This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008] See more...

Aliases for S1PR4 Gene

Aliases for S1PR4 Gene

  • Sphingosine-1-Phosphate Receptor 4 2 3 5
  • Endothelial Differentiation, Lysophosphatidic Acid G-Protein-Coupled Receptor, 6 2 3
  • Endothelial Differentiation G-Protein Coupled Receptor 6 3 4
  • Sphingosine 1-Phosphate Receptor Edg-6 3 4
  • Sphingosine 1-Phosphate Receptor 4 3 4
  • S1P Receptor Edg-6 3 4
  • S1P Receptor 4 3 4
  • EDG6 3 4
  • S1P4 3 4
  • Endothelial Differentiation, G-Protein-Coupled Receptor 6 2
  • LPC1 3
  • SLP4 3

External Ids for S1PR4 Gene

Previous HGNC Symbols for S1PR4 Gene

  • EDG6

Previous GeneCards Identifiers for S1PR4 Gene

  • GC19P003130
  • GC19P002945

Summaries for S1PR4 Gene

Entrez Gene Summary for S1PR4 Gene

  • This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]

GeneCards Summary for S1PR4 Gene

S1PR4 (Sphingosine-1-Phosphate Receptor 4) is a Protein Coding gene. Diseases associated with S1PR4 include Dermatitis, Atopic, 7 and Diversion Colitis. Among its related pathways are Signaling by GPCR and S1P3 pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is S1PR5.

UniProtKB/Swiss-Prot Summary for S1PR4 Gene

  • Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.

Tocris Summary for S1PR4 Gene

  • Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.

Gene Wiki entry for S1PR4 Gene

Additional gene information for S1PR4 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for S1PR4 Gene

Genomics for S1PR4 Gene

GeneHancer (GH) Regulatory Elements for S1PR4 Gene

Promoters and enhancers for S1PR4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J003171 Enhancer 0.8 ENCODE dbSUPER 500.7 +0.0 48 1.5 POLR2G ZSCAN9 USF1 MEF2B SMAD4 EBF1 ZBTB5 RB1 ZMYM3 ZSCAN16 S1PR4 GNA15 GNA11 lnc-AES-8
GH19J003175 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.4 +6.4 6376 6.2 SIN3A TCF12 EP300 ZIC2 POLR2A CLOCK CTBP1 REST PRPF4 SREBF2 NCLN SF3A2 GNA15 APBA3 S1PR4 CACTIN-AS1 ENSG00000267139 GNA11 CACTIN ENSG00000268670
GH19J002976 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 11 -194.9 -194883 2.5 EP300 CTCF SIN3A POLR2G USF1 SP1 NCOR1 FOS ZIC2 POLR2A TLE6 GNA11 ZNF77 S1PR4 NCLN ENSG00000253392 ZNF57 SLC39A3 RF00017-2740
GH19J002968 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.2 -200.6 -200589 6.7 USF1 ZNF10 ZNF263 AFF1 REST HES1 TOE1 MYC RUNX1 EP300 NCLN TLE6 TLE2 TLE5 ZNF77 GNA11 ENSG00000253392 ZNF57 S1PR4 ENSG00000267283
GH19J003210 Enhancer 1 Ensembl ENCODE 12.6 +38.5 38545 1 CTCF ZNF623 GABPA REST TRIM22 SMC3 HDAC2 ZNF341 POLR2A PCBP1 NCLN CACTIN ZNF77 SF3A2 S1PR4 GNA11 TLE6 CACTIN-AS1 CELF5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around S1PR4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for S1PR4

Top Transcription factor binding sites by QIAGEN in the S1PR4 gene promoter:
  • C/EBPalpha
  • GR
  • HEN1
  • HOXA5
  • HSF1 (long)
  • HSF1short
  • NRSF form 1
  • NRSF form 2
  • Pax-5
  • PPAR-alpha

Genomic Locations for S1PR4 Gene

Genomic Locations for S1PR4 Gene
chr19:3,172,346-3,180,332
(GRCh38/hg38)
Size:
7,987 bases
Orientation:
Plus strand
chr19:3,172,344-3,180,330
(GRCh37/hg19)
Size:
7,987 bases
Orientation:
Plus strand

Genomic View for S1PR4 Gene

Genes around S1PR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S1PR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S1PR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S1PR4 Gene

Proteins for S1PR4 Gene

  • Protein details for S1PR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95977-S1PR4_HUMAN
    Recommended name:
    Sphingosine 1-phosphate receptor 4
    Protein Accession:
    O95977
    Secondary Accessions:
    • D6W612

    Protein attributes for S1PR4 Gene

    Size:
    384 amino acids
    Molecular mass:
    41623 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for S1PR4 Gene

neXtProt entry for S1PR4 Gene

Post-translational modifications for S1PR4 Gene

  • Glycosylation at Asn2 and Asn30
  • Modification sites at PhosphoSitePlus

Other Protein References for S1PR4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for S1PR4 Gene

Domains & Families for S1PR4 Gene

Gene Families for S1PR4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for S1PR4 Gene

Blocks:
  • Sphingosine 1-phosphate receptor family signature
  • EDG-6 sphingosine 1-phosphate receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for S1PR4 Gene

GenScript: Design optimal peptide antigens:
  • Sphingosine 1-phosphate receptor Edg-6 (S1PR4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95977

UniProtKB/Swiss-Prot:

S1PR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with S1PR4: view

Function for S1PR4 Gene

Molecular function for S1PR4 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.

Phenotypes From GWAS Catalog for S1PR4 Gene

Gene Ontology (GO) - Molecular Function for S1PR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity TAS 10679247
GO:0008289 lipid binding TAS 10679247
GO:0038036 sphingosine-1-phosphate receptor activity IEA --
genes like me logo Genes that share ontologies with S1PR4: view
genes like me logo Genes that share phenotypes with S1PR4: view

Animal Models for S1PR4 Gene

MGI Knock Outs for S1PR4:

Animal Model Products

  • Taconic Biosciences Mouse Models for S1PR4

Clone Products

  • Addgene plasmids for S1PR4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for S1PR4 Gene

Localization for S1PR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S1PR4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S1PR4 gene
Compartment Confidence
plasma membrane 5
mitochondrion 4
extracellular 2
cytoskeleton 2
nucleus 2
cytosol 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for S1PR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005739 mitochondrion IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9790765
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with S1PR4: view

Pathways & Interactions for S1PR4 Gene

genes like me logo Genes that share pathways with S1PR4: view

Pathways by source for S1PR4 Gene

4 Qiagen pathways for S1PR4 Gene
  • Ceramide Pathway
  • eNOS Signaling
  • Human Embryonic Stem Cell Pluripotency
  • S-1P Stimulated Signaling

Gene Ontology (GO) - Biological Process for S1PR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003376 sphingosine-1-phosphate receptor signaling pathway IEA --
GO:0006955 immune response TAS 9790765
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with S1PR4: view

No data available for SIGNOR curated interactions for S1PR4 Gene

Drugs & Compounds for S1PR4 Gene

(13) Drugs for S1PR4 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0
AFD(R) Pharma Agonist 0
compound 26 [PMID:16190743] Pharma Agonist 0
phytosphingosine 1-phosphate Pharma Agonist 0

(2) Additional Compounds for S1PR4 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dihydrosp?aehingosine?ae-1-phosph?aeate
Full agonist, Agonist

(5) Tocris Compounds for S1PR4 Gene

Compound Action Cas Number
CYM 5442 hydrochloride Selective S1P1 receptor agonist 1094042-01-9
RP 001 hydrochloride Potent S1P1 agonist 1306761-53-4
SEW 2871 Cell-permeable, selective S1P1 receptor agonist 256414-75-2
Sphingosine-1-phosphate Endogenous agonist at S1P1-5 26993-30-6
TC-SP 14 Potent S1P1 receptor agonist 1257093-40-5

(1) ApexBio Compounds for S1PR4 Gene

Compound Action Cas Number
Fingolimod (FTY720) S1P receptors agonist 162359-56-0
genes like me logo Genes that share compounds with S1PR4: view

Drug Products

Transcripts for S1PR4 Gene

mRNA/cDNA for S1PR4 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for S1PR4

Alternative Splicing Database (ASD) splice patterns (SP) for S1PR4 Gene

No ASD Table

Relevant External Links for S1PR4 Gene

GeneLoc Exon Structure for
S1PR4

Expression for S1PR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for S1PR4 Gene

mRNA differential expression in normal tissues according to GTEx for S1PR4 Gene

This gene is overexpressed in Whole Blood (x43.1).

Protein differential expression in normal tissues from HIPED for S1PR4 Gene

This gene is overexpressed in Monocytes (39.2) and Peripheral blood mononuclear cells (21.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for S1PR4 Gene



Protein tissue co-expression partners for S1PR4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for S1PR4

SOURCE GeneReport for Unigene cluster for S1PR4 Gene:

Hs.662006

mRNA Expression by UniProt/SwissProt for S1PR4 Gene:

O95977-S1PR4_HUMAN
Tissue specificity: Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.

Evidence on tissue expression from TISSUES for S1PR4 Gene

  • Blood(4.4)
  • Lymph node(4.4)
  • Spleen(4.4)
genes like me logo Genes that share expression patterns with S1PR4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for S1PR4 Gene

Orthologs for S1PR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S1PR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S1PR4 31 30
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia S1PR4 31 30
  • 87.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia S1PR4 31 30
  • 85.5 (n)
OneToOne
mouse
(Mus musculus)
Mammalia S1pr4 17 31 30
  • 81.17 (n)
rat
(Rattus norvegicus)
Mammalia S1pr4 30
  • 80.37 (n)
oppossum
(Monodelphis domestica)
Mammalia S1PR4 31
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia S1PR4 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves S1PR4 31 30
  • 65.22 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia S1PR4 31
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia s1pr4 30
  • 53.72 (n)
zebrafish
(Danio rerio)
Actinopterygii s1pr4 31 30
  • 55.27 (n)
OneToOne
Species where no ortholog for S1PR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S1PR4 Gene

ENSEMBL:
Gene Tree for S1PR4 (if available)
TreeFam:
Gene Tree for S1PR4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for S1PR4: view image

Paralogs for S1PR4 Gene

(9) SIMAP similar genes for S1PR4 Gene using alignment to 1 proteins:

  • S1PR4_HUMAN
genes like me logo Genes that share paralogs with S1PR4: view

Variants for S1PR4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for S1PR4 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
724650 Benign: not provided 3,179,908(+) G/A SYNONYMOUS_VARIANT
771510 Benign: not provided 3,179,077(+) G/A SYNONYMOUS_VARIANT
rs3746072 - p.Arg365Leu

Additional dbSNP identifiers (rs#s) for S1PR4 Gene

Structural Variations from Database of Genomic Variants (DGV) for S1PR4 Gene

Variant ID Type Subtype PubMed ID
nsv509716 CNV insertion 20534489
nsv953948 CNV deletion 24416366

Variation tolerance for S1PR4 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S1PR4 Gene

Human Gene Mutation Database (HGMD)
S1PR4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
S1PR4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR4 Gene

Disorders for S1PR4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for S1PR4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dermatitis, atopic, 7
  • atod7
diversion colitis
brachydactyly, type e1
  • bde1
- elite association - COSMIC cancer census association via MalaCards
Search S1PR4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for S1PR4

genes like me logo Genes that share disorders with S1PR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S1PR4 Gene

Publications for S1PR4 Gene

  1. Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6. (PMID: 10753843) Van Brocklyn JR … Spiegel S (Blood 2000) 3 4 23 54
  2. EDG6, a novel G-protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue. (PMID: 9790765) Gräler MH … Lipp M (Genomics 1998) 2 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor. (PMID: 15298705) Holdsworth G … Parrill AL (BMC biochemistry 2004) 3 23 54
  5. Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. (PMID: 11919175) Idzko M … Norgauer J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002) 3 23 54

Products for S1PR4 Gene

Sources for S1PR4 Gene