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SAP30 Gene(Protein Coding)

Sin3A Associated Protein 30

GCID:
GC04P173369
GIFtS:
45
Genes Participants
UDN Logo

Aliases for SAP30 Gene

Aliases for SAP30 Gene

  • Sin3A Associated Protein 30 2 3 5
  • Sin3 Corepressor Complex Subunit SAP30 4
  • 30 KDa Sin3-Associated Polypeptide 4
  • Sin3A-Associated Protein, 30kDa 2
  • Sin3-Associated Polypeptide P30 4

External Ids for SAP30 Gene

Previous GeneCards Identifiers for SAP30 Gene

  • GC04P175212
  • GC04P174830
  • GC04P174987
  • GC04P174666
  • GC04P174528
  • GC04P174292
  • GC04P170039

Summaries for SAP30 Gene

Entrez Gene Summary for SAP30 Gene

  • Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]

GeneCards Summary for SAP30 Gene

SAP30 (Sin3A Associated Protein 30) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Regulation of Telomerase. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is SAP30L.

UniProtKB/Swiss-Prot for SAP30 Gene

  • Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.

Gene Wiki entry for SAP30 Gene

Additional gene information for SAP30 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAP30 Gene

Genomics for SAP30 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for SAP30 Gene

Promoters and enhancers for SAP30 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04I173369 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.1 1132 4.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LOC105377540 SAP30 HMGB2 ENSG00000248774 SCRG1 CEP44 FBXO8 LOC101928383 GC04M173250
GH04I173414 Enhancer 1.5 FANTOM5 Ensembl ENCODE 1.3 +46.2 46231 2.8 HDGF PKNOX1 SMAD1 ARNT NEUROD1 YBX1 ZNF2 TCF12 ARID2 E2F8 CEP44 HMGB2 ENSG00000261646 HAND2-AS1 SAP30 RPL5P11 LOC101928383 SCRG1 GC04M173250
GH04I173366 Enhancer 0.9 Ensembl ENCODE 0.8 -2.3 -2303 1.6 JUN JUNB CBFA2T3 DPF2 BATF ATF2 IRF4 CHAMP1 FOSL1 ZNF217 HMGB2 ENSG00000248774 SCRG1 RNU6-1096P CEP44 FBXO8 LOC105377540 SAP30 GC04P173358 GC04M173250
GH04I173374 Enhancer 0.3 Ensembl 0.8 +4.1 4132 0.2 ZEB2 HMGB2 ENSG00000248774 SCRG1 FBXO8 CEP44 LOC105377540 SAP30 LOC101928383 GC04M173250
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SAP30 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SAP30 gene promoter:

Genomic Locations for SAP30 Gene

Genomic Locations for SAP30 Gene
chr4:173,369,969-173,377,532
(GRCh38/hg38)
Size:
7,564 bases
Orientation:
Plus strand
chr4:174,291,120-174,298,683
(GRCh37/hg19)

Genomic View for SAP30 Gene

Genes around SAP30 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAP30 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAP30 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SAP30 Gene

Proteins for SAP30 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SAP30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75446-SAP30_HUMAN
    Recommended name:
    Histone deacetylase complex subunit SAP30
    Protein Accession:
    O75446
    Secondary Accessions:
    • D3DP38

    Protein attributes for SAP30 Gene

    Size:
    220 amino acids
    Molecular mass:
    23306 Da
    Quaternary structure:
    • Interacts with SIN3A, SIN3B, HDAC2 and NCOR1. Interacts with SAMS1. Component of the histone deacetylase complex that includes at least SIN3A, HDAC1 and HDAC2 (By similarity). Interacts with HDAC1 (PubMed:9651585). Interacts with HCFC1 (PubMed:12670868). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for SAP30 Gene

neXtProt entry for SAP30 Gene

Protein Expression for SAP30 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SAP30 Gene

  • Ubiquitination at isoforms=194
  • Modification sites at PhosphoSitePlus

Other Protein References for SAP30 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAP30 Gene

Domains & Families for SAP30 Gene

Gene Families for SAP30 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for SAP30 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SAP30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75446

UniProtKB/Swiss-Prot:

SAP30_HUMAN :
  • Belongs to the SAP30 family.
Family:
  • Belongs to the SAP30 family.
genes like me logo Genes that share domains with SAP30: view

Function for SAP30 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for SAP30 Gene

UniProtKB/Swiss-Prot Function:
Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.

Gene Ontology (GO) - Molecular Function for SAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity IDA 9651585
GO:0004407 histone deacetylase activity IBA,TAS --
GO:0005515 protein binding IPI 9651585
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SAP30: view
genes like me logo Genes that share phenotypes with SAP30: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAP30 Gene

Localization for SAP30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAP30 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAP30 gene
Compartment Confidence
nucleus 5
extracellular 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IDA 9651585
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with SAP30: view

Pathways & Interactions for SAP30 Gene

genes like me logo Genes that share pathways with SAP30: view

Gene Ontology (GO) - Biological Process for SAP30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA,IEA 9651585
GO:0016575 histone deacetylation IEA --
GO:0035914 skeletal muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with SAP30: view

No data available for SIGNOR curated interactions for SAP30 Gene

Drugs & Compounds for SAP30 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SAP30 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SAP30 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAP30 Gene

Sin3A-associated protein, 30kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAP30 Gene

No ASD Table

Relevant External Links for SAP30 Gene

GeneLoc Exon Structure for
SAP30
ECgene alternative splicing isoforms for
SAP30

Expression for SAP30 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAP30 Gene

mRNA expression in normal human tissues for SAP30 Gene
mRNA expression by BioGPS for SAP30 GenemRNA expression by GTEx for SAP30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SAP30 Gene

This gene is overexpressed in Breast (54.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SAP30 Gene



Protein tissue co-expression partners for SAP30 Gene

NURSA nuclear receptor signaling pathways regulating expression of SAP30 Gene:

SAP30

SOURCE GeneReport for Unigene cluster for SAP30 Gene:

Hs.591715

mRNA Expression by UniProt/SwissProt for SAP30 Gene:

O75446-SAP30_HUMAN
Tissue specificity: Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus; lowest levels in brain, placenta, lung and kidney.

Evidence on tissue expression from TISSUES for SAP30 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with SAP30: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAP30 Gene

Orthologs for SAP30 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAP30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia SAP30 33 34
  • 99.85 (n)
dog
(Canis familiaris)
 Mammalia SAP30 33 34
  • 95.15 (n)
cow
(Bos Taurus)
 Mammalia SAP30 33 34
  • 92.12 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia SAP30 34
  • 90 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Sap30 33
  • 89.85 (n)
mouse
(Mus musculus)
 Mammalia Sap30 33 16 34
  • 88.64 (n)
oppossum
(Monodelphis domestica)
 Mammalia SAP30 34
  • 85 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves SAP30 34
  • 85 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia SAP30 34
  • 67 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia sap30 33
  • 79.91 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.33498 33
fruit fly
(Drosophila melanogaster)
 Insecta CG4756 35
  • 52 (a)
Sap30 34
  • 49 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 34 (a)
 OneToMany
Species where no ortholog for SAP30 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SAP30 Gene

ENSEMBL:
Gene Tree for SAP30 (if available)
TreeFam:
Gene Tree for SAP30 (if available)

Paralogs for SAP30 Gene

Paralogs for SAP30 Gene

(1) SIMAP similar genes for SAP30 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SAP30 Gene

genes like me logo Genes that share paralogs with SAP30: view

Variants for SAP30 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for SAP30 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000691525 -- 173,377,592(+) A/T downstream_transcript_variant
rs1000723553 -- 173,377,901(+) C/G downstream_transcript_variant
rs1000872642 -- 173,372,457(+) C/T intron_variant
rs1001090751 -- 173,372,706(+) A/T intron_variant
rs1001211127 -- 173,372,380(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SAP30 Gene

Variant ID Type Subtype PubMed ID
nsv1074240 CNV deletion 25765185

Variation tolerance for SAP30 Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAP30 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAP30

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAP30 Gene

Disorders for SAP30 Gene

Additional Disease Information for SAP30

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SAP30 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAP30 Gene

Publications for SAP30 Gene

  1. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. (PMID: 9651585) Zhang Y … Reinberg D (Molecular cell 1998) 2 3 4 58
  2. SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. (PMID: 9702189) Laherty CD … Eisenman RN (Molecular cell 1998) 3 4 22 58
  3. DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides. (PMID: 19015240) Viiri KM … Lohi O (Molecular and cellular biology 2009) 3 22 58
  4. Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. (PMID: 17897615) Sichtig N … Steger G (Archives of biochemistry and biophysics 2007) 3 22 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for SAP30 Gene

Sources for SAP30 Gene

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