The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG rec... See more...

Aliases for S1PR5 Gene

Aliases for S1PR5 Gene

  • Sphingosine-1-Phosphate Receptor 5 2 3 5
  • Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 8 2 3
  • Endothelial Differentiation G-Protein-Coupled Receptor 8 3 4
  • Sphingosine 1-Phosphate Receptor Edg-8 3 4
  • Sphingosine 1-Phosphate Receptor 5 3 4
  • S1P Receptor Edg-8 3 4
  • S1P Receptor 5 3 4
  • Edg-8 2 3
  • EDG8 3 4
  • S1P5 3 4
  • Sphingosine 1-Phosphate Receptor EDG8 3
  • SPPR-1 3
  • SPPR-2 3
  • S1PR5 5

External Ids for S1PR5 Gene

Previous HGNC Symbols for S1PR5 Gene

  • EDG8

Previous GeneCards Identifiers for S1PR5 Gene

  • GC19M010485
  • GC19M010626
  • GC19M010201

Summaries for S1PR5 Gene

Entrez Gene Summary for S1PR5 Gene

  • The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]

GeneCards Summary for S1PR5 Gene

S1PR5 (Sphingosine-1-Phosphate Receptor 5) is a Protein Coding gene. Diseases associated with S1PR5 include Second-Degree Atrioventricular Block and Autoimmune Disease Of Central Nervous System. Among its related pathways are Ceramide Pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is S1PR1.

UniProtKB/Swiss-Prot Summary for S1PR5 Gene

  • Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

Tocris Summary for S1PR5 Gene

  • Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.

Gene Wiki entry for S1PR5 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for S1PR5 Gene

Genomics for S1PR5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for S1PR5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S1PR5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for S1PR5

Top Transcription factor binding sites by QIAGEN in the S1PR5 gene promoter:
  • Arnt
  • c-Myc
  • Egr-4
  • GATA-2
  • Max
  • MIF-1
  • Pax-4a
  • USF-1
  • USF1

Genomic Locations for S1PR5 Gene

Latest Assembly
chr19:10,512,742-10,517,965
(GRCh38/hg38)
Size:
5,224 bases
Orientation:
Minus strand

Previous Assembly
chr19:10,623,418-10,628,641
(GRCh37/hg19 by Entrez Gene)
Size:
5,224 bases
Orientation:
Minus strand

chr19:10,623,623-10,628,607
(GRCh37/hg19 by Ensembl)
Size:
4,985 bases
Orientation:
Minus strand

Genomic View for S1PR5 Gene

Genes around S1PR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S1PR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S1PR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S1PR5 Gene

Proteins for S1PR5 Gene

  • Protein details for S1PR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H228-S1PR5_HUMAN
    Recommended name:
    Sphingosine 1-phosphate receptor 5
    Protein Accession:
    Q9H228
    Secondary Accessions:
    • Q6NW11

    Protein attributes for S1PR5 Gene

    Size:
    398 amino acids
    Molecular mass:
    41775 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for S1PR5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for S1PR5 Gene

Post-translational modifications for S1PR5 Gene

  • Glycosylation at Asn20
  • Modification sites at PhosphoSitePlus

Other Protein References for S1PR5 Gene

No data available for DME Specific Peptides for S1PR5 Gene

Domains & Families for S1PR5 Gene

Gene Families for S1PR5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for S1PR5 Gene

InterPro:
Blocks:
  • Sphingosine 1-phosphate receptor family signature
  • EDG-8 sphingosine 1-phosphate receptor signature

Suggested Antigen Peptide Sequences for S1PR5 Gene

GenScript: Design optimal peptide antigens:
  • Sphingosine 1-phosphate receptor Edg-8 (S1PR5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H228

UniProtKB/Swiss-Prot:

S1PR5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with S1PR5: view

Function for S1PR5 Gene

Molecular function for S1PR5 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

Phenotypes From GWAS Catalog for S1PR5 Gene

Gene Ontology (GO) - Molecular Function for S1PR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0005515 protein binding IPI 32296183
GO:0038036 sphingosine-1-phosphate receptor activity IEA --
genes like me logo Genes that share ontologies with S1PR5: view
genes like me logo Genes that share phenotypes with S1PR5: view

Animal Models for S1PR5 Gene

MGI Knock Outs for S1PR5:

Animal Models for research

  • Taconic Biosciences Mouse Models for S1PR5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for S1PR5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S1PR5 Gene

Localization for S1PR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S1PR5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S1PR5 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for S1PR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with S1PR5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for S1PR5 Gene

Pathways & Interactions for S1PR5 Gene

genes like me logo Genes that share pathways with S1PR5: view

Pathways by source for S1PR5 Gene

4 Qiagen pathways for S1PR5 Gene
  • Ceramide Pathway
  • eNOS Signaling
  • Human Embryonic Stem Cell Pluripotency
  • S-1P Stimulated Signaling

SIGNOR curated interactions for S1PR5 Gene

Activates:

Gene Ontology (GO) - Biological Process for S1PR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003376 sphingosine-1-phosphate receptor signaling pathway IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
GO:0019222 regulation of metabolic process IBA 21873635
genes like me logo Genes that share ontologies with S1PR5: view

Drugs & Compounds for S1PR5 Gene

(16) Drugs for S1PR5 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fingolimod Approved, Investigational Pharma Target, modulator 0
Ozanimod Approved, Investigational Pharma Target, agonist 0
siponimod Approved, Investigational Pharma Target, modulator 0
Sphingosine Experimental Pharma 0
Sphingosine-1-phosphate Pharma Agonist endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0

(5) Tocris Compounds for S1PR5 Gene

Compound Action Cas Number
CYM 5442 hydrochloride Selective S1P1 receptor agonist 1094042-01-9
RP 001 hydrochloride Potent S1P1 agonist 1306761-53-4
SEW 2871 Cell-permeable, selective S1P1 receptor agonist 256414-75-2
Sphingosine-1-phosphate Endogenous agonist at S1P1-5 26993-30-6
TC-SP 14 Potent S1P1 receptor agonist 1257093-40-5

(1) ApexBio Compounds for S1PR5 Gene

Compound Action Cas Number
Fingolimod (FTY720) S1P receptors agonist 162359-56-0
genes like me logo Genes that share compounds with S1PR5: view

Drug products for research

Transcripts for S1PR5 Gene

mRNA/cDNA for S1PR5 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for S1PR5

Alternative Splicing Database (ASD) splice patterns (SP) for S1PR5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - - -
SP2: -
SP3:

Relevant External Links for S1PR5 Gene

GeneLoc Exon Structure for
S1PR5

Expression for S1PR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for S1PR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S1PR5 Gene

This gene is overexpressed in Whole Blood (x8.9), Brain - Spinal cord (cervical c-1) (x7.2), and Brain - Substantia nigra (x5.4).

Protein differential expression in normal tissues from HIPED for S1PR5 Gene

This gene is overexpressed in Liver, secretome (39.5), Frontal cortex (15.2), and NK cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for S1PR5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for S1PR5

SOURCE GeneReport for Unigene cluster for S1PR5 Gene:

Hs.501561

mRNA Expression by UniProt/SwissProt for S1PR5 Gene:

Q9H228-S1PR5_HUMAN
Tissue specificity: Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for S1PR5 Gene

  • Blood(4.5)
  • Skin(4.4)
  • Nervous system(4.4)
  • Spleen(2.4)
  • Liver(2.3)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with S1PR5: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for S1PR5 Gene

Orthologs for S1PR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S1PR5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia S1PR5 29
  • 99.32 (n)
Dog
(Canis familiaris)
Mammalia S1PR5 29 30
  • 85.68 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia S1PR5 29 30
  • 84.84 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia S1pr5 29 16 30
  • 79.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia S1pr5 29
  • 79.7 (n)
Oppossum
(Monodelphis domestica)
Mammalia S1PR5 30
  • 72 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia S1PR5 30
  • 52 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii s1pr5b 29 30
  • 62.02 (n)
OneToMany
s1pr5a 30
  • 47 (a)
OneToMany
Species where no ortholog for S1PR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for S1PR5 Gene

ENSEMBL:
Gene Tree for S1PR5 (if available)
TreeFam:
Gene Tree for S1PR5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for S1PR5: view image
Alliance of Genome Resources:
Additional Orthologs for S1PR5

Paralogs for S1PR5 Gene

(11) SIMAP similar genes for S1PR5 Gene using alignment to 3 proteins:

  • S1PR5_HUMAN
  • K7EIT5_HUMAN
  • L8ECK7_HUMAN
genes like me logo Genes that share paralogs with S1PR5: view

Variants for S1PR5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for S1PR5 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs140531381 Likely Benign: not provided 10,513,834(-) G/C
NM_030760.5(S1PR5):c.1178C>G (p.Ser393Ter)
NONSENSE
rs1445236954 Likely Benign: not provided 10,514,583(-) C/T
NM_030760.5(S1PR5):c.429G>A (p.Ala143=)
SYNONYMOUS
rs149806324 Benign: not provided 10,514,089(-) A/T
NM_030760.5(S1PR5):c.923T>A (p.Leu308His)
MISSENSE
rs34803021 Benign: not provided 10,514,445(-) G/A
NM_030760.5(S1PR5):c.567C>T (p.Tyr189=)
SYNONYMOUS
rs35940589 Benign: not provided 10,514,589(-) C/T
NM_030760.5(S1PR5):c.423G>A (p.Gly141=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for S1PR5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for S1PR5 Gene

Variant ID Type Subtype PubMed ID
nsv833744 CNV loss 17160897

Variation tolerance for S1PR5 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S1PR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S1PR5
Leiden Open Variation Database (LOVD)
S1PR5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR5 Gene

Disorders for S1PR5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for S1PR5 Gene - From: COP

Disorder Aliases PubMed IDs
second-degree atrioventricular block
  • second-degree heart block
autoimmune disease of central nervous system
- elite association - COSMIC cancer census association via MalaCards
Search S1PR5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for S1PR5

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with S1PR5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S1PR5 Gene

Publications for S1PR5 Gene

  1. Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers. (PMID: 15530552) Ulfig N … Briese M (Acta histochemica 2004) 3 4 22
  2. Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia. (PMID: 12427546) Kothapalli R … Loughran TP (Biochimica et biophysica acta 2002) 3 4 22
  3. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. (PMID: 11705398) Im DS … Lynch KR (Biochemistry 2001) 3 4 22
  4. A genome-wide study reveals copy number variants exclusive to childhood obesity cases. (PMID: 20950786) Glessner JT … Grant SF (American journal of human genetics 2010) 3 40
  5. The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. (PMID: 19211033) Gillies L … Pyne S (Cellular signalling 2009) 3 22

Products for S1PR5 Gene

Sources for S1PR5 Gene