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Aliases for SAAL1 Gene

Aliases for SAAL1 Gene

  • Serum Amyloid A Like 1 2 3 5
  • Synoviocyte Proliferation-Associated In Collagen-Induced Arthritis Protein 1 3 4
  • SPACIA1 3 4
  • Synoviocyte Proliferation-Associated In Collagen-Induced Arthritis 1 3
  • Protein SAAL1 3

External Ids for SAAL1 Gene

Previous GeneCards Identifiers for SAAL1 Gene

  • GC11M018059
  • GC11M017784

Summaries for SAAL1 Gene

GeneCards Summary for SAAL1 Gene

SAAL1 (Serum Amyloid A Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot for SAAL1 Gene

  • Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli.

Additional gene information for SAAL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SAAL1 Gene

Genomics for SAAL1 Gene

GeneHancer (GH) Regulatory Elements for SAAL1 Gene

Promoters and enhancers for SAAL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J018105 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 707.1 +0.2 229 1.7 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B SAAL1 HIGD1AP5 GTF2H1 SPTY2D1 ENSG00000256361 TSG101 MRGPRX3 ENSG00000256588 LOC100129966 TPH1
GH11J018320 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 75.3 -216.7 -216660 5.1 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 GTF2H1 HPS5 SAA2 SAAL1 SPTY2D1 ENSG00000256361 TSG101 LOC100129966 ENSG00000256588 LOC105376577
GH11J018010 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 47 +93.6 93552 3.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF143 ZNF548 SERGEF SAAL1 SNORD14A GTF2H1 SNORD14B SPTY2D1 ENSG00000256361 LOC100129966 TSG101 ENSG00000255448
GH11J017273 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 26 +829.2 829205 6.3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 NUCB2 OR7E14P SAAL1 SNORD14A SNORD14B GC11M017256 GC11P017338
GH11J018392 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 25.4 -288.6 -288620 5 CLOCK ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A SSRP1 LDHA LDHC SAAL1 GTF2H1 SPTY2D1 ENSG00000256006
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SAAL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SAAL1 gene promoter:
  • FOXD3
  • TBP
  • c-Myc
  • Max1
  • FOXJ2
  • FOXJ2 (long isoform)
  • Brachyury
  • HOXA5
  • HOXA9
  • HOXA9B

Genomic Locations for SAAL1 Gene

Genomic Locations for SAAL1 Gene
chr11:18,069,935-18,106,091
(GRCh38/hg38)
Size:
36,157 bases
Orientation:
Minus strand
chr11:18,091,482-18,127,638
(GRCh37/hg19)
Size:
36,157 bases
Orientation:
Minus strand

Genomic View for SAAL1 Gene

Genes around SAAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAAL1 Gene

Proteins for SAAL1 Gene

  • Protein details for SAAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ER3-SAAL1_HUMAN
    Recommended name:
    Protein SAAL1
    Protein Accession:
    Q96ER3
    Secondary Accessions:
    • A6NH05

    Protein attributes for SAAL1 Gene

    Size:
    474 amino acids
    Molecular mass:
    53558 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SAAL1 Gene

Post-translational modifications for SAAL1 Gene

  • Ubiquitination at posLast=254254 and isoforms=209
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SAAL1 Gene

Domains & Families for SAAL1 Gene

Gene Families for SAAL1 Gene

Protein Domains for SAAL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SAAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96ER3

UniProtKB/Swiss-Prot:

SAAL1_HUMAN :
  • Belongs to the SAAL1 family.
Family:
  • Belongs to the SAAL1 family.
genes like me logo Genes that share domains with SAAL1: view

Function for SAAL1 Gene

Molecular function for SAAL1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli.
genes like me logo Genes that share phenotypes with SAAL1: view

Animal Model Products

CRISPR Products

miRNA for SAAL1 Gene

miRTarBase miRNAs that target SAAL1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SAAL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SAAL1 Gene

Localization for SAAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAAL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAAL1 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SAAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IBA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SAAL1: view

Pathways & Interactions for SAAL1 Gene

SuperPathways for SAAL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SAAL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SAAL1 Gene

Drugs & Compounds for SAAL1 Gene

No Compound Related Data Available

Transcripts for SAAL1 Gene

mRNA/cDNA for SAAL1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(170) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SAAL1 Gene

Serum amyloid A-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SAAL1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAAL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5:
SP6:

Relevant External Links for SAAL1 Gene

GeneLoc Exon Structure for
SAAL1
ECgene alternative splicing isoforms for
SAAL1

Expression for SAAL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAAL1 Gene

Protein differential expression in normal tissues from HIPED for SAAL1 Gene

This gene is overexpressed in Bone (56.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SAAL1 Gene



Protein tissue co-expression partners for SAAL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SAAL1 Gene:

SAAL1

SOURCE GeneReport for Unigene cluster for SAAL1 Gene:

Hs.591998

mRNA Expression by UniProt/SwissProt for SAAL1 Gene:

Q96ER3-SAAL1_HUMAN
Tissue specificity: Highly expressed in testis and ovary, and to a lesser extend in the lung, spleen and the heart (at protein level).

Evidence on tissue expression from TISSUES for SAAL1 Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with SAAL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAAL1 Gene

Orthologs for SAAL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SAAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SAAL1 34 33
  • 99.58 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SAAL1 34 33
  • 91.49 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SAAL1 34 33
  • 90.49 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Saal1 16 34 33
  • 82.28 (n)
rat
(Rattus norvegicus)
Mammalia LOC691143 33
  • 82.21 (n)
oppossum
(Monodelphis domestica)
Mammalia SAAL1 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SAAL1 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SAAL1 34 33
  • 72.73 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SAAL1 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia saal1 33
  • 59.71 (n)
Str.3398 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7504 33
zebrafish
(Danio rerio)
Actinopterygii saal1 34 33
  • 57.25 (n)
OneToOne
zgc55505 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
OneToOne
Species where no ortholog for SAAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAAL1 Gene

ENSEMBL:
Gene Tree for SAAL1 (if available)
TreeFam:
Gene Tree for SAAL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SAAL1: view image

Paralogs for SAAL1 Gene

(1) SIMAP similar genes for SAAL1 Gene using alignment to 8 proteins:

  • SAAL1_HUMAN
  • E9PL53_HUMAN
  • E9PMD2_HUMAN
  • E9PRZ1_HUMAN
  • H0YCN7_HUMAN
  • H0YDM3_HUMAN
  • H0YEK5_HUMAN
  • J3KND1_HUMAN
genes like me logo Genes that share paralogs with SAAL1: view

No data available for Paralogs for SAAL1 Gene

Variants for SAAL1 Gene

Sequence variations from dbSNP and Humsavar for SAAL1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000105033 -- 18,105,527(-) T/C intron_variant
rs1000141027 -- 18,105,206(-) G/A intron_variant
rs1000169912 -- 18,086,797(-) G/T intron_variant
rs1000412021 -- 18,098,975(-) T/C intron_variant
rs1000508834 -- 18,095,155(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SAAL1 Gene

Variant ID Type Subtype PubMed ID
dgv1672n54 CNV loss 21841781
esv3625486 CNV gain 21293372
nsv553606 CNV loss 21841781

Variation tolerance for SAAL1 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.38; 85.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SAAL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SAAL1 Gene

Disorders for SAAL1 Gene

Additional Disease Information for SAAL1

No disorders were found for SAAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SAAL1 Gene

Publications for SAAL1 Gene

  1. Overexpression of SPACIA1/SAAL1, a newly identified gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans. (PMID: 22127701) Sato T … Nakajima T (Arthritis and rheumatism 2011) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58

Products for SAAL1 Gene

Sources for SAAL1 Gene

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