Aliases for S1PR2 Gene
Aliases for S1PR2 Gene
- Sphingosine-1-Phosphate Receptor 2 2 3 5
- Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 5 2 3
- Endothelial Differentiation G-Protein Coupled Receptor 5 3 4
- Sphingosine 1-Phosphate Receptor Edg-5 3 4
- Deafness, Autosomal Recessive 68 2 3
- S1P Receptor Edg-5 3 4
- S1P Receptor 2 3 4
- EDG5 3 4
- S1P2 3 4
- Sphingosine 1-Phosphate Receptor 2 3
External Ids for S1PR2 Gene
- HGNC: 3169
- Entrez Gene: 9294
- Ensembl: ENSG00000267534
- OMIM: 605111
- UniProtKB: O95136
Previous HGNC Symbols for S1PR2 Gene
- EDG5
- DFNB68
Previous GeneCards Identifiers for S1PR2 Gene
- GC19M010332
- GC19M009912
Summaries for S1PR2 Gene
-
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]
GeneCards Summary for S1PR2 Gene
S1PR2 (Sphingosine-1-Phosphate Receptor 2) is a Protein Coding gene. Diseases associated with S1PR2 include Deafness, Autosomal Recessive 68 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and integrin binding. An important paralog of this gene is S1PR1.
UniProtKB/Swiss-Prot for S1PR2 Gene
-
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
-
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.
Additional gene information for S1PR2 Gene
- Monarch Initiative
- Search for S1PR2 at DataMed
- Search for S1PR2 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S1PR2 Gene
Genomics for S1PR2 Gene
GeneHancer (GH) Regulatory Elements for S1PR2 Gene
Promoters and enhancers for S1PR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around S1PR2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the S1PR2 gene promoter:
Regulatory Element Products
Genomic Locations for S1PR2 Gene
Genomic Locations for S1PR2 Gene
- chr19:10,221,433-10,231,807
- (GRCh38/hg38)
- Size:
- 10,375 bases
- Orientation:
- Minus strand
- chr19:10,332,109-10,341,948
- (GRCh37/hg19)
Genomic View for S1PR2 Gene
Genes around S1PR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by Ensembl
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
S1PR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for S1PR2 Gene
Proteins for S1PR2 Gene
-
Protein details for S1PR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95136-S1PR2_HUMAN
- Recommended name:
- Sphingosine 1-phosphate receptor 2
- Protein Accession:
- O95136
- Q86UN8
Protein attributes for S1PR2 Gene
- Size:
- 353 amino acids
- Molecular mass:
- 38867 Da
- Quaternary structure:
- No Data Available
Protein Expression for S1PR2 Gene
Post-translational modifications for S1PR2 Gene
Other Protein References for S1PR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for S1PR2 (S1P2/EDG-5)
-
Custom Antibody ServicesOriGene Antibodies for S1PR2
- Novus Biologicals Antibodies for S1PR2
- Invitrogen Antibodies for S1PR2
- GeneTex S1PR2 antibody for S1PR2
-
Custom Antibody ServicesProSci Antibodies for S1PR2
-
Santa Cruz Biotechnology (SCBT) Antibodies for S1PR2
Protein Products
-
OriGene Purified Proteins for S1PR2
- Search Origene for MassSpec and Protein Over-expression Lysates for S1PR2
- Origene Custom Protein Services for S1PR2
- Search GeneTex for Proteins for S1PR2
Assay Products
No data available for DME Specific Peptides for S1PR2 Gene
Domains & Families for S1PR2 Gene
Gene Families for S1PR2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- G-protein coupled receptors
- Potential drug targets
- Predicted membrane proteins
Protein Domains for S1PR2 Gene
Suggested Antigen Peptide Sequences for S1PR2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O95136- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for S1PR2 Gene
Molecular function for S1PR2 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Phenotypes From GWAS Catalog for S1PR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001664 | G-protein coupled receptor binding | IPI | 24851274 |
| GO:0004871 | signal transducer activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | TAS | 8087418 |
| GO:0005178 | integrin binding | IPI | 24851274 |
| GO:0005515 | protein binding | IPI | 24453941 |
Phenotypes for S1PR2 Gene
- MGI mutant phenotypes for S1PR2:
-
inferred from 6 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- neoplasm
- reproductive system phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- hematopoietic system phenotype
- pigmentation phenotype
- GenomeRNAi human phenotypes for S1PR2:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- Negative genetic interaction between MUS81-/- and MUS81+/+
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased shRNA abundance (Z-score > 2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Synthetic lethal with imatinib mesylate
Animal Models for S1PR2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for S1PR2
- Cyagen custom Knockout/knockin (KOKI) mouse models for S1PR2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for S1PR2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for S1PR2 gene
- Search ViGene Biosciences for S1PR2
CRISPR Products
-
OriGene CRISPR knockouts for S1PR2
- genomics-online: gRNA clones - Search results for 96 available S1PR2 gene related products
- Overview of 96 available S1PR2 gene related products
- Applied Biological Materials CRISPR for S1PR2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for S1PR2
- GenScript: Design CRISPR guide RNA sequences for S1PR2
miRNA for S1PR2 Gene
- miRTarBase miRNAs that target S1PR2
-
- hsa-mir-488-3p (MIRT443955)
- hsa-mir-4635 (MIRT443956)
- hsa-mir-372-5p (MIRT443957)
- hsa-mir-371a-5p (MIRT443958)
- hsa-mir-616-5p (MIRT443959)
- hsa-mir-373-5p (MIRT443960)
- hsa-mir-371b-5p (MIRT443961)
- hsa-mir-3613-3p (MIRT443962)
- hsa-mir-548c-3p (MIRT443963)
- hsa-mir-6818-3p (MIRT514246)
- hsa-mir-548s (MIRT514247)
- hsa-mir-4684-5p (MIRT514248)
- hsa-mir-3606-5p (MIRT514249)
- hsa-mir-593-3p (MIRT514250)
- hsa-mir-6895-3p (MIRT514251)
- hsa-mir-6073 (MIRT514252)
- hsa-mir-3926 (MIRT514253)
- hsa-mir-769-5p (MIRT514254)
- hsa-mir-4786-5p (MIRT514255)
- hsa-mir-3190-5p (MIRT514256)
- hsa-mir-5699-3p (MIRT514257)
- hsa-mir-4421 (MIRT514258)
- hsa-mir-339-5p (MIRT514259)
- hsa-mir-6849-3p (MIRT514260)
- hsa-mir-10b-5p (MIRT514261)
- hsa-mir-10a-5p (MIRT514262)
- hsa-mir-6732-3p (MIRT514263)
- hsa-mir-4493 (MIRT632461)
- hsa-mir-3185 (MIRT632462)
- hsa-mir-5693 (MIRT632463)
- hsa-mir-3681-3p (MIRT632464)
- hsa-mir-216a-3p (MIRT632465)
- hsa-mir-128-3p (MIRT632466)
- hsa-mir-3714 (MIRT661164)
- hsa-mir-7703 (MIRT661165)
- hsa-mir-6720-5p (MIRT661166)
- hsa-mir-6512-3p (MIRT661167)
- hsa-mir-6721-5p (MIRT661168)
- hsa-mir-661 (MIRT661169)
- hsa-mir-4252 (MIRT661170)
- hsa-mir-6860 (MIRT661171)
- hsa-mir-612 (MIRT661172)
- hsa-mir-5189-5p (MIRT661173)
- hsa-mir-3187-5p (MIRT661174)
- hsa-mir-1285-3p (MIRT661175)
- hsa-mir-4793-3p (MIRT661176)
- hsa-mir-766-3p (MIRT661177)
- hsa-mir-939-3p (MIRT661178)
- hsa-mir-1273g-3p (MIRT661179)
- hsa-mir-152-3p (MIRT661180)
- hsa-mir-148b-3p (MIRT661181)
- hsa-mir-148a-3p (MIRT661182)
- hsa-mir-454-3p (MIRT661183)
- hsa-mir-4295 (MIRT661184)
- hsa-mir-3666 (MIRT661185)
- hsa-mir-301b-3p (MIRT661186)
- hsa-mir-301a-3p (MIRT661187)
- hsa-mir-130b-3p (MIRT661188)
- hsa-mir-130a-3p (MIRT661189)
- hsa-mir-4519 (MIRT661190)
- hsa-mir-508-5p (MIRT661191)
- hsa-mir-24-3p (MIRT672722)
- hsa-mir-19b-3p (MIRT726671)
- hsa-mir-19a-3p (MIRT726672)
- hsa-mir-1273h-5p (MIRT762076)
- hsa-mir-149-3p (MIRT762821)
- hsa-mir-30b-3p (MIRT764614)
- hsa-mir-30c-1-3p (MIRT764672)
- hsa-mir-30c-2-3p (MIRT764717)
- hsa-mir-3122 (MIRT764816)
- hsa-mir-3689a-3p (MIRT766842)
- hsa-mir-3689b-3p (MIRT766930)
- hsa-mir-3689c (MIRT767018)
- hsa-mir-3913-5p (MIRT767620)
- hsa-mir-4433a-3p (MIRT769038)
- hsa-mir-4459 (MIRT769339)
- hsa-mir-450a-1-3p (MIRT769855)
- hsa-mir-4683 (MIRT770956)
- hsa-mir-4728-5p (MIRT771737)
- hsa-mir-4767 (MIRT772045)
- hsa-mir-4768-3p (MIRT772131)
- hsa-mir-6087 (MIRT775700)
- hsa-mir-6089 (MIRT775748)
- hsa-mir-6502-3p (MIRT776551)
- hsa-mir-6513-5p (MIRT777006)
- hsa-mir-6779-5p (MIRT778920)
- hsa-mir-6780a-5p (MIRT779010)
- hsa-mir-6785-5p (MIRT779147)
- hsa-mir-6788-5p (MIRT779249)
- hsa-mir-6799-5p (MIRT779448)
- hsa-mir-6883-5p (MIRT780943)
- hsa-mir-6888-5p (MIRT781106)
- hsa-mir-7106-5p (MIRT781377)
- hsa-mir-887-5p (MIRT782567)
miRNA Products
- Search ViGene Biosciences for S1PR2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for S1PR2
- Browse OriGene Inhibitory RNA Products For S1PR2
- genomics-online: shRNA clones - Search results for 96 available S1PR2 gene related products
- Overview of 96 available S1PR2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for S1PR2 gene
Clone Products
- Sino Biological Human cDNA Clone for S1PR2
- VectorBuilder custom plasmid, inducible vectors for S1PR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for S1PR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for S1PR2
- Applied Biological Materials Clones for S1PR2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for S1PR2 (S1P2/EDG-5)
Cell Line Products
-
Horizon Cell Lines for S1PR2
-
ViGene Biosciences adenoviral particle packaged cDNA for S1PR2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for S1PR2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for S1PR2 gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for S1PR2 Gene
Localization for S1PR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for S1PR2 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 1 |
| nucleus | 1 |
| cytosol | 1 |
- Golgi apparatus (1)
- Nuclear speckles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for S1PR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | S1P3 pathway |
.44
.44
|
|
| 4 | Sphingolipid signaling pathway | ||
| 5 | Ceramide Pathway |
.32
|
|
Pathways by source for S1PR2 Gene
5 BioSystems pathways for S1PR2 Gene
7 Reactome pathways for S1PR2 Gene
2 KEGG pathways for S1PR2 Gene
4 Qiagen pathways for S1PR2 Gene
Interacting Proteins for S1PR2 Gene
Selected Interacting proteins:
O95136-S1PR2_HUMAN
ENSP00000466933
for S1PR2 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | TAS | 10617617 |
| GO:0003376 | sphingosine-1-phosphate signaling pathway | IMP,IEA | 23106337 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
| GO:0008284 | positive regulation of cell proliferation | TAS | 10617617 |
Drugs & Compounds for S1PR2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Sphingosine | Experimental | Pharma | 0 | |||
| CYM 5442 hydrochloride | Pharma | Selective S1P1 receptor agonist | 0 | |||
| JTE-013 | Pharma | Antagonist | 0 | |||
| sphingosine 1-phosphate | Pharma | Full agonist, Agonist | 0 | |||
| BAF312 (Siponimod) | Pharma | S1P agonist,potent and selective | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) Tocris Compounds for S1PR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CYM 5442 hydrochloride | Selective S1P1 receptor agonist | 1094042-01-9 |
| RP 001 hydrochloride | Potent S1P1 agonist | 1306761-53-4 |
| SEW 2871 | Cell-permeable, selective S1P1 receptor agonist | 256414-75-2 |
| Sphingosine-1-phosphate | Endogenous agonist at S1P1-5 | 26993-30-6 |
| TC-SP 14 | Potent S1P1 receptor agonist | 1257093-40-5 |
(14) ApexBio Compounds for S1PR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BAF312 (Siponimod) | S1P agonist,potent and selective | 1230487-00-9 |
| CS 2100 | 913827-99-3 | |
| CYM 50260 | 1355026-60-6 | |
| CYM 50308 | 1345858-76-5 | |
| CYM 50358 hydrochloride | ||
| CYM 5442 hydrochloride | 1094042-01-9 | |
| CYM 5541 | 945128-26-7 | |
| Fingolimod (FTY720) | S1P receptors agonist | 162359-56-0 |
| JTE 013 | 547756-93-4 | |
| N,N-Dimethylsphingosine | 119567-63-4 | |
| RP 001 hydrochloride | 1306761-53-4 | |
| SEW 2871 | 256414-75-2 | |
| TC-G 1006 | 1324003-64-6 | |
| W146 | 909725-61-7 |
Transcripts for S1PR2 Gene
mRNA/cDNA for S1PR2 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (307) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for S1PR2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for S1PR2
- genomics-online: gRNA clones - Search results for 96 available S1PR2 gene related products
- Overview of 96 available S1PR2 gene related products
- Applied Biological Materials CRISPR for S1PR2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for S1PR2
- GenScript: Design CRISPR guide RNA sequences for S1PR2
miRNA Products
- Search ViGene Biosciences for S1PR2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for S1PR2
- Browse OriGene Inhibitory RNA Products For S1PR2
- genomics-online: shRNA clones - Search results for 96 available S1PR2 gene related products
- Overview of 96 available S1PR2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for S1PR2 gene
Clone Products
- Sino Biological Human cDNA Clone for S1PR2
- VectorBuilder custom plasmid, inducible vectors for S1PR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for S1PR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for S1PR2
- Applied Biological Materials Clones for S1PR2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for S1PR2 (S1P2/EDG-5)
Expression for S1PR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Blood Islands
- Angioblasts Embryonic Blood Islands
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Blood Islands
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Angioblasts Embryonic Blood Islands
mRNA differential expression in normal tissues according to GTEx for S1PR2 Gene
This gene is overexpressed in Testis (x6.6).
This gene is overexpressed in Gallbladder (29.6), Placenta (16.9), Pancreas (7.5), and Testis (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for S1PR2 Gene
NURSA nuclear receptor signaling pathways regulating expression of S1PR2 Gene:
S1PR2SOURCE GeneReport for Unigene cluster for S1PR2 Gene:
Hs.655405Evidence on tissue expression from TISSUES for S1PR2 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for S1PR2
-
OriGene qPCR primer pairs for S1PR2
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for S1PR2 Gene
Orthologs for S1PR2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | S1PR2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | S1PR2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | S1PR2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | S1pr2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | S1pr2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | S1PR2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | S1PR2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | S1PR2 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | S1PR2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | s1pr2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | s1pr2 33 34 |
|
||
| edg5 33 |
|
- Species where no ortholog for S1PR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for S1PR2 Gene
Variants for S1PR2 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs869312749 | pathogenic, Deafness, autosomal recessive 68, Deafness, autosomal recessive, 68 (DFNB68) [MIM:610419] | 10,224,583(-) | C/G | coding_sequence_variant, missense_variant | |
| rs869312750 | pathogenic, Deafness, autosomal recessive 68, Deafness, autosomal recessive, 68 (DFNB68) [MIM:610419] | 10,224,487(-) | T/C | coding_sequence_variant, missense_variant | |
| rs1001005824 | -- | 10,229,566(-) | A/G | intron_variant | |
| rs1001021154 | -- | 10,231,882(-) | A/T | upstream_transcript_variant | |
| rs1001314264 | -- | 10,226,594(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.44;
28.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for S1PR2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR2 Gene
Disorders for S1PR2 Gene
(4) MalaCards diseases for S1PR2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| deafness, autosomal recessive 68 |
|
|
| autosomal recessive non-syndromic sensorineural deafness type dfnb |
|
|
| suppurative cholangitis |
|
|
| deafness, autosomal recessive |
|
|
Search S1PR2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
S1PR2_HUMAN- Deafness, autosomal recessive, 68 (DFNB68) [MIM:610419]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:26805784}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for S1PR2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for S1PR2 Gene
Publications for S1PR2 Gene
- Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2. (PMID: 26805784) Santos-Cortez RL … Leal SM (American journal of human genetics 2016) 2 3 4 58
- Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. (PMID: 10617617) An S … Bleu T (The Journal of biological chemistry 2000) 3 4 22 58
- Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema. (PMID: 20194630) Oskeritzian CA … Spiegel S (The Journal of experimental medicine 2010) 3 22 58
- Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M … Ramoni MF (Circulation 2009) 3 44 58
- Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. (PMID: 19903857) Cattoretti G … MacLennan AJ (Cancer research 2009) 3 22 58
Products for S1PR2 Gene
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- Mammalian expression: PiggyBac
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- antibodies-online: Search results for 62 available S1PR2 Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for S1PR2
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- genomics-online: cdna clones - Search results for 96 available S1PR2 gene related products
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Sources for S1PR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
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- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
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- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
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- (114) diseasecard
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- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
