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This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016] See more...
Aliases for S1PR2 Gene
Aliases for S1PR2 Gene
- Sphingosine-1-Phosphate Receptor 2 2 3 5
- Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 5 2 3
- Endothelial Differentiation G-Protein Coupled Receptor 5 3 4
- Sphingosine 1-Phosphate Receptor Edg-5 3 4
- Sphingosine 1-Phosphate Receptor 2 3 4
- Deafness, Autosomal Recessive 68 2 3
- S1P Receptor Edg-5 3 4
- S1P Receptor 2 3 4
- Gpcr13 2 3
External Ids for S1PR2 Gene
- HGNC: 3169
- NCBI Entrez Gene: 9294
- Ensembl: ENSG00000267534
- OMIM®: 605111
- UniProtKB/Swiss-Prot: O95136
Previous HGNC Symbols for S1PR2 Gene
- EDG5
- DFNB68
Previous GeneCards Identifiers for S1PR2 Gene
- GC19M010193
- GC19M010332
- GC19M009912
Summaries for S1PR2 Gene
-
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in this gene have been associated with congenital profound deafness. [provided by RefSeq, Mar 2016]
GeneCards Summary for S1PR2 Gene
S1PR2 (Sphingosine-1-Phosphate Receptor 2) is a Protein Coding gene. Diseases associated with S1PR2 include Deafness, Autosomal Recessive 68 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Ceramide Pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and integrin binding. An important paralog of this gene is S1PR1.
UniProtKB/Swiss-Prot Summary for S1PR2 Gene
-
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity).
-
Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.
Additional gene information for S1PR2 Gene
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for S1PR2 Gene
Genomics for S1PR2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for S1PR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around S1PR2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for S1PR2
- Top Transcription factor binding sites by QIAGEN in the S1PR2 gene promoter:
-
- AP-2gamma
- C/EBPalpha
- CREB
- Ik-2
- MyoD
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
- RORalpha1
- Zic1
Genomic Locations for S1PR2 Gene
Latest Assembly
- chr19:10,221,433-10,231,331
- (GRCh38/hg38)
- Size:
- 9,899 bases
- Orientation:
- Minus strand
Previous Assembly
- chr19:10,332,109-10,342,007
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 9,899 bases
- Orientation:
- Minus strand
Genomic View for S1PR2 Gene
Genes around S1PR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
S1PR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for S1PR2 Gene
Proteins for S1PR2 Gene
-
Protein details for S1PR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95136-S1PR2_HUMAN
- Recommended name:
- Sphingosine 1-phosphate receptor 2
- Protein Accession:
- O95136
- Q86UN8
Protein attributes for S1PR2 Gene
- Size:
- 353 amino acids
- Molecular mass:
- 38867 Da
- Quaternary structure:
- No Data Available
Protein Expression for S1PR2 Gene
Post-translational modifications for S1PR2 Gene
Other Protein References for S1PR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences SIPR2 / S1P2 / EDG5 Antibody (LS-A1018) and SIPR2 / S1P2 / EDG5 Antibody (LS-A1019)
-
Custom Antibody ServicesOriGene Antibodies for S1PR2
- Novus Biologicals Antibodies for S1PR2
- Invitrogen Antibodies for S1PR2 (AFLGC-S1PR2)
-
Biorbyt antibodies for S1PR2
-
Boster Bio Antibodies for S1PR2
-
Custom Antibody ServicesProSci Antibodies for S1PR2
-
Santa Cruz Biotechnology (SCBT) Antibodies for S1PR2
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for S1PR2
- Origene Custom Protein Services for S1PR2
No data available for DME Specific Peptides for S1PR2 Gene
Domains & Families for S1PR2 Gene
Gene Families for S1PR2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- G-protein coupled receptors
- Potential drug targets
- Predicted membrane proteins
Protein Domains for S1PR2 Gene
- InterPro:
- Blocks:
-
- Sphingosine 1-phosphate receptor family signature
- EDG-5 sphingosine 1-phosphate receptor signature
Suggested Antigen Peptide Sequences for S1PR2 Gene
- GenScript: Design optimal peptide antigens:
-
- Sphingosine 1-phosphate receptor Edg-5 (S1PR2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O95136- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for S1PR2 Gene
Molecular function for S1PR2 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity).
Phenotypes From GWAS Catalog for S1PR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001664 | G protein-coupled receptor binding | IPI | 24851274 |
| GO:0004930 | G protein-coupled receptor activity | TAS,IBA | 21873635 |
| GO:0005178 | integrin binding | IPI | 24851274 |
| GO:0005515 | protein binding | IPI | 24453941 |
| GO:0008289 | lipid binding | TAS | 10617617 |
Phenotypes for S1PR2 Gene
- MGI mutant phenotypes for S1PR2:
-
inferred from 7 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- hematopoietic system phenotype
- neoplasm
- reproductive system phenotype
- hearing/vestibular/ear phenotype
- integument phenotype
- pigmentation phenotype
- GenomeRNAi human phenotypes for S1PR2:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- no effect
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Synthetic lethal with imatinib mesylate
- Increased gamma-H2AX phosphorylation
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in pancreas lineage
- Decreased focal adhesion (FA) abundance, increased peripheral FA formation, increased cell elongation
Animal Models for S1PR2 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for S1PR2
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for S1PR2 - Starting at $85 >
- * S1PR2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for S1PR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for S1PR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for S1PR2
miRNA for S1PR2 Gene
- miRTarBase miRNAs that target S1PR2
-
- hsa-miR-488-3p (MIRT443955)
- hsa-miR-4635 (MIRT443956)
- hsa-miR-372-5p (MIRT443957)
- hsa-miR-371a-5p (MIRT443958)
- hsa-miR-616-5p (MIRT443959)
- hsa-miR-373-5p (MIRT443960)
- hsa-miR-371b-5p (MIRT443961)
- hsa-miR-3613-3p (MIRT443962)
- hsa-miR-548c-3p (MIRT443963)
- hsa-miR-6818-3p (MIRT514246)
- hsa-miR-548s (MIRT514247)
- hsa-miR-4684-5p (MIRT514248)
- hsa-miR-3606-5p (MIRT514249)
- hsa-miR-593-3p (MIRT514250)
- hsa-miR-6895-3p (MIRT514251)
- hsa-miR-6073 (MIRT514252)
- hsa-miR-3926 (MIRT514253)
- hsa-miR-769-5p (MIRT514254)
- hsa-miR-4786-5p (MIRT514255)
- hsa-miR-3190-5p (MIRT514256)
- hsa-miR-5699-3p (MIRT514257)
- hsa-miR-4421 (MIRT514258)
- hsa-miR-339-5p (MIRT514259)
- hsa-miR-6849-3p (MIRT514260)
- hsa-miR-10b-5p (MIRT514261)
- hsa-miR-10a-5p (MIRT514262)
- hsa-miR-6732-3p (MIRT514263)
- hsa-miR-4493 (MIRT632461)
- hsa-miR-3185 (MIRT632462)
- hsa-miR-5693 (MIRT632463)
- hsa-miR-3681-3p (MIRT632464)
- hsa-miR-216a-3p (MIRT632465)
- hsa-miR-128-3p (MIRT632466)
- hsa-miR-3714 (MIRT661164)
- hsa-miR-7703 (MIRT661165)
- hsa-miR-6720-5p (MIRT661166)
- hsa-miR-6512-3p (MIRT661167)
- hsa-miR-6721-5p (MIRT661168)
- hsa-miR-661 (MIRT661169)
- hsa-miR-4252 (MIRT661170)
- hsa-miR-6860 (MIRT661171)
- hsa-miR-612 (MIRT661172)
- hsa-miR-5189-5p (MIRT661173)
- hsa-miR-3187-5p (MIRT661174)
- hsa-miR-1285-3p (MIRT661175)
- hsa-miR-4793-3p (MIRT661176)
- hsa-miR-766-3p (MIRT661177)
- hsa-miR-939-3p (MIRT661178)
- hsa-miR-1273g-3p (MIRT661179)
- hsa-miR-152-3p (MIRT661180)
- hsa-miR-148b-3p (MIRT661181)
- hsa-miR-148a-3p (MIRT661182)
- hsa-miR-454-3p (MIRT661183)
- hsa-miR-4295 (MIRT661184)
- hsa-miR-3666 (MIRT661185)
- hsa-miR-301b-3p (MIRT661186)
- hsa-miR-301a-3p (MIRT661187)
- hsa-miR-130b-3p (MIRT661188)
- hsa-miR-130a-3p (MIRT661189)
- hsa-miR-4519 (MIRT661190)
- hsa-miR-508-5p (MIRT661191)
- hsa-miR-24-3p (MIRT672722)
- hsa-miR-19b-3p (MIRT726671)
- hsa-miR-19a-3p (MIRT726672)
- hsa-miR-1273h-5p (MIRT762076)
- hsa-miR-149-3p (MIRT762821)
- hsa-miR-30b-3p (MIRT764614)
- hsa-miR-30c-1-3p (MIRT764672)
- hsa-miR-30c-2-3p (MIRT764717)
- hsa-miR-3122 (MIRT764816)
- hsa-miR-3689a-3p (MIRT766842)
- hsa-miR-3689b-3p (MIRT766930)
- hsa-miR-3689c (MIRT767018)
- hsa-miR-3913-5p (MIRT767620)
- hsa-miR-4433a-3p (MIRT769038)
- hsa-miR-4459 (MIRT769339)
- hsa-miR-450a-1-3p (MIRT769855)
- hsa-miR-4683 (MIRT770956)
- hsa-miR-4728-5p (MIRT771737)
- hsa-miR-4767 (MIRT772045)
- hsa-miR-4768-3p (MIRT772131)
- hsa-miR-6087 (MIRT775700)
- hsa-miR-6089 (MIRT775748)
- hsa-miR-6502-3p (MIRT776551)
- hsa-miR-6513-5p (MIRT777006)
- hsa-miR-6779-5p (MIRT778920)
- hsa-miR-6780a-5p (MIRT779010)
- hsa-miR-6785-5p (MIRT779147)
- hsa-miR-6788-5p (MIRT779249)
- hsa-miR-6799-5p (MIRT779448)
- hsa-miR-6883-5p (MIRT780943)
- hsa-miR-6888-5p (MIRT781106)
- hsa-miR-7106-5p (MIRT781377)
- hsa-miR-887-5p (MIRT782567)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for S1PR2
- Browse OriGene Inhibitory RNA Products For S1PR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for S1PR2
Clone products for research
- Applied Biological Materials (abm): Clones for S1PR2 - Starting at $45 >
- * S1PR2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for S1PR2
- Addgene plasmids for S1PR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for S1PR2
Cell Lines for research
-
Horizon Cell Lines for S1PR2
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for S1PR2 Gene
Localization for S1PR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for S1PR2 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Golgi apparatus (1)
- Nuclear speckles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for S1PR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | S1P3 pathway |
.44
.44
|
|
| 4 | Sphingolipid signaling pathway | ||
| 5 | Ceramide Pathway |
Ceramide Pathway
.32
|
|
Pathways by source for S1PR2 Gene
5 BioSystems pathways for S1PR2 Gene
7 Reactome pathways for S1PR2 Gene
2 KEGG pathways for S1PR2 Gene
4 Qiagen pathways for S1PR2 Gene
- Ceramide Pathway
- eNOS Signaling
- Human Embryonic Stem Cell Pluripotency
- S-1P Stimulated Signaling
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | TAS | 10617617 |
| GO:0003376 | sphingosine-1-phosphate receptor signaling pathway | IMP | 23106337 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IBA | 21873635 |
Drugs & Compounds for S1PR2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Sphingosine | Experimental | Pharma | 0 | |||
| Sphingosine-1-phosphate | Pharma | Agonist | endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 | 0 | ||
| CYM 5442 hydrochloride | Pharma | Selective S1P1 receptor agonist | 0 | |||
| RP 001 hydrochloride | Pharma | Potent S1P1 agonist | 0 | |||
| SEW 2871 | Pharma | Cell-permeable, selective S1P1 receptor agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) Tocris Compounds for S1PR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CYM 5442 hydrochloride | Selective S1P1 receptor agonist | 1094042-01-9 |
| RP 001 hydrochloride | Potent S1P1 agonist | 1306761-53-4 |
| SEW 2871 | Cell-permeable, selective S1P1 receptor agonist | 256414-75-2 |
| Sphingosine-1-phosphate | Endogenous agonist at S1P1-5 | 26993-30-6 |
| TC-SP 14 | Potent S1P1 receptor agonist | 1257093-40-5 |
(14) ApexBio Compounds for S1PR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BAF312 (Siponimod) | S1P agonist,potent and selective | 1230487-00-9 |
| CS 2100 | 913827-99-3 | |
| CYM 50260 | 1355026-60-6 | |
| CYM 50308 | 1345858-76-5 | |
| CYM 50358 hydrochloride | ||
| CYM 5442 hydrochloride | 1094042-01-9 | |
| CYM 5541 | 945128-26-7 | |
| Fingolimod (FTY720) | S1P receptors agonist | 162359-56-0 |
| JTE 013 | 547756-93-4 | |
| N,N-Dimethylsphingosine | 119567-63-4 | |
| RP 001 hydrochloride | 1306761-53-4 | |
| SEW 2871 | 256414-75-2 | |
| TC-G 1006 | 1324003-64-6 | |
| W146 | 909725-61-7 |
Transcripts for S1PR2 Gene
mRNA/cDNA for S1PR2 Gene
- 1 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000646641 3643 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for S1PR2 - Starting at $85 >
- * S1PR2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for S1PR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for S1PR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for S1PR2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for S1PR2
- Browse OriGene Inhibitory RNA Products For S1PR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for S1PR2
Clone products for research
- Applied Biological Materials (abm): Clones for S1PR2 - Starting at $45 >
- * S1PR2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for S1PR2
- Addgene plasmids for S1PR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for S1PR2
Relevant External Links for S1PR2 Gene
- GeneLoc Exon Structure for
- S1PR2
Expression for S1PR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Blood Islands
- Angioblasts Embryonic Blood Islands
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Blood Islands
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Angioblasts Embryonic Blood Islands
mRNA differential expression in normal tissues according to GTEx for S1PR2 Gene
This gene is overexpressed in Testis (x6.6).
This gene is overexpressed in Gallbladder (29.6), Placenta (16.9), Pancreas (7.5), and Testis (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for S1PR2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for S1PR2
SOURCE GeneReport for Unigene cluster for S1PR2 Gene:
Hs.655405Evidence on tissue expression from TISSUES for S1PR2 Gene
- Nervous system(4.4)
- Blood(2.2)
- Heart(2.1)
- Muscle(2)
Primer products for research
-
OriGene qPCR primer pairs for S1PR2
-
OriGene qPCR primer pairs and template standards for S1PR2
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for S1PR2 Gene
Orthologs for S1PR2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | S1PR2 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | S1PR2 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | S1PR2 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | S1pr2 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | S1pr2 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | S1PR2 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | S1PR2 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | S1PR2 29 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | S1PR2 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | s1pr2 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | s1pr2 29 30 |
|
OneToOne | |
| edg5 29 |
|
- Species where no ortholog for S1PR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for S1PR2 Gene
- ENSEMBL:
- Gene Tree for S1PR2 (if available)
- TreeFam:
- Gene Tree for S1PR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for S1PR2: view image
- Alliance of Genome Resources:
- Additional Orthologs for S1PR2
Paralogs for S1PR2 Gene
Paralogs for S1PR2 Gene
(10) SIMAP similar genes for S1PR2 Gene using alignment to 1 proteins:
- S1PR2_HUMAN
Variants for S1PR2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for S1PR2 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 916333 | Likely Benign: not provided | 10,224,573(-) |
A/G NM_004230.4(S1PR2):c.333T>C (p.Ser111=) |
SYNONYMOUS | |
| 929888 | Likely Benign: not specified | 10,223,874(-) |
G/A NM_004230.4(S1PR2):c.1032C>T (p.Pro344=) |
SYNONYMOUS | |
| 929889 | Likely Benign: not specified | 10,223,983(-) |
G/A NM_004230.4(S1PR2):c.923C>T (p.Pro308Leu) |
MISSENSE | |
| 929890 | Likely Benign: not specified | 10,223,951(-) |
C/T NM_004230.4(S1PR2):c.955G>A (p.Gly319Arg) |
MISSENSE | |
| 930015 | Uncertain Significance: not specified | 10,224,125(-) |
C/T NM_004230.4(S1PR2):c.781G>A (p.Val261Ile) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.44;
28.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for S1PR2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR2 Gene
Disorders for S1PR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| deafness, autosomal recessive 68 |
|
|
| autosomal recessive non-syndromic sensorineural deafness type dfnb |
|
|
| pulmonary edema |
|
|
| brachydactyly, type e1 |
|
|
| leber plus disease |
|
|
Search S1PR2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
S1PR2_HUMAN- Deafness, autosomal recessive, 68 (DFNB68) [MIM:610419]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:26805784}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for S1PR2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for S1PR2 Gene
Publications for S1PR2 Gene
- Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2. (PMID: 26805784) Santos-Cortez RL … Leal SM (American journal of human genetics 2016) 2 3 4 72
- Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. (PMID: 10617617) An S … Bleu T (The Journal of biological chemistry 2000) 3 4 22
- Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2. (PMID: 29453251) Wang Y … Kong W (Circulation 2018) 3 4
- Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema. (PMID: 20194630) Oskeritzian CA … Spiegel S (The Journal of experimental medicine 2010) 3 22
- Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation. (PMID: 19903857) Cattoretti G … MacLennan AJ (Cancer research 2009) 3 22
ExternalLinks
Products for S1PR2 Gene
- Custom Antibody ServicesOriGene Antibodies for S1PR2
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- Taconic Biosciences Mouse Models for S1PR2
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- Humanized Mice
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- VectorBuilder Stable cell line generation for S1PR2
- Addgene plasmids for S1PR2
- antibodies-online: Show 11 available S1PR2 Antibodies ranked by validation data
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- antibodies-online: Show 17 available S1PR2 Elisa Kits ranked by validation data
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- antibodies-online: Show 3 available S1PR2 Proteins ranked by validation data
- Compare Top S1PR2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for S1PR2
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- Santa Cruz Biotechnology (SCBT) CRISPR for S1PR2
- Horizon Cell Lines for S1PR2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for S1PR2
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- Boster Bio Antibodies for S1PR2
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Sources for S1PR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
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