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Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]
SAP30 (Sin3A Associated Protein 30) is a Protein Coding gene. Diseases associated with SAP30 include Phlebotomus Fever and Rift Valley Fever. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Notch Signaling Pathway (WikiPathways). Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is SAP30L.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003712 | transcription coregulator activity | IBA | 21873635 |
GO:0003714 | transcription corepressor activity | IDA | 9651585 |
GO:0004407 | histone deacetylase activity | IBA | -- |
GO:0005515 | protein binding | IPI | 9651585 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000118 | histone deacetylase complex | IBA,IDA | 9651585 |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
2 | Development NOTCH1-mediated pathway for NF-KB activity modulation |
Development Notch Signaling Pathway
.55
Development NOTCH1-mediated pathway for NF-KB activity modulation
.55
|
Transcription Sin3 and NuRD in transcription regulation
.31
|
3 | Notch Signaling Pathway (WikiPathways) | ||
4 | Chromatin organization | ||
5 | Measles |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IDA | 9651585 |
GO:0016575 | histone deacetylation | IEA | -- |
GO:0035914 | skeletal muscle cell differentiation | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SAP30 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SAP30 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SAP30 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SAP30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Sap30 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Sap30 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SAP30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SAP30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SAP30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sap30 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.33498 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG4756 32 |
|
|
|
Sap30 31 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1074240 | CNV | deletion | 25765185 |
Disorder | Aliases | PubMed IDs |
---|---|---|
phlebotomus fever |
|
|
rift valley fever |
|
|