SAP30 Gene (Protein Coding)

Sin3A Associated Protein 30

GC04P173369
GIFtS:
39
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core hist... See more...

Aliases for SAP30 Gene

Aliases for SAP30 Gene

  • Sin3A Associated Protein 30 2 3 5
  • Histone Deacetylase Complex Subunit SAP30 3 4
  • Sin3 Corepressor Complex Subunit SAP30 3 4
  • 30 KDa Sin3-Associated Polypeptide 3 4
  • Sin3A-Associated Protein, 30kDa 2 3
  • Sin3-Associated Polypeptide P30 3 4
  • Sin3-Associated Polypeptide, 30 KDa 3
  • Sin3-Associated Polypeptide, 30kDa 3
  • SAP30 5

External Ids for SAP30 Gene

Previous GeneCards Identifiers for SAP30 Gene

  • GC04P175212
  • GC04P174830
  • GC04P174987
  • GC04P174666
  • GC04P174528
  • GC04P174292
  • GC04P170039

Summaries for SAP30 Gene

Entrez Gene Summary for SAP30 Gene

  • Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]

GeneCards Summary for SAP30 Gene

SAP30 (Sin3A Associated Protein 30) is a Protein Coding gene. Diseases associated with SAP30 include Phlebotomus Fever and Rift Valley Fever. Among its related pathways are Chromatin organization and Notch Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is SAP30L.

UniProtKB/Swiss-Prot Summary for SAP30 Gene

  • Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.

Gene Wiki entry for SAP30 Gene

Additional gene information for SAP30 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SAP30 Gene

Genomics for SAP30 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SAP30 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04J173332 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.3 -36.1 -36062 5.8 BCLAF1 SP1 ZNF207 MYC NCOR1 ZNF600 IKZF1 POLR2A CEBPA ZNF223 HMGB2 LOC105377541 lnc-SAP30-1-001 SAP30 CEP44 SCRG1 GALNT7 ENSG00000248774 lnc-GALNT7-1
GH04J173366 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.6 575 7.3 BCLAF1 ZNF600 NCOR1 MYC IKZF1 SIX5 ZNF580 KLF9 POLR2A NFIC HMGB2 HSALNG0038589 SAP30 SAP30-DT ENSG00000248774 SCRG1 RNU6-1096P CEP44 FBXO8 hsa-miR-5095-383
GH04J173414 Promoter/Enhancer 1.4 EPDnew FANTOM5 ENCODE 1.3 +46.6 46570 0.7 NCOR1 IKZF1 NFIC CTCF ZNF639 MNT ZNF217 HES1 CTBP1 NKRF SCRG1 HMGB2 SAP30 RPL5P11 lnc-SAP30-11
GH04J173365 Enhancer 0.4 Ensembl 0.7 -3.9 -3868 1 ZNF600 MEIS2 PKNOX1 MZF1 HMGB2 ENSG00000248774 SCRG1 RNU6-1096P HSALNG0038589 SAP30 lnc-SAP30-8 SAP30-DT
GH04J173399 Promoter 0.9 EPDnew Ensembl 0.3 +28.8 28832 0.8 ATF4 ATF3 CEBPB ENSG00000288025 SCRG1 lnc-HMGB2-7 LOC112268474 MK732524 SAP30
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SAP30 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SAP30

Top Transcription factor binding sites by QIAGEN in the SAP30 gene promoter:
  • AP-2gamma
  • CUTL1
  • E4BP4
  • GATA-1
  • HNF-1
  • HNF-1A
  • Nkx2-2
  • POU3F2
  • RSRFC4
  • S8

Genomic Locations for SAP30 Gene

Latest Assembly
chr4:173,369,969-173,377,532
(GRCh38/hg38)
Size:
7,564 bases
Orientation:
Plus strand

Previous Assembly
chr4:174,292,105-174,298,683
(GRCh37/hg19 by Entrez Gene)
Size:
6,579 bases
Orientation:
Plus strand

chr4:174,291,120-174,298,683
(GRCh37/hg19 by Ensembl)
Size:
7,564 bases
Orientation:
Plus strand

Genomic View for SAP30 Gene

Genes around SAP30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAP30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAP30 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SAP30 Gene

Proteins for SAP30 Gene

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  • Protein details for SAP30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75446-SAP30_HUMAN
    Recommended name:
    Histone deacetylase complex subunit SAP30
    Protein Accession:
    O75446
    Secondary Accessions:
    • D3DP38

    Protein attributes for SAP30 Gene

    Size:
    220 amino acids
    Molecular mass:
    23306 Da
    Quaternary structure:
    • Interacts with SIN3A, SIN3B, HDAC2 and NCOR1. Interacts with SAMS1. Component of the histone deacetylase complex that includes at least SIN3A, HDAC1 and HDAC2 (By similarity). Interacts with HDAC1 (PubMed:9651585). Interacts with HCFC1 (PubMed:12670868). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for SAP30 Gene

neXtProt entry for SAP30 Gene

Protein Expression for SAP30 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SAP30 Gene

  • Glycosylation at Asn34 and Asn209
  • Ubiquitination at Lys194
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SAP30_HUMAN (787)

Other Protein References for SAP30 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for SAP30
  • Boster Bio Antibodies for SAP30
  • Santa Cruz Biotechnology (SCBT) Antibodies for SAP30

No data available for DME Specific Peptides for SAP30 Gene

Domains & Families for SAP30 Gene

Gene Families for SAP30 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SAP30 Gene

InterPro:

Suggested Antigen Peptide Sequences for SAP30 Gene

GenScript: Design optimal peptide antigens:
  • Sin3-associated polypeptide p30 (SAP30_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75446

UniProtKB/Swiss-Prot:

SAP30_HUMAN :
  • Belongs to the SAP30 family.
Family:
  • Belongs to the SAP30 family.
genes like me logo Genes that share domains with SAP30: view

Function for SAP30 Gene

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  6. Cell Lines for research

Molecular function for SAP30 Gene

UniProtKB/Swiss-Prot Function:
Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.

Phenotypes From GWAS Catalog for SAP30 Gene

Gene Ontology (GO) - Molecular Function for SAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003712 transcription coregulator activity IBA 21873635
GO:0003714 transcription corepressor activity IDA 9651585
GO:0005515 protein binding IPI 9651585
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SAP30: view
genes like me logo Genes that share phenotypes with SAP30: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SAP30

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAP30 Gene

Localization for SAP30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAP30 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAP30 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IBA,IDA 9651585
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with SAP30: view

Pathways & Interactions for SAP30 Gene

genes like me logo Genes that share pathways with SAP30: view

Pathways by source for SAP30 Gene

1 KEGG pathway for SAP30 Gene
4 GeneGo (Thomson Reuters) pathways for SAP30 Gene
  • Development Notch Signaling Pathway
  • Development NOTCH1-mediated pathway for NF-KB activity modulation
  • Transcription Ligand-Dependent Transcription of Retinoid-Target genes
  • Transcription Sin3 and NuRD in transcription regulation
1 R&D Systems pathway for SAP30 Gene
1 Qiagen pathway for SAP30 Gene
  • DNA Methylation and Transcriptional Repression

Gene Ontology (GO) - Biological Process for SAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IDA 9651585
GO:0035914 skeletal muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with SAP30: view

No data available for SIGNOR curated interactions for SAP30 Gene

Drugs & Compounds for SAP30 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for SAP30 Gene

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mRNA/cDNA for SAP30 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SAP30

Alternative Splicing Database (ASD) splice patterns (SP) for SAP30 Gene

No ASD Table

Relevant External Links for SAP30 Gene

GeneLoc Exon Structure for
SAP30

Expression for SAP30 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SAP30 Gene

mRNA expression in normal human tissues for SAP30 Gene
mRNA expression by GTEx for SAP30 GenemRNA expression by BioGPS for SAP30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SAP30 Gene

This gene is overexpressed in Breast (54.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SAP30 Gene



Protein tissue co-expression partners for SAP30 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SAP30

SOURCE GeneReport for Unigene cluster for SAP30 Gene:

Hs.591715

mRNA Expression by UniProt/SwissProt for SAP30 Gene:

O75446-SAP30_HUMAN
Tissue specificity: Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus; lowest levels in brain, placenta, lung and kidney.

Evidence on tissue expression from TISSUES for SAP30 Gene

  • Liver(4.3)
  • Nervous system(2.3)
  • Heart(2.2)
  • Lung(2.1)
  • Spleen(2.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with SAP30: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAP30 Gene

Orthologs for SAP30 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAP30 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SAP30 29 30
  • 99.85 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SAP30 29 30
  • 95.15 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SAP30 29 30
  • 92.12 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia SAP30 30
  • 90 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Sap30 29
  • 89.85 (n)
Mouse
(Mus musculus)
 Mammalia Sap30 29 16 30
  • 88.64 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia SAP30 30
  • 85 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves SAP30 30
  • 85 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia SAP30 30
  • 67 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia sap30 29
  • 79.91 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.33498 29
Fruit Fly
(Drosophila melanogaster)
 Insecta CG4756 31
  • 52 (a)
Sap30 30
  • 49 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 34 (a)
 OneToMany
Species where no ortholog for SAP30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SAP30 Gene

ENSEMBL:
Gene Tree for SAP30 (if available)
TreeFam:
Gene Tree for SAP30 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SAP30: view image
Alliance of Genome Resources:
Additional Orthologs for SAP30

Paralogs for SAP30 Gene

Paralogs for SAP30 Gene

(1) SIMAP similar genes for SAP30 Gene using alignment to 1 proteins:

  • SAP30_HUMAN

Pseudogenes.org Pseudogenes for SAP30 Gene

genes like me logo Genes that share paralogs with SAP30: view

Variants for SAP30 Gene

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  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SAP30 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SAP30 Gene

Variant ID Type Subtype PubMed ID
nsv1074240 CNV deletion 25765185

Variation tolerance for SAP30 Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAP30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAP30
Leiden Open Variation Database (LOVD)
SAP30

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SAP30 Gene

Disorders for SAP30 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SAP30 Gene - From: COP

Disorder Aliases PubMed IDs
phlebotomus fever
  • pappataci fever
rift valley fever
- elite association - COSMIC cancer census association via MalaCards
Search SAP30 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SAP30

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SAP30: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SAP30 Gene

Publications for SAP30 Gene

  1. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. (PMID: 9651585) Zhang Y … Reinberg D (Molecular cell 1998) 2 3 4
  2. SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. (PMID: 9702189) Laherty CD … Eisenman RN (Molecular cell 1998) 3 4 22
  3. DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides. (PMID: 19015240) Viiri KM … Lohi O (Molecular and cellular biology 2009) 3 22
  4. Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. (PMID: 17897615) Sichtig N … Steger G (Archives of biochemistry and biophysics 2007) 3 22
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4

ExternalLinks

View latest publications for SAP30 gene in Mastermind

Products for SAP30 Gene

Sources for SAP30 Gene