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The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
S1PR5 (Sphingosine-1-Phosphate Receptor 5) is a Protein Coding gene. Diseases associated with S1PR5 include Second-Degree Atrioventricular Block. Among its related pathways are Signaling by GPCR and Sphingolipid signaling pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is S1PR1.
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA,IBA | 21873635 |
GO:0038036 | sphingosine-1-phosphate receptor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | S1P3 pathway |
.36
|
.01
|
4 | Sphingolipid signaling pathway | ||
5 | Ceramide Pathway |
Ceramide Pathway
.32
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003376 | sphingosine-1-phosphate receptor signaling pathway | IEA | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA,TAS | -- |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IBA | 21873635 |
GO:0019222 | regulation of metabolic process | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Fingolimod | Approved, Investigational | Pharma | Target, modulator | 0 | ||
Ozanimod | Approved, Investigational | Pharma | Target, agonist | 0 | ||
siponimod | Approved, Investigational | Pharma | Target, modulator | 0 | ||
Sphingosine | Experimental | Pharma | 0 | |||
Sphingosine-1-phosphate | Pharma | Agonist, Full agonist | endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 | 0 |
Compound | Action | Cas Number |
---|---|---|
CYM 5442 hydrochloride | Selective S1P1 receptor agonist | 1094042-01-9 |
RP 001 hydrochloride | Potent S1P1 agonist | 1306761-53-4 |
SEW 2871 | Cell-permeable, selective S1P1 receptor agonist | 256414-75-2 |
Sphingosine-1-phosphate | Endogenous agonist at S1P1-5 | 26993-30-6 |
TC-SP 14 | Potent S1P1 receptor agonist | 1257093-40-5 |
Compound | Action | Cas Number |
---|---|---|
Fingolimod (FTY720) | S1P receptors agonist | 162359-56-0 |
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||
SP2: | - | ||||||||||||
SP3: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | S1PR5 30 |
|
||
Dog (Canis familiaris) |
Mammalia | S1PR5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | S1PR5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | S1pr5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | S1pr5 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | S1PR5 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | S1PR5 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | s1pr5b 30 31 |
|
OneToMany | |
s1pr5a 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
748408 | Likely Benign: not provided | 10,514,583(-) | C/T | SYNONYMOUS_VARIANT | |
769957 | Benign: not provided | 10,514,445(-) | G/A | SYNONYMOUS_VARIANT | |
781454 | Benign: not provided | 10,514,187(-) | C/T | SYNONYMOUS_VARIANT | |
788017 | Likely Benign: not provided | 10,513,834(-) | G/C | NONSENSE | |
788018 | Benign: not provided | 10,514,089(-) | A/T | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
second-degree atrioventricular block |
|
|