Aliases for SARM1 Gene
- Sterile Alpha And TIR Motif Containing 1 2 3 5
- SAMD2 2 3 4
- SARM 2 3 4
- Sterile Alpha And TIR Motif-Containing Protein 1 3 4
- Sterile Alpha Motif Domain-Containing Protein 2 3 4
- Sterile Alpha And Armadillo Repeat Protein 3 4
- SAM Domain-Containing Protein 2 3 4
- NADP(+) Hydrolase SARM1 3 4
- NAD(+) Hydrolase SARM1 3 4
External Ids for SARM1 Gene
Previous GeneCards Identifiers for SARM1 Gene
GeneCards Summary for SARM1 Gene
SARM1 (Sterile Alpha And TIR Motif Containing 1) is a Protein Coding gene. Diseases associated with SARM1 include Wallerian Degeneration and Bullous Retinoschisis. Among its related pathways are Activated TLR4 signalling and IKK complex recruitment mediated by RIP1. Gene Ontology (GO) annotations related to this gene include binding.
UniProtKB/Swiss-Prot Summary for SARM1 Gene
NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+) cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439793, PubMed:31439792). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262).