Free for academic non-profit institutions. Other users need a Commercial license
This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]
SARS1 (Seryl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with SARS1 include Neurodevelopmental Disorder With Microcephaly, Ataxia, And Seizures and Arteriovenous Malformations Of The Brain. Among its related pathways are Viral mRNA Translation and tRNA Aminoacylation. An important paralog of this gene is ENSG00000269547.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000049 | tRNA binding | IBA | 21873635 |
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 24940000 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003723 | RNA binding | TAS | 9431993 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 28236339 |
GO:0005829 | cytosol | IDA,TAS | -- |
GO:0070062 | extracellular exosome | HDA | 20458337 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | tRNA Aminoacylation | ||
2 | Viral mRNA Translation | ||
3 | Gene Expression |
.48
|
|
4 | Metabolism |
.40
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 24940000 |
GO:0006412 | translation | TAS | 9431993 |
GO:0006418 | tRNA aminoacylation for protein translation | IEA,TAS | -- |
GO:0006434 | seryl-tRNA aminoacylation | IEA,IMP | 28236339 |
GO:0008033 | tRNA processing | TAS | 9431993 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SARS 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SARS 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SARS 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SARS 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SARS 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Sars 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sars 30 |
|
||
Chicken (Gallus gallus) |
Aves | SARS 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SARS 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sars 30 |
|
||
Str.657 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | sars-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | sars 30 31 |
|
OneToOne | |
Dr.29078 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG17259 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008265 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | sars-1 30 31 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A10593g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ABL088C 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SES1 30 31 33 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G27470 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.311 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.9981 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0559100 30 |
|
||
Os.5952 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.6290 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.20463 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.15927 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC29A4.15 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU01443 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3798 30 |
|
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs114191591 | Benign: not provided | 109,236,555(+) |
G/A NM_006513.4(SARS1):c.1257+7G>A |
INTRON | |
rs140717526 | Benign: not provided | 109,236,451(+) |
G/A NM_006513.4(SARS1):c.1160G>A (p.Gly387Glu) |
MISSENSE | |
rs1412278011 | Uncertain Significance: Neurodevelopmental disorder with microcephaly, ataxia, and seizures | 109,235,412(+) |
G/A NM_006513.4(SARS1):c.950G>A (p.Arg317Gln) |
MISSENSE | |
rs145465105 | Likely Benign: not provided | 109,235,353(+) |
G/T NM_006513.4(SARS1):c.891G>T (p.Leu297=) |
SYNONYMOUS | |
rs148902081 | Benign: not provided | 109,237,312(+) |
G/A NM_006513.4(SARS1):c.1326G>A (p.Glu442=) |
SYNONYMOUS |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1008458 | CNV | gain | 25217958 |
nsv1012267 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
neurodevelopmental disorder with microcephaly, ataxia, and seizures |
|
|
arteriovenous malformations of the brain |
|
|
autosomal recessive non-syndromic intellectual disability |
|
|
inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2 |
|
|
epidemic typhus |
|
|