Aliases for SAMD15 Gene

Aliases for SAMD15 Gene

  • Sterile Alpha Motif Domain Containing 15 2 3 5
  • Sterile Alpha Motif Domain-Containing Protein 15 3 4
  • Family With Sequence Similarity 15, Member A 2 3
  • SAM Domain-Containing Protein 15 3 4
  • C14orf174 3 4
  • FAM15A 3 4
  • SAM Domain-Containing Protein C14orf174 3
  • Chromosome 14 Open Reading Frame 174 2
  • FLJ35963 2
  • SAMD15 5

External Ids for SAMD15 Gene

Previous HGNC Symbols for SAMD15 Gene

  • FAM15A
  • C14orf174

Previous GeneCards Identifiers for SAMD15 Gene

  • GC14P077844

Summaries for SAMD15 Gene

GeneCards Summary for SAMD15 Gene

SAMD15 (Sterile Alpha Motif Domain Containing 15) is a Protein Coding gene. Diseases associated with SAMD15 include Visual Cortex Disease and Visual Pathway Disease. An important paralog of this gene is MDN1.

Additional gene information for SAMD15 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SAMD15 Gene

Genomics for SAMD15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SAMD15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SAMD15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SAMD15

Genomic Locations for SAMD15 Gene

Genomic Locations for SAMD15 Gene
chr14:77,376,689-77,391,497
(GRCh38/hg38)
Size:
14,809 bases
Orientation:
Plus strand
chr14:77,843,032-77,857,840
(GRCh37/hg19)
Size:
14,809 bases
Orientation:
Plus strand

Genomic View for SAMD15 Gene

Genes around SAMD15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAMD15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAMD15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD15 Gene

Proteins for SAMD15 Gene

  • Protein details for SAMD15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1V8-SAM15_HUMAN
    Recommended name:
    Sterile alpha motif domain-containing protein 15
    Protein Accession:
    Q9P1V8
    Secondary Accessions:
    • Q2M3P3

    Protein attributes for SAMD15 Gene

    Size:
    674 amino acids
    Molecular mass:
    77151 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SAMD15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAMD15 Gene

Post-translational modifications for SAMD15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAMD15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SAMD15 Gene

Domains & Families for SAMD15 Gene

Gene Families for SAMD15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SAMD15 Gene

InterPro:
Blocks:
  • Sterile alpha motif SAM
  • Sterile alpha motif homology 2
ProtoNet:

Suggested Antigen Peptide Sequences for SAMD15 Gene

GenScript: Design optimal peptide antigens:
  • Sterile alpha motif domain-containing protein 15 (SAM15_HUMAN)
genes like me logo Genes that share domains with SAMD15: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SAMD15 Gene

Function for SAMD15 Gene

Phenotypes From GWAS Catalog for SAMD15 Gene

Gene Ontology (GO) - Molecular Function for SAMD15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with SAMD15: view
genes like me logo Genes that share phenotypes with SAMD15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SAMD15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAMD15 Gene

Localization for SAMD15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAMD15 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SAMD15 Gene

Pathways & Interactions for SAMD15 Gene

PathCards logo

SuperPathways for SAMD15 Gene

No Data Available

Interacting Proteins for SAMD15 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 23)
STRING Interaction Network
Selected Interacting proteins: ENSP00000216471 Q9P1V8-SAM15_HUMAN for SAMD15 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SAMD15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAMD15 Gene

Drugs & Compounds for SAMD15 Gene

No Compound Related Data Available

Transcripts for SAMD15 Gene

mRNA/cDNA for SAMD15 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SAMD15

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD15 Gene

No ASD Table

Relevant External Links for SAMD15 Gene

GeneLoc Exon Structure for
SAMD15

Expression for SAMD15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SAMD15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for SAMD15 Gene

This gene is overexpressed in Testis (x17.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SAMD15

SOURCE GeneReport for Unigene cluster for SAMD15 Gene:

Hs.421961
genes like me logo Genes that share expression patterns with SAMD15: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAMD15 Gene

Orthologs for SAMD15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SAMD15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SAMD15 30 31
  • 98.91 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SAMD15 30 31
  • 73.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SAMD15 30 31
  • 72.18 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Samd15 30 17 31
  • 64.04 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Samd15 30
  • 53.91 (n)
Oppossum
(Monodelphis domestica)
Mammalia SAMD15 31
  • 31 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SAMD15 31
  • 31 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SAMD15 31
  • 45 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SAMD15 31
  • 69 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 42 (a)
OneToOne
Species where no ortholog for SAMD15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SAMD15 Gene

ENSEMBL:
Gene Tree for SAMD15 (if available)
TreeFam:
Gene Tree for SAMD15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SAMD15: view image

Paralogs for SAMD15 Gene

Paralogs for SAMD15 Gene

genes like me logo Genes that share paralogs with SAMD15: view

Variants for SAMD15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SAMD15 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs11844594 - p.Leu18Pro
rs2193595 - p.Lys454Glu
rs45527334 - p.Met168Ile
rs4903576 - p.Lys370Glu

Additional dbSNP identifiers (rs#s) for SAMD15 Gene

Structural Variations from Database of Genomic Variants (DGV) for SAMD15 Gene

Variant ID Type Subtype PubMed ID
esv3635003 CNV gain 21293372
nsv1362 CNV deletion 18451855

Variation tolerance for SAMD15 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAMD15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAMD15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAMD15 Gene

Disorders for SAMD15 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SAMD15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
visual cortex disease
  • visual cortex dysfunction
visual pathway disease
  • disorder of visual pathways
cortical blindness
  • blindness, cortical
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with SAMD15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SAMD15 Gene

Publications for SAMD15 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for SAMD15 Gene

Sources for SAMD15 Gene