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This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]
S1PR2 (Sphingosine-1-Phosphate Receptor 2) is a Protein Coding gene. Diseases associated with S1PR2 include Deafness, Autosomal Recessive 68 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Signaling by GPCR and Sphingolipid signaling pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and integrin binding. An important paralog of this gene is S1PR1.
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001664 | G protein-coupled receptor binding | IPI | 24851274 |
GO:0004930 | G protein-coupled receptor activity | TAS,IBA | 21873635 |
GO:0005178 | integrin binding | IPI | 24851274 |
GO:0005515 | protein binding | IPI | 24453941 |
GO:0008289 | lipid binding | TAS | 10617617 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | S1P3 pathway |
.44
.44
|
|
4 | Sphingolipid signaling pathway | ||
5 | Ceramide Pathway |
Ceramide Pathway
.32
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000187 | activation of MAPK activity | TAS | 10617617 |
GO:0003376 | sphingosine-1-phosphate receptor signaling pathway | IMP | 23106337 |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Sphingosine | Experimental | Pharma | 0 | |||
Sphingosine-1-phosphate | Pharma | Agonist, Full agonist | endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 | 0 | ||
CYM 5442 hydrochloride | Pharma | Selective S1P1 receptor agonist | 0 | |||
RP 001 hydrochloride | Pharma | Potent S1P1 agonist | 0 | |||
SEW 2871 | Pharma | Cell-permeable, selective S1P1 receptor agonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
CYM 5442 hydrochloride | Selective S1P1 receptor agonist | 1094042-01-9 |
RP 001 hydrochloride | Potent S1P1 agonist | 1306761-53-4 |
SEW 2871 | Cell-permeable, selective S1P1 receptor agonist | 256414-75-2 |
Sphingosine-1-phosphate | Endogenous agonist at S1P1-5 | 26993-30-6 |
TC-SP 14 | Potent S1P1 receptor agonist | 1257093-40-5 |
Compound | Action | Cas Number |
---|---|---|
BAF312 (Siponimod) | S1P agonist,potent and selective | 1230487-00-9 |
CS 2100 | 913827-99-3 | |
CYM 50260 | 1355026-60-6 | |
CYM 50308 | 1345858-76-5 | |
CYM 50358 hydrochloride | ||
CYM 5442 hydrochloride | 1094042-01-9 | |
CYM 5541 | 945128-26-7 | |
Fingolimod (FTY720) | S1P receptors agonist | 162359-56-0 |
JTE 013 | 547756-93-4 | |
N,N-Dimethylsphingosine | 119567-63-4 | |
RP 001 hydrochloride | 1306761-53-4 | |
SEW 2871 | 256414-75-2 | |
TC-G 1006 | 1324003-64-6 | |
W146 | 909725-61-7 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | S1PR2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | S1PR2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | S1PR2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | S1pr2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | S1pr2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | S1PR2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | S1PR2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | S1PR2 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | S1PR2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | s1pr2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | s1pr2 30 31 |
|
OneToOne | |
edg5 30 |
|
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
666749 | Likely Benign: not specified | 10,224,177(-) | G/A | SYNONYMOUS_VARIANT | |
666750 | Likely Benign: not specified; not provided | 10,224,348(-) | G/A | SYNONYMOUS_VARIANT | |
681377 | Likely Benign: not provided | 10,224,062(-) | G/A | SYNONYMOUS_VARIANT | |
681392 | Likely Benign: not provided | 10,224,615(-) | C/T | SYNONYMOUS_VARIANT | |
682601 | Likely Benign: not provided | 10,224,228(-) | C/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
deafness, autosomal recessive 68 |
|
|
autosomal recessive non-syndromic sensorineural deafness type dfnb |
|
|
pulmonary edema |
|
|