Aliases for SAP30 Gene
- Sin3A Associated Protein 30 2 3 5
- Histone Deacetylase Complex Subunit SAP30 3 4
- Sin3 Corepressor Complex Subunit SAP30 3 4
- 30 KDa Sin3-Associated Polypeptide 3 4
- Sin3A-Associated Protein, 30kDa 2 3
- Sin3-Associated Polypeptide P30 3 4
- Sin3-Associated Polypeptide, 30 KDa 3
- Sin3-Associated Polypeptide, 30kDa 3
External Ids for SAP30 Gene
Previous GeneCards Identifiers for SAP30 Gene
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]
GeneCards Summary for SAP30 Gene
SAP30 (Sin3A Associated Protein 30) is a Protein Coding gene. Diseases associated with SAP30 include Phlebotomus Fever and Rift Valley Fever. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Hedgehog signaling events mediated by Gli proteins. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is SAP30L.
UniProtKB/Swiss-Prot Summary for SAP30 Gene
Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.