Aliases for SAMD4B Gene

Aliases for SAMD4B Gene

  • Sterile Alpha Motif Domain Containing 4B 2 3 5
  • Sterile Alpha Motif Domain-Containing Protein 4B 3 4
  • SAM Domain-Containing Protein 4B 3 4
  • Protein Smaug Homolog 2 3 4
  • Smaug 2 3 4
  • HSmaug2 2 4
  • SMGB 2 3
  • Smaug Homolog B (Drosophila) 2
  • Smaug Homolog B 3
  • FLJ10211 2
  • MGC99832 2
  • Smaug2 3
  • SAMD4B 5
  • SMAUG2 4

External Ids for SAMD4B Gene

Previous GeneCards Identifiers for SAMD4B Gene

  • GC19P044525
  • GC19P039833
  • GC19P036279

Summaries for SAMD4B Gene

GeneCards Summary for SAMD4B Gene

SAMD4B (Sterile Alpha Motif Domain Containing 4B) is a Protein Coding gene. Diseases associated with SAMD4B include Protoplasmic Astrocytoma. An important paralog of this gene is SAMD4A.

UniProtKB/Swiss-Prot Summary for SAMD4B Gene

  • Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.

Additional gene information for SAMD4B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SAMD4B Gene

Genomics for SAMD4B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SAMD4B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SAMD4B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SAMD4B

Top Transcription factor binding sites by QIAGEN in the SAMD4B gene promoter:
  • AML1a
  • C/EBPalpha
  • HNF-4alpha1
  • HNF-4alpha2
  • Pax-4a
  • Sp1
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for SAMD4B Gene

Genomic Locations for SAMD4B Gene
chr19:39,342,396-39,390,748
(GRCh38/hg38)
Size:
48,353 bases
Orientation:
Plus strand
chr19:39,833,036-39,876,350
(GRCh37/hg19)
Size:
43,315 bases
Orientation:
Plus strand

Genomic View for SAMD4B Gene

Genes around SAMD4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAMD4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAMD4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD4B Gene

Proteins for SAMD4B Gene

  • Protein details for SAMD4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5PRF9-SMAG2_HUMAN
    Recommended name:
    Protein Smaug homolog 2
    Protein Accession:
    Q5PRF9
    Secondary Accessions:
    • A5Z0M6
    • Q6P194

    Protein attributes for SAMD4B Gene

    Size:
    694 amino acids
    Molecular mass:
    75483 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAMD4B Gene

Post-translational modifications for SAMD4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SAMD4B Gene

Domains & Families for SAMD4B Gene

Gene Families for SAMD4B Gene

Protein Domains for SAMD4B Gene

InterPro:
Blocks:
  • Sterile alpha motif SAM
ProtoNet:

Suggested Antigen Peptide Sequences for SAMD4B Gene

GenScript: Design optimal peptide antigens:
  • Sterile alpha motif domain containing 4B, isoform CRA_c (A5Z0M6_HUMAN)
  • SAMD4B protein (Q66K25_HUMAN)
  • SAMD4B protein (Q8IXP7_HUMAN)
  • Sterile alpha motif domain-containing protein 4B (SMAG2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5PRF9

UniProtKB/Swiss-Prot:

SMAG2_HUMAN :
  • Belongs to the SMAUG family.
Family:
  • Belongs to the SMAUG family.
genes like me logo Genes that share domains with SAMD4B: view

Function for SAMD4B Gene

Molecular function for SAMD4B Gene

UniProtKB/Swiss-Prot Function:
Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.

Phenotypes From GWAS Catalog for SAMD4B Gene

Gene Ontology (GO) - Molecular Function for SAMD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22681889
GO:0003729 mRNA binding IBA 21873635
GO:0005515 protein binding IEA,IPI 15161933
GO:0030371 translation repressor activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with SAMD4B: view
genes like me logo Genes that share phenotypes with SAMD4B: view

Animal Model Products

CRISPR Products

miRNA for SAMD4B Gene

miRTarBase miRNAs that target SAMD4B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SAMD4B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAMD4B Gene

Localization for SAMD4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAMD4B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAMD4B gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SAMD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IBA 21873635
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SAMD4B: view

Pathways & Interactions for SAMD4B Gene

PathCards logo

SuperPathways for SAMD4B Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAMD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening IBA 21873635
GO:0017148 negative regulation of translation IEA,IBA 21873635
GO:0043488 regulation of mRNA stability IEA,IBA 21873635
genes like me logo Genes that share ontologies with SAMD4B: view

No data available for Pathways by source and SIGNOR curated interactions for SAMD4B Gene

Drugs & Compounds for SAMD4B Gene

No Compound Related Data Available

Transcripts for SAMD4B Gene

mRNA/cDNA for SAMD4B Gene

30 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SAMD4B

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD4B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: - -
SP3:
SP4: -

Relevant External Links for SAMD4B Gene

GeneLoc Exon Structure for
SAMD4B

Expression for SAMD4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SAMD4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)
  • Ovary (Reproductive System)

Protein differential expression in normal tissues from HIPED for SAMD4B Gene

This gene is overexpressed in Breast (16.8), Lung (14.8), and Bone marrow stromal cell (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SAMD4B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SAMD4B

SOURCE GeneReport for Unigene cluster for SAMD4B Gene:

Hs.707137

mRNA Expression by UniProt/SwissProt for SAMD4B Gene:

Q5PRF9-SMAG2_HUMAN
Tissue specificity: Widely expressed in embryonic and adult tissues.

Evidence on tissue expression from TISSUES for SAMD4B Gene

  • Liver(4.5)
  • Heart(4.3)
  • Lung(4.1)
  • Nervous system(4.1)
  • Pancreas(3.9)
  • Kidney(3.1)
  • Skin(2.7)
  • Eye(2.7)
  • Muscle(2.4)
  • Thyroid gland(2.3)
  • Intestine(2.3)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with SAMD4B: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAMD4B Gene

Orthologs for SAMD4B Gene

This gene was present in the common ancestor of animals.

Orthologs for SAMD4B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SAMD4B 30 31
  • 99.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SAMD4B 30 31
  • 94.43 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SAMD4B 30 31
  • 93.32 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Samd4b 30 17 31
  • 92.92 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Samd4b 30
  • 92.82 (n)
Oppossum
(Monodelphis domestica)
Mammalia SAMD4B 31
  • 91 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 50 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia SAMD4B 31
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia samd4b 30
  • 69.71 (n)
Zebrafish
(Danio rerio)
Actinopterygii samd4b 30
  • 71.88 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta smg 31
  • 12 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ZC190.4 31
  • 16 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7136 31
  • 49 (a)
OneToMany
Species where no ortholog for SAMD4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SAMD4B Gene

ENSEMBL:
Gene Tree for SAMD4B (if available)
TreeFam:
Gene Tree for SAMD4B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SAMD4B: view image

Paralogs for SAMD4B Gene

Paralogs for SAMD4B Gene

(2) SIMAP similar genes for SAMD4B Gene using alignment to 9 proteins:

  • SMAG2_HUMAN
  • M0QX45_HUMAN
  • M0QXV2_HUMAN
  • M0QY61_HUMAN
  • M0QZ22_HUMAN
  • M0QZW7_HUMAN
  • M0R0X3_HUMAN
  • Q66K25_HUMAN
  • Q8IXP7_HUMAN
genes like me logo Genes that share paralogs with SAMD4B: view

Variants for SAMD4B Gene

Additional dbSNP identifiers (rs#s) for SAMD4B Gene

Structural Variations from Database of Genomic Variants (DGV) for SAMD4B Gene

Variant ID Type Subtype PubMed ID
dgv202n21 CNV loss 19592680
esv25791 CNV gain 19812545
esv3583388 CNV loss 25503493
nsv1126522 CNV deletion 24896259
nsv2480 CNV insertion 18451855
nsv833830 CNV loss 17160897

Variation tolerance for SAMD4B Gene

Residual Variation Intolerance Score: 4.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAMD4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAMD4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SAMD4B Gene

Disorders for SAMD4B Gene

MalaCards: The human disease database

(1) MalaCards diseases for SAMD4B Gene - From: DISEASES

Disorder Aliases PubMed IDs
protoplasmic astrocytoma
  • protoplasmic astrocytic tumor
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SAMD4B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SAMD4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SAMD4B Gene

Publications for SAMD4B Gene

  1. Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules. (PMID: 16221671) Baez MV … Boccaccio GL (The Journal of biological chemistry 2005) 2 3 4
  2. SAMD4B, a novel SAM-containing protein, inhibits AP-1-, p53- and p21-mediated transcriptional activity. (PMID: 20510020) Luo N … Wu X (BMB reports 2010) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for SAMD4B Gene

Sources for SAMD4B Gene