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Aliases for S1PR1 Gene

Aliases for S1PR1 Gene

  • Sphingosine-1-Phosphate Receptor 1 2 3 5
  • Endothelial Differentiation, Sphingolipid G-Protein-Coupled Receptor, 1 2 3
  • Endothelial Differentiation G-Protein Coupled Receptor 1 3 4
  • Sphingosine 1-Phosphate Receptor Edg-1 3 4
  • S1P Receptor Edg-1 3 4
  • S1P Receptor 1 3 4
  • CHEDG1 3 4
  • EDG1 3 4
  • S1P1 3 4
  • Sphingosine 1-Phosphate Receptor EDG1 3
  • Sphingosine 1-Phosphate Receptor 1 3
  • CD363 Antigen 4
  • D1S3362 3
  • CD363 3
  • ECGF1 3
  • EDG-1 3

External Ids for S1PR1 Gene

Previous HGNC Symbols for S1PR1 Gene

  • EDG1

Previous GeneCards Identifiers for S1PR1 Gene

  • GC01P101475
  • GC01P101702
  • GC01P099828

Summaries for S1PR1 Gene

Entrez Gene Summary for S1PR1 Gene

  • The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for S1PR1 Gene

S1PR1 (Sphingosine-1-Phosphate Receptor 1) is a Protein Coding gene. Diseases associated with S1PR1 include Autoimmune Encephalitis. Among its related pathways are GPCRs, Other and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and sphingosine-1-phosphate receptor activity. An important paralog of this gene is S1PR3.

UniProtKB/Swiss-Prot for S1PR1 Gene

  • G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.

Tocris Summary for S1PR1 Gene

  • Sphingosine-1-phosphate (S1P) receptors are a group of G-protein-coupled receptors that are currently divided into five subtypes; S1P1, S1P2, S1P3, S1P4 and S1P5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity.

Gene Wiki entry for S1PR1 Gene

Additional gene information for S1PR1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for S1PR1 Gene

Genomics for S1PR1 Gene

GeneHancer (GH) Regulatory Elements for S1PR1 Gene


GeneHancers around S1PR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the S1PR1 gene promoter:
  • LCR-F1
  • FOXL1
  • RelA
  • NF-kappaB1
  • NF-kappaB
  • FOXO3
  • FOXI1
  • HFH-3
  • FOXO3a
  • FOXO3b

Genomic Locations for S1PR1 Gene

Genomic Locations for S1PR1 Gene
chr1:101,236,749-101,241,520
(GRCh38/hg38)
Size:
4,772 bases
Orientation:
Plus strand
chr1:101,702,305-101,707,076
(GRCh37/hg19)
Size:
4,772 bases
Orientation:
Plus strand

Genomic View for S1PR1 Gene

Genes around S1PR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
S1PR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for S1PR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for S1PR1 Gene

Proteins for S1PR1 Gene

  • Protein details for S1PR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21453-S1PR1_HUMAN
    Recommended name:
    Sphingosine 1-phosphate receptor 1
    Protein Accession:
    P21453
    Secondary Accessions:
    • D3DT66
    • Q9BYY4
    • Q9NYN8

    Protein attributes for S1PR1 Gene

    Size:
    382 amino acids
    Molecular mass:
    42811 Da
    Quaternary structure:
    • Interacts with GNAI1 and GNAI3.

    Three dimensional structures from OCA and Proteopedia for S1PR1 Gene

neXtProt entry for S1PR1 Gene

Post-translational modifications for S1PR1 Gene

  • S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.
  • Glycosylation at posLast=3636, isoforms=30, posLast=55, and posLast=44
  • Modification sites at PhosphoSitePlus

Other Protein References for S1PR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for S1PR1 Gene

Domains & Families for S1PR1 Gene

Gene Families for S1PR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

P21453

UniProtKB/Swiss-Prot:

S1PR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with S1PR1: view

Function for S1PR1 Gene

Molecular function for S1PR1 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
UniProtKB/Swiss-Prot Induction:
By the tumor promoter phorbol 12-myristate 13-acetate (PMA) in the presence of cycloheximide.

Phenotypes From GWAS Catalog for S1PR1 Gene

Gene Ontology (GO) - Molecular Function for S1PR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 24851274
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 8626678
GO:0005515 protein binding IPI 16525420
GO:0038036 sphingosine-1-phosphate receptor activity IDA 22344443
genes like me logo Genes that share ontologies with S1PR1: view
genes like me logo Genes that share phenotypes with S1PR1: view

Animal Models for S1PR1 Gene

MGI Knock Outs for S1PR1:

Clone Products

  • Addgene plasmids for S1PR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for S1PR1 Gene

Localization for S1PR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for S1PR1 Gene

Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for S1PR1 gene
Compartment Confidence
plasma membrane 5
endosome 5
nucleus 4
extracellular 2
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for S1PR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with S1PR1: view

Pathways & Interactions for S1PR1 Gene

genes like me logo Genes that share pathways with S1PR1: view

SIGNOR curated interactions for S1PR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for S1PR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001955 blood vessel maturation IEA,ISS --
GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis IEA,ISS --
GO:0003376 sphingosine-1-phosphate signaling pathway IDA,IEA 22344443
GO:0006935 chemotaxis ISS --
genes like me logo Genes that share ontologies with S1PR1: view

Drugs & Compounds for S1PR1 Gene

(41) Drugs for S1PR1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Asfotase Alfa Approved, Investigational Pharma Target, agonist 0
Fingolimod Approved, Investigational Pharma modulator 0
Sphingosine Experimental Pharma 0
Ponesimod Investigational Pharma 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0

(10) Additional Compounds for S1PR1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14265-44-2

(5) Tocris Compounds for S1PR1 Gene

Compound Action Cas Number
CYM 5442 hydrochloride Selective S1P1 receptor agonist 1094042-01-9
RP 001 hydrochloride Potent S1P1 agonist 1306761-53-4
SEW 2871 Cell-permeable, selective S1P1 receptor agonist 256414-75-2
Sphingosine-1-phosphate Endogenous agonist at S1P1-5 26993-30-6
TC-SP 14 Potent S1P1 receptor agonist 1257093-40-5
genes like me logo Genes that share compounds with S1PR1: view

Transcripts for S1PR1 Gene

mRNA/cDNA for S1PR1 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(105) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for S1PR1 Gene

Sphingosine-1-phosphate receptor 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for S1PR1

Alternative Splicing Database (ASD) splice patterns (SP) for S1PR1 Gene

No ASD Table

Relevant External Links for S1PR1 Gene

GeneLoc Exon Structure for
S1PR1
ECgene alternative splicing isoforms for
S1PR1

Expression for S1PR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for S1PR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for S1PR1 Gene

This gene is overexpressed in Pancreatic juice (23.6), Heart (18.1), and Frontal cortex (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for S1PR1 Gene



Protein tissue co-expression partners for S1PR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of S1PR1 Gene:

S1PR1

SOURCE GeneReport for Unigene cluster for S1PR1 Gene:

Hs.154210

mRNA Expression by UniProt/SwissProt for S1PR1 Gene:

P21453-S1PR1_HUMAN
Tissue specificity: Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.

Evidence on tissue expression from TISSUES for S1PR1 Gene

  • Nervous system(4.8)
  • Heart(4.7)
  • Lung(4.5)
  • Lymph node(2.7)
  • Muscle(2.6)
  • Spleen(2.6)
  • Blood(2.5)
  • Intestine(2)
genes like me logo Genes that share expression patterns with S1PR1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for S1PR1 Gene

Orthologs for S1PR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for S1PR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia S1PR1 34 33
  • 99.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia S1PR1 34 33
  • 92.23 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia S1PR1 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia S1PR1 34 33
  • 90.75 (n)
OneToOne
mouse
(Mus musculus)
Mammalia S1pr1 16 34 33
  • 88.13 (n)
rat
(Rattus norvegicus)
Mammalia S1pr1 33
  • 87.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia S1PR1 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves S1PR1 34 33
  • 75.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia S1PR1 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia s1pr1 33
  • 69.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5574 33
zebrafish
(Danio rerio)
Actinopterygii s1pr1 34 33
  • 70.79 (n)
OneToOne
edg1 33
Species where no ortholog for S1PR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for S1PR1 Gene

ENSEMBL:
Gene Tree for S1PR1 (if available)
TreeFam:
Gene Tree for S1PR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for S1PR1: view image

Paralogs for S1PR1 Gene

Paralogs for S1PR1 Gene

(9) SIMAP similar genes for S1PR1 Gene using alignment to 1 proteins:

  • S1PR1_HUMAN
genes like me logo Genes that share paralogs with S1PR1: view

Variants for S1PR1 Gene

Sequence variations from dbSNP and Humsavar for S1PR1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000325160 -- 101,238,370(+) A/G intron_variant
rs1000648737 -- 101,237,667(+) G/A intron_variant
rs1000676695 -- 101,237,908(+) A/G intron_variant
rs1001562306 -- 101,238,277(+) G/A intron_variant
rs1001601173 -- 101,237,142(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for S1PR1 Gene

Variant ID Type Subtype PubMed ID
esv3586963 CNV gain 21293372

Variation tolerance for S1PR1 Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for S1PR1 Gene

Human Gene Mutation Database (HGMD)
S1PR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
S1PR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for S1PR1 Gene

Disorders for S1PR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for S1PR1 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
autoimmune encephalitis
  • hashimoto's encephalitis
- elite association - COSMIC cancer census association via MalaCards
Search S1PR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for S1PR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with S1PR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for S1PR1 Gene

Publications for S1PR1 Gene

  1. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. (PMID: 2160972) Hla T … Maciag T (The Journal of biological chemistry 1990) 2 3 4 22 58
  2. Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids. (PMID: 19286607) Singleton PA … Birukov KG (Circulation research 2009) 3 4 22 58
  3. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. (PMID: 11230698) Hobson JP … Spiegel S (Science (New York, N.Y.) 2001) 3 4 22 58
  4. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. (PMID: 10383399) Ancellin N … Hla T (The Journal of biological chemistry 1999) 3 4 22 58
  5. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. (PMID: 9488656) Lee MJ … Hla T (Science (New York, N.Y.) 1998) 2 3 4 58

Products for S1PR1 Gene

  • Addgene plasmids for S1PR1

Sources for S1PR1 Gene

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