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Aliases for SAR1A Gene

Aliases for SAR1A Gene

  • Secretion Associated Ras Related GTPase 1A 2 3 5
  • COPII-Associated Small GTPase 3 4
  • SARA1 3 4
  • SAR1 3 4
  • Secretion Associated, Ras Related GTPase 1A 2
  • SAR1a Gene Homolog (S. Cerevisiae) 1 2
  • SAR1a Gene Homolog 1 (S. Cerevisiae) 2
  • SAR1 Homolog A (S. Cerevisiae) 2
  • GTP-Binding Protein SAR1a 3
  • SAR1a Gene Homolog 1 3
  • SAR1 Gene Homolog A 3
  • SAR1 Homolog A 3
  • Masra2 3
  • Sara 3
  • SARA 4

External Ids for SAR1A Gene

Previous HGNC Symbols for SAR1A Gene

  • SARA1

Previous GeneCards Identifiers for SAR1A Gene

  • GC10M071580
  • GC10M071909
  • GC10M065902

Summaries for SAR1A Gene

GeneCards Summary for SAR1A Gene

SAR1A (Secretion Associated Ras Related GTPase 1A) is a Protein Coding gene. Among its related pathways are wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include GTP binding and obsolete signal transducer activity. An important paralog of this gene is SAR1B.

UniProtKB/Swiss-Prot for SAR1A Gene

  • Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).

Additional gene information for SAR1A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAR1A Gene

Genomics for SAR1A Gene

GeneHancer (GH) Regulatory Elements for SAR1A Gene

Promoters and enhancers for SAR1A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J070168 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 663 +0.4 367 2.7 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A YY1 POLR2B AIFM2 SAR1A TYSND1 PPA1 CALM2P2
GH10J070130 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 30.1 +38.6 38584 3.4 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FOS AIFM2 SAR1A PPA1 PIR50368
GH10J069179 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 29.3 +989.9 989870 3.3 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SUPV3L1 CCAR1 DDX50 TYSND1 HNRNPH3 DDX21 SAR1A RPL26P27 VPS26A HKDC1
GH10J069315 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.2 +851.8 851831 7.2 HDGF PKNOX1 SMAD1 FOXA2 ARNT SIN3A ZNF2 POLR2B ZNF213 E2F8 HK1 DDX50 HNRNPH3 CCAR1 TYSND1 SAR1A DDX21 ENSG00000231748 HKDC1 FAM241B
GH10J070144 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13 +24.1 24096 3.1 HDGF PKNOX1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF213 AIFM2 GC10M070148 PIR38078 PIR42845 TYSND1 PPA1 SAR1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SAR1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SAR1A gene promoter:

Genomic Locations for SAR1A Gene

Genomic Locations for SAR1A Gene
chr10:70,147,289-70,170,529
(GRCh38/hg38)
Size:
23,241 bases
Orientation:
Minus strand
chr10:71,907,045-71,930,285
(GRCh37/hg19)

Genomic View for SAR1A Gene

Genes around SAR1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAR1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAR1A Gene

Proteins for SAR1A Gene

  • Protein details for SAR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR31-SAR1A_HUMAN
    Recommended name:
    GTP-binding protein SAR1a
    Protein Accession:
    Q9NR31
    Secondary Accessions:
    • B4DQ19

    Protein attributes for SAR1A Gene

    Size:
    198 amino acids
    Molecular mass:
    22367 Da
    Quaternary structure:
    • Interacts with B3GAT1.

    Three dimensional structures from OCA and Proteopedia for SAR1A Gene

    Alternative splice isoforms for SAR1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAR1A Gene

Post-translational modifications for SAR1A Gene

  • Ubiquitination at posLast=166166 and isoforms=27
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SAR1A Gene

Domains & Families for SAR1A Gene

Gene Families for SAR1A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

Q9NR31

UniProtKB/Swiss-Prot:

SAR1A_HUMAN :
  • Belongs to the small GTPase superfamily. SAR1 family.
Family:
  • Belongs to the small GTPase superfamily. SAR1 family.
genes like me logo Genes that share domains with SAR1A: view

Function for SAR1A Gene

Molecular function for SAR1A Gene

UniProtKB/Swiss-Prot Function:
Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).

Phenotypes From GWAS Catalog for SAR1A Gene

Gene Ontology (GO) - Molecular Function for SAR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 19181664
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with SAR1A: view
genes like me logo Genes that share phenotypes with SAR1A: view

Animal Model Products

miRNA for SAR1A Gene

miRTarBase miRNAs that target SAR1A

Clone Products

  • Addgene plasmids for SAR1A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAR1A Gene

Localization for SAR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAR1A Gene

Endoplasmic reticulum. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAR1A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
cytosol 3
golgi apparatus 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SAR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0030127 COPII vesicle coat IDA 17499046
genes like me logo Genes that share ontologies with SAR1A: view

Pathways & Interactions for SAR1A Gene

genes like me logo Genes that share pathways with SAR1A: view

Gene Ontology (GO) - Biological Process for SAR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0090110 cargo loading into COPII-coated vesicle IDA 17499046
genes like me logo Genes that share ontologies with SAR1A: view

No data available for SIGNOR curated interactions for SAR1A Gene

Drugs & Compounds for SAR1A Gene

(1) Drugs for SAR1A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with SAR1A: view

Transcripts for SAR1A Gene

mRNA/cDNA for SAR1A Gene

Unigene Clusters for SAR1A Gene

SAR1 homolog A (S. cerevisiae):
Representative Sequences:

Clone Products

  • Addgene plasmids for SAR1A

Alternative Splicing Database (ASD) splice patterns (SP) for SAR1A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: -
SP3:

Relevant External Links for SAR1A Gene

GeneLoc Exon Structure for
SAR1A
ECgene alternative splicing isoforms for
SAR1A

Expression for SAR1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAR1A Gene

Protein differential expression in normal tissues from HIPED for SAR1A Gene

This gene is overexpressed in Platelet (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SAR1A Gene



Protein tissue co-expression partners for SAR1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SAR1A Gene:

SAR1A

SOURCE GeneReport for Unigene cluster for SAR1A Gene:

Hs.499960

Evidence on tissue expression from TISSUES for SAR1A Gene

  • Lung(4.5)
  • Skin(4.5)
  • Kidney(4.4)
  • Nervous system(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with SAR1A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAR1A Gene

Orthologs for SAR1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SAR1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAR1A 34 33
  • 99.83 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAR1A 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SAR1A 34 33
  • 95.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SAR1A 33
  • 94.78 (n)
rat
(Rattus norvegicus)
Mammalia Sar1a 33
  • 93.27 (n)
mouse
(Mus musculus)
Mammalia Sar1a 16 34 33
  • 93.1 (n)
oppossum
(Monodelphis domestica)
Mammalia SAR1A 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAR1A 34 33
  • 85.19 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAR1A 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sar1a 33
  • 84.18 (n)
sar1a-prov 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25405 33
zebrafish
(Danio rerio)
Actinopterygii sar1ab 34 33
  • 74.07 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sar1 34
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sar-1 34
  • 63 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAR1 34 33
  • 59.46 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02046g 33
  • 57.12 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL114W 33
  • 56.58 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SAR1B 33
  • 61.11 (n)
soybean
(Glycine max)
eudicotyledons Gma.6113 33
rice
(Oryza sativa)
Liliopsida Os01g0338000 33
  • 60.73 (n)
Os.10984 33
bread mold
(Neurospora crassa)
Ascomycetes NCU11181 33
  • 62.22 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sar1 33
  • 61.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.1569 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1569 33
Species where no ortholog for SAR1A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SAR1A Gene

ENSEMBL:
Gene Tree for SAR1A (if available)
TreeFam:
Gene Tree for SAR1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SAR1A: view image

Paralogs for SAR1A Gene

Paralogs for SAR1A Gene

(24) SIMAP similar genes for SAR1A Gene using alignment to 5 proteins:

  • SAR1A_HUMAN
  • B4DQ19_HUMAN
  • H0Y5E8_HUMAN
  • Q5SQT8_HUMAN
  • Q5SQT9_HUMAN

Pseudogenes.org Pseudogenes for SAR1A Gene

genes like me logo Genes that share paralogs with SAR1A: view

Variants for SAR1A Gene

Sequence variations from dbSNP and Humsavar for SAR1A Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000293945 -- 70,158,406(-) G/A intron_variant
rs1000602365 -- 70,160,572(-) A/G intron_variant
rs1000647144 -- 70,164,976(-) G/T intron_variant
rs1000658992 -- 70,157,959(-) G/A intron_variant
rs1000678383 -- 70,165,133(-) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SAR1A Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV gain+loss 17666407
nsv551479 CNV loss 21841781
nsv7054 CNV insertion 18451855

Variation tolerance for SAR1A Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAR1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAR1A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAR1A Gene

Disorders for SAR1A Gene

Additional Disease Information for SAR1A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SAR1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAR1A Gene

Publications for SAR1A Gene

  1. Distinct transport and intracellular activities of two GlcAT-P isoforms. (PMID: 19181664) Kizuka Y … Oka S (The Journal of biological chemistry 2009) 3 4 22 58
  2. Inhibitors of COPI and COPII do not block PEX3-mediated peroxisome synthesis. (PMID: 10871277) South ST … Gould SJ (The Journal of cell biology 2000) 2 3 4 58
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 44 58
  4. Fetal haemoglobin response to hydroxycarbamide treatment and sar1a promoter polymorphisms in sickle cell anaemia. (PMID: 18318767) Kumkhaek C … Rodgers GP (British journal of haematology 2008) 3 44 58
  5. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PMID: 17373700) Morgan AR … Williams J (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 44 58

Products for SAR1A Gene

Sources for SAR1A Gene

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