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Aliases for S1PR5 Gene

Aliases for S1PR5 Gene

  • Sphingosine-1-Phosphate Receptor 5 2 3 5
  • Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 8 2 3
  • Endothelial Differentiation G-Protein-Coupled Receptor 8 3 4
  • Sphingosine 1-Phosphate Receptor Edg-8 3 4
  • S1P Receptor Edg-8 3 4
  • S1P Receptor 5 3 4
  • EDG8 3 4
  • S1P5 3 4
  • Sphingosine 1-Phosphate Receptor EDG8 3
  • Sphingosine 1-Phosphate Receptor 5 3
  • SPPR-1 3
  • SPPR-2 3
  • Edg-8 3

External Ids for S1PR5 Gene

Previous HGNC Symbols for S1PR5 Gene

  • EDG8

Previous GeneCards Identifiers for S1PR5 Gene

  • GC19M010485
  • GC19M010626
  • GC19M010201

Summaries for S1PR5 Gene

Entrez Gene Summary for S1PR5 Gene

  • The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]

GeneCards Summary for S1PR5 Gene

S1PR5 (Sphingosine-1-Phosphate Receptor 5) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and S1P3 pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is S1PR1.

UniProtKB/Swiss-Prot for S1PR5 Gene

  • Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

Tocris Summary for S1PR5 Gene

  • Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.

Gene Wiki entry for S1PR5 Gene

Additional gene information for S1PR5 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S1PR5 Gene

Genomics for S1PR5 Gene

GeneHancer (GH) Regulatory Elements for S1PR5 Gene

Promoters and enhancers for S1PR5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I010514 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 582.8 +0.8 776 5.2 FOXA2 ZNF48 ZNF121 GLIS2 KLF7 ZNF263 SP3 ZNF623 ZNF610 GLIS1 S1PR5 LOC100419831 ILF3 KRI1 QTRT1 ATG4D ZNF846 CDKN2D SLC44A2 ZNF562
GH19I010100 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.2 +413.6 413605 8.3 HDGF FOXA2 PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 PPAN ANGPTL6 PPAN-P2RY11 ZNF699 ILF3 LOC100419831 ZNF317 FBXL12 ZNF559 KRI1
GH19I010235 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +280.6 280644 4.4 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 YBX1 IRF4 S1PR5 COL5A3 RDH8 MRPL4 S1PR2 ATG4D C19orf66 TYK2 DNM2 FBXL12
GH19I010717 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.4 -201.2 -201163 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 ZNF2 ZBTB7B DNM2 GC19P010718 MIR638 KRI1 EIF3G ILF3 FBXL12 RAVER1 TIMM29 PPAN
GH19I010601 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.1 -86.1 -86131 4.4 ARID4B DMAP1 ZNF2 TCF12 ZNF121 ZNF766 GLIS2 ZNF213 ZNF143 KLF7 SLC44A2 CDKN2D KRI1 ICAM3 ILF3 ZNF627 PRKCSH TYK2 DNM2 S1PR5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around S1PR5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the S1PR5 gene promoter:

Genomic Locations for S1PR5 Gene

Genomic Locations for S1PR5 Gene
chr19:10,512,742-10,517,992
(GRCh38/hg38)
Size:
5,251 bases
Orientation:
Minus strand
chr19:10,623,418-10,628,668
(GRCh37/hg19)

Genomic View for S1PR5 Gene

Genes around S1PR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S1PR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S1PR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S1PR5 Gene

Proteins for S1PR5 Gene

  • Protein details for S1PR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H228-S1PR5_HUMAN
    Recommended name:
    Sphingosine 1-phosphate receptor 5
    Protein Accession:
    Q9H228
    Secondary Accessions:
    • Q6NW11

    Protein attributes for S1PR5 Gene

    Size:
    398 amino acids
    Molecular mass:
    41775 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for S1PR5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for S1PR5 Gene

Post-translational modifications for S1PR5 Gene

Other Protein References for S1PR5 Gene

No data available for DME Specific Peptides for S1PR5 Gene

Domains & Families for S1PR5 Gene

Gene Families for S1PR5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for S1PR5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H228

UniProtKB/Swiss-Prot:

S1PR5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with S1PR5: view

Function for S1PR5 Gene

Molecular function for S1PR5 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

Phenotypes From GWAS Catalog for S1PR5 Gene

Gene Ontology (GO) - Molecular Function for S1PR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0038036 sphingosine-1-phosphate receptor activity IEA --
genes like me logo Genes that share ontologies with S1PR5: view
genes like me logo Genes that share phenotypes with S1PR5: view

Animal Models for S1PR5 Gene

MGI Knock Outs for S1PR5:

Animal Model Products

miRNA for S1PR5 Gene

miRTarBase miRNAs that target S1PR5

Clone Products

  • Addgene plasmids for S1PR5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S1PR5 Gene

Localization for S1PR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S1PR5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S1PR5 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for S1PR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with S1PR5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for S1PR5 Gene

Pathways & Interactions for S1PR5 Gene

genes like me logo Genes that share pathways with S1PR5: view

Gene Ontology (GO) - Biological Process for S1PR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003376 sphingosine-1-phosphate signaling pathway IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
GO:0045664 regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with S1PR5: view

No data available for SIGNOR curated interactions for S1PR5 Gene

Drugs & Compounds for S1PR5 Gene

(15) Drugs for S1PR5 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fingolimod Approved, Investigational Pharma Target, modulator 0
Sphingosine Experimental Pharma 0
AFD(R) Pharma Agonist 0
compound 26 [PMID:16190743] Pharma Agonist 0
FTY720-phosphate Pharma Agonist 0

(5) Tocris Compounds for S1PR5 Gene

Compound Action Cas Number
CYM 5442 hydrochloride Selective S1P1 receptor agonist 1094042-01-9
RP 001 hydrochloride Potent S1P1 agonist 1306761-53-4
SEW 2871 Cell-permeable, selective S1P1 receptor agonist 256414-75-2
Sphingosine-1-phosphate Endogenous agonist at S1P1-5 26993-30-6
TC-SP 14 Potent S1P1 receptor agonist 1257093-40-5

(1) ApexBio Compounds for S1PR5 Gene

Compound Action Cas Number
Fingolimod (FTY720) S1P receptors agonist 162359-56-0
genes like me logo Genes that share compounds with S1PR5: view

Drug Products

Transcripts for S1PR5 Gene

Unigene Clusters for S1PR5 Gene

Sphingosine-1-phosphate receptor 5:
Representative Sequences:

Clone Products

  • Addgene plasmids for S1PR5

Alternative Splicing Database (ASD) splice patterns (SP) for S1PR5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - - -
SP2: -
SP3:

Relevant External Links for S1PR5 Gene

GeneLoc Exon Structure for
S1PR5
ECgene alternative splicing isoforms for
S1PR5

Expression for S1PR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S1PR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for S1PR5 Gene

This gene is overexpressed in Whole Blood (x8.9), Brain - Spinal cord (cervical c-1) (x7.2), and Brain - Substantia nigra (x5.4).

Protein differential expression in normal tissues from HIPED for S1PR5 Gene

This gene is overexpressed in Liver, secretome (39.5), Frontal cortex (15.2), and NK cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for S1PR5 Gene



NURSA nuclear receptor signaling pathways regulating expression of S1PR5 Gene:

S1PR5

SOURCE GeneReport for Unigene cluster for S1PR5 Gene:

Hs.501561

mRNA Expression by UniProt/SwissProt for S1PR5 Gene:

Q9H228-S1PR5_HUMAN
Tissue specificity: Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for S1PR5 Gene

  • Blood(4.4)
  • Skin(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with S1PR5: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for S1PR5 Gene

Orthologs for S1PR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S1PR5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S1PR5 33
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia S1PR5 33 34
  • 85.68 (n)
cow
(Bos Taurus)
Mammalia S1PR5 33 34
  • 84.84 (n)
mouse
(Mus musculus)
Mammalia S1pr5 33 16 34
  • 79.93 (n)
rat
(Rattus norvegicus)
Mammalia S1pr5 33
  • 79.7 (n)
oppossum
(Monodelphis domestica)
Mammalia S1PR5 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia S1PR5 34
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii s1pr5b 33 34
  • 62.02 (n)
s1pr5a 34
  • 47 (a)
OneToMany
Species where no ortholog for S1PR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S1PR5 Gene

ENSEMBL:
Gene Tree for S1PR5 (if available)
TreeFam:
Gene Tree for S1PR5 (if available)

Paralogs for S1PR5 Gene

Paralogs for S1PR5 Gene

(11) SIMAP similar genes for S1PR5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with S1PR5: view

Variants for S1PR5 Gene

Sequence variations from dbSNP and Humsavar for S1PR5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1001150558 -- 10,513,294(-) C/G 3_prime_UTR_variant
rs1001320375 -- 10,519,115(-) C/T upstream_transcript_variant
rs1001535454 -- 10,516,935(-) G/T intron_variant
rs1001866094 -- 10,518,033(-) C/A upstream_transcript_variant
rs1001875917 -- 10,518,449(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for S1PR5 Gene

Variant ID Type Subtype PubMed ID
nsv833744 CNV loss 17160897

Variation tolerance for S1PR5 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S1PR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
S1PR5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR5 Gene

Disorders for S1PR5 Gene

Additional Disease Information for S1PR5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for S1PR5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for S1PR5 Gene

Publications for S1PR5 Gene

  1. Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers. (PMID: 15530552) Ulfig N … Briese M (Acta histochemica 2004) 3 4 22 58
  2. Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia. (PMID: 12427546) Kothapalli R … Loughran TP (Biochimica et biophysica acta 2002) 3 4 22 58
  3. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. (PMID: 11705398) Im DS … Lynch KR (Biochemistry 2001) 3 4 22 58
  4. A genome-wide study reveals copy number variants exclusive to childhood obesity cases. (PMID: 20950786) Glessner JT … Grant SF (American journal of human genetics 2010) 3 44 58
  5. The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. (PMID: 19211033) Gillies L … Pyne S (Cellular signalling 2009) 3 22 58

Products for S1PR5 Gene

Sources for S1PR5 Gene

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