Aliases for SAA2 Gene

Aliases for SAA2 Gene

  • Serum Amyloid A2 2 3 5
  • Serum Amyloid A-2 Protein 3 4
  • Serum Amyloid A-1 Protein 3
  • SAA1 3
  • SAA 3

External Ids for SAA2 Gene

Previous GeneCards Identifiers for SAA2 Gene

  • GC11M019387
  • GC11M019209
  • GC11M018293
  • GC11M018231
  • GC11M018223
  • GC11M018260
  • GC11M017943

Summaries for SAA2 Gene

GeneCards Summary for SAA2 Gene

SAA2 (Serum Amyloid A2) is a Protein Coding gene. Diseases associated with SAA2 include Amyloidosis Aa and Amyloidosis. Among its related pathways are Selenium Micronutrient Network. Gene Ontology (GO) annotations related to this gene include chemoattractant activity. An important paralog of this gene is SAA1.

UniProtKB/Swiss-Prot Summary for SAA2 Gene

Gene Wiki entry for SAA2 Gene

Additional gene information for SAA2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SAA2 Gene

Genomics for SAA2 Gene

GeneHancer (GH) Regulatory Elements for SAA2 Gene

Promoters and enhancers for SAA2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J018320 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.2 -73.7 -73727 6.4 FOXK2 SIN3A ZNF24 SP1 ZBTB40 SREBF1 LCORL MLX RBPJ SMARCE1 GTF2H1 HPS5 lnc-HPS5-1 lnc-SAA2-4 SAA2 SAAL1 SPTY2D1 ENSG00000256361 TSG101 ENSG00000256282
GH11J018248 Promoter/Enhancer 0.8 EPDnew Ensembl 750.6 -0.1 -126 0.4 HLF SP1 RXRA JUND YY1 HNF4A MAX RF00001-057 RNA5SP333 SAA2 SAA2-SAA4 lnc-SAA2-SAA4-1 piR-57461-029
GH11J018779 Enhancer 0.3 Ensembl 5 -531.5 -531549 1.2 POLR2A PTPN5 SAA2 piR-57133-070
GH11J018243 Enhancer 0.8 Ensembl ENCODE 0.6 +4.7 4700 0.5 CTCF ETV6 RAD21 ELF3 RELA REST TRIM22 ZNF143 IKZF2 JUND RF00001-057 RNA5SP333 SAA2 SAA2-SAA4 lnc-SAA2-SAA4-1 SAA4
GH11J018245 Enhancer 0.6 ENCODE 0.6 +2.2 2155 1.8 MLLT1 IKZF1 IKZF2 EED DPF2 ELF1 RUNX3 NR2F1 JUNB NBN RF00001-057 RNA5SP333 USH1C SAA2 SAA2-SAA4 lnc-SAA2-SAA4-1 SAA4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SAA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SAA2 gene promoter:
  • AP-1
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4

Genomic Locations for SAA2 Gene

Genomic Locations for SAA2 Gene
10,442 bases
Minus strand
10,442 bases
Minus strand

Genomic View for SAA2 Gene

Genes around SAA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SAA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SAA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SAA2 Gene

Proteins for SAA2 Gene

  • Protein details for SAA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serum amyloid A-2 protein
    Protein Accession:
    Secondary Accessions:
    • G3XAK9
    • P02735
    • P02736
    • P02737
    • Q16730
    • Q16834
    • Q16835
    • Q16879
    • Q3KRB3
    • Q6FG67
    • Q96QN0
    • Q9UCK9
    • Q9UCL0

    Protein attributes for SAA2 Gene

    122 amino acids
    Molecular mass:
    13527 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SAA2 Gene


neXtProt entry for SAA2 Gene

Post-translational modifications for SAA2 Gene

  • This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SAA2 Gene

No data available for DME Specific Peptides for SAA2 Gene

Domains & Families for SAA2 Gene

Gene Families for SAA2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted secreted proteins

Protein Domains for SAA2 Gene


Suggested Antigen Peptide Sequences for SAA2 Gene

GenScript: Design optimal peptide antigens:
  • Serum amyloid A protein (E9PR14_HUMAN)
  • Serum amyloid A protein (SAA_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SAA family.
  • Belongs to the SAA family.
genes like me logo Genes that share domains with SAA2: view

Function for SAA2 Gene

Molecular function for SAA2 Gene

UniProtKB/Swiss-Prot Function:
Major acute phase reactant. Apolipoprotein of the HDL complex.
UniProtKB/Swiss-Prot Induction:
Upon cytokine stimulation.
GENATLAS Biochemistry:
serum amyloid A,2,acute phase reactant

Phenotypes From GWAS Catalog for SAA2 Gene

Gene Ontology (GO) - Molecular Function for SAA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042056 chemoattractant activity IBA 21873635
genes like me logo Genes that share ontologies with SAA2: view
genes like me logo Genes that share phenotypes with SAA2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SAA2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SAA2 Gene

Localization for SAA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SAA2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SAA2 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SAA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0034364 high-density lipoprotein particle IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with SAA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SAA2 Gene

Pathways & Interactions for SAA2 Gene

PathCards logo

SuperPathways for SAA2 Gene

genes like me logo Genes that share pathways with SAA2: view

Pathways by source for SAA2 Gene

Gene Ontology (GO) - Biological Process for SAA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006953 acute-phase response IEA --
GO:0050918 positive chemotaxis IEA --
GO:0060326 cell chemotaxis IBA 21873635
genes like me logo Genes that share ontologies with SAA2: view

No data available for SIGNOR curated interactions for SAA2 Gene

Drugs & Compounds for SAA2 Gene

(1) Drugs for SAA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SAA2: view

Transcripts for SAA2 Gene

mRNA/cDNA for SAA2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SAA2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SAA2 Gene

No ASD Table

Relevant External Links for SAA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SAA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SAA2 Gene

mRNA differential expression in normal tissues according to GTEx for SAA2 Gene

This gene is overexpressed in Liver (x49.3).

Protein differential expression in normal tissues from HIPED for SAA2 Gene

This gene is overexpressed in Adipocyte (19.8), Serum (13.2), and Heart (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SAA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SAA2 Gene:


SOURCE GeneReport for Unigene cluster for SAA2 Gene:


mRNA Expression by UniProt/SwissProt for SAA2 Gene:

Tissue specificity: Expressed by the liver; secreted in plasma.

Evidence on tissue expression from TISSUES for SAA2 Gene

  • Liver(4.9)
  • Nervous system(4.1)
  • Thyroid gland(4)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with SAA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SAA2 Gene

Orthologs for SAA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SAA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SAA2 33
  • 98 (a)
(Bos Taurus)
Mammalia SAA1 33
  • 75 (a)
(Mus musculus)
Mammalia Saa2 33
  • 69 (a)
(Canis familiaris)
Mammalia -- 33
  • 66 (a)
(Monodelphis domestica)
Mammalia -- 33
  • 66 (a)
-- 33
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 64 (a)
-- 33
  • 61 (a)
-- 33
  • 46 (a)
(Gallus gallus)
Aves -- 33
  • 65 (a)
(Danio rerio)
Actinopterygii saa 33
  • 59 (a)
Species where no ortholog for SAA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SAA2 Gene

Gene Tree for SAA2 (if available)
Gene Tree for SAA2 (if available)
Evolutionary constrained regions (ECRs) for SAA2: view image

Paralogs for SAA2 Gene

Paralogs for SAA2 Gene

(3) SIMAP similar genes for SAA2 Gene using alignment to 4 proteins:

  • E9PR14_HUMAN
  • G3V1D9_HUMAN
  • L8E762_HUMAN Pseudogenes for SAA2 Gene

genes like me logo Genes that share paralogs with SAA2: view

Variants for SAA2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SAA2 Gene

At least 2 different SAA2 alleles have been described: SAA2.1 (SAA2alpha) and SAA2.2 (SAA2beta). We use here the revised nomenclature described in PubMed:10211414. The sequence shown is that of SAA2.2.

Sequence variations from dbSNP and Humsavar for SAA2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000157604 -- 18,246,593(-) A/T intron_variant
rs1000208051 -- 18,246,471(-) G/A/T intron_variant
rs1000390383 -- 18,240,393(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000564520 -- 18,242,842(-) G/A/C genic_downstream_transcript_variant, intron_variant
rs1000680297 -- 18,240,141(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SAA2 Gene

Variant ID Type Subtype PubMed ID
nsv982990 CNV duplication 23825009

Variation tolerance for SAA2 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SAA2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for SAA2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SAA2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
amyloidosis aa
  • aa amyloidosis
  • amyloid disease
familial mediterranean fever
  • fmf
amyloidosis, familial visceral
  • amyloidosis viii
- elite association - COSMIC cancer census association via MalaCards
Search SAA2 in MalaCards View complete list of genes associated with diseases


  • Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA2 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. {ECO:0000269 PubMed:1463770}.

Additional Disease Information for SAA2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SAA2: view

No data available for Genatlas for SAA2 Gene

Publications for SAA2 Gene

  1. Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study. (PMID: 19729864) Carty CL … Reiner AP (Journal of atherosclerosis and thrombosis 2009) 3 23 43 56
  2. The frequencies of the serum amyloid A2 alleles in healthy (Turkish, Azerbaijan and Kazakh) populations. (PMID: 16152805) Taştan H … Tuzun A (Genetika 2005) 3 23 43 56
  3. Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population. (PMID: 15170927) Bakkaloglu A … Yilmaz E (The Journal of rheumatology 2004) 3 23 43 56
  4. A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2). (PMID: 7686132) Steel DM … Whitehead AS (Genomics 1993) 2 3 23 56
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56

Products for SAA2 Gene

Sources for SAA2 Gene