Aliases for S1PR2 Gene
- Sphingosine-1-Phosphate Receptor 2 2 3 5
- Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 5 2 3
- Endothelial Differentiation G-Protein Coupled Receptor 5 3 4
- Sphingosine 1-Phosphate Receptor Edg-5 3 4
- Deafness, Autosomal Recessive 68 2 3
- S1P Receptor Edg-5 3 4
- S1P Receptor 2 3 4
- EDG5 3 4
- S1P2 3 4
- Sphingosine 1-Phosphate Receptor 2 3
External Ids for S1PR2 Gene
Previous HGNC Symbols for S1PR2 Gene
Previous GeneCards Identifiers for S1PR2 Gene
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]
GeneCards Summary for S1PR2 Gene
S1PR2 (Sphingosine-1-Phosphate Receptor 2) is a Protein Coding gene. Diseases associated with S1PR2 include Deafness, Autosomal Recessive 68 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Peptide ligand-binding receptors and Signal Transduction of S1P Receptor. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and integrin binding. An important paralog of this gene is S1PR1.
UniProtKB/Swiss-Prot for S1PR2 Gene
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.