Aliases for S1PR2 Gene
- Sphingosine-1-Phosphate Receptor 2 2 3 5
- Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 5 2 3
- Endothelial Differentiation G-Protein Coupled Receptor 5 3 4
- Sphingosine 1-Phosphate Receptor Edg-5 3 4
- Sphingosine 1-Phosphate Receptor 2 3 4
- Deafness, Autosomal Recessive 68 2 3
- S1P Receptor Edg-5 3 4
- S1P Receptor 2 3 4
- EDG5 3 4
- S1P2 3 4
External Ids for S1PR2 Gene
Previous HGNC Symbols for S1PR2 Gene
Previous GeneCards Identifiers for S1PR2 Gene
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]
GeneCards Summary for S1PR2 Gene
S1PR2 (Sphingosine-1-Phosphate Receptor 2) is a Protein Coding gene. Diseases associated with S1PR2 include Deafness, Autosomal Recessive 68 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Human Embryonic Stem Cell Pluripotency and Lysosphingolipid and LPA receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and integrin binding. An important paralog of this gene is S1PR1.
UniProtKB/Swiss-Prot for S1PR2 Gene
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity).
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.