Free for academic non-profit institutions. Other users need a Commercial license
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG rec... See more...
Aliases for S1PR5 Gene
Aliases for S1PR5 Gene
- Sphingosine-1-Phosphate Receptor 5 2 3 5
- Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 8 2 3
- Endothelial Differentiation G-Protein-Coupled Receptor 8 3 4
- Sphingosine 1-Phosphate Receptor Edg-8 3 4
- Sphingosine 1-Phosphate Receptor 5 3 4
- S1P Receptor Edg-8 3 4
- S1P Receptor 5 3 4
External Ids for S1PR5 Gene
- HGNC: 14299
- Entrez Gene: 53637
- Ensembl: ENSG00000180739
- OMIM: 605146
- UniProtKB: Q9H228
Previous HGNC Symbols for S1PR5 Gene
- EDG8
Previous GeneCards Identifiers for S1PR5 Gene
- GC19M010485
- GC19M010626
- GC19M010201
Summaries for S1PR5 Gene
-
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
GeneCards Summary for S1PR5 Gene
S1PR5 (Sphingosine-1-Phosphate Receptor 5) is a Protein Coding gene. Diseases associated with S1PR5 include Second-Degree Atrioventricular Block. Among its related pathways are Signaling by GPCR and Sphingolipid signaling pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is S1PR1.
UniProtKB/Swiss-Prot Summary for S1PR5 Gene
-
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
-
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.
Additional gene information for S1PR5 Gene
- HGNC(14299)
- Entrez Gene(53637)
- Ensembl(ENSG00000180739)
- OMIM(605146)
- UniProtKB(Q9H228)
- Open Targets Platform(ENSG00000180739)
- Search for S1PR5 at DataMed
- Search for S1PR5 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for S1PR5 Gene
Genomics for S1PR5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for S1PR5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around S1PR5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for S1PR5
- Top Transcription factor binding sites by QIAGEN in the S1PR5 gene promoter:
-
- Arnt
- c-Myc
- Egr-4
- GATA-2
- Max
- MIF-1
- Pax-4a
- USF-1
- USF1
Genomic Locations for S1PR5 Gene
Genomic Locations for S1PR5 Gene
- chr19:10,512,742-10,517,965
- (GRCh38/hg38)
- Size:
- 5,224 bases
- Orientation:
- Minus strand
- chr19:10,623,418-10,628,668
- (GRCh37/hg19)
- Size:
- 5,251 bases
- Orientation:
- Minus strand
Genomic View for S1PR5 Gene
Genes around S1PR5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
S1PR5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for S1PR5 Gene
Proteins for S1PR5 Gene
-
Protein details for S1PR5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H228-S1PR5_HUMAN
- Recommended name:
- Sphingosine 1-phosphate receptor 5
- Protein Accession:
- Q9H228
- Q6NW11
Protein attributes for S1PR5 Gene
- Size:
- 398 amino acids
- Molecular mass:
- 41775 Da
- Quaternary structure:
- No Data Available
Protein Expression for S1PR5 Gene
Post-translational modifications for S1PR5 Gene
Other Protein References for S1PR5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences S1PR5 / EDG8 / S1P5 Antibody (LS-A3802) and S1PR5 / EDG8 / S1P5 Antibody (LS-A316)
-
Custom Antibody ServicesOriGene Antibodies for S1PR5
- Novus Biologicals Antibodies for S1PR5
-
Abcam antibodies for S1PR5
- Invitrogen Antibodies for S1PR5 (AFLGC-S1PR5)
-
Biorbyt antibodies for S1PR5
-
Boster Bio Antibodies for S1PR5
Protein Products
-
OriGene Purified Proteins for S1PR5
- Search Origene for MassSpec and Protein Over-expression Lysates for S1PR5
- Origene Custom Protein Services for S1PR5
- antibodies-online: Show 4 available S1PR5 Proteins ranked by validation data
- Compare Top S1PR5 Proteins
-
Quality Products:
-
Abcam proteins for S1PR5
Assay Products
- Novus Biologicals ELISA Kits for S1PR5
- antibodies-online: Show 19 available S1PR5 Elisa Kits ranked by validation data
- Compare Top S1PR5 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for S1PR5 Gene
Domains & Families for S1PR5 Gene
Gene Families for S1PR5 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- FDA approved drug targets
- G-protein coupled receptors
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for S1PR5 Gene
- InterPro:
- Blocks:
-
- Sphingosine 1-phosphate receptor family signature
- EDG-8 sphingosine 1-phosphate receptor signature
- ProtoNet:
Suggested Antigen Peptide Sequences for S1PR5 Gene
- GenScript: Design optimal peptide antigens:
-
- Sphingosine 1-phosphate receptor Edg-8 (S1PR5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9H228- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for S1PR5 Gene
Molecular function for S1PR5 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.
Phenotypes From GWAS Catalog for S1PR5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IEA,IBA | 21873635 |
| GO:0038036 | sphingosine-1-phosphate receptor activity | IEA | -- |
Phenotypes for S1PR5 Gene
- MGI mutant phenotypes for S1PR5:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for S1PR5:
-
- Decreased hepcidin::fluc mRNA expression
- no effect
- Decreased viability
- Decreased vaccinia virus (VACV) infection
- Decreased viability of wild-type and TP53 knockout cells
- Synthetic lethal with Ras
- Increased gamma-H2AX phosphorylation
- Increased shRNA abundance (Z-score > 2)
- Decreased transferrin (TF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased shRNA abundance (Z-score < -2)
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Two nuclei (binuclear)
Animal Model Products
-
Taconic Biosciences Mouse Models for S1PR5
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for S1PR5 - Select products 50% OFF >
- * S1PR5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for S1PR5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for S1PR5
-
Santa Cruz Biotechnology (SCBT) CRISPR for S1PR5
miRNA for S1PR5 Gene
- miRTarBase miRNAs that target S1PR5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for S1PR5
- Browse OriGene Inhibitory RNA Products For S1PR5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for S1PR5
Clone Products
- Applied Biological Materials (abm): Clones for S1PR5 - Select products 50% OFF >
- * S1PR5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for S1PR5
- Addgene plasmids for S1PR5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for S1PR5
Cell Line Products
-
Horizon Cell Lines for S1PR5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S1PR5 Gene
Localization for S1PR5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for S1PR5 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for S1PR5 Gene
Pathways & Interactions for S1PR5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | S1P3 pathway |
.36
|
.01
|
| 4 | Sphingolipid signaling pathway | ||
| 5 | Ceramide Pathway |
Ceramide Pathway
.32
|
|
Pathways by source for S1PR5 Gene
4 BioSystems pathways for S1PR5 Gene
7 Reactome pathways for S1PR5 Gene
2 KEGG pathways for S1PR5 Gene
4 Qiagen pathways for S1PR5 Gene
- Ceramide Pathway
- eNOS Signaling
- Human Embryonic Stem Cell Pluripotency
- S-1P Stimulated Signaling
Interacting Proteins for S1PR5 Gene
Selected Interacting proteins:
Q9H228-S1PR5_HUMAN
ENSP00000328472
for S1PR5 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for S1PR5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003376 | sphingosine-1-phosphate receptor signaling pathway | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA,TAS | -- |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IBA | 21873635 |
| GO:0019222 | regulation of metabolic process | IBA | 21873635 |
Drugs & Compounds for S1PR5 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fingolimod | Approved, Investigational | Pharma | Target, modulator | 0 | ||
| Ozanimod | Approved, Investigational | Pharma | Target, agonist | 0 | ||
| siponimod | Approved, Investigational | Pharma | Target, modulator | 0 | ||
| Sphingosine | Experimental | Pharma | 0 | |||
| Sphingosine-1-phosphate | Pharma | Agonist, Full agonist | endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 | 0 |
(5) Tocris Compounds for S1PR5 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CYM 5442 hydrochloride | Selective S1P1 receptor agonist | 1094042-01-9 |
| RP 001 hydrochloride | Potent S1P1 agonist | 1306761-53-4 |
| SEW 2871 | Cell-permeable, selective S1P1 receptor agonist | 256414-75-2 |
| Sphingosine-1-phosphate | Endogenous agonist at S1P1-5 | 26993-30-6 |
| TC-SP 14 | Potent S1P1 receptor agonist | 1257093-40-5 |
(1) ApexBio Compounds for S1PR5 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Fingolimod (FTY720) | S1P receptors agonist | 162359-56-0 |
Transcripts for S1PR5 Gene
mRNA/cDNA for S1PR5 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000333430 2338 nts (view in UCSC)
- ENST00000439028 2191 nts (view in UCSC)
- ENST00000590601 565 nts (view in UCSC)
- ENST00000617721 1698 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for S1PR5 - Select products 50% OFF >
- * S1PR5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for S1PR5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for S1PR5
-
Santa Cruz Biotechnology (SCBT) CRISPR for S1PR5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for S1PR5
- Browse OriGene Inhibitory RNA Products For S1PR5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for S1PR5
Clone Products
- Applied Biological Materials (abm): Clones for S1PR5 - Select products 50% OFF >
- * S1PR5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for S1PR5
- Addgene plasmids for S1PR5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for S1PR5
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||
| SP2: | - | ||||||||||||
| SP3: |
Relevant External Links for S1PR5 Gene
- GeneLoc Exon Structure for
- S1PR5
Expression for S1PR5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Epithelial Cells
- Basal Cells Trachea
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
- Eye (Sensory Organs)
-
Epidermis (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for S1PR5 Gene
This gene is overexpressed in Whole Blood (x8.9), Brain - Spinal cord (cervical c-1) (x7.2), and Brain - Substantia nigra (x5.4).
This gene is overexpressed in Liver, secretome (39.5), Frontal cortex (15.2), and NK cells (10.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for S1PR5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for S1PR5
SOURCE GeneReport for Unigene cluster for S1PR5 Gene:
Hs.501561mRNA Expression by UniProt/SwissProt for S1PR5 Gene:
Q9H228-S1PR5_HUMAN
Tissue specificity:
Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.
Evidence on tissue expression from TISSUES for S1PR5 Gene
- Blood(4.5)
- Skin(4.4)
- Nervous system(4.4)
- Spleen(2.6)
- Liver(2.5)
- Bone marrow(2.4)
- Heart(2.2)
- Lymph node(2.2)
Primer Products
-
OriGene qPCR primer pairs for S1PR5
-
OriGene qPCR primer pairs and template standards for S1PR5
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for S1PR5 Gene
Orthologs for S1PR5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | S1PR5 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | S1PR5 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | S1PR5 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | S1pr5 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | S1pr5 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | S1PR5 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | S1PR5 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | s1pr5b 30 31 |
|
OneToMany | |
| s1pr5a 31 |
|
OneToMany |
- Species where no ortholog for S1PR5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for S1PR5 Gene
- ENSEMBL:
- Gene Tree for S1PR5 (if available)
- TreeFam:
- Gene Tree for S1PR5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for S1PR5: view image
Paralogs for S1PR5 Gene
Paralogs for S1PR5 Gene
(11) SIMAP similar genes for S1PR5 Gene using alignment to 3 proteins:
- S1PR5_HUMAN
- K7EIT5_HUMAN
- L8ECK7_HUMAN
Variants for S1PR5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for S1PR5 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 748408 | Likely Benign: not provided | 10,514,583(-) | C/T | SYNONYMOUS_VARIANT | |
| 769957 | Benign: not provided | 10,514,445(-) | G/A | SYNONYMOUS_VARIANT | |
| 781454 | Benign: not provided | 10,514,187(-) | C/T | SYNONYMOUS_VARIANT | |
| 788017 | Likely Benign: not provided | 10,513,834(-) | G/C | NONSENSE | |
| 788018 | Benign: not provided | 10,514,089(-) | A/T | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.33;
53.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for S1PR5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- S1PR5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR5 Gene
Disorders for S1PR5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| second-degree atrioventricular block |
|
|
Search S1PR5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for S1PR5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for S1PR5 Gene
Publications for S1PR5 Gene
- Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers. (PMID: 15530552) Ulfig N … Briese M (Acta histochemica 2004) 3 4 23
- Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia. (PMID: 12427546) Kothapalli R … Loughran TP (Biochimica et biophysica acta 2002) 3 4 23
- Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. (PMID: 11705398) Im DS … Lynch KR (Biochemistry 2001) 3 4 23
- A genome-wide study reveals copy number variants exclusive to childhood obesity cases. (PMID: 20950786) Glessner JT … Grant SF (American journal of human genetics 2010) 3 41
- The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. (PMID: 19211033) Gillies L … Pyne S (Cellular signalling 2009) 3 23
ExternalLinks
Products for S1PR5 Gene
- Custom Antibody ServicesOriGene Antibodies for S1PR5
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for S1PR5
- Search Origene for MassSpec and Protein Over-expression Lysates for S1PR5
- Origene Custom Protein Services for S1PR5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for S1PR5
- Browse OriGene Inhibitory RNA Products For S1PR5
- OriGene qPCR primer pairs for S1PR5
- OriGene qPCR primer pairs and template standards for S1PR5
- OriGene CRISPR knockouts for S1PR5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For S1PR5
- Sino Biological Human cDNA Clone for S1PR5
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for S1PR5
- Novus Biologicals proteins and lysates for S1PR5
- Novus Biologicals ELISA Kits for S1PR5
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for S1PR5
- Abcam proteins for S1PR5
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for S1PR5
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for S1PR5 (AFLGC-S1PR5)
- ApexBio compounds for S1PR5
- VectorBuilder Custom and pre-made DNA vectors for S1PR5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for S1PR5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for S1PR5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for S1PR5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for S1PR5
- Addgene plasmids for S1PR5
- antibodies-online: Show 26 available S1PR5 Antibodies ranked by validation data
- Compare Top S1PR5 Antibodies
- antibodies-online: Show 19 available S1PR5 Elisa Kits ranked by validation data
- Compare Top S1PR5 Elisa Kits
- Quality Products:
- antibodies-online: Show 4 available S1PR5 Proteins ranked by validation data
- Compare Top S1PR5 Proteins
- Quality Products:
- Horizon Cell Lines for S1PR5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for S1PR5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for S1PR5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for S1PR5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for S1PR5
- Boster Bio Antibodies for S1PR5
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for S1PR5
Sources for S1PR5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB