SARS1 Gene (Protein Coding)

Seryl-TRNA Synthetase 1

GCID:: GC01P109214

GIFtS:: 36

Genes Participants

This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010] See more...

Aliases for SARS1 Gene

Seryl-TRNA Synthetase 1 ² ³
Seryl-TRNA Synthetase ² ⁴ ⁵
Serine TRNA Ligase 1, Cytoplasmic ² ³
Serine--TRNA Ligase, Cytoplasmic ³ ⁴
Seryl-TRNA(Ser/Sec) Synthetase ³ ⁴
EC 6.1.1.11 ⁴ ⁵²

SARS ³ ⁵
SERS ³ ⁴
Seryl-TRNA Synthetase, Cytoplasmic ³
NEDMAS ³
SERRS ³
SerRS ⁴

External Ids for SARS1 Gene

HGNC: 10537
Entrez Gene: 6301
Ensembl: ENSG00000031698
OMIM: 607529
UniProtKB: P49591

Previous HGNC Symbols for SARS1 Gene

SARS

Search aliases for SARS1 gene in PubMed and other databases

Summaries for SARS1 Gene

Entrez Gene Summary for SARS1 Gene

This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]

GeneCards Summary for SARS1 Gene

SARS1 (Seryl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with SARS1 include Neurodevelopmental Disorder With Microcephaly, Ataxia, And Seizures and Arteriovenous Malformations Of The Brain. Among its related pathways are Viral mRNA Translation and Gene Expression. An important paralog of this gene is ENSG00000269547.

UniProtKB/Swiss-Prot Summary for SARS1 Gene

Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).
- SYSC_HUMAN,P49591

Gene Wiki entry for SARS1 Gene

Additional gene information for SARS1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SARS1 Gene

Genomics for SARS1 Gene

GeneHancer (GH) Regulatory Elements for SARS1 Gene

Promoters and enhancers for SARS1 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH01J109213	Promoter/Enhancer	2.2	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	500.7	+1.1	1134	3.7	HNRNPK SIN3A NRF1 MYC POLR2G POLR2A CLOCK ZNF263 AFF1 ZBTB26	SARS1 ENSG00000228665 ENSG00000244716 GNAI3 SORT1 PSRC1 CSF1 MYBPHL ENSG00000258634 CELSR2
GH01J109389	Promoter/Enhancer	2.7	EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER	9.7	+180.5	180489	10.5	FOXK2 HNRNPK ZNF217 EP300 CTCF NRF1 POLR2G SP1 NCOR1 GTF2E2	SORT1 SYPL2 PRPF38B PSRC1 ENSG00000258634 ENSG00000273373 MYBPHL STRIP1 SARS1 AMIGO1
GH01J109238	Enhancer	1.3	ENCODE CraniofacialAtlas dbSUPER	10.9	+26.3	26339	3.7	ZNF217 CTCF POLR2G ZFX ZIC2 SNRNP70 ZBTB10 CLOCK ZNF423 GABPA	lnc-PSRC1-2 PRPF38B ENSG00000258634 SORT1 SARS1 STRIP1 CELSR2 KIAA1324 HSALNG0005869
GH01J109179	Enhancer	1.3	Ensembl ENCODE dbSUPER	10.7	-29.4	-29356	10.1	FOXK2 TCF12 ZIC2 KDM6A ZBTB11 TCF7 FOXA1 MYC SKI NFRKB	KIAA1324 SARS1 TMEM167B ATXN7L2 piR-31162-027 NONHSAG002329.2
GH01J109132	Enhancer	1.3	Ensembl ENCODE dbSUPER	10.6	-77.6	-77628	7.4	EP300 NRF1 PHB2 ZNF10 ZIC2 KDM6A ZBTB11 AFF1 TARDBP RFX1	TMEM167B SARS1 SORT1 C1orf194 KIAA1324 GPSM2 HSALNG0005858 piR-31162-027

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SARS1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SARS1

Genomic Locations for SARS1 Gene

chr1:109,213,893-109,238,182: (GRCh38/hg38)

Size:: 24,290 bases
Orientation:: Plus strand

chr1:109,756,515-109,780,804: (GRCh37/hg19)

Size:: 24,290 bases
Orientation:: Plus strand

Genomic View for SARS1 Gene

Genes around SARS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

1p13.3 by HGNC
1p13.3 by Entrez Gene
1p13.3 by Ensembl

SARS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for SARS1 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SARS1 Gene

NC_000001.11

Proteins for SARS1 Gene

Protein details for SARS1 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P49591-SYSC_HUMAN

Recommended name:

Serine--tRNA ligase, cytoplasmic

Protein Accession:

P49591

Secondary Accessions:
- B2R6Y9
- Q5T5C8
- Q9NSE3
Protein attributes for SARS1 Gene
Size:

514 amino acids

Molecular mass:

58777 Da
Quaternary structure:
Homodimer (PubMed:22353712, PubMed:26433229). The tRNA molecule may bind across the dimer (PubMed:26433229). Interacts with SIRT2 (PubMed:24940000). Interacts with METTL6 (PubMed:28655767).
Three dimensional structures from OCA and Proteopedia for SARS1 Gene
- 3VBB (3D)
- 4L87 (3D)
- 4RQE (3D)
- 4RQF (3D)

neXtProt entry for SARS1 Gene

Selected DME Specific Peptides for SARS1 Gene

P49591:

LREIGNLLHPSVPIS
AILENYQ
VPEKLKEFMPPGLQELIPFVK
DLEAWFP
KKYSHVDLVVMVDGF
HGRDTRG
FVHMLNATMCATTR
GIFRVHQF
DTRGIFR
YLIATSE
LKVSQIKKVRLL
DEAILKCDAERIKLEAERFE
SNCTDYQ
YTPFFMRKEVMQEVAQLSQFD

Post-translational modifications for SARS1 Gene

Glycosylation at Asn427
- NX_P49591 (NX_P49591-1)
Ubiquitination at Lys376
- NX_P49591 (NX_P49591-1)
Modification sites at PhosphoSitePlus
- P49591
Glycosylation from GlyConnect
- SYSC_HUMAN (1738)

Other Protein References for SARS1 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

Creative Diagnostics Anti-SARS monoclonal antibody, clone FQS21795(C)

Creative Biolabs Recombinant Mouse Anti-Human SARS Antibody (clone 1H4)

OriGene Antibodies for SARS1
- TA337052
- TA337053
- TA337054
- TA345970
Custom Antibody Services

Novus Biologicals Antibodies for SARS1

Abcam antibodies for SARS1
- Seryl-tRNA synthetase

Invitrogen Antibodies for SARS1 (AFLGC-SARS)

antibodies-online: Show 124 available SARS Antibodies ranked by validation data
Compare Top SARS Antibodies
Quality Products:

Biorbyt antibodies for SARS1

Browse Boster Bio Antibodies

Browse Santa Cruz Biotechnology (SCBT) Antibodies

Browse Sino Biological Antibodies

Protein Products

Creative Biomart Recombinant Human Seryl-TRNA Synthetase, His-tagged

OriGene Purified Proteins for SARS1
Search Origene for MassSpec and Protein Over-expression Lysates for SARS1
Origene Custom Protein Services for SARS1

Novus Biologicals proteins and lysates for SARS1

ProSpec Recombinant Proteins for SARS1

antibodies-online: Show 3 available SARS Proteins ranked by validation data
Compare Top SARS Proteins
Quality Products:

Signalway Proteins for SARS1
- AP71845
- AP88021
- GP13426

Search for SARS1 Proteins at ProSci

Abcam proteins for SARS1
- Seryl-tRNA synthetase

Assay Products

antibodies-online: Search results for available SARS related products ranked by validation data

Browse Boster Bio ELISA Kits

Search for SARS1 ELISA kits at Signalway

Browse Sino Biological Assays

Domains & Families for SARS1 Gene

Gene Families for SARS1 Gene

HGNC:

Aminoacyl tRNA synthetases, Class II

Human Protein Atlas (HPA):

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Protein Domains for SARS1 Gene

Blocks:

Seryl-tRNA SYNTHETASE signature

InterPro:

ProtoNet:

P49591

Suggested Antigen Peptide Sequences for SARS1 Gene

GenScript: Design optimal peptide antigens:

SARS protein (Q0VGA5_HUMAN)
Seryl-tRNA(Ser/Sec) synthetase (SYSC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49591

UniProtKB/Swiss-Prot:

SYSC_HUMAN :

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

Domain:

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.

Family:

Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

Function for SARS1 Gene

Molecular function for SARS1 Gene

UniProtKB/Swiss-Prot Function:

Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).

SYSC_HUMAN,P49591

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser); Xref=Rhea:RHEA:12292, Rhea:RHEA-COMP:9669, Rhea:RHEA-COMP:9703, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:33384, ChEBI:CHEBI:78442, ChEBI:CHEBI:78533, ChEBI:CHEBI:456215; EC=6.1.1.11; Evidence={ECO:0000269 PubMed:22353712, ECO:0000269 PubMed:24095058, ECO:0000269 PubMed:26433229, ECO:0000269 PubMed:28236339, ECO:0000269 PubMed:9431993};.

SYSC_HUMAN,P49591

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec); Xref=Rhea:RHEA:42580, Rhea:RHEA-COMP:9742, Rhea:RHEA-COMP:10128, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:33384, ChEBI:CHEBI:78442, ChEBI:CHEBI:78533, ChEBI:CHEBI:456215; EC=6.1.1.11; Evidence={ECO:0000269 PubMed:22353712, ECO:0000269 PubMed:24095058, ECO:0000269 PubMed:26433229, ECO:0000269 PubMed:28236339, ECO:0000269 PubMed:9431993};.

SYSC_HUMAN,P49591

Enzyme Numbers (IUBMB) for SARS1 Gene

EC 6.1.1.11 ⁵² ⁴

Gene Ontology (GO) - Molecular Function for SARS1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000049	tRNA binding	IBA	21873635
GO:0000166	nucleotide binding	IEA	--
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	IDA	24940000
GO:0003677	DNA binding	IEA	--
GO:0003723	RNA binding	TAS	9431993

Phenotypes for SARS1 Gene

MGI mutant phenotypes for SARS1:

inferred from 1 alleles

GenomeRNAi human phenotypes for SARS1:

Human Phenotype Ontology for SARS1 Gene

HPO Id	HPO Name	Alternative Ids	Definition	Synonyms

Animal Models for SARS1 Gene

MGI Knock Outs for SARS1:

Sars ^{Sars<tm1.1(KOMP)Vlcg>}

Animal Model Products

Taconic Biosciences Mouse Models for SARS1
- Sars

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for SARS1 - Select products 50% OFF >
* SARS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene CRISPR knockouts for SARS1
- GA104275
- GA203765
- KN403665
- KN515301

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SARS1

genomics-online: gRNA clones - Search results for available SARS gene related products

Browse Santa Cruz Biotechnology (SCBT) for SARS1 CRISPR

miRNA for SARS1 Gene

miRTarBase miRNAs that target SARS1

miRNA Products

Search GeneCopoeia for miRNA 3'UTR Target clone products for SARS1

Browse OriGene miRNA Products For SARS1

Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for SARS1
Browse OriGene Inhibitory RNA Products For SARS1

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SARS1

genomics-online: shRNA clones - Search results for available SARS gene related products

Search Santa Cruz Biotechnology (SCBT) for SARS1 siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for SARS1 - Select products 50% OFF >
* SARS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene clones in human,mouse,rat for SARS1
- SC204269
- MC217577
- MC228113
- RN213075
- SC319289
OriGene ORF clones in human,mouse,rat for SARS1
- MG220183
- MR220183
- MR220183L3
- MR220183L4
- MR230324
- RC203665
- RC203665L3
- RC203665L4
- RG203665
- RR213075
- RR213075L3
- RR213075L4
- MR220183L3V
- MR220183L4V
- RC203665L3V
- RC203665L4V
- RR213075L3V
- RR213075L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for SARS1

Search Addgene for plasmids for SARS1

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SARS1

genomics-online: cdna clones - Search results for available SARS gene related products
orf clones - Search results for available SARS gene related products

Cell Line Products

Browse ESI BIO Cell Lines and PureStem Progenitors for SARS1

Browse GeneCopoeia Cell Lines

VectorBuilder Stable cell line generation for SARS1

Search Horizon for Cell Lines for SARS1

No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for SARS1 Gene

Localization for SARS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SARS1 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, but a minor proportion is also found in the nucleus. {ECO:0000269 PubMed:22353712}.

P49591-SYSC_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
cytosol	5
nucleus	4
mitochondrion	2
plasma membrane	1
extracellular	1
cytoskeleton	1
peroxisome	1
endoplasmic reticulum	1
lysosome	1
golgi apparatus	1

Subcellular locations from the

Human Protein Atlas (HPA)

Cytosol (4)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for SARS1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA,IDA	28236339
GO:0005829	cytosol	IDA,TAS	--
GO:0070062	extracellular exosome	HDA	20458337

Pathways & Interactions for SARS1 Gene

SuperPathways for SARS1 Gene

	SuperPathway	Contained pathways
1	tRNA Aminoacylation	Cytosolic tRNA aminoacylation .58 tRNA Aminoacylation .58	Aminoacyl-tRNA biosynthesis .50
2	Viral mRNA Translation	Selenocysteine synthesis .93 Selenoamino acid metabolism .78	Metabolism of amino acids and derivatives .34
3	Gene Expression	Gene Expression .48
4	Metabolism	Metabolism .40
5	Selenium Metabolism and Selenoproteins	Selenium Metabolism and Selenoproteins -

Pathways by source for SARS1 Gene

1 BioSystems pathway for SARS1 Gene

Selenium Metabolism and Selenoproteins

7 Reactome pathways for SARS1 Gene

1 KEGG pathway for SARS1 Gene

Aminoacyl-tRNA biosynthesis

UniProtKB/Swiss-Prot P49591-SYSC_HUMAN

Pathway: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.

Interacting Proteins for SARS1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: ENSP00000234677 P49591-SYSC_HUMAN for SARS1 Gene via STRING IID

Symbol	External ID(s)	Details
ACADSB	ENSP00000357873 ²¹ P45954 ¹²⁷	STRING: ENSP00000357873 IID: # exp=1 # pred=1
ACBD3	ENSP00000355777 ²¹ Q9H3P7 ¹²⁷	STRING: ENSP00000355777 IID: # exp=1
ANP32E	ENSP00000463154 ²¹ Q9BTT0 ¹²⁷	STRING: ENSP00000463154 IID: # exp=1
ARFIP1	ENSP00000395083 ²¹ P53367 ¹²⁷	STRING: ENSP00000395083 IID: # exp=1
ARFIP2	ENSP00000484121 ²¹ P53365 ¹²⁷	STRING: ENSP00000484121 IID: # exp=1

GPS-Prot Interaction Network for SARS1

;

SIGNOR curated interactions for SARS1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for SARS1 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	24940000
GO:0006412	translation	TAS	9431993
GO:0006418	tRNA aminoacylation for protein translation	TAS,IEA	--
GO:0006434	seryl-tRNA aminoacylation	IEA,IMP	28236339
GO:0008033	tRNA processing	TAS	9431993

Drugs & Compounds for SARS1 Gene

(6) Drugs for SARS1 Gene - From: DrugBank, HMDB, and Novoseek

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
Phosphoric acid	Approved	MalaCards Medline Plus	Pharma			0
Adenosine monophosphate	Approved, Investigational	MalaCards Medline Plus	Nutra			0
Serine	Investigational	MalaCards Medline Plus	Nutra	Full agonist, Agonist, Target	Weak endogenous glycine receptor agonist	1328
ATP	Investigational	MalaCards Medline Plus	Nutra	Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation		0

(5) Additional Compounds for SARS1 Gene - From: Novoseek and HMDB

Name	Synonyms	Role	CAS Number	PubChem IDs	PubMed IDs
pyrophosphate	[(ho)2P(O)OP(O)(OH)2] Acide diphosphorique Diphosphorsaeure H4P2O7 PYROphosphATE		MalaCards Medline Plus	14000-31-8	1023

Drug Products

Creative Biomart Recombinant Human Seryl-TRNA Synthetase, His-tagged

Browse Tocris compounds for SARS1

Browse compounds at ApexBio

Transcripts for SARS1 Gene

mRNA/cDNA for SARS1 Gene

2 REFSEQ mRNAs :

13 NCBI additional mRNA sequence :

6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

ENST00000234677 1914 bps (ENST00000234677.7)
ENST00000369923 1882 bps (ENST00000369923.4)
ENST00000468588 1582 bps (ENST00000468588.1)
ENST00000471705 851 bps (ENST00000471705.1)
ENST00000477544 694 bps (ENST00000477544.5)

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for SARS1 - Select products 50% OFF >
* SARS1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene CRISPR knockouts for SARS1
- GA104275
- GA203765
- KN403665
- KN515301

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SARS1

genomics-online: gRNA clones - Search results for available SARS gene related products

Browse Santa Cruz Biotechnology (SCBT) for SARS1 CRISPR

miRNA Products

Search GeneCopoeia for miRNA 3'UTR Target clone products for SARS1

Browse OriGene miRNA Products For SARS1

Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for SARS1
Browse OriGene Inhibitory RNA Products For SARS1

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SARS1

genomics-online: shRNA clones - Search results for available SARS gene related products

Search Santa Cruz Biotechnology (SCBT) for SARS1 siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for SARS1 - Select products 50% OFF >
* SARS1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene clones in human,mouse,rat for SARS1
- SC204269
- MC217577
- MC228113
- RN213075
- SC319289
OriGene ORF clones in human,mouse,rat for SARS1
- MG220183
- MR220183
- MR220183L3
- MR220183L4
- MR230324
- RC203665
- RC203665L3
- RC203665L4
- RG203665
- RR213075
- RR213075L3
- RR213075L4
- MR220183L3V
- MR220183L4V
- RC203665L3V
- RC203665L4V
- RR213075L3V
- RR213075L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for SARS1

Search Addgene for plasmids for SARS1

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SARS1

genomics-online: cdna clones - Search results for available SARS gene related products
orf clones - Search results for available SARS gene related products

Alternative Splicing Database (ASD) splice patterns (SP) for SARS1 Gene

No ASD Table

Relevant External Links for SARS1 Gene

GeneLoc Exon Structure for: SARS1

Expression for SARS1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SARS1

SOURCE GeneReport for Unigene cluster for SARS1 Gene:

Hs.531176

mRNA Expression by UniProt/SwissProt for SARS1 Gene:

P49591-SYSC_HUMAN

Tissue specificity: Brain.

Evidence on tissue expression from TISSUES for SARS1 Gene

Nervous system(5)
Liver(4.6)
Lung(4)
Skin(3.7)
Intestine(3.4)
Blood(3)
Eye(2.8)
Muscle(2.8)
Kidney(2.4)
Heart(2.1)
Thyroid gland(2.1)
Spleen(2)

Primer Products

OriGene qPCR primer pairs for SARS1
- HP209443
- MP215305
OriGene qPCR primer pairs and template standards for SARS1
- HK209872

genomics-online: primer clones - Search results for available SARS gene related products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SARS1 Gene

Orthologs for SARS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SARS1 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
chimpanzee (Pan troglodytes)	Mammalia	SARS ³¹ ³⁰	99.81 (n)	OneToOne	1:109943115-109968116 457085 XM_001148840.3 XP_001148840.1
oppossum (Monodelphis domestica)	Mammalia	SARS ³¹	94 (a)	OneToOne	2:478246708-478273852
platypus (Ornithorhynchus anatinus)	Mammalia	SARS ³¹	93 (a)	OneToOne	Contig10988:4266-15425
dog (Canis familiaris)	Mammalia	SARS ³¹ ³⁰	92.14 (n)	OneToOne	6:42585026-42605756 490124 XM_861121.3 XP_866214.1
cow (Bos Taurus)	Mammalia	SARS ³¹ ³⁰	91.57 (n)	OneToOne	3:34283445-34303242 281476 NM_174175.2 NP_776600.1
mouse (Mus musculus)	Mammalia	Sars ¹⁷ ³¹ ³⁰	90.49 (n)		108424865 3:108424865-108445209 20226 NM_011319.3 NP_035449.1
rat (Rattus norvegicus)	Mammalia	Sars ³⁰	90.3 (n)		266975 NM_001007606.1 NP_001007607.1
chicken (Gallus gallus)	Aves	SARS ³¹ ³⁰	78.4 (n)	OneToOne	26:1139129-1143022 426697 NM_001031392.1 NP_001026563.1
lizard (Anolis carolinensis)	Reptilia	SARS ³¹	87 (a)	OneToOne	4:124900718-124924821
tropical clawed frog (Silurana tropicalis)	Amphibia	sars ³⁰	73.32 (n)		407933 NM_213687.2 NP_998852.1
tropical clawed frog (Silurana tropicalis)	Amphibia	Str.657 ³⁰			BX719745.1
African clawed frog (Xenopus laevis)	Amphibia	sars-prov ³⁰			BC043975.1
zebrafish (Danio rerio)	Actinopterygii	sars ³¹ ³⁰	72.89 (n)	OneToOne	23:34342072-34355173 445405 NM_001003882.2 NP_001003882.1
zebrafish (Danio rerio)	Actinopterygii	Dr.29078 ³⁰			CK024591.1
fruit fly (Drosophila melanogaster)	Insecta	CG17259 ³¹ ³⁰	66.67 (n)	OneToOne	2L:3035493-3037403 33518 NM_134899.3 NP_608743.2
African malaria mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP008265 ³⁰	66.6 (n)		1277721 XM_317207.4 XP_317207.2
worm (Caenorhabditis elegans)	Secernentea	sars-1 ³¹ ³⁰	61.52 (n)	OneToOne	IV:10003726-10005583 177859 NM_069403.5 NP_501804.1
K. lactis yeast (Kluyveromyces lactis)	Saccharomycetes	KLLA0A10593g ³⁰	55.66 (n)		2896393 XM_451464.1 XP_451464.1
A. gosspyii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_ABL088C ³⁰	55.15 (n)		4618940 NM_208212.1 NP_982859.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SES1 ³³ ³¹ ³⁰	53.17 (n)		IV:489508-490896 851587 NP_010306.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G27470 ³⁰	58.3 (n)		832806 NM_122629.2 NP_198099.1
soybean (Glycine max)	eudicotyledons	Gma.9981 ³⁰			44513778
Alicante grape (Vitis vinifera)	eudicotyledons	Vvi.311 ³⁰			CB341220.2
rice (Oryza sativa)	Liliopsida	Os01g0559100 ³⁰	58.96 (n)		4324679 NM_001049875.1 NP_001043340.1
rice (Oryza sativa)	Liliopsida	Os.5952 ³⁰			AK059522.1
wheat (Triticum aestivum)	Liliopsida	Ta.20463 ³⁰			BT009342.1
barley (Hordeum vulgare)	Liliopsida	Hv.6290 ³⁰			AV926612.1
corn (Zea mays)	Liliopsida	Zm.15927 ³⁰			AY103609.1
sea squirt (Ciona savignyi)	Ascidiacea	-- ³¹	78 (a)	OneToMany	reftig_48:702255-704685
		-- ³¹	70 (a)	OneToMany	reftig_48:688626-705224
		Cin.3798 ³⁰			AV854596.1
fission yeast (Schizosaccharomyces pombe)	Schizosaccharomycetes	SPAC29A4.15 ³⁰	55.2 (n)		2542163 NP_594867.1
bread mold (Neurospora crassa)	Ascomycetes	NCU01443 ³⁰	55.11 (n)		3872116 XM_950872.2 XP_955965.2
sea squirt (Ciona intestinalis)	Ascidiacea	Cin.3798 ³⁰			AV854596.1

Species where no ortholog for SARS1 was found in the sources mined by GeneCards:

Actinobacteria (Mycobacterium tuberculosis)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
beta proteobacteria (Neisseria meningitidis)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
rainbow trout (Oncorhynchus mykiss)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)

Evolution for SARS1 Gene

ENSEMBL:: Gene Tree for SARS1 (if available)
TreeFam:: Gene Tree for SARS1 (if available)
Aminode:: Evolutionary constrained regions (ECRs) for SARS1: view image

Paralogs for SARS1 Gene

ENSG00000269547 ⁵
SARS2 ⁵

Variants for SARS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SARS1 Gene

SNP ID	Clinical significance and condition	Chr 01 pos	Variation	Type
638324	Uncertain Significance: NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ATAXIA, AND SEIZURES	109,235,412(+)	G/A	MISSENSE_VARIANT
711285	Benign: not provided	109,237,381(+)	T/C	INTRON_VARIANT
714605	Likely Benign: not provided	109,235,353(+)	G/T	SYNONYMOUS_VARIANT
721604	Likely Benign: not provided	109,236,048(+)	C/T	SYNONYMOUS_VARIANT
722047	Likely Benign: not provided	109,237,810(+)	G/A	SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SARS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SARS1 Gene

Variant ID	Type	Subtype	PubMed ID
nsv1008458	CNV	gain	25217958
nsv1012267	CNV	gain	25217958

Variation tolerance for SARS1 Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 1.58; 30.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SARS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for: SARS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SARS1 Gene

Disorders for SARS1 Gene

(5) MalaCards diseases for SARS1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder	Aliases	PubMed IDs
neurodevelopmental disorder with microcephaly, ataxia, and seizures	nedmas	28236339
arteriovenous malformations of the brain	bavm
autosomal recessive non-syndromic intellectual disability	autosomal recessive mental retardation
microcephaly	microcephalus
robinow syndrome, autosomal recessive 1	rrs1

- elite association - COSMIC cancer census association via MalaCards

Search SARS1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SYSC_HUMAN

Neurodevelopmental disorder with microcephaly, ataxia, and seizures (NEDMAS) [MIM:617709]: An autosomal recessive disorder characterized by delayed psychomotor development, intellectual disability, seizures apparent in infancy, impaired speech, and aggressive behavior. Additional features include microcephaly, ataxia, and muscle weakness. {ECO:0000269 PubMed:28236339}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Search disorders for SARS1 gene in PubMed and other databases

No data available for Genatlas and External Links for SARS1 Gene

Publications for SARS1 Gene

Genomic organization, cDNA sequence, bacterial expression, and purification of human seryl-tRNA synthase. (PMID: 9431993) Vincent C … Härtlein M (European journal of biochemistry 1997) ² ³ ⁴ ²³ ⁵⁴
Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development. (PMID: 19423847) Herzog W … Stainier DY (Circulation research 2009) ³ ⁴ ²³ ⁵⁴
Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability. (PMID: 28236339) Musante L … Kuss AW (Human mutation 2017) ³ ⁴ ⁵⁴
SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis. (PMID: 26433229) Wang C … Xie W (Nucleic acids research 2015) ³ ⁴ ⁵⁴
tRNA synthetase counteracts c-Myc to develop functional vasculature. (PMID: 24940000) Shi Y … Yang XL (eLife 2014) ³ ⁴ ⁵⁴