasm TAS --
GO:0005720 nuclear heterochromatin IEA --
genes like me logo Genes that share ontologies with SATB1: view

Pathways & Interactions for SATB1 Gene

genes like me logo Genes that share pathways with SATB1: view

Pathways by source for SATB1 Gene

1 Cell Signaling Technology pathway for SATB1 Gene

SIGNOR curated interactions for SATB1 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for SATB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 15851481
GO:0006325 chromatin organization TAS 1505028
GO:0006338 chromatin remodeling IBA,IEA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008544 epidermis development IEA --
genes like me logo Genes that share ontologies with SATB1: view

Drugs & Compounds for SATB1 Gene

No Compound Related Data Available

Transcripts for SATB1 Gene

mRNA/cDNA for SATB1 Gene

9 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SATB1

Clone Products

  • Addgene plasmids for SATB1

Alternative Splicing Database (ASD) splice patterns (SP) for SATB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - - - - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - -
SP9: - - -
SP10: - - - -
SP11:
SP12: -
SP13: - - - - - - - - -
SP14:
SP15: - - - - - - -

ExUns: 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for SATB1 Gene

GeneLoc Exon Structure for
SATB1

Expression for SATB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SATB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SATB1 Gene

This gene is overexpressed in Cervix (30.6), CD8 Tcells (11.8), and Serum (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SATB1 Gene



Protein tissue co-expression partners for SATB1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SATB1

SOURCE GeneReport for Unigene cluster for SATB1 Gene:

Hs.517717

mRNA Expression by UniProt/SwissProt for SATB1 Gene:

Q01826-SATB1_HUMAN
Tissue specificity: Expressed predominantly in thymus.

Evidence on tissue expression from TISSUES for SATB1 Gene

  • Nervous system(4.8)
  • Lung(4.4)
  • Blood(2.4)
  • Lymph node(2.4)
  • Intestine(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SATB1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SATB1 Gene

Orthologs for SATB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SATB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SATB1 31 30
  • 99.78 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SATB1 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SATB1 31 30
  • 94.52 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 93 (a)
OneToMany
-- 31
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Satb1 17 31 30
  • 91.26 (n)
rat
(Rattus norvegicus)
Mammalia Satb1 30
  • 90.52 (n)
cow
(Bos Taurus)
Mammalia SATB1 31 30
  • 86.4 (n)
OneToOne
chicken
(Gallus gallus)
Aves SATB1 31 30
  • 88.11 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SATB1 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia satb1 30
  • 79.54 (n)
Str.19640 30
zebrafish
(Danio rerio)
Actinopterygii LOC571757 30
  • 71.32 (n)
SATB1 31
  • 70 (a)
OneToOne
Species where no ortholog for SATB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SATB1 Gene

ENSEMBL:
Gene Tree for SATB1 (if available)
TreeFam:
Gene Tree for SATB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SATB1: view image

Paralogs for SATB1 Gene

Paralogs for SATB1 Gene

(1) SIMAP similar genes for SATB1 Gene using alignment to 8 proteins:

  • SATB1_HUMAN
  • C9IZC5_HUMAN
  • C9J3I0_HUMAN
  • C9J7F3_HUMAN
  • C9JGL9_HUMAN
  • C9JLL5_HUMAN
  • C9JP21_HUMAN
  • H0YN86_HUMAN
genes like me logo Genes that share paralogs with SATB1: view

Variants for SATB1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SATB1 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
689721 Uncertain Significance: Marfanoid habitus and intellectual disability 18,394,662(-) GTC/G FRAMESHIFT_VARIANT
709373 Benign: not provided 18,397,295(-) A/G INTRON_VARIANT
767889 Benign: not provided 18,394,794(-) T/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for SATB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SATB1 Gene

Variant ID Type Subtype PubMed ID
esv3330100 CNV insertion 20981092
nsv460455 CNV loss 19166990
nsv589853 CNV loss 21841781
nsv589854 CNV loss 21841781

Variation tolerance for SATB1 Gene

Residual Variation Intolerance Score: 4.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 61.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SATB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SATB1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SATB1 Gene

Disorders for SATB1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SATB1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
periampullary adenocarcinoma
bladder urothelial carcinoma
  • bladder transitional cell carcinoma
mixed cell uveal melanoma
  • intraocular mixed cell type melanoma
breast disease
  • breast diseases
- elite association - COSMIC cancer census association via MalaCards
Search SATB1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SATB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SATB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SATB1 Gene

Publications for SATB1 Gene

  1. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. (PMID: 1505028) Dickinson LA … Kohwi-Shigematsu T (Cell 1992) 2 3 4 23 54
  2. Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1. (PMID: 19103759) Purbey PK … Galande S (Molecular and cellular biology 2009) 3 4 23 54
  3. SATB1 regulates beta-like globin genes through matrix related nuclear relocation of the cluster. (PMID: 19332023) Gong H … Liang CC (Biochemical and biophysical research communications 2009) 3 4 23 54
  4. SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. (PMID: 18337816) Han HJ … Kohwi-Shigematsu T (Nature 2008) 3 4 23 54
  5. Structural basis for recognition of the matrix attachment region of DNA by transcription factor SATB1. (PMID: 17652321) Yamasaki K … Harata K (Nucleic acids research 2007) 3 4 23 54

Products for SATB1 Gene

Sources for SATB1 Gene