Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SAP25 Gene

Aliases for SAP25 Gene

  • Sin3A Associated Protein 25 2 3 5
  • Sin3 Corepressor Complex Subunit SAP25 4
  • 25 KDa Sin3-Associated Polypeptide 4
  • Sin3A-Associated Protein, 25kDa 2

External Ids for SAP25 Gene

Previous GeneCards Identifiers for SAP25 Gene

  • GC00U923410
  • GC07M100171

Summaries for SAP25 Gene

GeneCards Summary for SAP25 Gene

SAP25 (Sin3A Associated Protein 25) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SAP25 Gene

  • Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex.

Additional gene information for SAP25 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAP25 Gene

Genomics for SAP25 Gene

GeneHancer (GH) Regulatory Elements for SAP25 Gene

Promoters and enhancers for SAP25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I100573 Promoter 0.7 EPDnew 550.8 +0.2 185 0.1 CTCF POLR2A SAP25 ZASP IRS3P ENSG00000274272
GH07I100538 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 46.4 +29.3 29251 12.6 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 AGFG2 SAP25 PPP1R35 SRRT ZSCAN25 LRCH4 GIGYF1 AP4M1 MEPCE FBXO24
GH07I100581 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 30.7 -10.8 -10803 5.9 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC ZFP41 MEF2D SSRP1 ZNF610 FBXO24 LRCH4 ZSCAN25 AP4M1 ZSCAN21 SRRT SAP25 MEPCE PPP1R35 GIGYF1
GH07I100566 Enhancer 1.4 Ensembl ENCODE dbSUPER 32.3 +4.4 4418 5.9 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 KLF13 IRS3P SAP25 TMEM225B GPC2 MBLAC1 ENSG00000274272 AGFG2
GH07I100427 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.1 +140.7 140665 10.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPP1R35 MEPCE PIR54054 ZCWPW1 ZSCAN25 TRIM4 SRRT GIGYF1 ZNF3 PILRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SAP25 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SAP25 Gene

Genomic Locations for SAP25 Gene
1,639 bases
Minus strand

Genomic View for SAP25 Gene

Genes around SAP25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAP25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAP25 Gene

Proteins for SAP25 Gene

  • Protein details for SAP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histone deacetylase complex subunit SAP25
    Protein Accession:

    Protein attributes for SAP25 Gene

    199 amino acids
    Molecular mass:
    20873 Da
    Quaternary structure:
    • May be a component of the mSIN3A corepressor complex. Interacts with SIN3A. Interacts with HDAC2 (By similarity).
    • Sequence=BAB85001.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for SAP25 Gene

Post-translational modifications for SAP25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAP25 Gene

No data available for DME Specific Peptides for SAP25 Gene

Domains & Families for SAP25 Gene

Gene Families for SAP25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SAP25 Gene


Suggested Antigen Peptide Sequences for SAP25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAP25: view

No data available for UniProtKB/Swiss-Prot for SAP25 Gene

Function for SAP25 Gene

Molecular function for SAP25 Gene

UniProtKB/Swiss-Prot Function:
Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex.

Phenotypes From GWAS Catalog for SAP25 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SAP25 Gene

Localization for SAP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAP25 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAP25 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SAP25: view

Pathways & Interactions for SAP25 Gene

SuperPathways for SAP25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with SAP25: view

No data available for Pathways by source and SIGNOR curated interactions for SAP25 Gene

Drugs & Compounds for SAP25 Gene

No Compound Related Data Available

Transcripts for SAP25 Gene

mRNA/cDNA for SAP25 Gene

(7) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAP25 Gene

Sin3A-associated protein, 25kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAP25 Gene

No ASD Table

Relevant External Links for SAP25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SAP25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAP25 Gene

mRNA differential expression in normal tissues according to GTEx for SAP25 Gene

This gene is overexpressed in Whole Blood (x9.6) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for SAP25 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SAP25 Gene

Protein tissue co-expression partners for SAP25 Gene

NURSA nuclear receptor signaling pathways regulating expression of SAP25 Gene:


SOURCE GeneReport for Unigene cluster for SAP25 Gene:


Evidence on tissue expression from TISSUES for SAP25 Gene

  • Spleen(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with SAP25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAP25 Gene

Orthologs for SAP25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SAP25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SAP25 33 34
  • 99.5 (n)
(Canis familiaris)
Mammalia SAP25 34 33
  • 79.63 (n)
(Bos Taurus)
Mammalia SAP25 33 34
  • 77.44 (n)
(Rattus norvegicus)
Mammalia Sap25 33
  • 70.3 (n)
(Mus musculus)
Mammalia Sap25 33 16 34
  • 69.93 (n)
Species where no ortholog for SAP25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SAP25 Gene

Gene Tree for SAP25 (if available)
Gene Tree for SAP25 (if available)

Paralogs for SAP25 Gene Pseudogenes for SAP25 Gene

genes like me logo Genes that share paralogs with SAP25: view

No data available for Paralogs for SAP25 Gene

Variants for SAP25 Gene

Sequence variations from dbSNP and Humsavar for SAP25 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000014443 -- 100,573,435(-) G/T intron_variant
rs1000116950 -- 100,574,325(-) T/C upstream_transcript_variant
rs1000446188 -- 100,574,090(-) T/C upstream_transcript_variant
rs1000620119 -- 100,572,285(-) G/A 3_prime_UTR_variant
rs1001051589 -- 100,574,981(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SAP25 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv5868 CNV deletion 18451855
nsv831072 CNV loss 17160897
nsv951386 CNV deletion 24416366

Variation tolerance for SAP25 Gene

Gene Damage Index Score: 0.73; 15.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAP25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAP25 Gene

Disorders for SAP25 Gene

Additional Disease Information for SAP25

No disorders were found for SAP25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAP25 Gene

Publications for SAP25 Gene

  1. Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex. (PMID: 16449650) Shiio Y … Eisenman RN (Molecular and cellular biology 2006) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PMID: 12107411) Wistow G … Peterson K (Molecular vision 2002) 3 58

Products for SAP25 Gene

Sources for SAP25 Gene

Loading form....