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Aliases for SAGE1 Gene

Aliases for SAGE1 Gene

  • Sarcoma Antigen 1 2 3 5
  • Cancer/Testis Antigen 14 2 3 4
  • CT14 3 4
  • SAGE 3 4
  • Putative Tumor Antigen 3

External Ids for SAGE1 Gene

Previous GeneCards Identifiers for SAGE1 Gene

  • GC0XP133682
  • GC0XP134701
  • GC0XP134803
  • GC0XP134971
  • GC0XP124250

Summaries for SAGE1 Gene

Entrez Gene Summary for SAGE1 Gene

  • This gene belongs to a class of genes that are activated in tumors. These genes are expressed in tumors of different histologic types but not in normal tissues, except for spermatogenic cells and, for some, placenta. The proteins encoded by these genes appear to be strictly tumor specific, and hence may be excellent sources of antigens for cancer immunotherapy. This gene is expressed in sarcomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for SAGE1 Gene

SAGE1 (Sarcoma Antigen 1) is a Protein Coding gene. Diseases associated with SAGE1 include Sarcoma and Retroperitoneal Fibrosis. An important paralog of this gene is INTS6L.

Additional gene information for SAGE1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAGE1 Gene

Genomics for SAGE1 Gene

GeneHancer (GH) Regulatory Elements for SAGE1 Gene

Promoters and enhancers for SAGE1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI135896 Promoter 0.5 EPDnew 550.4 +6.9 6925 0.1 SAGE1 CT45A10 CT45A11P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SAGE1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SAGE1 gene promoter:

Genomic Locations for SAGE1 Gene

Genomic Locations for SAGE1 Gene
23,857 bases
Plus strand

Genomic View for SAGE1 Gene

Genes around SAGE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAGE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAGE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAGE1 Gene

Proteins for SAGE1 Gene

  • Protein details for SAGE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sarcoma antigen 1
    Protein Accession:
    Secondary Accessions:
    • Q5JNW0

    Protein attributes for SAGE1 Gene

    904 amino acids
    Molecular mass:
    99225 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAGE1 Gene

Post-translational modifications for SAGE1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SAGE1 Gene

Domains & Families for SAGE1 Gene

Gene Families for SAGE1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SAGE1 Gene


Suggested Antigen Peptide Sequences for SAGE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SAGE1: view

No data available for UniProtKB/Swiss-Prot for SAGE1 Gene

Function for SAGE1 Gene

Phenotypes for SAGE1 Gene

genes like me logo Genes that share phenotypes with SAGE1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SAGE1 Gene

Localization for SAGE1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAGE1 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SAGE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with SAGE1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SAGE1 Gene

Pathways & Interactions for SAGE1 Gene

SuperPathways for SAGE1 Gene

No Data Available

Interacting Proteins for SAGE1 Gene

Gene Ontology (GO) - Biological Process for SAGE1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SAGE1 Gene

Drugs & Compounds for SAGE1 Gene

(1) Additional Compounds for SAGE1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SAGE1: view

Transcripts for SAGE1 Gene

mRNA/cDNA for SAGE1 Gene

(8) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAGE1 Gene

Sarcoma antigen 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAGE1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - -
SP2: - -
SP3: - - -
SP4: -

ExUns: 20 ^ 21

Relevant External Links for SAGE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SAGE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAGE1 Gene

mRNA differential expression in normal tissues according to GTEx for SAGE1 Gene

This gene is overexpressed in Testis (x32.9).

Protein differential expression in normal tissues from HIPED for SAGE1 Gene

This gene is overexpressed in Lung (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SAGE1 Gene

Protein tissue co-expression partners for SAGE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SAGE1 Gene:


SOURCE GeneReport for Unigene cluster for SAGE1 Gene:


mRNA Expression by UniProt/SwissProt for SAGE1 Gene:

Tissue specificity: Expressed mainly in bladder, lung, head and neck carcinomas. Not expressed in normal tissues except for testis.
genes like me logo Genes that share expression patterns with SAGE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAGE1 Gene

Orthologs for SAGE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SAGE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SAGE1 33
  • 99.26 (n)
-- 34
  • 98 (a)
-- 34
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 17 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 13 (a)
(Gallus gallus)
Aves -- 34
  • 16 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 15 (a)
(Danio rerio)
Actinopterygii ddx26b 34
  • 14 (a)
fruit fly
(Drosophila melanogaster)
Insecta IntS6 34
  • 7 (a)
(Caenorhabditis elegans)
Secernentea dic-1 34
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 11 (a)
Species where no ortholog for SAGE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SAGE1 Gene

Gene Tree for SAGE1 (if available)
Gene Tree for SAGE1 (if available)

Paralogs for SAGE1 Gene

(7) SIMAP similar genes for SAGE1 Gene using alignment to 3 proteins: Pseudogenes for SAGE1 Gene

genes like me logo Genes that share paralogs with SAGE1: view

Variants for SAGE1 Gene

Sequence variations from dbSNP and Humsavar for SAGE1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000302091 -- 135,892,862(+) C/T upstream_transcript_variant
rs1001478751 -- 135,892,319(+) C/A upstream_transcript_variant
rs1001845807 -- 135,892,059(+) G/A upstream_transcript_variant
rs1002444008 -- 135,893,572(+) C/G upstream_transcript_variant
rs1006139820 -- 135,912,205(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SAGE1 Gene

Variant ID Type Subtype PubMed ID
nsv7460 OTHER inversion 18451855
nsv7107 CNV deletion 18451855
nsv527747 CNV gain 19592680
nsv527358 CNV gain 19592680
nsv471605 CNV gain+loss 15918152
nsv469568 CNV gain 16826518
nsv1125127 CNV duplication 24896259
esv3577402 CNV gain 25503493
esv2758895 CNV gain+loss 17122850
esv2740498 CNV deletion 23290073
esv1010013 CNV gain 20482838

Variation tolerance for SAGE1 Gene

Residual Variation Intolerance Score: 94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAGE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAGE1 Gene

Disorders for SAGE1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SAGE1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • connective and soft tissue neoplasm
retroperitoneal fibrosis
  • idiopathic retroperitoneal fibrosis
acute vascular insufficiency of intestine
  • acute gastrointestinal tract vascular insuffic.
- elite association - COSMIC cancer census association via MalaCards
Search SAGE1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SAGE1

genes like me logo Genes that share disorders with SAGE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SAGE1 Gene

Publications for SAGE1 Gene

  1. Identification on a human sarcoma of two new genes with tumor-specific expression. (PMID: 10919659) Martelange V … Boon T (Cancer research 2000) 2 3 4 22 58
  2. Determination of cellularly processed HLA-A2402-restricted novel CTL epitopes derived from two cancer germ line genes, MAGE-A4 and SAGE. (PMID: 16061876) Miyahara Y … Shiku H (Clinical cancer research : an official journal of the American Association for Cancer Research 2005) 3 22 58
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  4. Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer. (PMID: 26252478) Maheswaran E … Gjerstorff MF (PloS one 2015) 3 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for SAGE1 Gene

Sources for SAGE1 Gene

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