Aliases for SAMD14 Gene

Aliases for SAMD14 Gene

  • Sterile Alpha Motif Domain Containing 14 2 3 5
  • Sterile Alpha Motif Domain-Containing Protein 14 3 4
  • SAM Domain-Containing Protein 14 3 4
  • FLJ36890 2
  • SAMD14 5

External Ids for SAMD14 Gene

Previous GeneCards Identifiers for SAMD14 Gene

  • GC17M045544
  • GC17M048188
  • GC17M043557

Summaries for SAMD14 Gene

GeneCards Summary for SAMD14 Gene

SAMD14 (Sterile Alpha Motif Domain Containing 14) is a Protein Coding gene. Diseases associated with SAMD14 include Central Nervous System Lymphoma. An important paralog of this gene is PPP1R9A.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SAMD14 Gene

Genomics for SAMD14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SAMD14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J050127 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 261.4 +0.7 688 3.5 EZH2 IKZF1 ZNF600 ZIC2 ZNF341 NR2C1 GABPA KLF9 SAP130 ETV4 SAMD14 lnc-PPP1R9B-7 LUC7L3 LOC105371824 MYCBPAP SGCA PDK2 HSALNG0117254
GH17J050144 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11 -20.1 -20077 11.6 SP1 ZNF207 MYC NCOR1 ZNF600 IKZF1 ZNF580 ZNF592 ZMYM3 KLF9 PPP1R9B HSALNG0117258 HSALNG0117259 MK280241 lnc-SGCA-4 SGCA ENSG00000262837 LUC7L3 ENSG00000204584 COL1A1
GH17J050171 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11 -62.4 -62362 42 EZH2 BCLAF1 ZNF654 ZNF207 NCOR1 ZNF600 MYC IKZF1 JUND ZNF580 COL1A1 HSALNG0117266 SGCA ENSG00000262837 LUC7L3 TMEM92-AS1 TMEM92 XYLT2 PPP1R9B ENSG00000204584
GH17J050046 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 +73.2 73246 21.3 ZNF600 IKZF1 JUND ZNF592 CEBPA ZNF223 POLR2A ZIC2 NFIC ZBTB10 ITGA3 PICART1 HSALNG0117243 ENSG00000262837 LUC7L3 FAM117A ENSG00000204584 PDK2 ENSG00000250282 LOC105371824
GH17J050160 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -31.4 -31447 1.7 BCLAF1 ZNF654 MYC ZNF600 IKZF1 SSRP1 ZSCAN16 POLR2A ZIC2 ZBTB10 ENSG00000253730 ENSG00000262837 LUC7L3 FAM117A ENSG00000204584 SAMD14 TAC4 SGCA LOC105371818 PPP1R9B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SAMD14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SAMD14

Top Transcription factor binding sites by QIAGEN in the SAMD14 gene promoter:
  • AREB6
  • C/EBPalpha
  • E47
  • HSF2
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • NRF-2
  • Sox9
  • ZIC2

Genomic Locations for SAMD14 Gene

Latest Assembly
chr17:50,110,040-50,130,160
(GRCh38/hg38)
Size:
20,121 bases
Orientation:
Minus strand

Previous Assembly
chr17:48,187,404-48,207,524
(GRCh37/hg19 by Entrez Gene)
Size:
20,121 bases
Orientation:
Minus strand

chr17:48,187,404-48,207,246
(GRCh37/hg19 by Ensembl)
Size:
19,843 bases
Orientation:
Minus strand

Genomic View for SAMD14 Gene

Genes around SAMD14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAMD14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAMD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD14 Gene

Proteins for SAMD14 Gene

  • Protein details for SAMD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZD0-SAM14_HUMAN
    Recommended name:
    Sterile alpha motif domain-containing protein 14
    Protein Accession:
    Q8IZD0
    Secondary Accessions:
    • A5D8V1
    • Q8N2X0

    Protein attributes for SAMD14 Gene

    Size:
    417 amino acids
    Molecular mass:
    45056 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SAMD14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SAMD14 Gene

Post-translational modifications for SAMD14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SAMD14 Gene

Domains & Families for SAMD14 Gene

Gene Families for SAMD14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SAMD14 Gene

InterPro:
Blocks:
  • Sterile alpha motif SAM

Suggested Antigen Peptide Sequences for SAMD14 Gene

GenScript: Design optimal peptide antigens:
  • SAMD14 protein (Q86VX6_HUMAN)
  • Sterile alpha motif domain-containing protein 14 (SAM14_HUMAN)
genes like me logo Genes that share domains with SAMD14: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SAMD14 Gene

Function for SAMD14 Gene

Phenotypes From GWAS Catalog for SAMD14 Gene

Gene Ontology (GO) - Molecular Function for SAMD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0051015 actin filament binding IBA 21873635
genes like me logo Genes that share ontologies with SAMD14: view
genes like me logo Genes that share phenotypes with SAMD14: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SAMD14

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAMD14 Gene

Localization for SAMD14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAMD14 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
plasma membrane 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SAMD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0014069 postsynaptic density IBA 21873635
GO:0015629 actin cytoskeleton IBA 21873635
GO:0030425 dendrite IBA 21873635
genes like me logo Genes that share ontologies with SAMD14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SAMD14 Gene

Pathways & Interactions for SAMD14 Gene

PathCards logo

SuperPathways for SAMD14 Gene

No Data Available

Interacting Proteins for SAMD14 Gene

Gene Ontology (GO) - Biological Process for SAMD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IBA 21873635
GO:0019722 calcium-mediated signaling IBA 21873635
GO:0031175 neuron projection development IBA 21873635
genes like me logo Genes that share ontologies with SAMD14: view

No data available for Pathways by source and SIGNOR curated interactions for SAMD14 Gene

Drugs & Compounds for SAMD14 Gene

No Compound Related Data Available

Transcripts for SAMD14 Gene

mRNA/cDNA for SAMD14 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SAMD14

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD14 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6:
SP7:
SP8: -

Relevant External Links for SAMD14 Gene

GeneLoc Exon Structure for
SAMD14

Expression for SAMD14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SAMD14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SAMD14 Gene

This gene is overexpressed in Brain - Cerebellum (x7.3) and Brain - Cerebellar Hemisphere (x6.9).

Protein differential expression in normal tissues from HIPED for SAMD14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.9) and Platelet (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SAMD14 Gene



Protein tissue co-expression partners for SAMD14 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SAMD14

SOURCE GeneReport for Unigene cluster for SAMD14 Gene:

Hs.567769

Evidence on tissue expression from TISSUES for SAMD14 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with SAMD14: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAMD14 Gene

Orthologs for SAMD14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAMD14 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SAMD14 29 30
  • 99.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SAMD14 29 30
  • 92.25 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SAMD14 29 30
  • 91.13 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Samd14 29
  • 88.49 (n)
Mouse
(Mus musculus)
Mammalia Samd14 29 16 30
  • 88.25 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SAMD14 30
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SAMD14 30
  • 62 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SAMD14 29 30
  • 70.95 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SAMD14 30
  • 72 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii LOC100537418 29
  • 53.02 (n)
SAMD14 30
  • 39 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Spn 30
  • 4 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea nab-1 30
  • 11 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 10 (a)
OneToOne
Species where no ortholog for SAMD14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for SAMD14 Gene

ENSEMBL:
Gene Tree for SAMD14 (if available)
TreeFam:
Gene Tree for SAMD14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SAMD14: view image
Alliance of Genome Resources:
Additional Orthologs for SAMD14

Paralogs for SAMD14 Gene

Paralogs for SAMD14 Gene

(1) SIMAP similar genes for SAMD14 Gene using alignment to 4 proteins:

  • SAM14_HUMAN
  • D6RA16_HUMAN
  • J3KN99_HUMAN
  • Q86VX6_HUMAN
genes like me logo Genes that share paralogs with SAMD14: view

Variants for SAMD14 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SAMD14 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SAMD14 Gene

Variant ID Type Subtype PubMed ID
esv1003562 CNV loss 20482838
nsv1071392 CNV deletion 25765185
nsv952339 CNV deletion 24416366

Variation tolerance for SAMD14 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAMD14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAMD14
Leiden Open Variation Database (LOVD)
SAMD14

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SAMD14 Gene

Disorders for SAMD14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SAMD14 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
central nervous system lymphoma
  • microglioma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SAMD14

genes like me logo Genes that share disorders with SAMD14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SAMD14 Gene

Publications for SAMD14 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3
  4. SAMD14 promoter methylation is strongly associated with gene expression and poor prognosis in gastric cancer. (PMID: 32206938) Xu X … Dai D (International journal of clinical oncology 2020) 3
  5. Hyper-N-glycosylated SAMD14 and neurabin-I as driver autoantigens of primary central nervous system lymphoma. (PMID: 30249786) Thurner L … Pfreundschuh M (Blood 2018) 3

Products for SAMD14 Gene

Sources for SAMD14 Gene