Aliases for SARS1 Gene
External Ids for SARS1 Gene
Previous HGNC Symbols for SARS1 Gene
This gene belongs to the class II amino-acyl tRNA family. The encoded enzyme catalyzes the transfer of L-serine to tRNA (Ser) and is related to bacterial and yeast counterparts. Multiple alternatively spliced transcript variants have been described but the biological validity of all variants is unknown. [provided by RefSeq, Jul 2010]
GeneCards Summary for SARS1 Gene
SARS1 (Seryl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with SARS1 include Neurodevelopmental Disorder With Microcephaly, Ataxia, And Seizures and Arteriovenous Malformations Of The Brain. Among its related pathways are tRNA Aminoacylation and Viral mRNA Translation. An important paralog of this gene is SARS2.
UniProtKB/Swiss-Prot Summary for SARS1 Gene
Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).