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Aliases for SAMD10 Gene

Aliases for SAMD10 Gene

  • Sterile Alpha Motif Domain Containing 10 2 3 5
  • SAM Domain-Containing Protein 10 3 4
  • C20orf136 3 4
  • Sterile Alpha Motif Domain-Containing Protein 10 3
  • Chromosome 20 Open Reading Frame 136 2
  • D930033N23Rik 3
  • DJ591C20.7 3
  • DJ591C20 3

External Ids for SAMD10 Gene

Previous HGNC Symbols for SAMD10 Gene

  • C20orf136

Previous GeneCards Identifiers for SAMD10 Gene

  • GC20M062075
  • GC20M062605
  • GC20M059340

Summaries for SAMD10 Gene

GeneCards Summary for SAMD10 Gene

SAMD10 (Sterile Alpha Motif Domain Containing 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is SAMD12.

Additional gene information for SAMD10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAMD10 Gene

Genomics for SAMD10 Gene

GeneHancer (GH) Regulatory Elements for SAMD10 Gene

Promoters and enhancers for SAMD10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I063977 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 554 +1.2 1182 4.8 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PRPF6 SAMD10 C20orf204 GMEB2 CICP4 RTEL1 ZNF512B
GH20I064052 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.3 -74.7 -74650 5.7 HDGF MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B IRF4 SLC30A9 TCEA2 ENSG00000237371 SOX18 RGS19 PRPF6 OPRL1 SAMD10 ZNF512B C20orf204 UCKL1
GH20I063939 Enhancer 1.1 Ensembl ENCODE 11.7 +39.0 39003 4 HDAC1 HDGF PKNOX1 KLF17 SIN3A ZBTB40 GLIS2 ELK1 ZNF366 SCRT2 MIR647 MIR1914 PIR37009 PRPF6 UCKL1 GMEB2 RTEL1 RNU1-134P DNAJC5 ZNF512B
GH20I063884 Enhancer 0.9 ENCODE dbSUPER 11.3 +96.0 95976 1.7 GTF2F1 SIN3A EBF1 RFX5 HIC1 SCRT2 ATF7 RUNX3 ZNF687 NR2F1 MIR941-2 MIR941-4 RNU1-134P ZNF512B SAMD10 PRPF6 ENSG00000229299 ZBTB46 LIME1 SLC2A4RG
GH20I063857 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 5.2 +121.6 121580 4.3 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 SLC30A9 GLIS2 PAF1 SP5 ABHD16B SAMD10 ENSG00000268858 GC20M063809
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SAMD10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SAMD10 gene promoter:

Genomic Locations for SAMD10 Gene

Genomic Locations for SAMD10 Gene
chr20:63,974,113-63,980,986
(GRCh38/hg38)
Size:
6,874 bases
Orientation:
Minus strand
chr20:62,605,466-62,611,361
(GRCh37/hg19)

Genomic View for SAMD10 Gene

Genes around SAMD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAMD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAMD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAMD10 Gene

Proteins for SAMD10 Gene

  • Protein details for SAMD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYL1-SAM10_HUMAN
    Recommended name:
    Sterile alpha motif domain-containing protein 10
    Protein Accession:
    Q9BYL1

    Protein attributes for SAMD10 Gene

    Size:
    202 amino acids
    Molecular mass:
    22770 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAMD10 Gene

Post-translational modifications for SAMD10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAMD10 Gene

No data available for DME Specific Peptides for SAMD10 Gene

Domains & Families for SAMD10 Gene

Gene Families for SAMD10 Gene

Protein Domains for SAMD10 Gene

Suggested Antigen Peptide Sequences for SAMD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAMD10: view

No data available for UniProtKB/Swiss-Prot for SAMD10 Gene

Function for SAMD10 Gene

Phenotypes From GWAS Catalog for SAMD10 Gene

Phenotypes for SAMD10 Gene

genes like me logo Genes that share phenotypes with SAMD10: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAMD10 Gene

Localization for SAMD10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAMD10 gene
Compartment Confidence
nucleus 3
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SAMD10 Gene

Pathways & Interactions for SAMD10 Gene

SuperPathways for SAMD10 Gene

No Data Available

Interacting Proteins for SAMD10 Gene

Selected Interacting proteins: Q9BYL1-SAM10_HUMAN for SAMD10 Gene via IID

Gene Ontology (GO) - Biological Process for SAMD10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAMD10 Gene

Drugs & Compounds for SAMD10 Gene

No Compound Related Data Available

Transcripts for SAMD10 Gene

Unigene Clusters for SAMD10 Gene

Sterile alpha motif domain containing 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAMD10 Gene

No ASD Table

Relevant External Links for SAMD10 Gene

GeneLoc Exon Structure for
SAMD10
ECgene alternative splicing isoforms for
SAMD10

Expression for SAMD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAMD10 Gene

mRNA differential expression in normal tissues according to GTEx for SAMD10 Gene

This gene is overexpressed in Brain - Cerebellum (x4.1).

Protein differential expression in normal tissues from HIPED for SAMD10 Gene

This gene is overexpressed in Tlymphocyte (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SAMD10 Gene



Protein tissue co-expression partners for SAMD10 Gene

NURSA nuclear receptor signaling pathways regulating expression of SAMD10 Gene:

SAMD10

SOURCE GeneReport for Unigene cluster for SAMD10 Gene:

Hs.27189

Evidence on tissue expression from TISSUES for SAMD10 Gene

  • Liver(3.8)
genes like me logo Genes that share expression patterns with SAMD10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAMD10 Gene

Orthologs for SAMD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAMD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAMD10 33 34
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia SAMD10 33 34
  • 91.25 (n)
cow
(Bos Taurus)
Mammalia SAMD10 33 34
  • 90.43 (n)
rat
(Rattus norvegicus)
Mammalia Samd10 33
  • 89.6 (n)
mouse
(Mus musculus)
Mammalia Samd10 33 16 34
  • 89.27 (n)
oppossum
(Monodelphis domestica)
Mammalia SAMD10 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAMD10 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAMD10 33 34
  • 79.92 (n)
lizard
(Anolis carolinensis)
Reptilia SAMD10 34
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14313 33
zebrafish
(Danio rerio)
Actinopterygii samd10b 33 34
  • 70.76 (n)
samd10a 34
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ave 34
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToMany
Species where no ortholog for SAMD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAMD10 Gene

ENSEMBL:
Gene Tree for SAMD10 (if available)
TreeFam:
Gene Tree for SAMD10 (if available)

Paralogs for SAMD10 Gene

Paralogs for SAMD10 Gene

(1) SIMAP similar genes for SAMD10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SAMD10: view

Variants for SAMD10 Gene

Sequence variations from dbSNP and Humsavar for SAMD10 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs114227570 likely-benign, Retinitis Pigmentosa, Dominant 63,981,167(-) C/T upstream_transcript_variant
rs115265032 likely-benign, Retinitis Pigmentosa, Dominant 63,981,127(-) G/A upstream_transcript_variant
rs180973296 likely-benign, Retinitis Pigmentosa, Dominant 63,981,171(-) G/A upstream_transcript_variant
rs186249212 likely-benign, Retinitis Pigmentosa, Dominant 63,981,287(-) C/G/T upstream_transcript_variant
rs189115287 uncertain-significance, Retinitis Pigmentosa, Dominant 63,981,168(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SAMD10 Gene

Variant ID Type Subtype PubMed ID
nsv1160691 CNV deletion 26073780
nsv428381 CNV gain+loss 18775914
nsv469773 CNV gain 16826518
nsv509784 CNV insertion 20534489
nsv586703 CNV loss 21841781
nsv953309 CNV deletion 24416366
nsv9830 CNV gain 18304495

Variation tolerance for SAMD10 Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAMD10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAMD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAMD10 Gene

Disorders for SAMD10 Gene

Additional Disease Information for SAMD10

No disorders were found for SAMD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAMD10 Gene

Publications for SAMD10 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  3. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles RA … Easton DF (Nature genetics 2013) 3 58
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for SAMD10 Gene

Sources for SAMD10 Gene

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