Aliases for SAP30BP Gene
Aliases for SAP30BP Gene
External Ids for SAP30BP Gene
- HGNC: 30785
- Entrez Gene: 29115
- Ensembl: ENSG00000161526
- OMIM: 610218
- UniProtKB: Q9UHR5
Previous GeneCards Identifiers for SAP30BP Gene
- GC17P071175
- GC17P073663
- GC17P069087
Summaries for SAP30BP Gene
GeneCards Summary for SAP30BP Gene
SAP30BP (SAP30 Binding Protein) is a Protein Coding gene. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.
UniProtKB/Swiss-Prot for SAP30BP Gene
-
Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes.
Additional gene information for SAP30BP Gene
- Monarch Initiative
- Search for SAP30BP at DataMed
- Search for SAP30BP at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAP30BP Gene
Genomics for SAP30BP Gene
GeneHancer (GH) Regulatory Elements for SAP30BP Gene
Promoters and enhancers for SAP30BP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SAP30BP on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SAP30BP gene promoter:
Regulatory Element Products
Genomic Locations for SAP30BP Gene
Genomic Locations for SAP30BP Gene
- chr17:75,667,116-75,708,062
- (GRCh38/hg38)
- Size:
- 40,947 bases
- Orientation:
- Plus strand
- chr17:73,663,196-73,704,142
- (GRCh37/hg19)
Genomic View for SAP30BP Gene
Genes around SAP30BP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by Ensembl
- 17q25.1 by Entrez Gene
- 17q25.1 by HGNC
SAP30BP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SAP30BP Gene
Proteins for SAP30BP Gene
-
Protein details for SAP30BP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UHR5-S30BP_HUMAN
- Recommended name:
- SAP30-binding protein
- Protein Accession:
- Q9UHR5
- B3KML7
- Q8N1R5
- Q8TDR8
- Q96D27
Protein attributes for SAP30BP Gene
- Size:
- 308 amino acids
- Molecular mass:
- 33870 Da
- Quaternary structure:
-
- Interacts with SAP30.
Protein Expression for SAP30BP Gene
Post-translational modifications for SAP30BP Gene
Other Protein References for SAP30BP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SAP30BP
-
Abcam antibodies for SAP30BP
- Invitrogen Antibodies for SAP30BP
- GeneTex SAP30BP antibody for SAP30BP
-
Santa Cruz Biotechnology (SCBT) Antibodies for SAP30BP
Protein Products
-
OriGene Purified Proteins for SAP30BP
- Search Origene for MassSpec and Protein Over-expression Lysates for SAP30BP
- Origene Custom Protein Services for SAP30BP
- antibodies-online: Search results for 4 available SAP30BP Proteins ranked by validation data
- Compare Top SAP30BP Proteins
-
Quality Products:
- Search GeneTex for Proteins for SAP30BP
-
Abcam proteins for SAP30BP
Assay Products
No data available for DME Specific Peptides for SAP30BP Gene
Domains & Families for SAP30BP Gene
Gene Families for SAP30BP Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SAP30BP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SAP30BP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UHR5- Family:
-
- Belongs to the HCNGP family.
Function for SAP30BP Gene
Molecular function for SAP30BP Gene
- UniProtKB/Swiss-Prot Function:
- Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes.
- UniProtKB/Swiss-Prot Induction:
- In fibroblasts by binding of HSV1.
Phenotypes From GWAS Catalog for SAP30BP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 9651585 |
Phenotypes for SAP30BP Gene
- MGI mutant phenotypes for SAP30BP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SAP30BP:
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for SAP30BP
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SAP30BP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SAP30BP gene
- Search ViGene Biosciences for SAP30BP
CRISPR Products
-
OriGene CRISPR knockouts for SAP30BP
- genomics-online: gRNA clones - Search results for available SAP30BP gene related products
- Applied Biological Materials CRISPR for SAP30BP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SAP30BP
- GenScript: Design CRISPR guide RNA sequences for SAP30BP
miRNA for SAP30BP Gene
- miRTarBase miRNAs that target SAP30BP
miRNA Products
- Search ViGene Biosciences for SAP30BP
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SAP30BP
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-
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Clone Products
- Sino Biological Human cDNA Clone for SAP30BP
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SAP30BP gene related products
- orf clones - Search results for available SAP30BP gene related products
- Applied Biological Materials Clones for SAP30BP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SAP30BP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SAP30BP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SAP30BP gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAP30BP Gene
Localization for SAP30BP Gene
Subcellular locations from UniProtKB/Swiss-Prot for SAP30BP Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 2 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 9651585 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0045111 | intermediate filament cytoskeleton | IDA | -- |
Pathways & Interactions for SAP30BP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Gene Expression |
.48
|
|
Pathways by source for SAP30BP Gene
4 Reactome pathways for SAP30BP Gene
Interacting Proteins for SAP30BP Gene
Selected Interacting proteins:
Q9UHR5-S30BP_HUMAN
ENSP00000462116
for SAP30BP Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0010942 | positive regulation of cell death | IDA | 15496587 |
No data available for SIGNOR curated interactions for SAP30BP Gene
Transcripts for SAP30BP Gene
mRNA/cDNA for SAP30BP Gene
- (12) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (394) Selected AceView cDNA sequences:
- (26) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SAP30BP Gene
CRISPR Products
-
OriGene CRISPR knockouts for SAP30BP
- genomics-online: gRNA clones - Search results for available SAP30BP gene related products
- Applied Biological Materials CRISPR for SAP30BP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SAP30BP
- GenScript: Design CRISPR guide RNA sequences for SAP30BP
miRNA Products
- Search ViGene Biosciences for SAP30BP
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SAP30BP
- Browse OriGene Inhibitory RNA Products For SAP30BP
- genomics-online: shRNA clones - Search results for available SAP30BP gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SAP30BP gene
Clone Products
- Sino Biological Human cDNA Clone for SAP30BP
- VectorBuilder custom plasmid, inducible vectors for SAP30BP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SAP30BP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SAP30BP gene related products
- orf clones - Search results for available SAP30BP gene related products
- Applied Biological Materials Clones for SAP30BP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b | ^ | 13a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP16: | - |
| ExUns: | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | · | 16d | · | 16e | · | 16f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||
| SP2: | - | - | |||||||||||||||
| SP3: | - | - | |||||||||||||||
| SP4: | - | ||||||||||||||||
| SP5: | |||||||||||||||||
| SP6: | - | - | |||||||||||||||
| SP7: | |||||||||||||||||
| SP8: | |||||||||||||||||
| SP9: | |||||||||||||||||
| SP10: | |||||||||||||||||
| SP11: | |||||||||||||||||
| SP12: | |||||||||||||||||
| SP13: | - | ||||||||||||||||
| SP14: | - | - | |||||||||||||||
| SP15: | - | - | |||||||||||||||
| SP16: |
Expression for SAP30BP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (17.5), Blymphocyte (11.2), and Fetal Brain (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SAP30BP Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SAP30BP Gene:
SAP30BPSOURCE GeneReport for Unigene cluster for SAP30BP Gene:
Hs.655088Evidence on tissue expression from TISSUES for SAP30BP Gene
- Nervous system(4.4)
- Liver(4.3)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs for SAP30BP
-
OriGene qPCR primer pairs and template standards for SAP30BP
- genomics-online: primer clones - Search results for available SAP30BP gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAP30BP Gene
Orthologs for SAP30BP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SAP30BP 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SAP30BP 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SAP30BP 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Sap30bp 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Sap30bp 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SAP30BP 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | SAP30BP 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SAP30BP 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SAP30BP 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sap30bp 33 |
|
||
| Str.7176 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8637 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | sap30bp 33 34 |
|
||
| wufb33d03 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10416 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG2063 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | Y67D2.7 34 |
|
OneToOne |
- Species where no ortholog for SAP30BP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SAP30BP Gene
(1) SIMAP similar genes for SAP30BP Gene using alignment to 10 proteins:
No data available for Paralogs for SAP30BP Gene
Variants for SAP30BP Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000008003 | -- | 75,708,133(+) | C/T | downstream_transcript_variant | |
| rs1000013488 | -- | 75,679,232(+) | G/A | intron_variant | |
| rs1000222606 | -- | 75,707,237(+) | A/C | 3_prime_UTR_variant, non_coding_transcript_variant | |
| rs1000256498 | -- | 75,685,025(+) | G/A/C | intron_variant | |
| rs1000278223 | -- | 75,667,385(+) | A/T | 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, stop_gained, upstream_transcript_variant |
Residual Variation Intolerance Score:
26.1% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SAP30BP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SAP30BP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAP30BP Gene
Disorders for SAP30BP Gene
Additional Disease Information for SAP30BP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SAP30BP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAP30BP Gene
Publications for SAP30BP Gene
- HTRP--an immediate-early gene product induced by HSV1 infection in human embryo fibroblasts, is involved in cellular co-repressors. (PMID: 15496587) Li JF … Li QH (Journal of biochemistry 2004) 2 3 4 22 58
- Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J … ENGAGE Consortium (PLoS genetics 2010) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 58
Products for SAP30BP Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for SAP30BP
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SAP30BP
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 40 available SAP30BP Antibodies ranked by validation data
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- antibodies-online: Search results for available SAP30BP related products ranked by validation data
- antibodies-online: Search results for 4 available SAP30BP Proteins ranked by validation data
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- Quality Products:
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- ViGene Biosciences adenoviral particle packaged cDNA for SAP30BP gene
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Sources for SAP30BP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
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