Aliases for S1PR3 Gene
- Sphingosine-1-Phosphate Receptor 3 2 3 5
- Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 3 2 3
- Endothelial Differentiation G-Protein Coupled Receptor 3 3 4
- Sphingosine 1-Phosphate Receptor Edg-3 3 4
- Sphingosine 1-Phosphate Receptor 3 3 4
- S1P Receptor Edg-3 3 4
- S1P Receptor 3 3 4
External Ids for S1PR3 Gene
Previous HGNC Symbols for S1PR3 Gene
Previous GeneCards Identifiers for S1PR3 Gene
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]
GeneCards Summary for S1PR3 Gene
S1PR3 (Sphingosine-1-Phosphate Receptor 3) is a Protein Coding gene. Diseases associated with S1PR3 include Bacterial Sepsis and Second-Degree Atrioventricular Block. Among its related pathways are Ceramide Pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and integrin binding. An important paralog of this gene is S1PR1.
UniProtKB/Swiss-Prot Summary for S1PR3 Gene
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.