Aliases for S1PR4 Gene
External Ids for S1PR4 Gene
Previous HGNC Symbols for S1PR4 Gene
Previous GeneCards Identifiers for S1PR4 Gene
This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]
GeneCards Summary for S1PR4 Gene
S1PR4 (Sphingosine-1-Phosphate Receptor 4) is a Protein Coding gene. Diseases associated with S1PR4 include Diversion Colitis and Brachydactyly, Type E1. Among its related pathways are Signaling by GPCR and Sphingolipid signaling pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is S1PR5.
UniProtKB/Swiss-Prot Summary for S1PR4 Gene
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.