Aliases for SARM1 Gene

Aliases for SARM1 Gene

  • Sterile Alpha And TIR Motif Containing 1 2 3 5
  • Sterile Alpha And TIR Motif-Containing Protein 1 3 4
  • Sterile Alpha Motif Domain-Containing Protein 2 3 4
  • Sterile Alpha And Armadillo Repeat Protein 3 4
  • SAM Domain-Containing Protein 2 3 4
  • Tir-1 Homolog 3 4
  • MyD88-5 3 4
  • SAMD2 3 4
  • SARM 3 4
  • Sterile Alpha And HEAT/Armadillo Motif Protein, Ortholog Of Drosophila 3
  • KIAA0524 4

External Ids for SARM1 Gene

Previous GeneCards Identifiers for SARM1 Gene

  • GC17P026550
  • GC17P026844
  • GC17P023723
  • GC17P026685
  • GC17P026698
  • GC17P022907

Summaries for SARM1 Gene

GeneCards Summary for SARM1 Gene

SARM1 (Sterile Alpha And TIR Motif Containing 1) is a Protein Coding gene. Diseases associated with SARM1 include Wallerian Degeneration. Among its related pathways are Activated TLR4 signalling and IKK complex recruitment mediated by RIP1. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot Summary for SARM1 Gene

  • Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.

Additional gene information for SARM1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SARM1 Gene

Genomics for SARM1 Gene

GeneHancer (GH) Regulatory Elements for SARM1 Gene

Promoters and enhancers for SARM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J028368 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.4 +6.7 6704 4.3 ZNF785 LCORL FOXA1 MLX RBPJ SMARCE1 TCF7L2 USF2 NR2F1 NR2F6 VTN SARM1 ENSG00000264029 ENSG00000263781 ENSG00000238007 ENSG00000263613 NOS2P1 ENSG00000265041 ENSG00000266111 ENSG00000264044
GH17J028355 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 22.4 -6.9 -6923 3.1 ZNF24 ZBTB40 SREBF1 SIX5 FOXA1 MLX RBPJ POLR2A USF2 HDAC2 TMEM199 ENSG00000258924 POLDIP2 SUPT6H ENSG00000264577 NUFIP2 ITM2BP1 ENSG00000265205 SARM1 PHF12
GH17J029290 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 +928.8 928770 5.1 ZNF785 SIN3A SP1 ZBTB40 CTCF ZBTB6 FOXA1 MLX SMARCE1 RBPJ NUFIP2 lnc-CRYBA1-4 PHF12 LOC101927018 ENSG00000265908 ENSG00000264577 SUPT6H SDF2 ANKRD13B ENSG00000264647
GH17J028901 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 12.1 +538.2 538182 2.3 PPP1R10 ZNF785 SIN3A ZNF24 ZBTB40 SP1 CTCF ZBTB6 SMARCE1 RBPJ DHRS13 lnc-PHF12-1 SUPT6H ENSG00000264577 NUFIP2 PHF12 ENSG00000265908 LOC101927018 SDF2 TMEM199
GH17J028715 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 +358.6 358568 14.4 PPP1R10 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF SREBF1 SIX5 ZBTB6 ENSG00000264577 RPL23A NEK8 RAB34 SNORD42A SNORD4A SNORD4B X96641 piR-31970 TLCD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SARM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SARM1 gene promoter:
  • AhR
  • ARP-1
  • ATF
  • GATA-2
  • LyF-1
  • NF-kappaB
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2
  • p300

Genomic Locations for SARM1 Gene

Genomic Locations for SARM1 Gene
chr17:28,364,356-28,404,049
(GRCh38/hg38)
Size:
39,694 bases
Orientation:
Plus strand
chr17:26,691,378-26,728,065
(GRCh37/hg19)
Size:
36,688 bases
Orientation:
Plus strand

Genomic View for SARM1 Gene

Genes around SARM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SARM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SARM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SARM1 Gene

Proteins for SARM1 Gene

  • Protein details for SARM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6SZW1-SARM1_HUMAN
    Recommended name:
    Sterile alpha and TIR motif-containing protein 1
    Protein Accession:
    Q6SZW1
    Secondary Accessions:
    • O60277
    • Q7LGG3
    • Q9NXY5

    Protein attributes for SARM1 Gene

    Size:
    724 amino acids
    Molecular mass:
    79388 Da
    Quaternary structure:
    • Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function. Interacts with MAPK10/JNK3 and SDC2 (via cytoplasmic domain) (By similarity).

    Alternative splice isoforms for SARM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SARM1 Gene

Post-translational modifications for SARM1 Gene

  • Ubiquitination at Lys363
  • Modification sites at PhosphoSitePlus

Other Protein References for SARM1 Gene

No data available for DME Specific Peptides for SARM1 Gene

Domains & Families for SARM1 Gene

Gene Families for SARM1 Gene

Suggested Antigen Peptide Sequences for SARM1 Gene

GenScript: Design optimal peptide antigens:
  • SARM1 protein (Q05B42_HUMAN)
  • SARM1 protein (Q0D2N8_HUMAN)
  • Tir-1 homolog (SARM1_HUMAN)
genes like me logo Genes that share domains with SARM1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SARM1 Gene

Function for SARM1 Gene

Molecular function for SARM1 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
UniProtKB/Swiss-Prot Induction:
Up-regulated by lipopolysaccharides (LPS).

Phenotypes From GWAS Catalog for SARM1 Gene

Gene Ontology (GO) - Molecular Function for SARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI,IEA 17258210
GO:0035591 signaling adaptor activity IEA --
genes like me logo Genes that share ontologies with SARM1: view
genes like me logo Genes that share phenotypes with SARM1: view

Animal Models for SARM1 Gene

MGI Knock Outs for SARM1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SARM1 Gene

Localization for SARM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SARM1 Gene

Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Mitochondrion. Note=Associated with microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SARM1 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 4
cytosol 4
plasma membrane 1
nucleus 1
endosome 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion IEA,IDA 22145856
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA,ISS --
GO:0015630 microtubule cytoskeleton IEA --
genes like me logo Genes that share ontologies with SARM1: view

Pathways & Interactions for SARM1 Gene

genes like me logo Genes that share pathways with SARM1: view

Pathways by source for SARM1 Gene

SIGNOR curated interactions for SARM1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for SARM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007399 nervous system development IEA --
GO:0009749 response to glucose IEA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SARM1: view

Drugs & Compounds for SARM1 Gene

No Compound Related Data Available

Transcripts for SARM1 Gene

mRNA/cDNA for SARM1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SARM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - -
SP6: - -
SP7:
SP8:

Relevant External Links for SARM1 Gene

GeneLoc Exon Structure for
SARM1
ECgene alternative splicing isoforms for
SARM1

Expression for SARM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SARM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SARM1 Gene

This gene is overexpressed in Testis (14.5), Fetal Brain (12.8), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SARM1 Gene



Protein tissue co-expression partners for SARM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SARM1 Gene:

SARM1

SOURCE GeneReport for Unigene cluster for SARM1 Gene:

Hs.743510

mRNA Expression by UniProt/SwissProt for SARM1 Gene:

Q6SZW1-SARM1_HUMAN
Tissue specificity: Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta.

Evidence on tissue expression from TISSUES for SARM1 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with SARM1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SARM1 Gene

Orthologs for SARM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SARM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SARM1 33 32
  • 99.95 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SARM1 33 32
  • 92.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sarm1 17 33 32
  • 88.18 (n)
rat
(Rattus norvegicus)
Mammalia Sarm1 32
  • 88.13 (n)
cow
(Bos Taurus)
Mammalia SARM1 33
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SARM1 33
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SARM1 33
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves SARM1 33 32
  • 72.35 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SARM1 33
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sarm1 32
  • 63.83 (n)
zebrafish
(Danio rerio)
Actinopterygii sarm1 33 32
  • 64.53 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005901 32
  • 56.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ect4 33 32
  • 54.99 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tir-1 33 32
  • 47.1 (n)
OneToOne
Species where no ortholog for SARM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SARM1 Gene

ENSEMBL:
Gene Tree for SARM1 (if available)
TreeFam:
Gene Tree for SARM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SARM1: view image

Paralogs for SARM1 Gene

No data available for Paralogs for SARM1 Gene

Variants for SARM1 Gene

Sequence variations from dbSNP and Humsavar for SARM1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs112801276 uncertain-significance, Congenital defect of folate absorption 28,398,964(+) T/A 3_prime_UTR_variant
rs1128161 benign, Congenital defect of folate absorption 28,394,876(+) G/A intron_variant
rs1128162 benign, Congenital defect of folate absorption 28,394,772(+) C/A intron_variant
rs114008979 uncertain-significance, Congenital defect of folate absorption 28,398,008(+) C/T 3_prime_UTR_variant
rs117397871 uncertain-significance, Congenital defect of folate absorption 28,395,340(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SARM1 Gene

Variant ID Type Subtype PubMed ID
esv2715786 CNV deletion 23290073
esv2715788 CNV deletion 23290073
esv2715789 CNV deletion 23290073
nsv1056839 CNV gain 25217958
nsv1062056 CNV gain 25217958
nsv1125214 CNV deletion 24896259
nsv519388 CNV loss 19592680
nsv574653 CNV gain 21841781

Variation tolerance for SARM1 Gene

Gene Damage Index Score: 1.99; 36.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SARM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SARM1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SARM1 Gene

Disorders for SARM1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SARM1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
wallerian degeneration
  • wallerian degeneration of the pyramidal tract
- elite association - COSMIC cancer census association via MalaCards
Search SARM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SARM1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SARM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SARM1 Gene

Publications for SARM1 Gene

  1. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. (PMID: 15123841) Liberati NT … Ausubel FM (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 23 56
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 56
  3. Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence. (PMID: 22145856) Panneerselvam P … Ding JL (The Biochemical journal 2012) 3 4 56
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  5. SARM inhibits both TRIF- and MyD88-mediated AP-1 activation. (PMID: 20306472) Peng J … Ding JL (European journal of immunology 2010) 3 4 56

Products for SARM1 Gene

Sources for SARM1 Gene