Aliases for SART3 Gene
- Spliceosome Associated Factor 3, U4/U6 Recycling Protein 2 3 5
- Squamous Cell Carcinoma Antigen Recognized By T-Cells 3 2 3 4
- TIP110 2 3 4
- Squamous Cell Carcinoma Antigen Recognized By T Cells 3 2 3
- HIV-1 Tat-Interacting Protein Of 110kDa 2 3
- Tat-Interacting Protein Of 110 KDa 3 4
- P110 Nuclear RNA-Binding Protein 3 4
- PRP24 Homolog 2 3
- RP11-13G14 2 3
External Ids for SART3 Gene
Previous GeneCards Identifiers for SART3 Gene
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]
GeneCards Summary for SART3 Gene
SART3 (Spliceosome Associated Factor 3, U4/U6 Recycling Protein) is a Protein Coding gene. Diseases associated with SART3 include Porokeratosis and Brain Cancer. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.
UniProtKB/Swiss-Prot Summary for SART3 Gene
U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). May play a role in hematopoiesis probably through transcription regulation of specific genes including MYC (By similarity).
Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.